Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies
10.1007/s00401-005-0027-7
Crossref journal-article
Springer Science and Business Media LLC
Acta Neuropathologica (297)
Bibliography

Klucken, J., Ingelsson, M., Shin, Y., Irizarry, M. C., Hedley-Whyte, E. T., Frosch, M. P., Growdon, J. H., McLean, P. J., & Hyman, B. T. (2006). Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies. Acta Neuropathologica, 111(2), 101–108.

Authors 9
  1. Jochen Klucken (first)
  2. Martin Ingelsson (additional)
  3. Youngah Shin (additional)
  4. Michael C. Irizarry (additional)
  5. E. T. Hedley-Whyte (additional)
  6. Matthew P. Frosch (additional)
  7. John H. Growdon (additional)
  8. Pamela J. McLean (additional)
  9. Bradley T. Hyman (additional)
References 37 Referenced 53
  1. Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson’s disease. Science 295:865–868 (10.1126/science.1067389) / Science by PK Auluck (2002)
  2. Auluck PK, Meulener MC, Bonini NM (2005) Mechanisms of suppression of alpha-synuclein neurotoxicity by geldanamycin in Drosophila. J Biol Chem 280:2873–2878 (10.1074/jbc.M412106200) / J Biol Chem by PK Auluck (2005)
  3. Bonini NM (2002) Chaperoning brain degeneration. Proc Natl Acad Sci USA 99(Suppl 4):16407–16411 (10.1073/pnas.152330499) / Proc Natl Acad Sci USA by NM Bonini (2002)
  4. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res 318:121–134 (10.1007/s00441-004-0956-9) / Cell Tissue Res by H Braak (2004)
  5. Buldyrev SV, Cruz L, Gomez-Isla T, Gomez-Tortosa E, Havlin S, Le R, Stanley HE, Urbanc B, Hyman BT (2000) Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias. Proc Natl Acad Sci USA 97:5039–5043 (10.1073/pnas.060009897) / Proc Natl Acad Sci USA by SV Buldyrev (2000)
  6. Campbell BC, Li QX, Culvenor JG, Jakala P, Cappai R, Beyreuther K, Masters CL, McLean CA (2000) Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies. Neurobiol Dis 7:192–200 (10.1006/nbdi.2000.0286) / Neurobiol Dis by BC Campbell (2000)
  7. Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, Keller-McGandy CE, McLean PJ, Frosch M, Hyman BT, Standaert DG (2005) Altered expression and solubility of alpha-synuclein and chaperones in dementia with Lewy bodies. J Neuropathol Exp Neurol 64:1058–1066 (10.1097/01.jnen.0000190063.90440.69)
  8. Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8:79–84 (10.1038/nn1372) / Nat Neurosci by JP Cleary (2005)
  9. Colosimo C, Hughes AJ, Kilford L, Lees AJ (2003) Lewy body cortical involvement may not always predict dementia in Parkinson’s disease. J Neurol Neurosurg Psychiatry 74:852–856 (10.1136/jnnp.74.7.852) / J Neurol Neurosurg Psychiatry by C Colosimo (2003)
  10. Dalfo E, Albasanz JL, Martin M, Ferrer I (2004) Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions. Brain Pathol 14:388–398 (10.1111/j.1750-3639.2004.tb00082.x) / Brain Pathol by E Dalfo (2004)
  11. Dickson DW, Davies P, Mayeux R, Crystal H, Horoupian DS, Thompson A, Goldman JE (1987) Diffuse Lewy body disease. Neuropathological and biochemical studies of six patients. Acta Neuropathol (Berl) 75:8–15 (10.1007/BF00686786) / Acta Neuropathol (Berl) by DW Dickson (1987)
  12. Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 24:6715–6723 (10.1523/JNEUROSCI.1594-04.2004) / J Neurosci by DL Fortin (2004)
  13. Fukumoto H, Cheung BS, Hyman BT, Irizarry MC (2002) Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 59:1381–1389 (10.1001/archneur.59.9.1381) / Arch Neurol by H Fukumoto (2002)
  14. Galvin JE, Giasson B, Hurtig HI, Lee VM, Trojanowski JQ (2000) Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Am J Pathol 157:361–368 (10.1016/S0002-9440(10)64548-8) / Am J Pathol by JE Galvin (2000)
  15. Gomez-Isla T, Growdon WB, McNamara M, Newell K, Gomez-Tortosa E, Hedley-Whyte ET, Hyman BT (1999) Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies. Neurology 53:2003–2009 (10.1212/WNL.53.9.2003) / Neurology by T Gomez-Isla (1999)
  16. Gomez-Tortosa E, Irizarry MC, Gomez-Isla T, Hyman BT (2000) Clinical and neuropathological correlates of dementia with Lewy bodies. Ann NY Acad Sci 920:9–15 (10.1111/j.1749-6632.2000.tb06899.x) / Ann NY Acad Sci by E Gomez-Tortosa (2000)
  17. Hishikawa N, Hashizume Y, Yoshida M, Sobue G (2003) Clinical and neuropathological correlates of Lewy body disease. Acta Neuropathol (Berl) 105:341–350 (10.1007/s00401-002-0651-4) / Acta Neuropathol (Berl) by N Hishikawa (2003)
  18. Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC (2004) Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62:925–931 (10.1212/01.WNL.0000115115.98960.37) / Neurology by M Ingelsson (2004)
  19. Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C (2001) Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 159:2215–2225 (10.1016/S0002-9440(10)63072-6) / Am J Pathol by PJ Kahle (2001)
  20. Klucken J, McLean P, Gomez-Tortosa E, Ingelsson M, Hyman B (2003) Neuritic alterations and neural system dysfunction in Alzheimer’s disease and dementia with Lewy bodies. Neurochem Res 11:1683–1691 (10.1023/A:1026061021946) / Neurochem Res by J Klucken (2003)
  21. Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ (2004) Hsp70 reduces alpha-synuclein aggregation and toxicity. J Biol Chem 279:25497–25502 (10.1074/jbc.M400255200) / J Biol Chem by J Klucken (2004)
  22. Kovari E, Gold G, Herrmann FR, Canuto A, Hof PR, Bouras C, Giannakopoulos P (2003) Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson’s disease. Acta Neuropathol (Berl) 106:83–88 (10.1007/s00401-003-0705-2) / Acta Neuropathol (Berl) by E Kovari (2003)
  23. Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease. Nat Genet 18:106–108 (10.1038/ng0298-106) / Nat Genet by R Kruger (1998)
  24. Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL (2005) A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem 280:31664–31672 (10.1074/jbc.M504894200) / J Biol Chem by S Kubo (2005)
  25. Lippa CF, Smith TW, Swearer JM (1994) Alzheimer’s disease and Lewy body disease: a comparative clinicopathological study. Ann Neurol 35:81–88 (10.1002/ana.410350113) / Ann Neurol by CF Lippa (1994)
  26. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47:1113–24 (10.1212/WNL.47.5.1113) / Neurology by IG McKeith (1996)
  27. McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT (2002) TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J Neurochem 83:846–854 (10.1046/j.1471-4159.2002.01190.x) / J Neurochem by PJ McLean (2002)
  28. Newell KL, Hyman BT, Growdon JH, Hedley-Whyte ET (1999) Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. J Neuropathol Exp Neurol 58:1147–1155 (10.1097/00005072-199911000-00004) / J Neuropathol Exp Neurol by KL Newell (1999)
  29. Perry R, McKeith I, Perry E (1997) Lewy body dementia—clinical, pathological and neurochemical interconnections. J Neural Transm Suppl 51:95–109 (10.1007/978-3-7091-6846-2_8) / J Neural Transm Suppl by R Perry (1997)
  30. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 276:2045–2047 (10.1126/science.276.5321.2045) / Science by MH Polymeropoulos (1997)
  31. Sabbagh MN, Corey-Bloom J, Tiraboschi P, Thomas R, Masliah E, Thal LJ (1999) Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease. Arch Neurol 56:1458–1461 (10.1001/archneur.56.12.1458) / Arch Neurol by MN Sabbagh (1999)
  32. Samuel W, Alford M, Hofstetter CR, Hansen L (1997) Dementia with Lewy bodies versus pure Alzheimer disease: differences in cognition, neuropathology, cholinergic dysfunction, and synapse density. J Neuropathol Exp Neurol 56:499–508 (10.1097/00005072-199705000-00006) / J Neuropathol Exp Neurol by W Samuel (1997)
  33. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ (2003) The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson’s disease. Neuron 37:583–595 (10.1016/S0896-6273(03)00024-2) / Neuron by R Sharon (2003)
  34. Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K (2003) Alpha-synuclein locus triplication causes Parkinson’s disease. Science 302:841 (10.1126/science.1090278) / Science by AB Singleton (2003)
  35. de Vos RA, Jansen EN, Stam FC, Ravid R, Swaab DF (1995) ‘Lewy body disease’: clinico-pathological correlations in 18 consecutive cases of Parkinson’s disease with and without dementia. Clin Neurol Neurosurg 97:13–22 (10.1016/0303-8467(94)00060-J) / Clin Neurol Neurosurg by RA Vos de (1995)
  36. White CLI, Welch EM, Brown DR, Speciale SG, Sontag E (1997) Production and characterization of a recombinant synaptophysin fragment suitable for use as a standard in immunoassays. J Neuropath Exp Neurol 56:608 (10.1097/00005072-199705000-00163) / J Neuropath Exp Neurol by CLI White (1997)
  37. Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, Llorens V, Gomez Tortosa E, del Ser T, Munoz DG, de Yebenes JG (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55:164–173 (10.1002/ana.10795) / Ann Neurol by JJ Zarranz (2004)
Dates
Type When
Created 19 years, 6 months ago (Feb. 15, 2006, 11:32 a.m.)
Deposited 5 years, 4 months ago (April 12, 2020, 2:58 p.m.)
Indexed 11 months, 3 weeks ago (Sept. 4, 2024, 1:56 a.m.)
Issued 19 years, 6 months ago (Feb. 1, 2006)
Published 19 years, 6 months ago (Feb. 1, 2006)
Published Online 19 years, 6 months ago (Feb. 16, 2006)
Published Print 19 years, 6 months ago (Feb. 1, 2006)
Funders 0

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@article{Klucken_2006, title={Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies}, volume={111}, ISSN={1432-0533}, url={http://dx.doi.org/10.1007/s00401-005-0027-7}, DOI={10.1007/s00401-005-0027-7}, number={2}, journal={Acta Neuropathologica}, publisher={Springer Science and Business Media LLC}, author={Klucken, Jochen and Ingelsson, Martin and Shin, Youngah and Irizarry, Michael C. and Hedley-Whyte, E. T. and Frosch, Matthew P. and Growdon, John H. and McLean, Pamela J. and Hyman, Bradley T.}, year={2006}, month=feb, pages={101–108} }