Cytochrome c oxidase: exciting progress and remaining mysteries
10.1007/s10863-008-9181-7
Crossref journal-article
Springer Science and Business Media LLC
Journal of Bioenergetics and Biomembranes (297)
Bibliography

Brzezinski, P., & Gennis, R. B. (2008). Cytochrome c oxidase: exciting progress and remaining mysteries. Journal of Bioenergetics and Biomembranes, 40(5), 521–531.

Authors 2
  1. Peter Brzezinski (first)
  2. Robert B. Gennis (additional)
References 73 Referenced 244
  1. Abramson J, Riistama S et al (2000) The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Nature Struct Biol 7:910–917 (10.1038/82824) / Nature Struct Biol by J Abramson (2000)
  2. Artzatbanov VY, Konstantinov AA et al (1978) Involvement of intramitochondrial protons in redox reactions of cytochrome a. FEBS Lett 87:180–185 (10.1016/0014-5793(78)80327-5) / FEBS Lett by VY Artzatbanov (1978)
  3. Babcock GT, Varotsis C (1993) Discrete steps in dioxygen activation—the cytochrome oxidase/O2 reaction. J Bioenerg Biomemb 25(2):71–80 (10.1007/BF00762849) / J Bioenerg Biomemb by GT Babcock (1993)
  4. Belevich I, Bloch DA et al (2007) Exploring the proton pump mechanism of cytochrome c oxidase in real time. Proc Natl Acad Sci U S A 104(8):2685–2690 (10.1073/pnas.0608794104) / Proc Natl Acad Sci U S A by I Belevich (2007)
  5. Bloch D, Belevich I et al (2004) The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. PNAS 101(2):529–533 (10.1073/pnas.0306036101) / PNAS by D Bloch (2004)
  6. Brändén G, Pawate AS et al (2006) Controlled uncoupling and recoupling of proton pumping in cytochrome c oxidase. Proc Natl Acad Sci U S A 103(2):317–322 (10.1073/pnas.0507734103) / Proc Natl Acad Sci U S A by G Brändén (2006)
  7. de Vries S (2008) The role of the conserved tryptophan272 of the Paracoccus denitrificans cytochrome c oxidase in proton pumping. Biochim Biophys Acta 1777(7–8):925–928 (10.1016/j.bbabio.2008.05.008) / Biochim Biophys Acta by S Vries de (2008)
  8. Fadda E, Yu CH et al (2008) Electrostatic control of proton pumping in cytochrome c oxidase. Biochim Biophys Acta 1777(3):277–284 (10.1016/j.bbabio.2007.11.010) / Biochim Biophys Acta by E Fadda (2008)
  9. Faxén K, Gilderson G et al (2005) A mechanistic principle for proton pumping by cytochrome c oxidase. Nature 437:286 (10.1038/nature03921) / Nature by K Faxén (2005)
  10. Ferguson-Miller S, Babcock GT (1996) Heme/copper terminal oxidases. Chem Rev 7(96):2889–2907 (10.1021/cr950051s) / Chem Rev by S Ferguson-Miller (1996)
  11. Fetter JR, Qian J et al (1995) Possible proton relay pathways in cytochrome c oxidase. Proc Natl Acad Sci U S A 92:1604–1608 (10.1073/pnas.92.5.1604) / Proc Natl Acad Sci U S A by JR Fetter (1995)
  12. Gorbikova EA, Belevich NP et al (2007) Time-resolved ATR-FTIR spectroscopy of the oxygen reaction in the D124N mutant of cytochrome c oxidase from Paracoccus denitrificans. Biochemistry 46(45):13141–13148 (10.1021/bi701614w) / Biochemistry by EA Gorbikova (2007)
  13. Hallén S, Brzezinski P et al (1994) Internal electron transfer in cytochrome c oxidase is coupled to the protonation of a group close to the bimetallic site. Biochemistry 33:1467–1472 (10.1021/bi00172a024) / Biochemistry by S Hallén (1994)
  14. Han S, Takahashi S et al (2000) Time dependence of the catalytic intermediates in cytochrome c oxidase. J Biol Chem 275(3):1910–1919 (10.1074/jbc.275.3.1910) / J Biol Chem by S Han (2000)
  15. Han D, Namslauer A et al (2006) Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pump. Biochemistry 45(47):14064–14074 (10.1021/bi061465q) / Biochemistry by D Han (2006)
  16. Hellwig P, Behr J et al (1998) Involvement of glutamic acid 278 in the redox reaction of the cytochrome c oxidase from Paracoccus denitrificans investigated by FT-IR spectroscopy. Biochemistry 37:7390–7399 (10.1021/bi9725576) / Biochemistry by P Hellwig (1998)
  17. Hemp J, Robinson DE et al (2006) Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme–copper oxygen reductases. Biochemistry 45(51):15405–15410 (10.1021/bi062026u) / Biochemistry by J Hemp (2006)
  18. Iwata S, Ostermeier C et al (1995) Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature 376:660–669 (10.1038/376660a0) / Nature by S Iwata (1995)
  19. Jasaitis A, Verkhovsky MI et al (1999) Assignment and charge translocation stoichiometries of the major electrogenic phases in the reaction of cytochrome c oxidase with dioxygen. Biochemistry 38:2697–2706 (10.1021/bi982275l) / Biochemistry by A Jasaitis (1999)
  20. Kaila VR, Verkhovsky M et al (2008a) Prevention of leak in the proton pump of cytochrome c oxidase. Biochim Biophys Acta 1777(7–8):890–892 (10.1016/j.bbabio.2008.03.016) / Biochim Biophys Acta by VR Kaila (2008)
  21. Kaila VR, Verkhovsky MI et al (2008b) Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase. Proc Natl Acad Sci U S A 105(17):6255–6259 (10.1073/pnas.0800770105) / Proc Natl Acad Sci U S A by VR Kaila (2008)
  22. Kannt A, Soulimane T et al (1998) Electrical current generation and proton pumping catalyzed by the ba3-type cytochrome c oxidase from Thermus thermophilus. FEBS 434:17–22 (10.1016/S0014-5793(98)00942-9) / FEBS by A Kannt (1998)
  23. Kitagawa T, Ogura T (1997) Oxygen activation mechanism at the binuclear site of heme–copper oxidase superfamily as revealed by time-resolved resonance Raman spectroscopy. Prog Inorg Chem 45:431–479 / Prog Inorg Chem by T Kitagawa (1997)
  24. Konstantinov AA, Siletsky S et al (1997) The roles of the two proton input channels in cytochrome c oxidase from Rhodobacter sphaeroides probed by the effects of site-directed mutations on time-resolved electrogenic intraprotein proton transfer. Proc Natl Acad Sci U S A 94:9085–9090 (10.1073/pnas.94.17.9085) / Proc Natl Acad Sci U S A by AA Konstantinov (1997)
  25. Lee H-m, Das TK et al (2000) Mutations in the putative H-channel in the cytochrome c oxidase from Rhodobacter sphaeroides show that this channel is not important for proton conduction but reveal modulation of the properties of heme a. Biochemistry 39:2989–2996 (10.1021/bi9924821) / Biochemistry by H-m Lee (2000)
  26. Lepp H, Salomonsson L et al (2008a) Impaired proton pumping in cytochrome c oxidase upon structural alteration of the D pathway. Biochim Biophys Acta 1777(7–8):897–903 (10.1016/j.bbabio.2008.04.013) / Biochim Biophys Acta by H Lepp (2008)
  27. Lepp H, Svahn E et al (2008b) Charge transfer in the K proton pathway linked to electron transfer to the catalytic site in cytochrome c oxidase. Biochemistry 47(17):4929–4935 (10.1021/bi7024707) / Biochemistry by H Lepp (2008)
  28. Luna VM, Chen Y et al (2008) Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme–Cu oxidases. Biochemistry 47(16):4657–4665 (10.1021/bi800045y) / Biochemistry by VM Luna (2008)
  29. Muramoto K, Hirata K et al (2007) A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase. Proc Natl Acad Sci U S A 104(19):7881–7886 (10.1073/pnas.0610031104) / Proc Natl Acad Sci U S A by K Muramoto (2007)
  30. Nagle JF, Tristam-Nagle S (1983) Hydrogen bonded chain mechanisms for proton conduction and proton pumping. J Membr Biol 74:1–14 (10.1007/BF01870590) / J Membr Biol by JF Nagle (1983)
  31. Namslauer A, Aagaard A et al (2003a) Intramolecular proton-transfer reactions in a membrane-bound proton pump: the effect of pH on the peroxy to ferryl transition in cytochrome c oxidase. Bichemistry 42:1488–1498 (10.1021/bi026524o) / Bichemistry by A Namslauer (2003)
  32. Namslauer A, Pawate A et al (2003b) Redox-coupled proton translocation in biological systems: proton shuttling in cytochrome c oxidase. Proc Natl Acad Sci U S A 100(26):15543–15547 (10.1073/pnas.2432106100) / Proc Natl Acad Sci U S A by A Namslauer (2003)
  33. Nyquist RM, Heitbrink D et al (2001) Perfusion-induced redox differences in cytochrome c oxidase: ATR/FT-IR spectroscopy. FEBS Letters 505:63–67 (10.1016/S0014-5793(01)02769-7) / FEBS Letters by RM Nyquist (2001)
  34. Ogura T, Takahashi S et al (1993) Time-resolved resonance Raman elucidation of the pathway for dioxygen reduction by cytochrome c oxidase`. J Am Chem Soc 115:8527–8536 (10.1021/ja00072a002) / J Am Chem Soc by T Ogura (1993)
  35. Olsson MH, Warshel A (2006) Monte Carlo simulations of proton pumps: on the working principles of the biological valve that controls proton pumping in cytochrome c oxidase. Proc Natl Acad Sci USA 103(17):6500–6505 (10.1073/pnas.0510860103) / Proc Natl Acad Sci USA by MH Olsson (2006)
  36. Ostermeier C, Harrenga A et al (1997) Structure at 2.7 Å resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody Fv fragment. Proc Natl Acad Sci U S A 94:10547–10553 (10.1073/pnas.94.20.10547) / Proc Natl Acad Sci U S A by C Ostermeier (1997)
  37. Pawate AS et al (2002) A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides results in an increase in steady-state activity but completely eliminates proton pumping. Biochemistry 41:13417–13423 (10.1021/bi026582+) / Biochemistry by AS Pawate (2002)
  38. Pereira MM, Santana M et al (2001) A novel scenario for the evaluation of haem-copper oxygen reductases. Biochim Biophys Acta 1505:185–208 (10.1016/S0005-2728(01)00169-4) / Biochim Biophys Acta by MM Pereira (2001)
  39. Pereira MM, Sousa FL et al (2008) Looking for the minimum common denominator in haem-copper oxygen reductases: towards a unified catalytic mechanism. Biochim Biophys Acta 1777(7–8):929–934 (10.1016/j.bbabio.2008.05.441) / Biochim Biophys Acta by MM Pereira (2008)
  40. Pfitzner U, Hoffmeier K et al (2000) Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans. Biochemistry 39(23):6756–6762 (10.1021/bi992235x) / Biochemistry by U Pfitzner (2000)
  41. Pisliakov AV, Sharma PK et al (2008) Electrostatic basis for the unidirectionality of the primary proton transfer in cytochrome c oxidase. Proc Natl Acad Sci U S A 105(22):7726–7731 (10.1073/pnas.0800580105) / Proc Natl Acad Sci U S A by AV Pisliakov (2008)
  42. Popovic DM, Stuchebrukhov AA (2004) Proton pumping mechanism and catalytic cycle of cytochrome c oxidase: coulomb pump model with kinetic gating. FEBS Lett 566:126–130 (10.1016/j.febslet.2004.04.016) / FEBS Lett by DM Popovic (2004)
  43. Popovic DM, Stuchebrukhov AA (2005) Proton exit channels in bovine cytochrome c oxidase. J Phys Chem B 109:1999–2006 (10.1021/jp0464371) / J Phys Chem B by DM Popovic (2005)
  44. Proshlyakov DA, Pressler MA et al (2000) Oxygen activation and reduction in respiration: involvement of redox-active tyrosine 244. Science 290:1588–1591 (10.1126/science.290.5496.1588) / Science by DA Proshlyakov (2000)
  45. Qin L, Hiser C et al (2006) Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase. Proc Natl Acad Sci U S A 103(44):16117–16122 (10.1073/pnas.0606149103) / Proc Natl Acad Sci U S A by L Qin (2006)
  46. Qin L, Mills DA et al (2007) Crystallographic location and mutational analysis of zn and cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome C oxidase. Biochemistry 46(21):6239–6248 (10.1021/bi700173w) / Biochemistry by L Qin (2007)
  47. Rich PR (1995) Towards an understanding of the chemistry of oxygen reduction and proton translocation in the iron–copper respiratory oxidases. Aust J Plant Physiol 22:479–486 / Aust J Plant Physiol by PR Rich (1995)
  48. Rich PR, Meunier B et al (1996) Coupling of charge and proton movement in cytochrome c oxidase. Biochim Biophys Acta 1275:91–95 (10.1016/0005-2728(96)00055-2) / Biochim Biophys Acta by PR Rich (1996)
  49. Rich PR, Jünemann S et al (1997) Protonmotive mechanism of haem-copper oxidases. J Bioenerg Biomembr 30(1):131–137 (10.1023/A:1020524014920) / J Bioenerg Biomembr by PR Rich (1997)
  50. Riistama S, Hummer G et al (1997) Bound water in the proton translocation mechanism of the heme–copper oxidases. FEBS Lett 414(2):275–280 (10.1016/S0014-5793(97)01003-X) / FEBS Lett by S Riistama (1997)
  51. Salomonsson L, Faxen K et al (2005) The timing of proton migration in membrane-reconstituted cytochrome c oxidase. Proc Natl Acad Sci U S A 102(49):17624–17629 (10.1073/pnas.0505431102) / Proc Natl Acad Sci U S A by L Salomonsson (2005)
  52. Shimokata K, Katayama Y et al (2007) The proton pumping pathway of bovine heart cytochrome c oxidase. Proc Natl Acad Sci U S A 104(10):4200–4205 (10.1073/pnas.0611627104) / Proc Natl Acad Sci U S A by K Shimokata (2007)
  53. Shinzawa-Itoh K, Aoyama H et al (2007) Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase. EMBO J 26(6):1713–1725 (10.1038/sj.emboj.7601618) / EMBO J by K Shinzawa-Itoh (2007)
  54. Siegbahn PE, Blomberg MR (2007) Energy diagrams and mechanism for proton pumping in cytochrome c oxidase. Biochim Biophys Acta 1767(9):1143–1156 (10.1016/j.bbabio.2007.06.009) / Biochim Biophys Acta by PE Siegbahn (2007)
  55. Siletsky SA, Pawate AS et al (2004) Transmembrane charge separation during the Ferryl-oxo ∅ oxidized transition in a nonpumping mutant of cytochrome c oxidase. J Biol Chem 279(50):52558–52565 (10.1074/jbc.M407549200) / J Biol Chem by SA Siletsky (2004)
  56. Siletsky SA, Belevich I et al (2007) Time-resolved single-turnover of ba3 oxidase from Thermus thermophilus. Biochim Biophys Acta 1767(12):1383–1392 (10.1016/j.bbabio.2007.09.010) / Biochim Biophys Acta by SA Siletsky (2007)
  57. Smirnova IA, Ädelroth P et al (1999) Aspartate-132 in cytochrome c oxidase from Rhodobacter sphaeroides is involved in a two-step proton transfer during Oxo-Ferryl formation. Biochemistry 38:6826–6833 (10.1021/bi982865j) / Biochemistry by IA Smirnova (1999)
  58. Soulimane T, Buse G et al (2000) Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus. EMBO J 19(8):1766–1776 (10.1093/emboj/19.8.1766) / EMBO J by T Soulimane (2000)
  59. Sugitani R, Medvedev ES et al (2008) Theoretical and computational analysis of the membrane potential generated by cytochrome c oxidase upon single electron injection into the enzyme. Biochim Biophys Acta 1777:1129–1139 (10.1016/j.bbabio.2008.05.006) / Biochim Biophys Acta by R Sugitani (2008)
  60. Svensson-Ek M, Abramson J et al (2002) The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides. J Mol Biol 321:329–339 (10.1016/S0022-2836(02)00619-8) / J Mol Biol by M Svensson-Ek (2002)
  61. Tsukihara T, Aoyama H et al (1995) Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 Å. Science 269:1069–1074 (10.1126/science.7652554) / Science by T Tsukihara (1995)
  62. Tsukihara T, Aoyama H et al (1996) The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 Å. Science 272:1136–1144 (10.1126/science.272.5265.1136) / Science by T Tsukihara (1996)
  63. Vakkasoglu AS, Morgan JE et al (2006) Mutations which decouple the proton pump of the cytochrome c oxidase from Rhodobacter sphaeroides perturb the environment of glutamate 286. FEBS Lett 580(19):4613–4617 (10.1016/j.febslet.2006.07.036) / FEBS Lett by AS Vakkasoglu (2006)
  64. Varotsis C, Zhang Y et al (1993) Resolution of the reaction sequence during the reduction of O2 by cytochrome oxidase. Proc Natl Acad Sci U S A 90:237–241 (10.1073/pnas.90.1.237) / Proc Natl Acad Sci U S A by C Varotsis (1993)
  65. Verkhovsky MI, Morgan JE et al (1992) Intramolecular electron transfer in cytochrome c oxidase: a cascade of equilibria. Biochemistry 31:11860–11863 (10.1021/bi00162a026) / Biochemistry by MI Verkhovsky (1992)
  66. Verkhovsky MI, Morgan JE et al (1994) Oxygen binding and activation: early steps in the reaction of oxygen with cytochrome c oxidase. Biochemistry 33:3079–3086 (10.1021/bi00176a042) / Biochemistry by MI Verkhovsky (1994)
  67. Verkhovsky MI, Morgan JE et al (1997) Translocation of electrical charge during a single turnover of cytochrome-c oxidase. Biochim Biophys Acta 1318:6–10 (10.1016/S0005-2728(96)00147-8) / Biochim Biophys Acta by MI Verkhovsky (1997)
  68. Wikström M (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266:271–273 (10.1038/266271a0) / Nature by M Wikström (1977)
  69. Wikstrom M, Verkhovsky MI (2007) Mechanism and energetics of proton translocation by the respiratory heme–copper oxidases. Biochim Biophys Acta 1767(10):1200–1214 (10.1016/j.bbabio.2007.06.008) / Biochim Biophys Acta by M Wikstrom (2007)
  70. Wikström M, Verkhovsky MI et al (2003) Water-gated mechanism of proton translocation by cytochrome c oxidase. Biochim Biophys Acta 1604:61–65 (10.1016/S0005-2728(03)00041-0) / Biochim Biophys Acta by M Wikström (2003)
  71. Xu J, Sharpe MA et al (2007) Storage of an excess proton in the hydrogen-bonded network of the d-pathway of cytochrome C oxidase: identification of a protonated water cluster. J Am Chem Soc 129(10):2910–2913 (10.1021/ja067360s) / J Am Chem Soc by J Xu (2007)
  72. Yoshikawa S, Shinzawa-Itoh K et al (2000) X-ray structure and the reaction mechanism of bovine heart cytochrome c oxidase. J Inorg Biochem 82:1–7 (10.1016/S0162-0134(00)00137-9) / J Inorg Biochem by S Yoshikawa (2000)
  73. Zheng X, Medvedev DM et al (2003) Computer simulation of water in cytochrome c oxidase. Biochim Biophys Acta 1557:99–107 (10.1016/S0005-2728(03)00002-1) / Biochim Biophys Acta by X Zheng (2003)
Dates
Type When
Created 16 years, 10 months ago (Oct. 30, 2008, 4:04 a.m.)
Deposited 6 years, 3 months ago (May 30, 2019, 11:53 p.m.)
Indexed 3 weeks, 3 days ago (Aug. 6, 2025, 9:58 a.m.)
Issued 16 years, 10 months ago (Oct. 1, 2008)
Published 16 years, 10 months ago (Oct. 1, 2008)
Published Online 16 years, 10 months ago (Oct. 31, 2008)
Published Print 16 years, 10 months ago (Oct. 1, 2008)
Funders 0

None

@article{Brzezinski_2008, title={Cytochrome c oxidase: exciting progress and remaining mysteries}, volume={40}, ISSN={1573-6881}, url={http://dx.doi.org/10.1007/s10863-008-9181-7}, DOI={10.1007/s10863-008-9181-7}, number={5}, journal={Journal of Bioenergetics and Biomembranes}, publisher={Springer Science and Business Media LLC}, author={Brzezinski, Peter and Gennis, Robert B.}, year={2008}, month=oct, pages={521–531} }