DOI: 10.1016/0006-2952(93)90222-i. Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo

Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo

10.1016/0006-2952(93)90222-i

Crossref journal-article

Elsevier BV

Biochemical Pharmacology (78)

Bibliography

Waldmeier, P. C., Buchle, A.-M., & Steulet, A.-F. (1993). Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo. Biochemical Pharmacology, 45(12), 2417â2424.

Authors 3

Peter C. Waldmeier (first)
Anne-Marthe Buchle (additional)
Anne-Françoise Steulet (additional)

References 29 Referenced 42

10.1016/S0950-3536(89)80018-6 / Bailliere's Clin Haematol / The development of iron chelating drugs by Porter (1989)
10.1136/bmj.303.6813.1279 / Br Med J / Oral iron chelation is here by Kontoghiorghes (1991)
10.1182/blood.V79.7.1882.1882 / Blood / A comparison of the iron-clearing properties of 1,2-dimethyl-3-hydroxypirid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one, and deferox-amine by Bergeron (1992)
10.1021/jm00263a047 / J Med Chem / Catechol-O-methyltransferase. 4. In vitro inhibition by 3-hydroxy-4-pyrones, 3-hydroxy-2-pyridones, 3-hydroxy-4-pyridones by Borchardt (1973)
10.1111/j.1600-0773.1990.tb00756.x / Pharmacol Toxicol / Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease by Männistö (1990)
10.1111/j.1471-4159.1989.tb09133.x / J Neurochem / Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease by Dexter (1989)
10.1111/j.1471-4159.1989.tb07264.x / J Neurochem / Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease by Dexter (1989)
10.1111/j.1471-4159.1991.tb02017.x / J Neurochem / Selective increase of iron in substantia nigra zona compacta of parkinsonian brains by Sofic (1991)
10.1038/334345a0 / Nature / Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease by Hirsch (1988)
10.1111/j.1471-4159.1991.tb06358.x / J Neurochem / Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease by Ben-Shachar (1991)
10.1002/ana.410320718 / Ann Neurol / Role of iron and iron chelation in dopaminergic-induced neurodegeneration: implication for Parkinson's disease by Ben-Shachar (1992)
{'key': '10.1016/0006-2952(93)90222-I_BIB12', 'first-page': '241', 'article-title': 'Further studies on generation of hydrogen peroxide by 6-hydroxy-dopamine: potentiation by ascorbic acid', 'volume': '8', 'author': 'Heikkila', 'year': '1972', 'journal-title': 'Mol Pharmacol'} / Mol Pharmacol / Further studies on generation of hydrogen peroxide by 6-hydroxy-dopamine: potentiation by ascorbic acid by Heikkila (1972)
{'key': '10.1016/0006-2952(93)90222-I_BIB13', 'first-page': '1', 'article-title': 'Mechanism of action of 6-hydroxydopamine', 'volume': '24', 'author': 'Sachs', 'year': '1975', 'journal-title': 'Pharmacology'} / Pharmacology / Mechanism of action of 6-hydroxydopamine by Sachs (1975)
{'key': '10.1016/0006-2952(93)90222-I_BIB14', 'first-page': '644', 'article-title': 'Autooxidation versus covalent binding quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds towards C1300 neuroblastoma cells in vitro', 'volume': '14', 'author': 'Graham', 'year': '1978', 'journal-title': 'Mol Pharmacol'} / Mol Pharmacol / Autooxidation versus covalent binding quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds towards C1300 neuroblastoma cells in vitro by Graham (1978)
{'key': '10.1016/0006-2952(93)90222-I_BIB15', 'first-page': '427', 'article-title': 'The role of tyrosine hydroxylase in the regulation of catecholamine synthesis', 'volume': 'Vol. 90/II', 'author': 'Masserano', 'year': '1989'} / The role of tyrosine hydroxylase in the regulation of catecholamine synthesis by Masserano (1989)
10.1016/0006-2952(69)90083-5 / Biochem Pharmacol / Tyrosine hydroxylase inhibition in vitro and in vivo by chelating agents by Taylor (1969)
{'key': '10.1016/0006-2952(93)90222-I_BIB17', 'series-title': 'Metabolism of Aromatic Amino Acids and Amines', 'first-page': '83', 'article-title': 'Tryptophan 5-mono-oxygenase fom rat brain stem', 'volume': 'Vol. 142', 'author': 'Fujisawa', 'year': '1987'} / Metabolism of Aromatic Amino Acids and Amines / Tryptophan 5-mono-oxygenase fom rat brain stem by Fujisawa (1987)
10.1007/BF01244661 / J Neural Transm / In vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain by Carlsson (1973)
10.1007/BF00169442 / Naunyn Schmiedebergs Arch Pharmacol / CGP 28014, a new inhibitor of cerebral catechoi-O-methylation with a non-catechol structure by Waldmeier (1990)
10.1007/BF00256471 / Eur J Nucl Med / Tropolone: a lipid solubilizing agent for cationic metals by Hendershott (1982)
{'key': '10.1016/0006-2952(93)90222-I_BIB21', 'first-page': '256', 'article-title': 'Urinary metabolic profiles in man and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones', 'volume': '20', 'author': 'Singh', 'year': '1992', 'journal-title': 'Drug Metab Dispos'} / Drug Metab Dispos / Urinary metabolic profiles in man and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones by Singh (1992)
10.1111/j.1471-4159.1991.tb02098.x / J Neurochem / Conversion of tyrosine hydroxylase to stable and inactive form by the end products by Okuno (1991)
10.1016/0006-2952(91)90636-J / Biochem Pharmacol / Inhibition of tryptophan hydroxylase by benserazide and other catechols by Johansen (1991)
10.1016/S0021-9258(18)37330-7 / J Biol Chem / Resonance raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase) by Andersson (1988)
10.1021/jm00313a013 / J Med Chem / Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase by De Graw (1967)
10.1016/0024-3205(65)90025-1 / Life Sci / Inhibition of rat liver tryptophan hydroxylase in vitro by Fuller (1965)
10.1097/00002826-199012000-00009 / Clin Neuropharmacol / Acute dystonic reaction in normal humans caused by catecholamine depletion by McCann (1990)
10.1172/JCI105754 / J Clin Invest / Biochemical and pharmacologic effects of alpha-methyl-para-tyrosine in man by Engelman (1968)
10.1016/0006-3223(91)90299-2 / Biol Psychiatry / Panic attacks in healthy volunteers treated with a catecholamine synthesis inhibitor by McCann (1991)

Dates

Type	When
Created	22 years, 8 months ago (Dec. 13, 2002, 5:04 p.m.)
Deposited	4 years, 2 months ago (June 1, 2021, 8:55 a.m.)
Indexed	11 months, 1 week ago (Sept. 15, 2024, 8:55 p.m.)
Issued	32 years, 2 months ago (June 1, 1993)
Published	32 years, 2 months ago (June 1, 1993)
Published Print	32 years, 2 months ago (June 1, 1993)

Funders 0

None

BibTeX

@article{Waldmeier_1993, title={Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo}, volume={45}, ISSN={0006-2952}, url={http://dx.doi.org/10.1016/0006-2952(93)90222-i}, DOI={10.1016/0006-2952(93)90222-i}, number={12}, journal={Biochemical Pharmacology}, publisher={Elsevier BV}, author={Waldmeier, Peter C. and Buchle, Anne-Marthe and Steulet, Anne-Françoise}, year={1993}, month=jun, pages={2417–2424} }

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  "container-title-short": "Biochemical Pharmacology",
  "published": {
    "date-parts": [
      [
        1993,
        6
      ]
    ]
  }
}