DOI: 10.1007/s00268-007-0727-3. Nitric Oxide Accelerates the Recovery from Burn Wounds

Nitric Oxide Accelerates the Recovery from Burn Wounds

10.1007/s00268-007-0727-3

Crossref journal-article

Wiley

World Journal of Surgery (311)

Abstract

AbstractA full‐thickness burn wound model was used to evaluate the effects of a topically applied gel‐based nitric oxide donor on wound healing in rats. The histological study demonstrated that the nitric oxide (NO) application significantly promoted re‐epithelization that resulted in a fast recovery of burn wound. The histological sections further revealed that inflammatory cell infiltration in the NO‐treated group was significantly increased in comparison to the control group. The enhanced accumulation of inflammatory cells resulted in a higher expression of myeloperoxidase (MPO) that was detected with imunoblotting. An immunohistochemistry study with CD31, a specific marker for endothelial cells, indicated that NO treatment markedly stimulated angiogenesis. Evaluation of collagen synthesis by immunohistochemistry with procollagen antibody demonstrated a significantly increased collagen synthesis in NO‐treated wound bed. We concluded that NO treatment promoted re‐epithelialization and wound closure by means of enhanced inflammatory cell infiltration, and that it promoted angiogenesis and facilitated collagen synthesis in the wound bed.

Bibliography

Zhu, H., Ka, B., & Murad, F. (2007). Nitric Oxide Accelerates the Recovery from Burn Wounds. World Journal of Surgery, 31(4), 624â631. Portico.

Authors 3

Haifeng Zhu (first)
Bian Ka (additional)
Ferid Murad (additional)

References 25 Referenced 75

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{'issue': '4', 'key': 'e_1_2_6_6_2', 'first-page': 'H1600', 'article-title': 'Impaired wound healing and angiogenesis in eNOS‐deficient mice', 'volume': '277', 'author': 'Lee PC', 'year': '1999', 'journal-title': 'Am J Physiol'} / Am J Physiol / Impaired wound healing and angiogenesis in eNOS‐deficient mice by Lee PC (1999)
10.1172/JCI2067
{'issue': '2', 'key': 'e_1_2_6_8_2', 'first-page': 'E181', 'article-title': 'Differential regulation of macrophage arginine metabolism: a proposed role in wound healing', 'volume': '272', 'author': 'Shearer JD', 'year': '1997', 'journal-title': 'Am J Physiol'} / Am J Physiol / Differential regulation of macrophage arginine metabolism: a proposed role in wound healing by Shearer JD (1997)
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{'issue': '1', 'key': 'e_1_2_6_21_2', 'first-page': 'H411', 'article-title': 'Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium', 'volume': '270', 'author': 'Morbidelli L', 'year': '1996', 'journal-title': 'Am J Physiol'} / Am J Physiol / Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium by Morbidelli L (1996)
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Dates

Type	When
Created	18 years, 6 months ago (Feb. 16, 2007, 10:10 a.m.)
Deposited	1 year, 8 months ago (Dec. 24, 2023, 5:35 a.m.)
Indexed	1 year, 1 month ago (July 10, 2024, 1:59 a.m.)
Issued	18 years, 6 months ago (Feb. 1, 2007)
Published	18 years, 6 months ago (Feb. 1, 2007)
Published Online	18 years, 6 months ago (Feb. 1, 2007)
Published Print	18 years, 4 months ago (April 1, 2007)

Funders 1

National Institutes of Health 10.13039/100000002
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards3
1. NL64221
2. GM061731
3. P30DK56338

BibTeX

@article{Zhu_2007, title={Nitric Oxide Accelerates the Recovery from Burn Wounds}, volume={31}, ISSN={1432-2323}, url={http://dx.doi.org/10.1007/s00268-007-0727-3}, DOI={10.1007/s00268-007-0727-3}, number={4}, journal={World Journal of Surgery}, publisher={Wiley}, author={Zhu, Haifeng and Ka, Bian and Murad, Ferid}, year={2007}, month=feb, pages={624–631} }

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