DOI: 10.1007/s11030-005-1314-x. What can a chemist learn from nature?s macrocycles? ? A brief, conceptual view

What can a chemist learn from nature?s macrocycles? ? A brief, conceptual view

10.1007/s11030-005-1314-x

Crossref journal-article

Springer Science and Business Media LLC

Molecular Diversity (297)

Bibliography

Wessjohann, L. A., Ruijter, E., Garcia-Rivera, D., & Brandt, W. (2005). What can a chemist learn from nature?s macrocycles?â¯? A brief, conceptual view. Molecular Diversity, 9(1â3), 171â186.

Authors 4

Ludger A. Wessjohann (first)
Eelco Ruijter (additional)
Daniel Garcia-Rivera (additional)
Wolfganf Brandt (additional)

References 103 Referenced 202

Newman, D.J., Cragg, G.M. and Snader, K.M., Natural products as sources of new drugs over the period 1981?2002, J. Nat. Prod., 66 (2003) 1022?1037. (10.1021/np030096l) / J. Nat. Prod. by D.J. Newman (2003)
Rouhi, A.M., Rediscovering natural products, Chem. Eng., (2003) 77?107. (10.1021/cen-v081n041.p077)
Wessjohann, L.A. and Ruijter, E., Total and diversity-oriented synthesis of natural product(-like) macrocycles, in Mulzer, J.H. (Ed.) Topics in Current Chemistry, Vol. 243: Springer, Heidelberg, 2004, pp. 137?184. / Topics in Current Chemistry, Vol. 243 by L.A. Wessjohann (2004)
Henkel, T., Brunne, R.M., Mueller, H. and Reichel, F., Statistical investigation into the structural complementarity of natural products and synthetic compounds, Angew. Chem., 111 (1999) 688?691; Angew. Chem. Int. Ed., 38 (1999) 643?647. (10.1002/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO;2-G) / Angew. Chem. Int. Ed., 111 (1999) 688?691; Angew. Chem. Int. Ed. by T. Henkel (1999)
Feher, M. and Schmidt, J.M., Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry, J. Chem. Inf. Comput. Sci., 43 (2003) 218?227. (10.1021/ci0200467) / J. Chem. Inf. Comput. Sci. by M. Feher (2003)
Link, A., Ma�geschneiderte Nadeln aus dem kombinatorischen Heuh-aufen, Pharmazeutische Zeitung, (2001) 3760?3766.
Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv. Drug Delivery Rev., 46 (1997) 3?25. (10.1016/S0169-409X(00)00129-0) / Adv. Drug Delivery Rev. by C.A. Lipinski (1997)
Lee, M.-L. and Schneider, G., Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries, J. Comb. Chem., 3 (2001) 284?289. (10.1021/cc000097l) / J. Comb. Chem. by M.-L. Lee (2001)
Nielsen, J., Combinatorial synthesis of natural products, Curr. Opin. Chem. Biol., 6 (2002) 297?305. (10.1016/S1367-5931(02)00330-7) / Curr. Opin. Chem. Biol. by J. Nielsen (2002)
Wessjohann, L.A., Synthesis of natural product-based compound libraries, Curr. Opin. Chem. Biol., 4 (2000) 303?309. (10.1016/S1367-5931(00)00093-4) / Curr. Opin. Chem. Biol. by L.A. Wessjohann (2000)
Breinbauer, R., Manger, M., Scheck, M. and Waldmann, H., Natural product guided compound library development, Curr. Med. Chem., 9 (2002) 2129?2145. (10.2174/0929867023368773) / Curr. Med. Chem. by R. Breinbauer (2002)
Breinbauer, R., Vetter, I.R. and Waldmann, H., Von Proteindom�nen zu Wirkstoffkandidaten?Naturstoffe als Leitstrukturen f�r das Design und die Synthese von Substanzbibliotheken, Angew. Chem., 114 (2002) 3002?3015; Angew. Chem. Int. Ed., 41 (2002) 2878?2890. (10.1002/1521-3773(20020816)41:16<2878::AID-ANIE2878>3.0.CO;2-B) / Angew. Chem., 114 (2002) 3002?3015; Angew. Chem. Int. Ed. by R. Breinbauer (2002)
Stahl, P., Kissau, L., Mazitschek, R., Huwe, A., Furet, P., Giannis, A. and Waldmann, H., Total synthesis and biological evaluation of the nakajiquinones, J. Am. Chem. Soc., 123 (2001) 11586?11593. (10.1021/ja011413i) / J. Am. Chem. Soc. by P. Stahl (2001)
Stahl, P., Kissau, L., Mazitschek, R., Giannis, A. and Waldmann, H., Naturstoffanaloga als Tyrosinkinaseinhibitoren: Identifikation von IGF1R-, Tie-2- und VEGFR-3-Inhibitoren, Angew. Chem., 114 (2002) 1222?1226; Angew. Chem. Int. Ed., 41 (2002) 1174?1178. (10.1002/1521-3773(20020402)41:7<1174::AID-ANIE1174>3.0.CO;2-V) / Angew. Chem., 114 (2002) 1222?1226; Angew. Chem. Int. Ed. by P. Stahl (2002)
Lindsley, C.W., Chan, L.K., Goess, B.C., Joseph, R. and Shair, M.D., Solid-phase biomimetic synthesis of carpanone-like molecules, J. Am. Chem. Soc., 122 (2000) 422?423. (10.1021/ja993674m) / J. Am. Chem. Soc. by C.W. Lindsley (2000)
Corey, E.J. and Cheng, X.-M., The Logic of Chemical Synthesis, 1st edn., John Wiley & Sons, NewYork, 1989. / The Logic of Chemical Synthesis by E.J. Corey (1989)
Nuhn, P., Naturstoffchemie, 3rd edn., S. Hirzel, Leipzig, 1997. / Naturstoffchemie by P. Nuhn (1997)
Nuhn, P. and Wessjohann, L.A., Naturstoffchemie ? Mikrobielle, Pflanzliche und Tierische Naturstoffe, 4th edn., S. Hirzel, Stuttgart, 2005. / Naturstoffchemie ? Mikrobielle, Pflanzliche und Tierische Naturstoffe by P. Nuhn (2005)
Dictionary of Natural Products on CD-ROM, Version 11:2, Chapman & Hall/CRC Press, 2003.
MDL Information Systems GmbH, http://www.beilstein.com/
Schmidt, H., Porzel, A., Wessjohann, L. and Vill, V., Phytobase ? Trademark of the Leibniz-Institute of Plant Biochemistry, Halle (D), http://www.phytobase.de/.
SciDex?Volkmar Vill, LCI-Publisher GmbH, Hamburg (D), http://www.lci-publisher.com/..
Nicolaou, K.C., Boddy, C.N.C., Br�se, S. and Winssinger, N., Chemistry, biology, and medicine of the glycopeptide antibiotics, Angew. Chem., 111 (1999) 2230?2287; Angew. Chem. Int. Ed., 38 (1999) 2096?2152. (10.1002/(SICI)1521-3773(19990802)38:15<2096::AID-ANIE2096>3.0.CO;2-F) / Angew. Chem., 111 (1999) 2230?2287; Angew. Chem. Int. Ed. by K.C. Nicolaou (1999)
Bode, H.B., Bethe, B., Hofs, R. and Zeeck, A., Big effects from small changes: Possible ways to explore nature?s chemical diversity, ChemBioChem, 3 (2002) 619?627. (10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9) / ChemBioChem by H.B. Bode (2002)
Galm, U., Dessoy, M.-A., Schmidt, J., Wessjohann, L.A. and Heide, L., In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach, Chem. Biol., 11 (2004) 173?183. (10.1016/j.chembiol.2004.01.012) / Chem. Biol. by U. Galm (2004)
von Roepenack-Lahaye, E., Degenkolb, T., Zerjeski, M., Franz, M., Roth, U., Wessjohann, L., Schmidt, J., Scheel, D. and Clemens, S., Profiling of arabidopsis secondary metabolites by capillary liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry, Plant Physiol., 134 (2004) 548?559. (10.1104/pp.103.032714) / Plant Physiol. by E. von Roepenack-Lahaye (2004)
Wessjohann, L.A., Brandt, W. and Thiemann, T., Biosynthesis and metabolism of cyclopropane-rings in natural compounds, Chem. Rev., 103 (2003) 1625?1647. (10.1021/cr0100188) / Chem. Rev. by L.A. Wessjohann (2003)
Gournelis, D.C., Laskaris, G.G. and Verpoorte, R., Cyclopeptide alkaloids, Nat. Prod. Rep., 14 (1997) 75?82. (10.1039/np9971400075) / Nat. Prod. Rep. by D.C. Gournelis (1997)
Morel, A.F., Machado, E.C.S., Moreira, J.J., Menezes, A.S., Mostar deiro, M.A. and Wessjohann, L.A., Cyclopeptide alkaloids of Scutia buxifolia (Rhamnaceae), Phytochemistry, 47 (1998) 125?129. (10.1016/S0031-9422(97)00491-3) / Phytochemistry by A.F. Morel (1998)
Hardt, I.H., Steinmetz, H., Gerth, K., Sasse, F., Reichenbach, H. and H�fle, G., New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies, J. Nat. Prod., 64 (2001) 847?856. (10.1021/np000629f) / J. Nat. Prod. by I.H. Hardt (2001)
Wessjohann, L.A., Epothilones: Promising natural products with taxol-like activity, Angew. Chem., 109 (1997) 739?742; Angew. Chem. Int. Ed., (1997) 715?718. (10.1002/ange.19971090707) / Angew. Chem. by L.A. Wessjohann (1997)
Wessjohann, L.A., Scheid, G.O., Bornscheuer, U., Henke, E., Kuit, W. and Orru, R.V.A., Epothilone synthesis components III and IV: Asymmetrically substituted acyloins and acyloin derivatives, method for the production thereof and method for the production of epothilone B, D, and epothilone derivatives, In CAS 136:340534. 2002: Int. Patent Application WO2002/032844A2 (25.04.2002), EP 200111992 (16.10.2001).
Jin, Z., Muscarine, imidazol, oxazole and thiazole alkaloids, Nat. Prod. Rep., 20 (2003) 584?605. (10.1039/b304142p) / Nat. Prod. Rep. by Z. Jin (2003)
F�rstner, A., Total syntheses and biological assessment of macrocyclic glycolipids, Eur. J. Org. Chem., (2004) 943?958. (10.1002/ejoc.200300728)
Bigot, A., Bois-Choussy, M. and Zhu, J., An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I, Tetrahedron Lett., 41 (2000) 4573?4578. (10.1016/S0040-4039(00)00695-X) / Tetrahedron Lett. by A. Bigot (2000)
Marques, M.M.B., Pichlmair, S., Martin, H.J. and Mulzer, J., Stereocontrolled synthesis of C-arylglycosides applied to the south west fragment of the antibiotic kendomycin, Synthesis, (2002) 2766?2770. (10.1055/s-2002-35990)
Martin, H.J., Drescher, M., Kaehlig, H., Schneider, S. and Mulzer, J., Synthesis of the C1?C13 fragment of kendomycin: Atropisomerism around a C-aryl glycoside bond, Angew. Chem., 131 (2001) 3287?3289; Angew. Chem. Int. Ed., 40 (2001) 3186?3188. (10.1002/1521-3773(20010903)40:17<3186::AID-ANIE3186>3.0.CO;2-W) / Angew. Chem., 131 (2001) 3287?3289; Angew. Chem. Int. Ed. by H.J. Martin (2001)
Pichlmair, S., Marques, M.M.B., Green, M.P., Martin, H.J. and Mulzer, J., A novel approach toward the synthesis of kendomycin: Selective synthesis of a C-aryl glycoside as a single atropisomer, Org. Lett., 5 (2003) 4657?4659. (10.1021/ol035846x) / Org. Lett. by S. Pichlmair (2003)
Bode, H.B. and Zeeck, A., Biosynthesis of kendomycin: Origin of the oxygen atoms and further investigations, J. Chem. Soc. Perkin Trans., 1 (2000) 2665?2670. (10.1039/b003362f) / J. Chem. Soc. Perkin Trans. by H.B. Bode (2000)
Bode, H.B. and Zeeck, A., Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces, J. Chem. Soc. Perkin Trans., 1 (2000) 323?328. (10.1039/a908387a) / J. Chem. Soc. Perkin Trans. by H.B. Bode (2000)
Kohli, R.M., Walsh, C.T. and Burkart, M.D., Biomimetic synthesis and optimization of cyclic peptide antibiotics, Nature, 418 (2002) 658?661. (10.1038/nature00907) / Nature by R.M. Kohli (2002)
Kingston, D.G.I., Taxol, a molecule for all seasons, Chem. Commun., (2001) 867?878. (10.1039/b100070p)
Walker, F. and Croteau, R.B., The taxol biosynthetic genes, Phytochemistry, 58 (2001) 1?7. (10.1016/S0031-9422(01)00160-1) / Phytochemistry by F. Walker (2001)
Wessjohann, L.A., The first total syntheses of taxol, Angew. Chem., 106 (1994) 1011?1013; Angew. Chem. Int. Ed. Engl., 33 (1994) 959?961. (10.1002/anie.199409591) / Angew. Chem., 106 (1994) 1011?1013; Angew. Chem. Int. Ed. Engl. by L.A. Wessjohann (1994)
D?Souza, V.T. and Lipkowitz, K.B., Cyclodextrins: Introduction, Chem. Rev., 98 (1998) 1741?1742. (10.1021/cr980027p) / Chem. Rev. by V.T. D?Souza (1998)
Saenger, W., Jacob, J., Gessler, K., Steiner, T., Hoffmann, D., Sanbe, H., Koizumi, K., Smith, S.M. and Takaha, T., Structures of the common cyclodextrins and their larger analogues-beyond the doughnut, Chem. Rev., 98 (1998) 1787?1802. (10.1021/cr9700181) / Chem. Rev. by W. Saenger (1998)
Szejtli, J., Introduction and general overview of cyclodextrin chemistry, Chem. Rev., 98 (1998) 1743?1754. (10.1021/cr970022c) / Chem. Rev. by J. Szejtli (1998)
Uekama, K., Hirayama, F. and Irie, T., Cyclodextrin drug carrier systems, Chem. Rev., 98 (1998) 2045?2076. (10.1021/cr970025p) / Chem. Rev. by K. Uekama (1998)
Voigt, B., Schaks, A., B�gel, M., Brandt, W. and Wessjohann, L.A., Synthesis of steroid containing macrocycles via multi component reactions, In 2nd International Conference on Multi Component Reactions, Combinatorial and Related Chemistry (MCR 2003), 2003, Genua, Italy.
Katz, L., Manipulation of modular polyketide synthases, Chem. Rev., 97 (1997) 2557?2575. (10.1021/cr960025+) / Chem. Rev. by L. Katz (1997)
Khosla, C., Harnessing the biosynthetic potential of modular polyketide synthases, Chem. Rev., 97 (1997) 2577?2590. (10.1021/cr960027u) / Chem. Rev. by C. Khosla (1997)
Staunton, J. and Wilkinson, B., Biosynthesis of erythromyin and rapamycin, Chem. Rev., 97 (1997) 2611?2629. (10.1021/cr9600316) / Chem. Rev. by J. Staunton (1997)
Gokhale, R.S., Hunziker, D., Cane, D.E. and Khosla, C., Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase, Chem. Biol., 6 (1999) 117?125. (10.1016/S1074-5521(99)80008-8) / Chem. Biol. by R.S. Gokhale (1999)
Moffitt, M.C. and Neilan, B.A., The expansion of mechanistic and organismic diversity associated with non-ribosomal peptides, FEBS Microbiol. Lett., 191 (2000) 159?167. (10.1111/j.1574-6968.2000.tb09334.x) / FEBS Microbiol. Lett. by M.C. Moffitt (2000)
Mootz, H.D. and Marahiel, M.A., Biosynthetic systems for nonribosomal peptide antibiotic assembly, Curr. Opin. Chem. Biol., 1 (1997) 543?551. (10.1016/S1367-5931(97)80051-8) / Curr. Opin. Chem. Biol. by H.D. Mootz (1997)
Schwarzer, D., Mootz, H.D. and Marahiel, M.A., Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases, Chem. Biol., 8 (2001) 997?1010. (10.1016/S1074-5521(01)00068-0) / Chem. Biol. by D. Schwarzer (2001)
Trauger, J.W., Kohli, R.M. and Walsh, C.T., Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase, Biochemistry, 40 (2001) 7092?7098. (10.1021/bi010035r) / Biochemistry by J.W. Trauger (2001)
Bordusa, F., Enzymes for peptide cyclization, ChemBioChem, 2 (2001) 405?409. (10.1002/1439-7633(20010601)2:6<405::AID-CBIC405>3.0.CO;2-6) / ChemBioChem by F. Bordusa (2001)
Tseng, C.C., Bruner, S.D., Kohli, R.M., Marahiel, M.A., Walsh, C.T. and Sieber, S.A., Characterization of the surfactin synthase C-terminal thioesterase domain as a cyclic depsipeptide synthase, Biochemistry, 41 (2002) 13350?13359. (10.1021/bi026592a) / Biochemistry by C.C. Tseng (2002)
Brandt, W., Dessoy, M.A., Fulhorst, M., Gao, W., Zenk, M.H. and Wessjohann, L.A., Structural basis for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP-pathway to isoprenoids, ChemBioChem, 5 (2004) 311?323. (10.1002/cbic.200300743) / ChemBioChem by W. Brandt (2004)
Gao, W., Loeser, R., Raschke, M., Dessoy, M.A., Fulhorst, M., Alpermann, H., Wessjohann, L.A. and Zenk, M.H., (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: An intermediate in the formation of terpenoids in plant chromoplasts, Angew. Chem., 114 (2002) 2716?2719; Angew. Chem. Int. Ed., (2002) 2604?2607. (10.1002/1521-3757(20020715)114:14<2716::AID-ANGE2716>3.0.CO;2-A) / Angew. Chem. by W. Gao (2002)
Bohlman, J., Meyer-Gauen, G. and Croteau, R.B., Plant terpenoid synthases: Molecular biology and phylogenetic analysis, Proc. Nat. Acad. Sci. U.S.A., 95 (1998) 4126?4133. (10.1073/pnas.95.8.4126) / Proc. Nat. Acad. Sci. U.S.A. by J. Bohlman (1998)
Trapp, S. and Croteau, R.B., Genomic organization of plant terpene synthases and molecular evolutionary implications, Genetics, 158 (2001) 811?832. (10.1093/genetics/158.2.811) / Genetics by S. Trapp (2001)
Dewick, P.M., The biosynthesis of C5?C25 terpenoids compounds, Nat. Prod. Rep., 16 (1999) 97?130. (10.1039/a708935j) / Nat. Prod. Rep. by P.M. Dewick (1999)
Dewick, P.M., The biosynthesis of C5?C25 terpenoids compounds, Nat. Prod. Rep., 19 (2002) 181?222. (10.1039/b002685i) / Nat. Prod. Rep. by P.M. Dewick (2002)
Pyun, H.-J., Wagschal, K.C., Jung, D.-I., Coates, R.M. and Croteau, R., Monoterpene biosynthesis: Isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis), Arch. Biochem. Biophys., (1994) 488?496. (10.1006/abbi.1994.1068)
Caruthers, J.M., Kang, I., Rynkiewicz, M.J., Cane, D.E. and Christianson, D.W., Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti, J. Biol. Chem., 275 (2000) 25533?25539. (10.1074/jbc.M000433200) / J. Biol. Chem. by J.M. Caruthers (2000)
Rynkiewicz, M.J., Cane, D.E. and Christianson, D.W., From the cover: Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade, Proc. Nat. Acad. Sci. U.S.A., 98 (2001) 13543?13548. (10.1073/pnas.231313098) / Proc. Nat. Acad. Sci. U.S.A. by M.J. Rynkiewicz (2001)
Br�uer, L., Brandt, W. and Wessjohann, L.A., Modeling of the E. coli 4-hydroxybenzoic acid oligoprenyl transferase (ubiA-transferase) and characterization of potential active sites, J. Mol. Mod., 10 (2004) 317?327. (10.1007/s00894-004-0197-6) / J. Mol. Mod. by L. Br�uer (2004)
Starks, C.M., Back, K., Chappel, J. and Noel, J.P., Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase, Science, 277 (1997) 1815?1820. (10.1126/science.277.5333.1815) / Science by C.M. Starks (1997)
Conolly, J.D. and Hill, R.A., Dictionary of Terpenoids, Chapman & Hall, New York, 1992. / Dictionary of Terpenoids by J.D. Conolly (1992)
Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B. and Christianson, D.W., Biochemistry, 24 (2002) 15375?15380. / Biochemistry by D.A. Whittington (2002)
Brown, G.D., The biosynthesis of steroids and triterpenoids, Nat. Prod. Rep., 16 (1998) 653?696. (10.1039/a815653y) / Nat. Prod. Rep. by G.D. Brown (1998)
MacMillan, J. and Beale, M.H., Comprehensive Natural Products Chemistry, Elsevier Science Publishing Co., Inc., New York, 1999. / Comprehensive Natural Products Chemistry by J. MacMillan (1999)
Ait-Ali, T., Swain, S.M., Reid, J.B., Sun, T.P. and Kamiya, Y., The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A, Plant J., 11 (1997) 443?454. (10.1046/j.1365-313X.1997.11030443.x) / Plant J. by T. Ait-Ali (1997)
Hedden, P. and Kamiya, Y., Gibbelerin biosynthesis: Enzymes, genes and their regulation, Ann. Rev. Plant Physiol. Plant Mol. Biol., 48 (1997) 431?460. (10.1146/annurev.arplant.48.1.431) / Ann. Rev. Plant Physiol. Plant Mol. Biol. by P. Hedden (1997)
Wendt, K.U., Poralra, K. and Schulz, E., Structure and function of a squalene cyclase, Science, 277 (1997) 1811?1815. (10.1126/science.277.5333.1811) / Science by K.U. Wendt (1997)
Wendt, K.U., Lenhart, A. and Schulz, E., The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution, J. Mol. Biol., 286 (1999) 175?187. (10.1006/jmbi.1998.2470) / J. Mol. Biol. by K.U. Wendt (1999)
Wendt, K.U., Schulz, E., Corey, E.J. and Liu, D.R., Enzyme mechanisms for polycyclic triterpene formation, Angew. Chem., 112 (2000) 2930?2952; Angew. Chem. Int. Ed., 39 (2000) 2812?2833. (10.1002/1521-3773(20000818)39:16<2812::AID-ANIE2812>3.0.CO;2-#) / Angew. Chem., 112 (2000) 2930?2952; Angew. Chem. Int. Ed., by K.U. Wendt (2000)
Wessjohann, L.A. and Sontag, B., Prenylation of benzoic acid derivatives catalyzed by a transferase from Escherichia coli overproduction: Method development and substrate specificity, Angew. Chem., 108 (1996) 1821?1823; Angew. Chem. Int. Ed. Engl., (1996) 1697?1699. (10.1002/ange.19961081527) / Angew. Chem. by L.A. Wessjohann (1996)
Wessjohann, L.A., Sontag, B. and Dessoy, M.-A., Enzymatic C?C coupling: The development of aromatic prenylation for organic synthesis, In Diederichsen, U., Lindhorst, T.L., Wessjohann, L.A. and Westermann, B. (Eds.) Bioorganic Chemistry ? Highlights and New Aspects, Wiley-VCH, Weinheim, 1999, pp. 79?88. / Bioorganic Chemistry ? Highlights and New Aspects by L.A. Wessjohann (1999)
Huang, K., Huang, Q. and Scott, A.I., Overexpression, single-step purification, and site-directed mutagenetic analysis of casbene synthase, Arch. Biochem. Biophys., 352 (1998) 144?152. (10.1006/abbi.1998.0578) / Arch. Biochem. Biophys. by K. Huang (1998)
Hill, A.M., Cane, D.E., Mau, C.J. and West, C.A., High level expression of Ricinus communis casbene synthase in Escherichia coli and characterization of the recombinant enzyme, Arch. Biochem. Biophys., 336 (1996) 283?289. (10.1006/abbi.1996.0559) / Arch. Biochem. Biophys. by A.M. Hill (1996)
Wildung, M. and Croteau, R.B., A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis, J. Biol. Chem., 271 (1996) 9201?9204. (10.1074/jbc.271.16.9201) / J. Biol. Chem. by M. Wildung (1996)
Hamano, Y., Kuzumaya, T., Itoh, N., Furihata, K., Seto, H. and Dairi, T., Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin, J. Biol. Chem., 277 (2002) 37098?37104. (10.1074/jbc.M206382200) / J. Biol. Chem. by Y. Hamano (2002)
Hanson, J.R., Diterpenoids, Nat. Prod. Rep., 19 (2002) 125?132. (10.1039/b009027l) / Nat. Prod. Rep. by J.R. Hanson (2002)
Hanson, J.R., Diterpenoids, Nat. Prod. Rep., 17 (2000) 165?174. (10.1039/a808395i) / Nat. Prod. Rep. by J.R. Hanson (2000)
Hanson, J.R., Diterpenoids, Nat. Prod. Rep., 20 (2003) 70?78. (10.1039/b108963n) / Nat. Prod. Rep. by J.R. Hanson (2003)
Lambert, J.N., Mitchell, J.P. and Roberts, K.D., The synthesis of cyclic peptides, J. Chem. Soc. Perkin Trans. 1, (2001) 471?484. (10.1039/b001942i) / J. Chem. Soc. Perkin Trans. by J.N. Lambert (2001)
van Maarseveen, J.H., den Hartog, J.A.J., Engelen, V., Finner, E., Visser, G. and Kruse, C.G., Solid phase ring-closing metathesis: Cyclization/cleavage approach towards a seven membered cycloolefin, Tetrahedron Lett., 37 (1996) 8249?8252. (10.1016/0040-4039(96)01881-3) / Tetrahedron Lett. by J.H. van Maarseveen (1996)
van Maarseveen, J.H., Solid phase synthesis of heterocycles by cyclization/cleavage methodologies, Comb. Chem. High Thr. Scr., 1 (1998) 185?214. / Comb. Chem. High Thr. Scr. by J.H. van Maarseveen (1998)
Park, K.-H. and Kurth, M.J., Cyclo-elimination release strategies applied to solid-phase organic synthesis in drug discovery, Drugs Fut., 25 (2000) 1265?1294. (10.1358/dof.2000.025.12.616456) / Drugs Fut. by K.-H. Park (2000)
Akritopoulou-Zanze, I. and Sowin, T.J., Solid-phase synthesis of macrolide analogues, J. Comb. Chem., 3 (2001) 301?311. (10.1021/cc0100013) / J. Comb. Chem. by I. Akritopoulou-Zanze (2001)
Cristau, P., Vors, J.-P. and Zhu, J., Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR andNAr-based cycloetherification, Tetrahedron Lett., 44 (2003) 5575?5578. (10.1016/S0040-4039(03)01378-9) / Tetrahedron Lett. by P. Cristau (2003)
Brohm, D., Philipe, N., Metzger, S., Bhargava, A., M�ller, O., Lieb, F. and Waldmann, H., Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors, J. Am. Chem. Soc., 124 (2002) 13171?13178. (10.1021/ja027609f) / J. Am. Chem. Soc. by D. Brohm (2002)
Sieber, S.A., Tao, J., Walsh, C.T. and Marahiel, M.A., Peptidyl thiophenols as substrates for nonribosomal peptide cyclases, Angew. Chem., 116 (2004) 499?504; Angew. Chem. Int. Ed., 43 (2004) 493?498. (10.1002/anie.200352787) / Angew. Chem., 116 (2004) 499?504; Angew. Chem. Int. Ed., by S.A. Sieber (2004)
Ulijn, R.V., Baragana, B., Halling, P.J. and Flitsch, S.L., Protease-catalyzed peptide synthesis on solid support, J. Am. Chem. Soc., 124 (2002) 10988?10989. (10.1021/ja026912d) / J. Am. Chem. Soc. by R.V. Ulijn (2002)
Basso, A., De Martin, L., Gardossi, L., Margetts, G., Brazendale, I., Bosma, A.Y., Ulijn, R.V. and Flitsch, S.L., Improved biotransformations on charged PEGA supports, Chem. Commun., (2003) 1296?1297. (10.1039/b301680c)
Zhu, M., Ruijter, E. and Wessjohann, L.A., A new scavenger resin for the reversible linking and monoprotection of functionalized aromatic aldehydes, Org. Lett., 6 (2004) 3921?3924. (10.1021/ol048610h) / Org. Lett. by M. Zhu (2004)
Makita, A., Nihira, T. and Yamada, Y., Lipase catalyzed synthesis of macrocyclic lactones in organic solvents, Tetrahedron Lett., 28 (1987) 805?808. (10.1016/S0040-4039(01)80995-3) / Tetrahedron Lett. by A. Makita (1987)
Antczak, U., Gora, J., Antczak, T. and Galas, E., Enzymatic lactonization of 15-dihydroxypentadecanoic acid and 16-hydroxyhexadecanoic acids to macrocyclic lactones, Enzyme Microb. Technol., 13 (1991) 589?593. (10.1016/0141-0229(91)90095-R) / Enzyme Microb. Technol. by U. Antczak (1991)
Mori, K. and Tomioka, H., Synthesis of four macrolide pheromones to define the scope and limitation of enzymatic macrolactonization, Liebigs Ann., (1992) 1011?1018. (10.1002/jlac.1992199201167)
Lu, W. and Sih, C.J., Chemoenzymatic synthesis of macrocyclic polyamines, Tetrahedron Lett., 40 (1999) 4965?4968. (10.1016/S0040-4039(99)00954-5) / Tetrahedron Lett. by W. Lu (1999)

Dates

Type	When
Created	20 years, 6 months ago (Feb. 28, 2005, 4:43 p.m.)
Deposited	4 years, 1 month ago (July 6, 2021, 12:55 a.m.)
Indexed	1 day, 12 hours ago (Aug. 30, 2025, 12:55 p.m.)
Issued	20 years, 8 months ago (Jan. 1, 2005)
Published	20 years, 8 months ago (Jan. 1, 2005)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Wessjohann_2005, title={What can a chemist learn from nature?s macrocycles? ? A brief, conceptual view}, volume={9}, ISSN={1573-501X}, url={http://dx.doi.org/10.1007/s11030-005-1314-x}, DOI={10.1007/s11030-005-1314-x}, number={1–3}, journal={Molecular Diversity}, publisher={Springer Science and Business Media LLC}, author={Wessjohann, Ludger A. and Ruijter, Eelco and Garcia-Rivera, Daniel and Brandt, Wolfganf}, year={2005}, month=jan, pages={171–186} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T16:55:00Z",
    "timestamp": 1756572900244
  },
  "reference-count": 103,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "1-3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            1,
            1
          ]
        ],
        "date-time": "2005-01-01T00:00:00Z",
        "timestamp": 1104537600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  },
  "DOI": "10.1007/s11030-005-1314-x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        2,
        28
      ]
    ],
    "date-time": "2005-02-28T21:43:50Z",
    "timestamp": 1109627030000
  },
  "page": "171-186",
  "source": "Crossref",
  "is-referenced-by-count": 202,
  "title": "What can a chemist learn from nature?s macrocycles? ? A brief, conceptual view",
  "prefix": "10.1007",
  "volume": "9",
  "author": [
    {
      "given": "Ludger A.",
      "family": "Wessjohann",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Eelco",
      "family": "Ruijter",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Daniel",
      "family": "Garcia-Rivera",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wolfganf",
      "family": "Brandt",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "CR1",
      "doi-asserted-by": "crossref",
      "first-page": "1022",
      "DOI": "10.1021/np030096l",
      "volume": "66",
      "author": "D.J. Newman",
      "year": "2003",
      "unstructured": "Newman, D.J., Cragg, G.M. and Snader, K.M., Natural products as sources of new drugs over the period 1981?2002, J. Nat. Prod., 66 (2003) 1022?1037.",
      "journal-title": "J. Nat. Prod."
    },
    {
      "key": "CR2",
      "doi-asserted-by": "crossref",
      "unstructured": "Rouhi, A.M., Rediscovering natural products, Chem. Eng., (2003) 77?107.",
      "DOI": "10.1021/cen-v081n041.p077"
    },
    {
      "key": "CR3",
      "first-page": "137",
      "volume-title": "Topics in Current Chemistry, Vol. 243",
      "author": "L.A. Wessjohann",
      "year": "2004",
      "unstructured": "Wessjohann, L.A. and Ruijter, E., Total and diversity-oriented synthesis of natural product(-like) macrocycles, in Mulzer, J.H. (Ed.) Topics in Current Chemistry, Vol. 243: Springer, Heidelberg, 2004, pp. 137?184."
    },
    {
      "key": "CR4",
      "doi-asserted-by": "crossref",
      "first-page": "643",
      "DOI": "10.1002/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO;2-G",
      "volume": "38",
      "author": "T. Henkel",
      "year": "1999",
      "unstructured": "Henkel, T., Brunne, R.M., Mueller, H. and Reichel, F., Statistical investigation into the structural complementarity of natural products and synthetic compounds, Angew. Chem., 111 (1999) 688?691; Angew. Chem. Int. Ed., 38 (1999) 643?647.",
      "journal-title": "Angew. Chem. Int. Ed., 111 (1999) 688?691; Angew. Chem. Int. Ed."
    },
    {
      "key": "CR5",
      "doi-asserted-by": "crossref",
      "first-page": "218",
      "DOI": "10.1021/ci0200467",
      "volume": "43",
      "author": "M. Feher",
      "year": "2003",
      "unstructured": "Feher, M. and Schmidt, J.M., Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry, J. Chem. Inf. Comput. Sci., 43 (2003) 218?227.",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "CR6",
      "unstructured": "Link, A., Ma\ufffdgeschneiderte Nadeln aus dem kombinatorischen Heuh-aufen, Pharmazeutische Zeitung, (2001) 3760?3766."
    },
    {
      "key": "CR7",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/S0169-409X(00)00129-0",
      "volume": "46",
      "author": "C.A. Lipinski",
      "year": "1997",
      "unstructured": "Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv. Drug Delivery Rev., 46 (1997) 3?25.",
      "journal-title": "Adv. Drug Delivery Rev."
    },
    {
      "key": "CR8",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1021/cc000097l",
      "volume": "3",
      "author": "M.-L. Lee",
      "year": "2001",
      "unstructured": "Lee, M.-L. and Schneider, G., Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries, J. Comb. Chem., 3 (2001) 284?289.",
      "journal-title": "J. Comb. Chem."
    },
    {
      "key": "CR9",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1016/S1367-5931(02)00330-7",
      "volume": "6",
      "author": "J. Nielsen",
      "year": "2002",
      "unstructured": "Nielsen, J., Combinatorial synthesis of natural products, Curr. Opin. Chem. Biol., 6 (2002) 297?305.",
      "journal-title": "Curr. Opin. Chem. Biol."
    },
    {
      "key": "CR10",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1016/S1367-5931(00)00093-4",
      "volume": "4",
      "author": "L.A. Wessjohann",
      "year": "2000",
      "unstructured": "Wessjohann, L.A., Synthesis of natural product-based compound libraries, Curr. Opin. Chem. Biol., 4 (2000) 303?309.",
      "journal-title": "Curr. Opin. Chem. Biol."
    },
    {
      "key": "CR11",
      "doi-asserted-by": "crossref",
      "first-page": "2129",
      "DOI": "10.2174/0929867023368773",
      "volume": "9",
      "author": "R. Breinbauer",
      "year": "2002",
      "unstructured": "Breinbauer, R., Manger, M., Scheck, M. and Waldmann, H., Natural product guided compound library development, Curr. Med. Chem., 9 (2002) 2129?2145.",
      "journal-title": "Curr. Med. Chem."
    },
    {
      "key": "CR12",
      "doi-asserted-by": "crossref",
      "first-page": "2878",
      "DOI": "10.1002/1521-3773(20020816)41:16<2878::AID-ANIE2878>3.0.CO;2-B",
      "volume": "41",
      "author": "R. Breinbauer",
      "year": "2002",
      "unstructured": "Breinbauer, R., Vetter, I.R. and Waldmann, H., Von Proteindom\ufffdnen zu Wirkstoffkandidaten?Naturstoffe als Leitstrukturen f\ufffdr das Design und die Synthese von Substanzbibliotheken, Angew. Chem., 114 (2002) 3002?3015; Angew. Chem. Int. Ed., 41 (2002) 2878?2890.",
      "journal-title": "Angew. Chem., 114 (2002) 3002?3015; Angew. Chem. Int. Ed."
    },
    {
      "key": "CR13",
      "doi-asserted-by": "crossref",
      "first-page": "11586",
      "DOI": "10.1021/ja011413i",
      "volume": "123",
      "author": "P. Stahl",
      "year": "2001",
      "unstructured": "Stahl, P., Kissau, L., Mazitschek, R., Huwe, A., Furet, P., Giannis, A. and Waldmann, H., Total synthesis and biological evaluation of the nakajiquinones, J. Am. Chem. Soc., 123 (2001) 11586?11593.",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "CR14",
      "doi-asserted-by": "crossref",
      "first-page": "1174",
      "DOI": "10.1002/1521-3773(20020402)41:7<1174::AID-ANIE1174>3.0.CO;2-V",
      "volume": "41",
      "author": "P. Stahl",
      "year": "2002",
      "unstructured": "Stahl, P., Kissau, L., Mazitschek, R., Giannis, A. and Waldmann, H., Naturstoffanaloga als Tyrosinkinaseinhibitoren: Identifikation von IGF1R-, Tie-2- und VEGFR-3-Inhibitoren, Angew. Chem., 114 (2002) 1222?1226; Angew. Chem. Int. Ed., 41 (2002) 1174?1178.",
      "journal-title": "Angew. Chem., 114 (2002) 1222?1226; Angew. Chem. Int. Ed."
    },
    {
      "key": "CR15",
      "doi-asserted-by": "crossref",
      "first-page": "422",
      "DOI": "10.1021/ja993674m",
      "volume": "122",
      "author": "C.W. Lindsley",
      "year": "2000",
      "unstructured": "Lindsley, C.W., Chan, L.K., Goess, B.C., Joseph, R. and Shair, M.D., Solid-phase biomimetic synthesis of carpanone-like molecules, J. Am. Chem. Soc., 122 (2000) 422?423.",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "CR16",
      "volume-title": "The Logic of Chemical Synthesis",
      "author": "E.J. Corey",
      "year": "1989",
      "unstructured": "Corey, E.J. and Cheng, X.-M., The Logic of Chemical Synthesis, 1st edn., John Wiley & Sons, NewYork, 1989.",
      "edition": "1"
    },
    {
      "key": "CR17",
      "volume-title": "Naturstoffchemie",
      "author": "P. Nuhn",
      "year": "1997",
      "unstructured": "Nuhn, P., Naturstoffchemie, 3rd edn., S. Hirzel, Leipzig, 1997.",
      "edition": "3"
    },
    {
      "key": "CR18",
      "volume-title": "Naturstoffchemie ? Mikrobielle, Pflanzliche und Tierische Naturstoffe",
      "author": "P. Nuhn",
      "year": "2005",
      "unstructured": "Nuhn, P. and Wessjohann, L.A., Naturstoffchemie ? Mikrobielle, Pflanzliche und Tierische Naturstoffe, 4th edn., S. Hirzel, Stuttgart, 2005.",
      "edition": "4"
    },
    {
      "key": "CR19",
      "unstructured": "Dictionary of Natural Products on CD-ROM, Version 11:2, Chapman & Hall/CRC Press, 2003."
    },
    {
      "key": "CR20",
      "unstructured": "MDL Information Systems GmbH, http://www.beilstein.com/"
    },
    {
      "key": "CR21",
      "unstructured": "Schmidt, H., Porzel, A., Wessjohann, L. and Vill, V., Phytobase ? Trademark of the Leibniz-Institute of Plant Biochemistry, Halle (D), http://www.phytobase.de/."
    },
    {
      "key": "CR22",
      "unstructured": "SciDex?Volkmar Vill, LCI-Publisher GmbH, Hamburg (D), http://www.lci-publisher.com/.."
    },
    {
      "key": "CR23",
      "doi-asserted-by": "crossref",
      "first-page": "2096",
      "DOI": "10.1002/(SICI)1521-3773(19990802)38:15<2096::AID-ANIE2096>3.0.CO;2-F",
      "volume": "38",
      "author": "K.C. Nicolaou",
      "year": "1999",
      "unstructured": "Nicolaou, K.C., Boddy, C.N.C., Br\ufffdse, S. and Winssinger, N., Chemistry, biology, and medicine of the glycopeptide antibiotics, Angew. Chem., 111 (1999) 2230?2287; Angew. Chem. Int. Ed., 38 (1999) 2096?2152.",
      "journal-title": "Angew. Chem., 111 (1999) 2230?2287; Angew. Chem. Int. Ed."
    },
    {
      "key": "CR24",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9",
      "volume": "3",
      "author": "H.B. Bode",
      "year": "2002",
      "unstructured": "Bode, H.B., Bethe, B., Hofs, R. and Zeeck, A., Big effects from small changes: Possible ways to explore nature?s chemical diversity, ChemBioChem, 3 (2002) 619?627.",
      "journal-title": "ChemBioChem"
    },
    {
      "key": "CR25",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/j.chembiol.2004.01.012",
      "volume": "11",
      "author": "U. Galm",
      "year": "2004",
      "unstructured": "Galm, U., Dessoy, M.-A., Schmidt, J., Wessjohann, L.A. and Heide, L., In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach, Chem. Biol., 11 (2004) 173?183.",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "CR26",
      "doi-asserted-by": "crossref",
      "first-page": "548",
      "DOI": "10.1104/pp.103.032714",
      "volume": "134",
      "author": "E. von Roepenack-Lahaye",
      "year": "2004",
      "unstructured": "von Roepenack-Lahaye, E., Degenkolb, T., Zerjeski, M., Franz, M., Roth, U., Wessjohann, L., Schmidt, J., Scheel, D. and Clemens, S., Profiling of arabidopsis secondary metabolites by capillary liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry, Plant Physiol., 134 (2004) 548?559.",
      "journal-title": "Plant Physiol."
    },
    {
      "key": "CR27",
      "doi-asserted-by": "crossref",
      "first-page": "1625",
      "DOI": "10.1021/cr0100188",
      "volume": "103",
      "author": "L.A. Wessjohann",
      "year": "2003",
      "unstructured": "Wessjohann, L.A., Brandt, W. and Thiemann, T., Biosynthesis and metabolism of cyclopropane-rings in natural compounds, Chem. Rev., 103 (2003) 1625?1647.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR28",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1039/np9971400075",
      "volume": "14",
      "author": "D.C. Gournelis",
      "year": "1997",
      "unstructured": "Gournelis, D.C., Laskaris, G.G. and Verpoorte, R., Cyclopeptide alkaloids, Nat. Prod. Rep., 14 (1997) 75?82.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR29",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1016/S0031-9422(97)00491-3",
      "volume": "47",
      "author": "A.F. Morel",
      "year": "1998",
      "unstructured": "Morel, A.F., Machado, E.C.S., Moreira, J.J., Menezes, A.S., Mostar deiro, M.A. and Wessjohann, L.A., Cyclopeptide alkaloids of Scutia buxifolia (Rhamnaceae), Phytochemistry, 47 (1998) 125?129.",
      "journal-title": "Phytochemistry"
    },
    {
      "key": "CR30",
      "doi-asserted-by": "crossref",
      "first-page": "847",
      "DOI": "10.1021/np000629f",
      "volume": "64",
      "author": "I.H. Hardt",
      "year": "2001",
      "unstructured": "Hardt, I.H., Steinmetz, H., Gerth, K., Sasse, F., Reichenbach, H. and H\ufffdfle, G., New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies, J. Nat. Prod., 64 (2001) 847?856.",
      "journal-title": "J. Nat. Prod."
    },
    {
      "key": "CR31",
      "doi-asserted-by": "crossref",
      "first-page": "739",
      "DOI": "10.1002/ange.19971090707",
      "volume": "109",
      "author": "L.A. Wessjohann",
      "year": "1997",
      "unstructured": "Wessjohann, L.A., Epothilones: Promising natural products with taxol-like activity, Angew. Chem., 109 (1997) 739?742; Angew. Chem. Int. Ed., (1997) 715?718.",
      "journal-title": "Angew. Chem."
    },
    {
      "key": "CR32",
      "unstructured": "Wessjohann, L.A., Scheid, G.O., Bornscheuer, U., Henke, E., Kuit, W. and Orru, R.V.A., Epothilone synthesis components III and IV: Asymmetrically substituted acyloins and acyloin derivatives, method for the production thereof and method for the production of epothilone B, D, and epothilone derivatives, In CAS 136:340534. 2002: Int. Patent Application WO2002/032844A2 (25.04.2002), EP 200111992 (16.10.2001)."
    },
    {
      "key": "CR33",
      "doi-asserted-by": "crossref",
      "first-page": "584",
      "DOI": "10.1039/b304142p",
      "volume": "20",
      "author": "Z. Jin",
      "year": "2003",
      "unstructured": "Jin, Z., Muscarine, imidazol, oxazole and thiazole alkaloids, Nat. Prod. Rep., 20 (2003) 584?605.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR34",
      "doi-asserted-by": "crossref",
      "unstructured": "F\ufffdrstner, A., Total syntheses and biological assessment of macrocyclic glycolipids, Eur. J. Org. Chem., (2004) 943?958.",
      "DOI": "10.1002/ejoc.200300728"
    },
    {
      "key": "CR35",
      "doi-asserted-by": "crossref",
      "first-page": "4573",
      "DOI": "10.1016/S0040-4039(00)00695-X",
      "volume": "41",
      "author": "A. Bigot",
      "year": "2000",
      "unstructured": "Bigot, A., Bois-Choussy, M. and Zhu, J., An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I, Tetrahedron Lett., 41 (2000) 4573?4578.",
      "journal-title": "Tetrahedron Lett."
    },
    {
      "key": "CR36",
      "doi-asserted-by": "crossref",
      "unstructured": "Marques, M.M.B., Pichlmair, S., Martin, H.J. and Mulzer, J., Stereocontrolled synthesis of C-arylglycosides applied to the south west fragment of the antibiotic kendomycin, Synthesis, (2002) 2766?2770.",
      "DOI": "10.1055/s-2002-35990"
    },
    {
      "key": "CR37",
      "doi-asserted-by": "crossref",
      "first-page": "3186",
      "DOI": "10.1002/1521-3773(20010903)40:17<3186::AID-ANIE3186>3.0.CO;2-W",
      "volume": "40",
      "author": "H.J. Martin",
      "year": "2001",
      "unstructured": "Martin, H.J., Drescher, M., Kaehlig, H., Schneider, S. and Mulzer, J., Synthesis of the C1?C13 fragment of kendomycin: Atropisomerism around a C-aryl glycoside bond, Angew. Chem., 131 (2001) 3287?3289; Angew. Chem. Int. Ed., 40 (2001) 3186?3188.",
      "journal-title": "Angew. Chem., 131 (2001) 3287?3289; Angew. Chem. Int. Ed."
    },
    {
      "key": "CR38",
      "doi-asserted-by": "crossref",
      "first-page": "4657",
      "DOI": "10.1021/ol035846x",
      "volume": "5",
      "author": "S. Pichlmair",
      "year": "2003",
      "unstructured": "Pichlmair, S., Marques, M.M.B., Green, M.P., Martin, H.J. and Mulzer, J., A novel approach toward the synthesis of kendomycin: Selective synthesis of a C-aryl glycoside as a single atropisomer, Org. Lett., 5 (2003) 4657?4659.",
      "journal-title": "Org. Lett."
    },
    {
      "key": "CR39",
      "doi-asserted-by": "crossref",
      "first-page": "2665",
      "DOI": "10.1039/b003362f",
      "volume": "1",
      "author": "H.B. Bode",
      "year": "2000",
      "unstructured": "Bode, H.B. and Zeeck, A., Biosynthesis of kendomycin: Origin of the oxygen atoms and further investigations, J. Chem. Soc. Perkin Trans., 1 (2000) 2665?2670.",
      "journal-title": "J. Chem. Soc. Perkin Trans."
    },
    {
      "key": "CR40",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1039/a908387a",
      "volume": "1",
      "author": "H.B. Bode",
      "year": "2000",
      "unstructured": "Bode, H.B. and Zeeck, A., Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces, J. Chem. Soc. Perkin Trans., 1 (2000) 323?328.",
      "journal-title": "J. Chem. Soc. Perkin Trans."
    },
    {
      "key": "CR41",
      "doi-asserted-by": "crossref",
      "first-page": "658",
      "DOI": "10.1038/nature00907",
      "volume": "418",
      "author": "R.M. Kohli",
      "year": "2002",
      "unstructured": "Kohli, R.M., Walsh, C.T. and Burkart, M.D., Biomimetic synthesis and optimization of cyclic peptide antibiotics, Nature, 418 (2002) 658?661.",
      "journal-title": "Nature"
    },
    {
      "key": "CR42",
      "doi-asserted-by": "crossref",
      "unstructured": "Kingston, D.G.I., Taxol, a molecule for all seasons, Chem. Commun., (2001) 867?878.",
      "DOI": "10.1039/b100070p"
    },
    {
      "key": "CR43",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0031-9422(01)00160-1",
      "volume": "58",
      "author": "F. Walker",
      "year": "2001",
      "unstructured": "Walker, F. and Croteau, R.B., The taxol biosynthetic genes, Phytochemistry, 58 (2001) 1?7.",
      "journal-title": "Phytochemistry"
    },
    {
      "key": "CR44",
      "doi-asserted-by": "crossref",
      "first-page": "959",
      "DOI": "10.1002/anie.199409591",
      "volume": "33",
      "author": "L.A. Wessjohann",
      "year": "1994",
      "unstructured": "Wessjohann, L.A., The first total syntheses of taxol, Angew. Chem., 106 (1994) 1011?1013; Angew. Chem. Int. Ed. Engl., 33 (1994) 959?961.",
      "journal-title": "Angew. Chem., 106 (1994) 1011?1013; Angew. Chem. Int. Ed. Engl."
    },
    {
      "key": "CR45",
      "doi-asserted-by": "crossref",
      "first-page": "1741",
      "DOI": "10.1021/cr980027p",
      "volume": "98",
      "author": "V.T. D?Souza",
      "year": "1998",
      "unstructured": "D?Souza, V.T. and Lipkowitz, K.B., Cyclodextrins: Introduction, Chem. Rev., 98 (1998) 1741?1742.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR46",
      "doi-asserted-by": "crossref",
      "first-page": "1787",
      "DOI": "10.1021/cr9700181",
      "volume": "98",
      "author": "W. Saenger",
      "year": "1998",
      "unstructured": "Saenger, W., Jacob, J., Gessler, K., Steiner, T., Hoffmann, D., Sanbe, H., Koizumi, K., Smith, S.M. and Takaha, T., Structures of the common cyclodextrins and their larger analogues-beyond the doughnut, Chem. Rev., 98 (1998) 1787?1802.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR47",
      "doi-asserted-by": "crossref",
      "first-page": "1743",
      "DOI": "10.1021/cr970022c",
      "volume": "98",
      "author": "J. Szejtli",
      "year": "1998",
      "unstructured": "Szejtli, J., Introduction and general overview of cyclodextrin chemistry, Chem. Rev., 98 (1998) 1743?1754.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR48",
      "doi-asserted-by": "crossref",
      "first-page": "2045",
      "DOI": "10.1021/cr970025p",
      "volume": "98",
      "author": "K. Uekama",
      "year": "1998",
      "unstructured": "Uekama, K., Hirayama, F. and Irie, T., Cyclodextrin drug carrier systems, Chem. Rev., 98 (1998) 2045?2076.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR49",
      "unstructured": "Voigt, B., Schaks, A., B\ufffdgel, M., Brandt, W. and Wessjohann, L.A., Synthesis of steroid containing macrocycles via multi component reactions, In 2nd International Conference on Multi Component Reactions, Combinatorial and Related Chemistry (MCR 2003), 2003, Genua, Italy."
    },
    {
      "key": "CR50",
      "doi-asserted-by": "crossref",
      "first-page": "2557",
      "DOI": "10.1021/cr960025+",
      "volume": "97",
      "author": "L. Katz",
      "year": "1997",
      "unstructured": "Katz, L., Manipulation of modular polyketide synthases, Chem. Rev., 97 (1997) 2557?2575.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR51",
      "doi-asserted-by": "crossref",
      "first-page": "2577",
      "DOI": "10.1021/cr960027u",
      "volume": "97",
      "author": "C. Khosla",
      "year": "1997",
      "unstructured": "Khosla, C., Harnessing the biosynthetic potential of modular polyketide synthases, Chem. Rev., 97 (1997) 2577?2590.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR52",
      "doi-asserted-by": "crossref",
      "first-page": "2611",
      "DOI": "10.1021/cr9600316",
      "volume": "97",
      "author": "J. Staunton",
      "year": "1997",
      "unstructured": "Staunton, J. and Wilkinson, B., Biosynthesis of erythromyin and rapamycin, Chem. Rev., 97 (1997) 2611?2629.",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "CR53",
      "doi-asserted-by": "crossref",
      "first-page": "117",
      "DOI": "10.1016/S1074-5521(99)80008-8",
      "volume": "6",
      "author": "R.S. Gokhale",
      "year": "1999",
      "unstructured": "Gokhale, R.S., Hunziker, D., Cane, D.E. and Khosla, C., Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase, Chem. Biol., 6 (1999) 117?125.",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "CR54",
      "doi-asserted-by": "crossref",
      "first-page": "159",
      "DOI": "10.1111/j.1574-6968.2000.tb09334.x",
      "volume": "191",
      "author": "M.C. Moffitt",
      "year": "2000",
      "unstructured": "Moffitt, M.C. and Neilan, B.A., The expansion of mechanistic and organismic diversity associated with non-ribosomal peptides, FEBS Microbiol. Lett., 191 (2000) 159?167.",
      "journal-title": "FEBS Microbiol. Lett."
    },
    {
      "key": "CR55",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1016/S1367-5931(97)80051-8",
      "volume": "1",
      "author": "H.D. Mootz",
      "year": "1997",
      "unstructured": "Mootz, H.D. and Marahiel, M.A., Biosynthetic systems for nonribosomal peptide antibiotic assembly, Curr. Opin. Chem. Biol., 1 (1997) 543?551.",
      "journal-title": "Curr. Opin. Chem. Biol."
    },
    {
      "key": "CR56",
      "doi-asserted-by": "crossref",
      "first-page": "997",
      "DOI": "10.1016/S1074-5521(01)00068-0",
      "volume": "8",
      "author": "D. Schwarzer",
      "year": "2001",
      "unstructured": "Schwarzer, D., Mootz, H.D. and Marahiel, M.A., Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases, Chem. Biol., 8 (2001) 997?1010.",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "CR57",
      "doi-asserted-by": "crossref",
      "first-page": "7092",
      "DOI": "10.1021/bi010035r",
      "volume": "40",
      "author": "J.W. Trauger",
      "year": "2001",
      "unstructured": "Trauger, J.W., Kohli, R.M. and Walsh, C.T., Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase, Biochemistry, 40 (2001) 7092?7098.",
      "journal-title": "Biochemistry"
    },
    {
      "key": "CR58",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1002/1439-7633(20010601)2:6<405::AID-CBIC405>3.0.CO;2-6",
      "volume": "2",
      "author": "F. Bordusa",
      "year": "2001",
      "unstructured": "Bordusa, F., Enzymes for peptide cyclization, ChemBioChem, 2 (2001) 405?409.",
      "journal-title": "ChemBioChem"
    },
    {
      "key": "CR59",
      "doi-asserted-by": "crossref",
      "first-page": "13350",
      "DOI": "10.1021/bi026592a",
      "volume": "41",
      "author": "C.C. Tseng",
      "year": "2002",
      "unstructured": "Tseng, C.C., Bruner, S.D., Kohli, R.M., Marahiel, M.A., Walsh, C.T. and Sieber, S.A., Characterization of the surfactin synthase C-terminal thioesterase domain as a cyclic depsipeptide synthase, Biochemistry, 41 (2002) 13350?13359.",
      "journal-title": "Biochemistry"
    },
    {
      "key": "CR60",
      "doi-asserted-by": "crossref",
      "first-page": "311",
      "DOI": "10.1002/cbic.200300743",
      "volume": "5",
      "author": "W. Brandt",
      "year": "2004",
      "unstructured": "Brandt, W., Dessoy, M.A., Fulhorst, M., Gao, W., Zenk, M.H. and Wessjohann, L.A., Structural basis for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP-pathway to isoprenoids, ChemBioChem, 5 (2004) 311?323.",
      "journal-title": "ChemBioChem"
    },
    {
      "key": "CR61",
      "doi-asserted-by": "crossref",
      "first-page": "2716",
      "DOI": "10.1002/1521-3757(20020715)114:14<2716::AID-ANGE2716>3.0.CO;2-A",
      "volume": "114",
      "author": "W. Gao",
      "year": "2002",
      "unstructured": "Gao, W., Loeser, R., Raschke, M., Dessoy, M.A., Fulhorst, M., Alpermann, H., Wessjohann, L.A. and Zenk, M.H., (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: An intermediate in the formation of terpenoids in plant chromoplasts, Angew. Chem., 114 (2002) 2716?2719; Angew. Chem. Int. Ed., (2002) 2604?2607.",
      "journal-title": "Angew. Chem."
    },
    {
      "key": "CR62",
      "doi-asserted-by": "crossref",
      "first-page": "4126",
      "DOI": "10.1073/pnas.95.8.4126",
      "volume": "95",
      "author": "J. Bohlman",
      "year": "1998",
      "unstructured": "Bohlman, J., Meyer-Gauen, G. and Croteau, R.B., Plant terpenoid synthases: Molecular biology and phylogenetic analysis, Proc. Nat. Acad. Sci. U.S.A., 95 (1998) 4126?4133.",
      "journal-title": "Proc. Nat. Acad. Sci. U.S.A."
    },
    {
      "key": "CR63",
      "doi-asserted-by": "crossref",
      "first-page": "811",
      "DOI": "10.1093/genetics/158.2.811",
      "volume": "158",
      "author": "S. Trapp",
      "year": "2001",
      "unstructured": "Trapp, S. and Croteau, R.B., Genomic organization of plant terpene synthases and molecular evolutionary implications, Genetics, 158 (2001) 811?832.",
      "journal-title": "Genetics"
    },
    {
      "key": "CR64",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1039/a708935j",
      "volume": "16",
      "author": "P.M. Dewick",
      "year": "1999",
      "unstructured": "Dewick, P.M., The biosynthesis of C5?C25 terpenoids compounds, Nat. Prod. Rep., 16 (1999) 97?130.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR65",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1039/b002685i",
      "volume": "19",
      "author": "P.M. Dewick",
      "year": "2002",
      "unstructured": "Dewick, P.M., The biosynthesis of C5?C25 terpenoids compounds, Nat. Prod. Rep., 19 (2002) 181?222.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR66",
      "doi-asserted-by": "crossref",
      "unstructured": "Pyun, H.-J., Wagschal, K.C., Jung, D.-I., Coates, R.M. and Croteau, R., Monoterpene biosynthesis: Isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis), Arch. Biochem. Biophys., (1994) 488?496.",
      "DOI": "10.1006/abbi.1994.1068"
    },
    {
      "key": "CR67",
      "doi-asserted-by": "crossref",
      "first-page": "25533",
      "DOI": "10.1074/jbc.M000433200",
      "volume": "275",
      "author": "J.M. Caruthers",
      "year": "2000",
      "unstructured": "Caruthers, J.M., Kang, I., Rynkiewicz, M.J., Cane, D.E. and Christianson, D.W., Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti, J. Biol. Chem., 275 (2000) 25533?25539.",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "CR68",
      "doi-asserted-by": "crossref",
      "first-page": "13543",
      "DOI": "10.1073/pnas.231313098",
      "volume": "98",
      "author": "M.J. Rynkiewicz",
      "year": "2001",
      "unstructured": "Rynkiewicz, M.J., Cane, D.E. and Christianson, D.W., From the cover: Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade, Proc. Nat. Acad. Sci. U.S.A., 98 (2001) 13543?13548.",
      "journal-title": "Proc. Nat. Acad. Sci. U.S.A."
    },
    {
      "key": "CR69",
      "doi-asserted-by": "crossref",
      "first-page": "317",
      "DOI": "10.1007/s00894-004-0197-6",
      "volume": "10",
      "author": "L. Br\ufffduer",
      "year": "2004",
      "unstructured": "Br\ufffduer, L., Brandt, W. and Wessjohann, L.A., Modeling of the E. coli 4-hydroxybenzoic acid oligoprenyl transferase (ubiA-transferase) and characterization of potential active sites, J. Mol. Mod., 10 (2004) 317?327.",
      "journal-title": "J. Mol. Mod."
    },
    {
      "key": "CR70",
      "doi-asserted-by": "crossref",
      "first-page": "1815",
      "DOI": "10.1126/science.277.5333.1815",
      "volume": "277",
      "author": "C.M. Starks",
      "year": "1997",
      "unstructured": "Starks, C.M., Back, K., Chappel, J. and Noel, J.P., Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase, Science, 277 (1997) 1815?1820.",
      "journal-title": "Science"
    },
    {
      "key": "CR71",
      "volume-title": "Dictionary of Terpenoids",
      "author": "J.D. Conolly",
      "year": "1992",
      "unstructured": "Conolly, J.D. and Hill, R.A., Dictionary of Terpenoids, Chapman & Hall, New York, 1992."
    },
    {
      "key": "CR72",
      "first-page": "15375",
      "volume": "24",
      "author": "D.A. Whittington",
      "year": "2002",
      "unstructured": "Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B. and Christianson, D.W., Biochemistry, 24 (2002) 15375?15380.",
      "journal-title": "Biochemistry"
    },
    {
      "key": "CR73",
      "doi-asserted-by": "crossref",
      "first-page": "653",
      "DOI": "10.1039/a815653y",
      "volume": "16",
      "author": "G.D. Brown",
      "year": "1998",
      "unstructured": "Brown, G.D., The biosynthesis of steroids and triterpenoids, Nat. Prod. Rep., 16 (1998) 653?696.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR74",
      "volume-title": "Comprehensive Natural Products Chemistry",
      "author": "J. MacMillan",
      "year": "1999",
      "unstructured": "MacMillan, J. and Beale, M.H., Comprehensive Natural Products Chemistry, Elsevier Science Publishing Co., Inc., New York, 1999."
    },
    {
      "key": "CR75",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1046/j.1365-313X.1997.11030443.x",
      "volume": "11",
      "author": "T. Ait-Ali",
      "year": "1997",
      "unstructured": "Ait-Ali, T., Swain, S.M., Reid, J.B., Sun, T.P. and Kamiya, Y., The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A, Plant J., 11 (1997) 443?454.",
      "journal-title": "Plant J."
    },
    {
      "key": "CR76",
      "doi-asserted-by": "crossref",
      "first-page": "431",
      "DOI": "10.1146/annurev.arplant.48.1.431",
      "volume": "48",
      "author": "P. Hedden",
      "year": "1997",
      "unstructured": "Hedden, P. and Kamiya, Y., Gibbelerin biosynthesis: Enzymes, genes and their regulation, Ann. Rev. Plant Physiol. Plant Mol. Biol., 48 (1997) 431?460.",
      "journal-title": "Ann. Rev. Plant Physiol. Plant Mol. Biol."
    },
    {
      "key": "CR77",
      "doi-asserted-by": "crossref",
      "first-page": "1811",
      "DOI": "10.1126/science.277.5333.1811",
      "volume": "277",
      "author": "K.U. Wendt",
      "year": "1997",
      "unstructured": "Wendt, K.U., Poralra, K. and Schulz, E., Structure and function of a squalene cyclase, Science, 277 (1997) 1811?1815.",
      "journal-title": "Science"
    },
    {
      "key": "CR78",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1006/jmbi.1998.2470",
      "volume": "286",
      "author": "K.U. Wendt",
      "year": "1999",
      "unstructured": "Wendt, K.U., Lenhart, A. and Schulz, E., The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution, J. Mol. Biol., 286 (1999) 175?187.",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "CR79",
      "doi-asserted-by": "crossref",
      "first-page": "2812",
      "DOI": "10.1002/1521-3773(20000818)39:16<2812::AID-ANIE2812>3.0.CO;2-#",
      "volume": "39",
      "author": "K.U. Wendt",
      "year": "2000",
      "unstructured": "Wendt, K.U., Schulz, E., Corey, E.J. and Liu, D.R., Enzyme mechanisms for polycyclic triterpene formation, Angew. Chem., 112 (2000) 2930?2952; Angew. Chem. Int. Ed., 39 (2000) 2812?2833.",
      "journal-title": "Angew. Chem., 112 (2000) 2930?2952; Angew. Chem. Int. Ed.,"
    },
    {
      "key": "CR80",
      "doi-asserted-by": "crossref",
      "first-page": "1821",
      "DOI": "10.1002/ange.19961081527",
      "volume": "108",
      "author": "L.A. Wessjohann",
      "year": "1996",
      "unstructured": "Wessjohann, L.A. and Sontag, B., Prenylation of benzoic acid derivatives catalyzed by a transferase from Escherichia coli overproduction: Method development and substrate specificity, Angew. Chem., 108 (1996) 1821?1823; Angew. Chem. Int. Ed. Engl., (1996) 1697?1699.",
      "journal-title": "Angew. Chem."
    },
    {
      "key": "CR81",
      "first-page": "79",
      "volume-title": "Bioorganic Chemistry ? Highlights and New Aspects",
      "author": "L.A. Wessjohann",
      "year": "1999",
      "unstructured": "Wessjohann, L.A., Sontag, B. and Dessoy, M.-A., Enzymatic C?C coupling: The development of aromatic prenylation for organic synthesis, In Diederichsen, U., Lindhorst, T.L., Wessjohann, L.A. and Westermann, B. (Eds.) Bioorganic Chemistry ? Highlights and New Aspects, Wiley-VCH, Weinheim, 1999, pp. 79?88."
    },
    {
      "key": "CR82",
      "doi-asserted-by": "crossref",
      "first-page": "144",
      "DOI": "10.1006/abbi.1998.0578",
      "volume": "352",
      "author": "K. Huang",
      "year": "1998",
      "unstructured": "Huang, K., Huang, Q. and Scott, A.I., Overexpression, single-step purification, and site-directed mutagenetic analysis of casbene synthase, Arch. Biochem. Biophys., 352 (1998) 144?152.",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "CR83",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1006/abbi.1996.0559",
      "volume": "336",
      "author": "A.M. Hill",
      "year": "1996",
      "unstructured": "Hill, A.M., Cane, D.E., Mau, C.J. and West, C.A., High level expression of Ricinus communis casbene synthase in Escherichia coli and characterization of the recombinant enzyme, Arch. Biochem. Biophys., 336 (1996) 283?289.",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "CR84",
      "doi-asserted-by": "crossref",
      "first-page": "9201",
      "DOI": "10.1074/jbc.271.16.9201",
      "volume": "271",
      "author": "M. Wildung",
      "year": "1996",
      "unstructured": "Wildung, M. and Croteau, R.B., A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis, J. Biol. Chem., 271 (1996) 9201?9204.",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "CR85",
      "doi-asserted-by": "crossref",
      "first-page": "37098",
      "DOI": "10.1074/jbc.M206382200",
      "volume": "277",
      "author": "Y. Hamano",
      "year": "2002",
      "unstructured": "Hamano, Y., Kuzumaya, T., Itoh, N., Furihata, K., Seto, H. and Dairi, T., Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin, J. Biol. Chem., 277 (2002) 37098?37104.",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "CR86",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1039/b009027l",
      "volume": "19",
      "author": "J.R. Hanson",
      "year": "2002",
      "unstructured": "Hanson, J.R., Diterpenoids, Nat. Prod. Rep., 19 (2002) 125?132.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR87",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1039/a808395i",
      "volume": "17",
      "author": "J.R. Hanson",
      "year": "2000",
      "unstructured": "Hanson, J.R., Diterpenoids, Nat. Prod. Rep., 17 (2000) 165?174.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR88",
      "doi-asserted-by": "crossref",
      "first-page": "70",
      "DOI": "10.1039/b108963n",
      "volume": "20",
      "author": "J.R. Hanson",
      "year": "2003",
      "unstructured": "Hanson, J.R., Diterpenoids, Nat. Prod. Rep., 20 (2003) 70?78.",
      "journal-title": "Nat. Prod. Rep."
    },
    {
      "key": "CR89",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1039/b001942i",
      "volume": "1",
      "author": "J.N. Lambert",
      "year": "2001",
      "unstructured": "Lambert, J.N., Mitchell, J.P. and Roberts, K.D., The synthesis of cyclic peptides, J. Chem. Soc. Perkin Trans. 1, (2001) 471?484.",
      "journal-title": "J. Chem. Soc. Perkin Trans."
    },
    {
      "key": "CR90",
      "doi-asserted-by": "crossref",
      "first-page": "8249",
      "DOI": "10.1016/0040-4039(96)01881-3",
      "volume": "37",
      "author": "J.H. van Maarseveen",
      "year": "1996",
      "unstructured": "van Maarseveen, J.H., den Hartog, J.A.J., Engelen, V., Finner, E., Visser, G. and Kruse, C.G., Solid phase ring-closing metathesis: Cyclization/cleavage approach towards a seven membered cycloolefin, Tetrahedron Lett., 37 (1996) 8249?8252.",
      "journal-title": "Tetrahedron Lett."
    },
    {
      "key": "CR91",
      "first-page": "185",
      "volume": "1",
      "author": "J.H. van Maarseveen",
      "year": "1998",
      "unstructured": "van Maarseveen, J.H., Solid phase synthesis of heterocycles by cyclization/cleavage methodologies, Comb. Chem. High Thr. Scr., 1 (1998) 185?214.",
      "journal-title": "Comb. Chem. High Thr. Scr."
    },
    {
      "key": "CR92",
      "doi-asserted-by": "crossref",
      "first-page": "1265",
      "DOI": "10.1358/dof.2000.025.12.616456",
      "volume": "25",
      "author": "K.-H. Park",
      "year": "2000",
      "unstructured": "Park, K.-H. and Kurth, M.J., Cyclo-elimination release strategies applied to solid-phase organic synthesis in drug discovery, Drugs Fut., 25 (2000) 1265?1294.",
      "journal-title": "Drugs Fut."
    },
    {
      "key": "CR93",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1021/cc0100013",
      "volume": "3",
      "author": "I. Akritopoulou-Zanze",
      "year": "2001",
      "unstructured": "Akritopoulou-Zanze, I. and Sowin, T.J., Solid-phase synthesis of macrolide analogues, J. Comb. Chem., 3 (2001) 301?311.",
      "journal-title": "J. Comb. Chem."
    },
    {
      "key": "CR94",
      "doi-asserted-by": "crossref",
      "first-page": "5575",
      "DOI": "10.1016/S0040-4039(03)01378-9",
      "volume": "44",
      "author": "P. Cristau",
      "year": "2003",
      "unstructured": "Cristau, P., Vors, J.-P. and Zhu, J., Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR andNAr-based cycloetherification, Tetrahedron Lett., 44 (2003) 5575?5578.",
      "journal-title": "Tetrahedron Lett."
    },
    {
      "key": "CR95",
      "doi-asserted-by": "crossref",
      "first-page": "13171",
      "DOI": "10.1021/ja027609f",
      "volume": "124",
      "author": "D. Brohm",
      "year": "2002",
      "unstructured": "Brohm, D., Philipe, N., Metzger, S., Bhargava, A., M\ufffdller, O., Lieb, F. and Waldmann, H., Solid-phase synthesis of dysidiolide-derived protein phosphatase inhibitors, J. Am. Chem. Soc., 124 (2002) 13171?13178.",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "CR96",
      "doi-asserted-by": "crossref",
      "first-page": "493",
      "DOI": "10.1002/anie.200352787",
      "volume": "43",
      "author": "S.A. Sieber",
      "year": "2004",
      "unstructured": "Sieber, S.A., Tao, J., Walsh, C.T. and Marahiel, M.A., Peptidyl thiophenols as substrates for nonribosomal peptide cyclases, Angew. Chem., 116 (2004) 499?504; Angew. Chem. Int. Ed., 43 (2004) 493?498.",
      "journal-title": "Angew. Chem., 116 (2004) 499?504; Angew. Chem. Int. Ed.,"
    },
    {
      "key": "CR97",
      "doi-asserted-by": "crossref",
      "first-page": "10988",
      "DOI": "10.1021/ja026912d",
      "volume": "124",
      "author": "R.V. Ulijn",
      "year": "2002",
      "unstructured": "Ulijn, R.V., Baragana, B., Halling, P.J. and Flitsch, S.L., Protease-catalyzed peptide synthesis on solid support, J. Am. Chem. Soc., 124 (2002) 10988?10989.",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "CR98",
      "doi-asserted-by": "crossref",
      "unstructured": "Basso, A., De Martin, L., Gardossi, L., Margetts, G., Brazendale, I., Bosma, A.Y., Ulijn, R.V. and Flitsch, S.L., Improved biotransformations on charged PEGA supports, Chem. Commun., (2003) 1296?1297.",
      "DOI": "10.1039/b301680c"
    },
    {
      "key": "CR99",
      "doi-asserted-by": "crossref",
      "first-page": "3921",
      "DOI": "10.1021/ol048610h",
      "volume": "6",
      "author": "M. Zhu",
      "year": "2004",
      "unstructured": "Zhu, M., Ruijter, E. and Wessjohann, L.A., A new scavenger resin for the reversible linking and monoprotection of functionalized aromatic aldehydes, Org. Lett., 6 (2004) 3921?3924.",
      "journal-title": "Org. Lett."
    },
    {
      "key": "CR100",
      "doi-asserted-by": "crossref",
      "first-page": "805",
      "DOI": "10.1016/S0040-4039(01)80995-3",
      "volume": "28",
      "author": "A. Makita",
      "year": "1987",
      "unstructured": "Makita, A., Nihira, T. and Yamada, Y., Lipase catalyzed synthesis of macrocyclic lactones in organic solvents, Tetrahedron Lett., 28 (1987) 805?808.",
      "journal-title": "Tetrahedron Lett."
    },
    {
      "key": "CR101",
      "doi-asserted-by": "crossref",
      "first-page": "589",
      "DOI": "10.1016/0141-0229(91)90095-R",
      "volume": "13",
      "author": "U. Antczak",
      "year": "1991",
      "unstructured": "Antczak, U., Gora, J., Antczak, T. and Galas, E., Enzymatic lactonization of 15-dihydroxypentadecanoic acid and 16-hydroxyhexadecanoic acids to macrocyclic lactones, Enzyme Microb. Technol., 13 (1991) 589?593.",
      "journal-title": "Enzyme Microb. Technol."
    },
    {
      "key": "CR102",
      "doi-asserted-by": "crossref",
      "unstructured": "Mori, K. and Tomioka, H., Synthesis of four macrolide pheromones to define the scope and limitation of enzymatic macrolactonization, Liebigs Ann., (1992) 1011?1018.",
      "DOI": "10.1002/jlac.1992199201167"
    },
    {
      "key": "CR103",
      "doi-asserted-by": "crossref",
      "first-page": "4965",
      "DOI": "10.1016/S0040-4039(99)00954-5",
      "volume": "40",
      "author": "W. Lu",
      "year": "1999",
      "unstructured": "Lu, W. and Sih, C.J., Chemoenzymatic synthesis of macrocyclic polyamines, Tetrahedron Lett., 40 (1999) 4965?4968.",
      "journal-title": "Tetrahedron Lett."
    }
  ],
  "container-title": "Molecular Diversity",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://link.springer.com/content/pdf/10.1007/s11030-005-1314-x.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://link.springer.com/article/10.1007/s11030-005-1314-x/fulltext.html",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://link.springer.com/content/pdf/10.1007/s11030-005-1314-x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        6
      ]
    ],
    "date-time": "2021-07-06T04:55:27Z",
    "timestamp": 1625547327000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://link.springer.com/10.1007/s11030-005-1314-x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  },
  "references-count": 103,
  "journal-issue": {
    "issue": "1-3",
    "published-print": {
      "date-parts": [
        [
          2005,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "1314"
  ],
  "URL": "http://dx.doi.org/10.1007/s11030-005-1314-x",
  "relation": {},
  "ISSN": [
    "1381-1991",
    "1573-501X"
  ],
  "subject": [],
  "container-title-short": "Mol Divers",
  "published": {
    "date-parts": [
      [
        2005,
        1
      ]
    ]
  }
}