DOI: 10.1007/s12195-010-0102-6. Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact

Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact

10.1007/s12195-010-0102-6

Crossref journal-article

Springer Science and Business Media LLC

Cellular and Molecular Bioengineering (297)

Bibliography

Califano, J. P., & Reinhart-King, C. A. (2010). Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact. Cellular and Molecular Bioengineering, 3(1), 68â75.

Authors 2

Joseph P. Califano (first)
Cynthia A. Reinhart-King (additional)

References 33 Referenced 290

An, S. S., et al. Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am. J. Respir. Cell Mol. Biol. 35(1):55–64, 2006. (10.1165/rcmb.2005-0453OC) / Am. J. Respir. Cell Mol. Biol. by SS An (2006)
Califano, J. P., and C. A. Reinhart-King. A balance of substrate mechanics and matrix chemistry regulates endothelial cell network assembly. Cel. Mol. Bioeng. 1(2–3):122–132, 2008. (10.1007/s12195-008-0022-x) / Cel. Mol. Bioeng. by JP Califano (2008)
Califano, J. P., and C. A. Reinhart-King. Exogenous and endogenous force regulation of endothelial cell behavior. J. Biomech., 2009. doi: 10.1016/j.jbiomech.2009.09.012 . (10.1016/j.jbiomech.2009.09.012)
Chen, C. S. Mechanotransduction—a field pulling together? J. Cell Sci. 121(Pt 20):3285–3292, 2008. (10.1242/jcs.023507) / J. Cell Sci. by CS Chen (2008)
Dembo, M., et al. Imaging the traction stresses exerted by locomoting cells with the elastic substratum method. Biophys. J. 70(4):2008–2022, 1996. (10.1016/S0006-3495(96)79767-9) / Biophys. J. by M Dembo (1996)
Dembo, M., and Y. L. Wang. Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys. J. 76(4):2307–2316, 1999. (10.1016/S0006-3495(99)77386-8) / Biophys. J. by M Dembo (1999)
du Roure, O., et al. Force mapping in epithelial cell migration. Proc. Natl Acad. Sci. USA 102(7):2390–2395, 2005. (10.1073/pnas.0408482102) / Proc. Natl Acad. Sci. USA by O du Roure (2005)
Engler, A., et al. Substrate compliance versus ligand density in cell on gel responses. Biophys. J. 86(1 Pt 1):617–628, 2004. (10.1016/S0006-3495(04)74140-5) / Biophys. J. by A Engler (2004)
Engler, A., L. Richert, J. Wong, C. Picart, and D. Discher. Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion. Surf. Sci. 570:142–154, 2004. (10.1016/j.susc.2004.06.179) / Surf. Sci. by A Engler (2004)
Georges, P. C., and P. A. Janmey. Cell type-specific response to growth on soft materials. J. Appl. Physiol. 98(4):1547–1553, 2005. (10.1152/japplphysiol.01121.2004) / J. Appl. Physiol. by PC Georges (2005)
Guo, W. H., et al. Substrate rigidity regulates the formation and maintenance of tissues. Biophys. J. 90(6):2213–2220, 2006. (10.1529/biophysj.105.070144) / Biophys. J. by WH Guo (2006)
Lemmon, C. A., C. S. Chen, and L. H. Romer. Cell traction forces direct fibronectin matrix assembly. Biophys. J. 96(2):729–738, 2009. (10.1016/j.bpj.2008.10.009) / Biophys. J. by CA Lemmon (2009)
Lemmon, C. A., et al. Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mech. Chem. Biosyst. 2(1):1–16, 2005. / Mech. Chem. Biosyst. by CA Lemmon (2005)
Li, B., et al. Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude. J. Biomech. 42(11):1622–1627, 2009. (10.1016/j.jbiomech.2009.04.033) / J. Biomech. by B Li (2009)
Li, Y., Z. B. Hu, and C. F. Li. New method for measuring poisson ratio in polymer gels. J. Appl. Polym. Sci. 50(6):1107–1111, 1993. (10.1002/app.1993.070500619) / J. Appl. Polym. Sci. by Y Li (1993)
Lo, C. M., et al. Cell movement is guided by the rigidity of the substrate. Biophys. J. 79(1):144–152, 2000. (10.1016/S0006-3495(00)76279-5) / Biophys. J. by CM Lo (2000)
Marganski, W. A., M. Dembo, and Y. L. Wang. Measurements of cell-generated deformations on flexible substrata using correlation-based optical flow. Methods Enzymol. 361:197–211, 2003. (10.1016/S0076-6879(03)61012-8) / Methods Enzymol. by WA Marganski (2003)
Munevar, S., Y. Wang, and M. Dembo. Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts. Biophys. J. 80(4):1744–1757, 2001. (10.1016/S0006-3495(01)76145-0) / Biophys. J. by S Munevar (2001)
Nelson, C. M., et al. Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl Acad. Sci. USA 102(33):11594–11599, 2005. (10.1073/pnas.0502575102) / Proc. Natl Acad. Sci. USA by CM Nelson (2005)
Ott, R. L., and M. Longnecker. An Introduction to Statistical Methods and Data Analysis. Pacific Grove, CA: Duxbury Press, 2001, 1184 pp.
Paszek, M. J., and V. M. Weaver. The tension mounts: mechanics meets morphogenesis and malignancy. J. Mammary Gland. Biol. Neoplasia 9(4):325–342, 2004. (10.1007/s10911-004-1404-x) / J. Mammary Gland. Biol. Neoplasia by MJ Paszek (2004)
Paszek, M. J., et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241–254, 2005. (10.1016/j.ccr.2005.08.010) / Cancer Cell by MJ Paszek (2005)
Pless, D. D., et al. Specific cell adhesion to immobilized glycoproteins demonstrated using new reagents for protein and glycoprotein immobilization. J. Biol. Chem. 258(4):2340–2349, 1983. (10.1016/S0021-9258(18)32929-6) / J. Biol. Chem. by DD Pless (1983)
Reinhart-King, C. A. Endothelial cell adhesion and migration. Methods Enzymol. 443:45–64, 2008. (10.1016/S0076-6879(08)02003-X) / Methods Enzymol. by CA Reinhart-King (2008)
Reinhart-King, C. A., M. Dembo, and D. A. Hammer. Endothelial cell traction forces on RGD-derivatized polyacrylamide substrata. Langmuir 19(5):1573–1579, 2003. (10.1021/la026142j) / Langmuir by CA Reinhart-King (2003)
Reinhart-King, C. A., M. Dembo, and D. A. Hammer. The dynamics and mechanics of endothelial cell spreading. Biophys. J. 89(1):676–689, 2005. (10.1529/biophysj.104.054320) / Biophys. J. by CA Reinhart-King (2005)
Reinhart-King, C. A., M. Dembo, and D. A. Hammer. Cell-cell mechanical communication through compliant substrates. Biophys. J. 95(12):6044–6051, 2008. (10.1529/biophysj.107.127662) / Biophys. J. by CA Reinhart-King (2008)
Tsai, J., and L. Kam. Rigidity-dependent cross talk between integrin and cadherin signaling. Biophys. J. 96(6):L39–L41, 2009. (10.1016/j.bpj.2009.01.005) / Biophys. J. by J Tsai (2009)
Wang, N., et al. Micropatterning tractional forces in living cells. Cell Motil. Cytoskeleton 52(2):97–106, 2002. (10.1002/cm.10037) / Cell Motil. Cytoskeleton by N Wang (2002)
Wang, Y., et al. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc. Natl Acad. Sci. USA 103(6):1774–1779, 2006. (10.1073/pnas.0510774103) / Proc. Natl Acad. Sci. USA by Y Wang (2006)
Wang, Y. L., and R. J. Pelham, Jr. Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells. Methods Enzymol. 298:489–496, 1998. (10.1016/S0076-6879(98)98041-7) / Methods Enzymol. by YL Wang (1998)
Yeung, T., et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil. Cytoskeleton 60(1):24–34, 2005. (10.1002/cm.20041) / Cell Motil. Cytoskeleton by T Yeung (2005)
Zemel, A., and S. A. Safran. Active self-polarization of contractile cells in asymmetrically shaped domains. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(2 Pt 1):021905, 2007. (10.1103/PhysRevE.76.021905) / Phys. Rev. E Stat. Nonlin. Soft Matter Phys. by A Zemel (2007)

Dates

Type	When
Created	15 years, 6 months ago (Feb. 5, 2010, 11:46 a.m.)
Deposited	3 years, 10 months ago (Oct. 22, 2021, 6:57 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 7, 2025, 4:57 a.m.)
Issued	15 years, 6 months ago (Feb. 6, 2010)
Published	15 years, 6 months ago (Feb. 6, 2010)
Published Online	15 years, 6 months ago (Feb. 6, 2010)
Published Print	15 years, 5 months ago (March 1, 2010)

Funders 0

None

BibTeX

@article{Califano_2010, title={Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact}, volume={3}, ISSN={1865-5033}, url={http://dx.doi.org/10.1007/s12195-010-0102-6}, DOI={10.1007/s12195-010-0102-6}, number={1}, journal={Cellular and Molecular Bioengineering}, publisher={Springer Science and Business Media LLC}, author={Califano, Joseph P. and Reinhart-King, Cynthia A.}, year={2010}, month=feb, pages={68–75} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        7
      ]
    ],
    "date-time": "2025-08-07T08:57:58Z",
    "timestamp": 1754557078118
  },
  "reference-count": 33,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2010,
            2,
            6
          ]
        ],
        "date-time": "2010-02-06T00:00:00Z",
        "timestamp": 1265414400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2010,
        3
      ]
    ]
  },
  "DOI": "10.1007/s12195-010-0102-6",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        2,
        5
      ]
    ],
    "date-time": "2010-02-05T16:46:42Z",
    "timestamp": 1265388402000
  },
  "page": "68-75",
  "source": "Crossref",
  "is-referenced-by-count": 290,
  "title": "Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact",
  "prefix": "10.1007",
  "volume": "3",
  "author": [
    {
      "given": "Joseph P.",
      "family": "Califano",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Cynthia A.",
      "family": "Reinhart-King",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2010,
        2,
        6
      ]
    ]
  },
  "reference": [
    {
      "issue": "1",
      "key": "102_CR1",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1165/rcmb.2005-0453OC",
      "volume": "35",
      "author": "SS An",
      "year": "2006",
      "unstructured": "An, S. S., et al. Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am. J. Respir. Cell Mol. Biol. 35(1):55\u201364, 2006.",
      "journal-title": "Am. J. Respir. Cell Mol. Biol."
    },
    {
      "issue": "2\u20133",
      "key": "102_CR2",
      "doi-asserted-by": "crossref",
      "first-page": "122",
      "DOI": "10.1007/s12195-008-0022-x",
      "volume": "1",
      "author": "JP Califano",
      "year": "2008",
      "unstructured": "Califano, J. P., and C. A. Reinhart-King. A balance of substrate mechanics and matrix chemistry regulates endothelial cell network assembly. Cel. Mol. Bioeng. 1(2\u20133):122\u2013132, 2008.",
      "journal-title": "Cel. Mol. Bioeng."
    },
    {
      "key": "102_CR3",
      "doi-asserted-by": "crossref",
      "unstructured": "Califano, J. P., and C. A. Reinhart-King. Exogenous and endogenous force regulation of endothelial cell behavior. J. Biomech., 2009. doi: 10.1016/j.jbiomech.2009.09.012 .",
      "DOI": "10.1016/j.jbiomech.2009.09.012"
    },
    {
      "issue": "Pt 20",
      "key": "102_CR4",
      "doi-asserted-by": "crossref",
      "first-page": "3285",
      "DOI": "10.1242/jcs.023507",
      "volume": "121",
      "author": "CS Chen",
      "year": "2008",
      "unstructured": "Chen, C. S. Mechanotransduction\u2014a field pulling together? J. Cell Sci. 121(Pt 20):3285\u20133292, 2008.",
      "journal-title": "J. Cell Sci."
    },
    {
      "issue": "4",
      "key": "102_CR5",
      "doi-asserted-by": "crossref",
      "first-page": "2008",
      "DOI": "10.1016/S0006-3495(96)79767-9",
      "volume": "70",
      "author": "M Dembo",
      "year": "1996",
      "unstructured": "Dembo, M., et al. Imaging the traction stresses exerted by locomoting cells with the elastic substratum method. Biophys. J. 70(4):2008\u20132022, 1996.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "4",
      "key": "102_CR6",
      "doi-asserted-by": "crossref",
      "first-page": "2307",
      "DOI": "10.1016/S0006-3495(99)77386-8",
      "volume": "76",
      "author": "M Dembo",
      "year": "1999",
      "unstructured": "Dembo, M., and Y. L. Wang. Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys. J. 76(4):2307\u20132316, 1999.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "7",
      "key": "102_CR7",
      "doi-asserted-by": "crossref",
      "first-page": "2390",
      "DOI": "10.1073/pnas.0408482102",
      "volume": "102",
      "author": "O du Roure",
      "year": "2005",
      "unstructured": "du Roure, O., et al. Force mapping in epithelial cell migration. Proc. Natl Acad. Sci. USA 102(7):2390\u20132395, 2005.",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "issue": "1 Pt 1",
      "key": "102_CR8",
      "doi-asserted-by": "crossref",
      "first-page": "617",
      "DOI": "10.1016/S0006-3495(04)74140-5",
      "volume": "86",
      "author": "A Engler",
      "year": "2004",
      "unstructured": "Engler, A., et al. Substrate compliance versus ligand density in cell on gel responses. Biophys. J. 86(1 Pt 1):617\u2013628, 2004.",
      "journal-title": "Biophys. J."
    },
    {
      "key": "102_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "142",
      "DOI": "10.1016/j.susc.2004.06.179",
      "volume": "570",
      "author": "A Engler",
      "year": "2004",
      "unstructured": "Engler, A., L. Richert, J. Wong, C. Picart, and D. Discher. Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion. Surf. Sci. 570:142\u2013154, 2004.",
      "journal-title": "Surf. Sci."
    },
    {
      "issue": "4",
      "key": "102_CR10",
      "doi-asserted-by": "crossref",
      "first-page": "1547",
      "DOI": "10.1152/japplphysiol.01121.2004",
      "volume": "98",
      "author": "PC Georges",
      "year": "2005",
      "unstructured": "Georges, P. C., and P. A. Janmey. Cell type-specific response to growth on soft materials. J. Appl. Physiol. 98(4):1547\u20131553, 2005.",
      "journal-title": "J. Appl. Physiol."
    },
    {
      "issue": "6",
      "key": "102_CR11",
      "doi-asserted-by": "crossref",
      "first-page": "2213",
      "DOI": "10.1529/biophysj.105.070144",
      "volume": "90",
      "author": "WH Guo",
      "year": "2006",
      "unstructured": "Guo, W. H., et al. Substrate rigidity regulates the formation and maintenance of tissues. Biophys. J. 90(6):2213\u20132220, 2006.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "2",
      "key": "102_CR12",
      "doi-asserted-by": "crossref",
      "first-page": "729",
      "DOI": "10.1016/j.bpj.2008.10.009",
      "volume": "96",
      "author": "CA Lemmon",
      "year": "2009",
      "unstructured": "Lemmon, C. A., C. S. Chen, and L. H. Romer. Cell traction forces direct fibronectin matrix assembly. Biophys. J. 96(2):729\u2013738, 2009.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "1",
      "key": "102_CR13",
      "first-page": "1",
      "volume": "2",
      "author": "CA Lemmon",
      "year": "2005",
      "unstructured": "Lemmon, C. A., et al. Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mech. Chem. Biosyst. 2(1):1\u201316, 2005.",
      "journal-title": "Mech. Chem. Biosyst."
    },
    {
      "issue": "11",
      "key": "102_CR14",
      "doi-asserted-by": "crossref",
      "first-page": "1622",
      "DOI": "10.1016/j.jbiomech.2009.04.033",
      "volume": "42",
      "author": "B Li",
      "year": "2009",
      "unstructured": "Li, B., et al. Spatial patterning of cell proliferation and differentiation depends on mechanical stress magnitude. J. Biomech. 42(11):1622\u20131627, 2009.",
      "journal-title": "J. Biomech."
    },
    {
      "issue": "6",
      "key": "102_CR15",
      "doi-asserted-by": "crossref",
      "first-page": "1107",
      "DOI": "10.1002/app.1993.070500619",
      "volume": "50",
      "author": "Y Li",
      "year": "1993",
      "unstructured": "Li, Y., Z. B. Hu, and C. F. Li. New method for measuring poisson ratio in polymer gels. J. Appl. Polym. Sci. 50(6):1107\u20131111, 1993.",
      "journal-title": "J. Appl. Polym. Sci."
    },
    {
      "issue": "1",
      "key": "102_CR16",
      "doi-asserted-by": "crossref",
      "first-page": "144",
      "DOI": "10.1016/S0006-3495(00)76279-5",
      "volume": "79",
      "author": "CM Lo",
      "year": "2000",
      "unstructured": "Lo, C. M., et al. Cell movement is guided by the rigidity of the substrate. Biophys. J. 79(1):144\u2013152, 2000.",
      "journal-title": "Biophys. J."
    },
    {
      "key": "102_CR17",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1016/S0076-6879(03)61012-8",
      "volume": "361",
      "author": "WA Marganski",
      "year": "2003",
      "unstructured": "Marganski, W. A., M. Dembo, and Y. L. Wang. Measurements of cell-generated deformations on flexible substrata using correlation-based optical flow. Methods Enzymol. 361:197\u2013211, 2003.",
      "journal-title": "Methods Enzymol."
    },
    {
      "issue": "4",
      "key": "102_CR18",
      "doi-asserted-by": "crossref",
      "first-page": "1744",
      "DOI": "10.1016/S0006-3495(01)76145-0",
      "volume": "80",
      "author": "S Munevar",
      "year": "2001",
      "unstructured": "Munevar, S., Y. Wang, and M. Dembo. Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts. Biophys. J. 80(4):1744\u20131757, 2001.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "33",
      "key": "102_CR19",
      "doi-asserted-by": "crossref",
      "first-page": "11594",
      "DOI": "10.1073/pnas.0502575102",
      "volume": "102",
      "author": "CM Nelson",
      "year": "2005",
      "unstructured": "Nelson, C. M., et al. Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl Acad. Sci. USA 102(33):11594\u201311599, 2005.",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "102_CR20",
      "unstructured": "Ott, R. L., and M. Longnecker. An Introduction to Statistical Methods and Data Analysis. Pacific Grove, CA: Duxbury Press, 2001, 1184\u00a0pp."
    },
    {
      "issue": "4",
      "key": "102_CR21",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1007/s10911-004-1404-x",
      "volume": "9",
      "author": "MJ Paszek",
      "year": "2004",
      "unstructured": "Paszek, M. J., and V. M. Weaver. The tension mounts: mechanics meets morphogenesis and malignancy. J. Mammary Gland. Biol. Neoplasia 9(4):325\u2013342, 2004.",
      "journal-title": "J. Mammary Gland. Biol. Neoplasia"
    },
    {
      "issue": "3",
      "key": "102_CR22",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/j.ccr.2005.08.010",
      "volume": "8",
      "author": "MJ Paszek",
      "year": "2005",
      "unstructured": "Paszek, M. J., et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241\u2013254, 2005.",
      "journal-title": "Cancer Cell"
    },
    {
      "issue": "4",
      "key": "102_CR23",
      "doi-asserted-by": "crossref",
      "first-page": "2340",
      "DOI": "10.1016/S0021-9258(18)32929-6",
      "volume": "258",
      "author": "DD Pless",
      "year": "1983",
      "unstructured": "Pless, D. D., et al. Specific cell adhesion to immobilized glycoproteins demonstrated using new reagents for protein and glycoprotein immobilization. J. Biol. Chem. 258(4):2340\u20132349, 1983.",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "102_CR24",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/S0076-6879(08)02003-X",
      "volume": "443",
      "author": "CA Reinhart-King",
      "year": "2008",
      "unstructured": "Reinhart-King, C. A. Endothelial cell adhesion and migration. Methods Enzymol. 443:45\u201364, 2008.",
      "journal-title": "Methods Enzymol."
    },
    {
      "issue": "5",
      "key": "102_CR25",
      "doi-asserted-by": "crossref",
      "first-page": "1573",
      "DOI": "10.1021/la026142j",
      "volume": "19",
      "author": "CA Reinhart-King",
      "year": "2003",
      "unstructured": "Reinhart-King, C. A., M. Dembo, and D. A. Hammer. Endothelial cell traction forces on RGD-derivatized polyacrylamide substrata. Langmuir 19(5):1573\u20131579, 2003.",
      "journal-title": "Langmuir"
    },
    {
      "issue": "1",
      "key": "102_CR26",
      "doi-asserted-by": "crossref",
      "first-page": "676",
      "DOI": "10.1529/biophysj.104.054320",
      "volume": "89",
      "author": "CA Reinhart-King",
      "year": "2005",
      "unstructured": "Reinhart-King, C. A., M. Dembo, and D. A. Hammer. The dynamics and mechanics of endothelial cell spreading. Biophys. J. 89(1):676\u2013689, 2005.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "12",
      "key": "102_CR27",
      "doi-asserted-by": "crossref",
      "first-page": "6044",
      "DOI": "10.1529/biophysj.107.127662",
      "volume": "95",
      "author": "CA Reinhart-King",
      "year": "2008",
      "unstructured": "Reinhart-King, C. A., M. Dembo, and D. A. Hammer. Cell-cell mechanical communication through compliant substrates. Biophys. J. 95(12):6044\u20136051, 2008.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "6",
      "key": "102_CR28",
      "doi-asserted-by": "crossref",
      "first-page": "L39",
      "DOI": "10.1016/j.bpj.2009.01.005",
      "volume": "96",
      "author": "J Tsai",
      "year": "2009",
      "unstructured": "Tsai, J., and L. Kam. Rigidity-dependent cross talk between integrin and cadherin signaling. Biophys. J. 96(6):L39\u2013L41, 2009.",
      "journal-title": "Biophys. J."
    },
    {
      "issue": "2",
      "key": "102_CR29",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1002/cm.10037",
      "volume": "52",
      "author": "N Wang",
      "year": "2002",
      "unstructured": "Wang, N., et al. Micropatterning tractional forces in living cells. Cell Motil. Cytoskeleton 52(2):97\u2013106, 2002.",
      "journal-title": "Cell Motil. Cytoskeleton"
    },
    {
      "issue": "6",
      "key": "102_CR30",
      "doi-asserted-by": "crossref",
      "first-page": "1774",
      "DOI": "10.1073/pnas.0510774103",
      "volume": "103",
      "author": "Y Wang",
      "year": "2006",
      "unstructured": "Wang, Y., et al. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc. Natl Acad. Sci. USA 103(6):1774\u20131779, 2006.",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "102_CR31",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1016/S0076-6879(98)98041-7",
      "volume": "298",
      "author": "YL Wang",
      "year": "1998",
      "unstructured": "Wang, Y. L., and R. J. Pelham, Jr. Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells. Methods Enzymol. 298:489\u2013496, 1998.",
      "journal-title": "Methods Enzymol."
    },
    {
      "issue": "1",
      "key": "102_CR32",
      "doi-asserted-by": "crossref",
      "first-page": "24",
      "DOI": "10.1002/cm.20041",
      "volume": "60",
      "author": "T Yeung",
      "year": "2005",
      "unstructured": "Yeung, T., et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil. Cytoskeleton 60(1):24\u201334, 2005.",
      "journal-title": "Cell Motil. Cytoskeleton"
    },
    {
      "issue": "2 Pt 1",
      "key": "102_CR33",
      "doi-asserted-by": "crossref",
      "first-page": "021905",
      "DOI": "10.1103/PhysRevE.76.021905",
      "volume": "76",
      "author": "A Zemel",
      "year": "2007",
      "unstructured": "Zemel, A., and S. A. Safran. Active self-polarization of contractile cells in asymmetrically shaped domains. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(2 Pt 1):021905, 2007.",
      "journal-title": "Phys. Rev. E Stat. Nonlin. Soft Matter Phys."
    }
  ],
  "container-title": "Cellular and Molecular Bioengineering",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://link.springer.com/content/pdf/10.1007/s12195-010-0102-6.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://link.springer.com/article/10.1007/s12195-010-0102-6/fulltext.html",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://link.springer.com/content/pdf/10.1007/s12195-010-0102-6",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        10,
        22
      ]
    ],
    "date-time": "2021-10-22T10:57:18Z",
    "timestamp": 1634900238000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://link.springer.com/10.1007/s12195-010-0102-6"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2010,
        2,
        6
      ]
    ]
  },
  "references-count": 33,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2010,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "102"
  ],
  "URL": "http://dx.doi.org/10.1007/s12195-010-0102-6",
  "relation": {},
  "ISSN": [
    "1865-5025",
    "1865-5033"
  ],
  "subject": [],
  "container-title-short": "Cel. Mol. Bioeng.",
  "published": {
    "date-parts": [
      [
        2010,
        2,
        6
      ]
    ]
  }
}