DOI: 10.1007/bfb0115593. Transport of proteins into mitochondria

10.1007/bfb0115593

Crossref book-chapter

Springer Berlin Heidelberg

Reviews of Physiology, Biochemistry and Pharmacology (297)

Bibliography

Truscott, K. N., Pfanner, N., & Voos, W. (n.d.). Transport of proteins into mitochondria. Reviews of Physiology, Biochemistry and Pharmacology, 81â136.

Authors 3

K. N. Truscott (first)
N. Pfanner (additional)
W. Voos (additional)

References 203 Referenced 34

Abe Y, Shodia T, Muto T, Mihara K, Torii H, Nishikawa S, Endo T, Kohda D (2000) Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell 100:551–560 (10.1016/S0092-8674(00)80691-1) / Cell by Y Abe (2000)
Adam A, Endres M, Sirrenberg C, Lottspeich F, Neupert W, Brunner M (1999) Tim9, a new component of the TIM22·54 translocase in mitochondria. EMBO J 18:313–319 (10.1093/emboj/18.2.313) / EMBO J by A Adam (1999)
Alconada A, Kübrich M, Moczko M, Hönlinger A, Pfanner N (1995) The mitochondrial receptor complex: the small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins. Mol Cell Biol 15:6196–6205 (10.1128/MCB.15.11.6196) / Mol Cell Biol by A Alconada (1995)
Allison DS, Schatz G (1986) Artificial mitochondrial presequences. Proc Natl Acad Sci USA 83:9011–9015 (10.1073/pnas.83.23.9011) / Proc Natl Acad Sci USA by DS Allison (1986)
Amaya Y, Arakawa H, Takiguchi M, Ebina Y, Yokota S, Mori M (1988) A noncleavable signal for mitochondrial import of 3-oxoacyl-CoA thiolase. J Biol Chem 263:14463–14470 (10.1016/S0021-9258(18)68242-0) / J Biol Chem by Y Amaya (1988)
Argan C, Lusty CJ, Shore G (1983) Membrane and cytosolic components affecting transport of the precursor of ornithine carbamyltransferase into mitochondria. J Biol Chem 258:6667–6670. (10.1016/S0021-9258(18)32263-4) / J Biol Chem by C Argan (1983)
Arnold I, Fölsch H, Neupert W, Stuart RA (1998) Two distinct and independent mitochondrial targeting signals function in the sorting of an inner membrane protein, cytochrome c 1. J Biol Chem 273:1469–1476 (10.1074/jbc.273.3.1469) / J Biol Chem by I Arnold (1998)
Baker A, Schatz G (1987) Sequences from a prokaryotic genome or the mouse dihydrofolate reductase gene can restore the import of a truncated precursor protein into yeast mitochondria. Proc Natl Acad Sci USA 84:3117–3121 (10.1073/pnas.84.10.3117) / Proc Natl Acad Sci USA by A Baker (1987)
Baker KP, Schaniel A, Vestweber D, Schatz G (1990) A yeast mitochondrial outer membrane protein essential for protein import and cell viability. Nature 348:605–609 (10.1038/348605a0) / Nature by KP Baker (1990)
Bauer MF, Sirrenberg C, Neupert W, Brunner M (1996) Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell 87:33–41 (10.1016/S0092-8674(00)81320-3) / Cell by MF Bauer (1996)
Beasley EM, Wachter C, Schatz G (1992) Putting energy into mitochondrial protein import. Curr Opin Cell Biol 4:646–651 (10.1016/0955-0674(92)90084-P) / Curr Opin Cell Biol by EM Beasley (1992)
Bedwell DM, Klionsky DJ, Emr SD (1987) The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information. Mol Cell Biol 7:4038–4047 (10.1128/MCB.7.11.4038) / Mol Cell Biol by DM Bedwell (1987)
Blobel G (1980) Intracellular protein topogenesis. Proc Natl Acad Sci USA 77:1496–1500 (10.1073/pnas.77.3.1496) / Proc Natl Acad Sci USA by G Blobel (1980)
Blom J, Kübrich M, Rassow J, Voos W, Dekker PJ, Maarse AC, Meijer M, Pfanner N (1993) The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane. Mol Cell Biol 13:7364–7371 (10.1128/MCB.13.12.7364) / Mol Cell Biol by J Blom (1993)
Bolliger L, Deloche O, Glick BS, Georgopoulos C, Jenö P, Kronidou N, Horst M, Morishima N, Schatz G (1994) A mitochondrial homologue of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J 13:1998–2006 (10.1002/j.1460-2075.1994.tb06469.x) / EMBO J by L Bolliger (1994)
Bolliger L, Junne T, Schatz G, Lithgow T (1995) Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria. EMBO J 14:6318–6326 (10.1002/j.1460-2075.1995.tb00322.x) / EMBO J by L Bolliger (1995)
Bömer U, Pfanner N, Dietmeier K (1996) Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats. FEBS Lett 382:153–158 (10.1016/0014-5793(96)00156-1) / FEBS Lett by U Bömer (1996)
Bömer U, Meijer M, Maarse AC, Hönlinger A, Dekker PJ, Pfanner N, Rassow J (1997) Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane. EMBO J 16:2205–2216 (10.1093/emboj/16.9.2205) / EMBO J by U Bömer (1997)
Bömer U, Maarse AC, Martin F, Geissler A, Merlin A, Schönfisch B, Meijer M, Pfanner N, Rassow J (1998) Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins. EMBO J 17:4226–4237 (10.1093/emboj/17.15.4226) / EMBO J by U Bömer (1998)
Brix J, Dietmeier K, Pfanner N (1997) Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70. J Biol Chem 272:20730–20735 (10.1074/jbc.272.33.20730) / J Biol Chem by J Brix (1997)
Brix J, Rüdiger S, Bukau B, Schneider-Mergener J, Pfanner N (1999) Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem 274:16522–16530 (10.1074/jbc.274.23.16522) / J Biol Chem by J Brix (1999)
Bruch MD, Hoyt DW (1992) Conformational analysis of a mitochondrial presequence derived from the F1-ATPase beta-subunit by CD and NMR spectroscopy. Biochim Biophys Acta 1159:81–93 (10.1016/0167-4838(92)90078-R) / Biochim Biophys Acta by MD Bruch (1992)
Buchberger A, Reinstein J, Bukau B (1999) in Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism (Bukau B, ed) pp, 609–635 Harwood Academic Publishers, Amsterdam / Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism by A Buchberger (1999)
Chauwin JF, Oster G, Glick BS (1998) Strong precursor-pore interactions constrain models for mitochondrial protein import. Biophys J 74:1732–1743 (10.1016/S0006-3495(98)77884-1) / Biophys J by JF Chauwin (1998)
Chirico W, Waters MG, Blobel G (1988) 70K heat shock related proteins stimulate protein translocation into microsomes. Nature 332:805–810 (10.1038/332805a0) / Nature by W Chirico (1988)
Craig EA, Kramer J, Shilling J, Werner-Washburne M, Holmes S, Kosic-Smithers J, Nicolet CM (1989) SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein. Mol Cell Biol 9:3000–3008 (10.1128/MCB.9.7.3000) / Mol Cell Biol by EA Craig (1989)
Crowley KS, Liao S, Worrell VE, Reinhart GD, Johnson AE (1994) Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore. Cell 78:461–471 (10.1016/0092-8674(94)90424-3) / Cell by KS Crowley (1994)
Crowley KS, Payne RM (1998) Ribosome binding to mitochondria is regulated by GTP and the transit peptide. J Biol Chem 273:17278–17285 (10.1074/jbc.273.27.17278) / J Biol Chem by KS Crowley (1998)
Cyr DM, Stuart RA, Neupert W (1993) A matrix ATP requirement for presequence translocation across the inner membrane of mitochondria. J Biol Chem 268:23751–23754 (10.1016/S0021-9258(20)80443-8) / J Biol Chem by DM Cyr (1993)
Davis AJ, Ryan KR, Jensen RE (1998) Tim23p contains separate and distinct signals for targeting to mitochondria and insertion into the inner membrane. Mol Biol Cell 9:2577–93 (10.1091/mbc.9.9.2577) / Mol Biol Cell by AJ Davis (1998)
Dekker PJT, Keil P, Rassow J, Maarse AC, Pfanner N, Meijer M (1993) Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett 330:66–70 (10.1016/0014-5793(93)80921-G) / FEBS Lett by PJT Dekker (1993)
Dekker PJT, Pfanner N (1997) Role of mitochondrial GrpE and phosphate in the ATPase cycle of matrix Hsp70. J Mol Biol 270:321–327 (10.1006/jmbi.1997.1131) / J Mol Biol by PJT Dekker (1997)
Dekker PJT, Martin F, Maarse AC, Bömer U, Müller H, Guiard B, Meijer M, Rassow J, Pfanner N (1997) The Tim core complex defines the number of mitochondrial translation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44. EMBO J 16:5408–5419 (10.1093/emboj/16.17.5408) / EMBO J by PJT Dekker (1997)
Dekker PJT, Ryan MT, Brix J, Müller H, Hönlinger A, Pfanner N (1998) Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol 18:6515–6524 (10.1128/MCB.18.11.6515) / Mol Cell Biol by PJT Dekker (1998)
Dekker PJT, Pfanner N (1999) in Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism (Bukau B, ed) pp 235–262, Harwood Academic Publishers, Amsterdam / Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism by PJT Dekker (1999)
Deshaies R, Koch B, Werner-Washburne M, Craig EA, Schekman R (1988) A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature 332:800–805 (10.1038/332800a0) / Nature by R Deshaies (1988)
Dietmeier K, Hönlinger A, Bömer U, Dekker PJ, Eckerskorn C, Lottspeich F, Kübrich M, Pfanner N (1997) Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature 388:195–200 (10.1038/40663) / Nature by K Dietmeier (1997)
Donzeau M, Kaldi K, Adam A, Paschen S, Wanner G, Guiard B, Bauer MF, Neupert W, Brunner M (2000) Tim23 links the inner and outer mitochondrial membranes. Cell 101:401–412 (10.1016/S0092-8674(00)80850-8) / Cell by M Donzeau (2000)
Eilers M, Oppliger W, Schatz G (1987) Both ATP and an energized inner membrane are required to import a purified precursor protein into mitochondria. EMBO J 6:1073–1077 (10.1002/j.1460-2075.1987.tb04860.x) / EMBO J by M Eilers (1987)
Emtage JL, Jensen RE (1993) MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J Cell Biol 122:1003–1012 (10.1083/jcb.122.5.1003) / J Cell Biol by JL Emtage (1993)
Endo T, Shimada I, Roise D, Inagaki F (1989) N-terminal half of a mitochondrial presequence peptide takes a helical conformation when bound to dodecylphosphocholine micelles: a proton nuclear magnetic resonance study. J Biochem 106:396–400 (10.1093/oxfordjournals.jbchem.a122864) / J Biochem by T Endo (1989)
Finocchiaro G, Colombo I, Garavaglia B, Gellera C, Valdameri G, Garbuglio N, Didonato S (1993) cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein. Eur J Biochem 213:1003–1008 (10.1111/j.1432-1033.1993.tb17847.x) / Eur J Biochem by G Finocchiaro (1993)
Fünfschilling U, Rospert S (1999) Nascent Polypeptide-associated Complex stimulates protein import into yeast mitochondria. Mol Biol Cell 10:3289–3299 (10.1091/mbc.10.10.3289) / Mol Biol Cell by U Fünfschilling (1999)
Gambill BD, Voos W, Kang PJ, Miao B, Langer T, Craig EA, Pfanner N (1993) A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol 123:109–117 (10.1083/jcb.123.1.109) / J Cell Biol by BD Gambill (1993)
Gärtner F, Bömer U, Guiard B, Pfanner N (1995) The sorting signal of cytochrome b 2 promotes early divergence from the general mitochondrial import pathway and restricts the unfoldase activity of matrix Hsp70. EMBO J 14:6043–6057 (10.1002/j.1460-2075.1995.tb00293.x) / EMBO J by F Gärtner (1995)
Gasser SM, Daum G, Schatz G (1982) Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria. J Biol Chem 257:13034–13041 (10.1016/S0021-9258(18)33618-4) / J Biol Chem by SM Gasser (1982)
Gässler CS, Buchberger A, Laufen T, Mayer MP, Schröder H, Valencia A, Bukau B (1998) Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone. Proc Natl Acad Sci USA 95:15229–15234 (10.1073/pnas.95.26.15229) / Proc Natl Acad Sci USA by CS Gässler (1998)
Gaume B, Klaus C, Ungermann C, Guiard B, Neupert W, Brunner M (1998) Unfolding of preproteins upon import into mitochondria. EMBO J 17:6497–6507 (10.1093/emboj/17.22.6497) / EMBO J by B Gaume (1998)
Geli V, Yang MJ, Suda K, Lustig A, Schatz G (1990) The MAS-encoded processing protease of yeast mitochondria. Overproduction and characterization of its two nonidentical subunits. J Biol Chem 265:19216–19222 (10.1016/S0021-9258(17)30646-4) / J Biol Chem by V Geli (1990)
George R, Beddoe T, Landl K, Lithgow T (1998) The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. Proc Natl Acad Sci USA 95:2296–2301 (10.1073/pnas.95.5.2296) / Proc Natl Acad Sci USA by R George (1998)
Goping IS, Millar DG, Shore GC (1995) Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of Δmas20 in yeast. FEBS Lett 373:45–50 (10.1016/0014-5793(95)01010-C) / FEBS Lett by IS Goping (1995)
Gragerov A, Zeng L, Zhao X, Burkholder W, Gottesman ME (1994) Specificity of DnaK-peptide binding. J Mol Biol 235:848–854 (10.1006/jmbi.1994.1043) / J Mol Biol by A Gragerov (1994)
Gratzer S, Lithgow T, Bauer RE, Lamping E, Paltauf F, Kohlwein SD, Haucke V, Junne T, Schatz G, Horst M (1995) Mas37p, a novel receptor subunit for protein import into mitochondria. J Cell Biol 129:25–34 (10.1083/jcb.129.1.25) / J Cell Biol by S Gratzer (1995)
Gruhler A, Ono H, Guiard B, Neupert W, Stuart RA (1995) A novel intermediate on the import pathway of cytochrome b2 into mitochondria: evidence for conservative sorting. EMBO J 14:1349–1359 (10.1002/j.1460-2075.1995.tb07121.x) / EMBO J by A Gruhler (1995)
Guiard B (1985) Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast (L(+)-lactate cytochrome c oxidoreductase (cytochrome b 2). EMBO J 14:3265–3272 (10.1002/j.1460-2075.1985.tb04076.x) / EMBO J by B Guiard (1985)
Ha J-H, Johnson ER, Mckay DB, Sousa MC, Takeda S, Wilbanks SM (1999) in Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism (Bukau B, ed) pp 573–607, Harwood Academic Publishers, Amsterdam / Molecular Chaperones and Folding Catalysts. Regulation, Cellular Function and Mechanism by J-H Ha (1999)
Hachiya N, Alam R, Sakasegawa Y, Sakaguchi M, Mihara K, Omura T (1993) A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins. EMBO J 12:1579–1586 (10.1002/j.1460-2075.1993.tb05802.x) / EMBO J by N Hachiya (1993)
Hachiya N, Komiya T, Alam R, Iwahashi J, Sakaguchi M, Omura T, Mihara K (1994) MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria. EMBO J 13:5146–5154 (10.1002/j.1460-2075.1994.tb06844.x) / EMBO J by N Hachiya (1994)
Hachiya N, Mihara K, Suda K, Horst M, Schatz G, Lithgow T (1995) Reconstitution of the initial steps of mitochondrial protein import. Nature 376:705–709 (10.1038/376705a0) / Nature by N Hachiya (1995)
Hammen PK, Gorenstein DG, Weiner H (1994) Structure of the signal sequences for two mitochondrial matrix proteins that are not proteolytically processed upon import. Biochem 33:8610–8617 (10.1021/bi00194a028) / Biochem by PK Hammen (1994)
Hanson B, Nuttal S, Hoogenraad N (1996) A receptor for the import of proteins into human mitochondria. Eur J Biochem 235:750–753 (10.1111/j.1432-1033.1996.t01-1-00750.x) / Eur J Biochem by B Hanson (1996)
Harkness TA, Nargang FE, van der Klei I, Neupert W, Lill R (1994) A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria. J Cell Biol 124:637–648 (10.1083/jcb.124.5.637) / J Cell Biol by TA Harkness (1994)
Hartl F-U, Schmidt B, Wachter E, Weiss H, Neupert W (1986) Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinolcytochrome c reductase. Cell 47:939–951 (10.1016/0092-8674(86)90809-3) / Cell by F-U Hartl (1986)
Hartl F-U, Ostermann J, Guiard B, Neupert W (1987) Successive translocation into and out of the mitochondrial matrix: targeting of proteins to the intermembrane space by a bipartite signal peptide. Cell 51:1027–1037 (10.1016/0092-8674(87)90589-7) / Cell by F-U Hartl (1987)
Haucke V, Lithgow T, Rospert S, Hahne K, Schatz G (1995) The yeast mitochondrial protein import receptor Mas20p binds precursor proteins through electrostatic interaction with the positively charged presequence. J Biol Chem 270:5565–5570 (10.1074/jbc.270.10.5565) / J Biol Chem by V Haucke (1995)
Hill K, Model K, Ryan MT, Dietmeier K, Martin F, Wagner R, Pfanner N (1998) Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins. Nature 395:516–521 (10.1038/26780) / Nature by K Hill (1998)
Hines V, Brandt A, Griffith G, Horstmann H, Brütsch H, Schatz G (1990) Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70. EMBO J 9:3191–3200. (10.1002/j.1460-2075.1990.tb07517.x) / EMBO J by V Hines (1990)
Hönlinger A, Kübrich M, Moczko M, Gärtner F, Mallet L, Bussereau F, Eckerskorn C, Lottspeich F, Dietmeier K, Jacquet M, Pfanner N (1995) The mitochondrial receptor complex: Mom22 is essential for cell viability and directly interacts with pre-proteins. Mol Cell Biol 15:3382–3389 (10.1128/MCB.15.6.3382) / Mol Cell Biol by A Hönlinger (1995)
Hönlinger A, Bömer U, Alconada A, Eckerskorn C, Lottspeich F, Dietmeier K, Pfanner N (1996) Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. EMBO J 15:2125–2137 (10.1002/j.1460-2075.1996.tb00566.x) / EMBO J by A Hönlinger (1996)
Horst M, Jenö P, Kronidou NG, Bolliger L, Oppliger, W, Scherer P, Manning-Krieg U, Jascur T, Schatz G (1993) Protein import into yeast mitochondria: the inner membrane import site protein ISP45 is the MPI1 gene product. EMBO J 12:3035–3041 (10.1002/j.1460-2075.1993.tb05972.x) / EMBO J by M Horst (1993)
Horst M, Oppliger W, Rospert S, Schonfeld HJ, Schatz G, Azem A (1997) Sequential action of two Hsp70 complexes during protein import into mitochondria. EMBO J 16:1842–1849 (10.1093/emboj/16.8.1842) / EMBO J by M Horst (1997)
Horwich AL, Kalousek F, Mellman I Rosenberg LE (1985) A leader peptide is sufficient to direct, mitochondrial import of a chimeric protein. EMBO J 4:1129–1135 (10.1002/j.1460-2075.1985.tb03750.x) / EMBO J by AL Horwich (1985)
Huang S, Ratliff KS, Schwartz MP, Spenner JM, Matouschek A (1999) Mitochondria unfold precursor proteins by unravelling them from their N-termini. Nat Struct Biol 6:1132–1138 (10.1038/70073) / Nat Struct Biol by S Huang (1999)
Hurt EC, Pesold-Hurt B, Schatz G (1984) The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix. FEBS Lett 178:306–310 (10.1016/0014-5793(84)80622-5) / FEBS Lett by EC Hurt (1984)
Hurt EC, Persold-Hurt B, Suda K, Oppliger W, Schatz G (1985) The first twelve amino acids (less than half of the pre-sequence) of an imported mitochondrial protein can direct mouse cytosolic dihydrofolate reductase into the yeast mitochondrial matrix. EMBO J 4:2061–2068 (10.1002/j.1460-2075.1985.tb03892.x) / EMBO J by EC Hurt (1985)
Hurt EC, Van Loon APMG (1986) How proteins find mitochondria and intramitochondrial compartments. Trends Biochem Sci 11:204–207 (10.1016/0968-0004(86)90007-1) / Trends Biochem Sci by EC Hurt (1986)
Hwang ST, Schatz G (1989) Translocation of proteins across the mitochondrial inner membrane, but not into the outer membrane, requires nucleoside triphosphates in the matrix. Proc Natl Acad Sci USA 86:8432–8436 (10.1073/pnas.86.21.8432) / Proc Natl Acad Sci USA by ST Hwang (1989)
Hwang S, Jascur T, Vestweber D, Pon L, Schatz G (1989) Disrupted yeast mitochondria can import precursor proteins directly through their inner membrane. J Cell Biol 109:487–493 (10.1083/jcb.109.2.487) / J Cell Biol by S Hwang (1989)
Ikeda E, Yoshida S, Mitsuzawa H, Uno I, Toh-e A (1994) YGE1 is a yeast homologue of Escherichia coli grpE, and is required for maintenance of mitochondrial functions. FEBS Lett 339:265–268 (10.1016/0014-5793(94)80428-1) / FEBS Lett by E Ikeda (1994)
Isaya G, Miklos D, Rollins RA (1994) MIP1, a new yeast gene homologous to the rat mitochondrial intermediate peptidase gene, is required for oxidative metabolism in Saccharomyces cerevisiae. Mol Cell Biol 14:5603–5616 (10.1128/MCB.14.8.5603) / Mol Cell Biol by G Isaya (1994)
Ishihara N, Mihara K (1998) Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. J Biochem 123:722–732 (10.1093/oxfordjournals.jbchem.a021997) / J Biochem by N Ishihara (1998)
Jarosch B, Tuller G, Daum G, Waldherr M, Voskova A, Schweyen RJ (1996) Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria. J Biol Chem 271:17219–17225 (10.1074/jbc.271.29.17219) / J Biol Chem by B Jarosch (1996)
Jarvis JA, Ryan MT, Hoogenraad NJ, Craik DJ, Høj PB (1995) Solution structure of the acetylated and noncleavable mitochondrial targeting signal of rat chaperonin 10. J Biol Chem 270:1323–1331 (10.1074/jbc.270.32.18825) / J Biol Chem by JA Jarvis (1995)
Jin H, May M, Tranebjaerg L, Kendall E, Fontan G, Jackson J, Subramony SH, Arena F, Lubs H, Smith S, Stevenson R, Schwartz C, Vetrie D (1996) A novel X-linked gene, DDP, shows mutations in families with deafness (DFN-1), dystonia, mental deficiency and blindness. Nat Genet 14:177–180 (10.1038/ng1096-177) / Nat Genet by H Jin (1996)
Káldi K, Bauer MF, Sirrenberg C, Neupert W, Brunner M (1998) Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins. EMBO J 17:1569–1576 (10.1093/emboj/17.6.1569) / EMBO J by K Káldi (1998)
Kalousek F, Isaya G, Rosenberg LE (1992) Rat liver mitochondrial intermediate peptidase (MIP): purification and initial characterization. EMBO J 11:2803–2809 (10.1002/j.1460-2075.1992.tb05347.x) / EMBO J by F Kalousek (1992)
Kanamori T, Nishikawa S, Shin I, Schultz PG, Endo T (1997) Probing the environment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking. Proc Natl Acad Sci USA 94:485–490 (10.1073/pnas.94.2.485) / Proc Natl Acad Sci USA by T Kanamori (1997)
Kang PJ, Ostermann J, Shilling J, Neupert W, Craig EA, Pfanner N (1990) Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature 348:137–143. (10.1038/348137a0) / Nature by PJ Kang (1990)
Kaput J, Goltz S, Blobel G (1982) Nucleotide sequence of the yeast nuclear gene for cytochrome c peroxidase precursor. Functional implications of the presequence for protein transport into mitochondria. J Biol Chem 257:15054–15058 (10.1016/S0021-9258(18)33392-1) / J Biol Chem by J Kaput (1982)
Karslake C, Piotto ME, Pak YK, Weiner H, Gorenstein DG (1990) 2D NMR and structural model for a mitochondrial signal peptide bound to a micelle. Biochem 29:9872–9878 (10.1021/bi00494a017) / Biochem by C Karslake (1990)
Kassenbrock CK, Cao W, Douglas MG (1993) Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. EMBO J 12:3023–3034 (10.1002/j.1460-2075.1993.tb05971.x) / EMBO J by CK Kassenbrock (1993)
Keil P Pfanner N (1993) Insertion of MOM22 into the mitochondrial outer membrane strictly depends on surface-receptors. FEBS Lett 321:197–200 (10.1016/0014-5793(93)80107-6) / FEBS Lett by P Keil (1993)
Kerscher O, Holder J, Srinivasan M, Leung RS, Jensen RE (1997) The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. J Cell Biol 139:1663–1675 (10.1083/jcb.139.7.1663) / J Cell Biol by O Kerscher (1997)
Kerscher O, Sepuri NB, Jensen RE (2000) Tim18p is a new component of the Tim54p–Tim22p translocon in the mitochondrial inner membrane. Mol Biol Cell 11:103–116 (10.1091/mbc.11.1.103) / Mol Biol Cell by O Kerscher (2000)
Kiebler M, Keil P, Schneider H, van der Klei IJ, Pfanner N, Neupert W (1993) The mitochondrial receptor, complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell 74:483–492 (10.1016/0092-8674(93)80050-O) / Cell by M Kiebler (1993)
Koehler CM, Merchant S, Oppliger W, Schmid K, Jarosch E, Dolfini L, Junne T, Schatz G, Tokatlidis K (1998a) Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins. EMBO J 17:6477–6486 (10.1093/emboj/17.22.6477) / EMBO J by CM Koehler (1998)
Koehler CM, Jarosch E, Tokatlidis K, Schmid K, Schweyen RJ, Schatz G (1998b) Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science 279:369–373 (10.1126/science.279.5349.369) / Science by CM Koehler (1998)
Koehler CM, Leuenberger D, Merchant S, Renold A, Junne T, Schatz G (1999) Human deafness dystonia is a mitochondrial disease. Proc Natl Acad Sci USA 96:2141–2146 (10.1073/pnas.96.5.2141) / Proc Natl Acad Sci USA by CM Koehler (1999)
Koehler CM, Murphy MP Bally NA, Leuenberger D, Oppliger W, Dolfini L, Junne T, Schatz G, Or E (2000) Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane. Mol Cell Biol 20:1187–1193 (10.1128/MCB.20.4.1187-1193.2000) / Mol Cell Biol by CM Koehler (2000)
Koll H, Guiard B, Rassow J, Ostermann J, Horwich AL, Neupert W, Hartl F-U (1992) Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell 68:1163–1175 (10.1016/0092-8674(92)90086-R) / Cell by H Koll (1992)
Komiya T, Sakaguchi M, Mihara K (1996) Cytoplasmic chaperones determine the targeting pathway of precursor proteins to mitochondria. EMBO J 15:399–407 (10.1002/j.1460-2075.1996.tb00370.x) / EMBO J by T Komiya (1996)
Komiya T, Rospert S, Schatz G, Mihara K (1997) Binding of mitochondrial precursor proteins to the cytoplasmic domains of the import receptors Tom70 and Tom20 is determined by cytoplasmic chaperones. EMBO J 16:4267–4275 (10.1093/emboj/16.14.4267) / EMBO J by T Komiya (1997)
Komiya T, Rospert S Koehler C, Looser R, Schatz G, Mihara K (1998) Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the ‘acid chain’ hypothesis. EMBO J 17:3886–3898 (10.1093/emboj/17.14.3886) / EMBO J by T Komiya (1998)
Krimmer T, Rassow J, Kunau W-H Voos W, Pfanner N (2000) Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role. Mol Cell Biol 20:5879–5887 (10.1128/MCB.20.16.5879-5887.2000) / Mol Cell Biol by T Krimmer (2000)
Kronidou NG, Oppliger W, Bolliger L, Hannavy K, Glick BS, Schatz G, Horst M (1994) Dynamic interaction between Isp45 and mitochondrial Hsp70 in the protein import system of the yeast mitochondrial inner, membrane. Proc Natl Acad Sci USA 91:12818–12822 (10.1073/pnas.91.26.12818) / Proc Natl Acad Sci USA by NG Kronidou (1994)
Kübrich M, Keil P, Rassow J, Dekker PJ, Blom J, Meijer M, Pfanner N (1994) The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site. FEBS Lett 349:222–228 (10.1016/0014-5793(94)00670-9) / FEBS Lett by M Kübrich (1994)
Künkele KP, Heins S, Dembowski M, Nargang FE, Benz R, Thieffry M, Walz J, Lill R, Nussberger S, Neupert W (1998) The preprotein translocation channel of the outer membrane of mitochondria. Cell 93:1009–1019 (10.1016/S0092-8674(00)81206-4) / Cell by KP Künkele (1998)
Kurz M, Martin H, Rassow J, Pfanner N, Ryan MT (1999) Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing-over with the main import pathway. Mol Biol Cell 10:2461–2474 (10.1091/mbc.10.7.2461) / Mol Biol Cell by M Kurz (1999)
Lalorya S, Gambill BD, Craig EA (1994) A role for a eukaryotic GrpE-related protein Mge1p, in protein translocation. Proc Natl Acad Sci USA 91:6481–6485 (10.1073/pnas.91.14.6481) / Proc Natl Acad Sci USA by S Lalorya (1994)
Lalorya S, Dekker PJT, Voos W, Craig EA, Pfanner N (1995) Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins. Mol Cell Biol 15:7098–7105 (10.1128/MCB.15.12.7098) / Mol Cell Biol by S Lalorya (1995)
Landry SJ, Jordan R, McMacken R, Gierasch LM (1992) Different conformations for the same polypeptide bound to chaperones DnaK and GroEL. Nature 355:455–457 (10.1038/355455a0) / Nature by SJ Landry (1992)
Lemire BD, Fankhauser C, Baker A, Schatz G (1989) The mitochondrial targeting function of randomly generated peptide sequences correlates with predicted helical amphiphilicity. J Biol Chem 264:20206–20215 (10.1016/S0021-9258(19)47048-8) / J Biol Chem by BD Lemire (1989)
Leuenberger D, Bally NA, Schatz G, Koehler CM (1999) Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J 18:4816–4822 (10.1093/emboj/18.17.4816) / EMBO J by D Leuenberger (1999)
Lithgow T, Junne T, Suda K, Gratzer S, Schatz G (1994) The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast. Proc Natl Acad Sci USA 91:11973–11977 (10.1073/pnas.91.25.11973) / Proc Natl Acad Sci USA by T Lithgow (1994)
Lohret TA, Jensen RE, Kinnally KW (1997) Tim23, a protein import component of the mitochondrial inner membrane, is required for normal activity of the multiple conductance channel, MCC. J Cell Biol 137:377–386 (10.1083/jcb.137.2.377) / J Cell Biol by TA Lohret (1997)
Maarse AC, Blom J, Grivell LA, Meijer M (1992) MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. EMBO J 11:3619–3628 (10.1002/j.1460-2075.1992.tb05446.x) / EMBO J by AC Maarse (1992)
Maarse AC, Blom J, Keil P Pfanner N, Meijer M (1994) Identification of the essentia yeast protein MIM17, an integral mitochondrial inner membrane protein involved in protein import. FEBS Lett 349:215–221 (10.1016/0014-5793(94)00669-5) / FEBS Lett by AC Maarse (1994)
Mahlke K, Pfanner N, Martin J, Horwich AL, Hartl FU, Neupert W (1990) Sorting pathways of mitochondrial inner membrane proteins. Eur J Biochem 192:551–555 (10.1111/j.1432-1033.1990.tb19260.x) / Eur J Biochem by K Mahlke (1990)
Martin J, Mahlke K, Pfanner N (1991) Role of an energized inner membrane in mitochondrial protein import. J Biol Chem 266:18051–18057 (10.1016/S0021-9258(18)55235-2) / J Biol Chem by J Martin (1991)
Matouschek A, Azem A, Ratliff K, Glick BS, Schmid K, Schatz G (1997) Active unfolding of precursor proteins during mitochondrial protein import. EMBO J 16:6727–6736 (10.1093/emboj/16.22.6727) / EMBO J by A Matouschek (1997)
Mayer A, Nargang FE, Neupert W, Lill R (1995) MOM22 is a receptor for mitochondrial targeting sequences and cooperates with MOM19. EMBO J 14:4204–4211 (10.1002/j.1460-2075.1995.tb00094.x) / EMBO J by A Mayer (1995)
Merlin A, Voos W, Maarse AC, Meijer M, Pfanner N, Rassow J (1999) The J-related segment of Tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation. J Cell Biol 145:961–972 (10.1083/jcb.145.5.961) / J Cell Biol by A Merlin (1999)
Miao B, Davis JE, Craig EA (1997) Mge1 functions as a nucleotide release factor for Ssc1, a mitochondrial Hsp70 of Saccharomyces cerevisiae. J Mol Biol 265:541–552 (10.1006/jmbi.1996.0762) / J Mol Biol by B Miao (1997)
Miller DM, Delgado R, Chirgwin JM, Hardies SC, Horowitz PM (1991) Expression of cloned bovine adrenal rhodanese. J Biol Chem 266:4686–4691 (10.1016/S0021-9258(19)67703-3) / J Biol Chem by DM Miller (1991)
Miura S, Mori M, Tatibana M (1983) Transport of ornithine carbamoyltransferase precursor into mitochondria. J Biol Chem 258:6671–6674 (10.1016/S0021-9258(18)32264-6) / J Biol Chem by S Miura (1983)
Moczko M, Ehmann B, Gärtner F, Hönlinger A, Schäfer E, Pfanner N (1994) Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria. J Biol Chem 269:9045–9051 (10.1016/S0021-9258(17)37074-6) / J Biol Chem by M Moczko (1994)
Moczko M, Bömer U, Kübrich M, Zufall N, Hönlinger A, Pfanner N (1997) The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences. Mol Cell Biol 17:6574–6584 (10.1128/MCB.17.11.6574) / Mol Cell Biol by M Moczko (1997)
Murakami H, Pain D, Blobel G (1988) 70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria. J Cell Biol 107:2051–2057 (10.1083/jcb.107.6.2051) / J Cell Biol by H Murakami (1988)
Murakami K, Mori M (1990) Purified presequence binding factor (PBF) forms an import-competent complex with a purified mitochondrial precursor protein. EMBO J 9:3201–3208 (10.1002/j.1460-2075.1990.tb07518.x) / EMBO J by K Murakami (1990)
Miura S, Mori M, Tatibana M (1983) Transport of ornithine carbamoyltransferase precursor into mitochondria. J Biol Chem 258:6671–6674. (10.1016/S0021-9258(18)32264-6) / J Biol Chem by S Miura (1983)
Nakai M, Kato Y, Toh-e A, Endo T (1994) Y ge1p, a eukaryotic GrpE-homologue, is localized in the mitochondrial matrix and interacts with mitochondrial hsp70. Biochem Biophys Res Commun 200:435–442 (10.1006/bbrc.1994.1468) / Biochem Biophys Res Commun by M Nakai (1994)
Nakai M, Endo T (1995) Identification of yeast MAS17 encoding the functional counterpart of the mitochondrial receptor complex protein MOM22 of Neurospora crassa. FEBS Lett 357:202–206 (10.1016/0014-5793(94)01362-5) / FEBS Lett by M Nakai (1995)
Nargang FE, Künkele KP, Mayer A, Ritzel RG, Neupert W, Lill R (1995) 'sheltered disruption’ of Neurospora crassa MOM22, an essential component of the mitochondrial protein import complex. EMBO J 14:1099–1108 (10.1002/j.1460-2075.1995.tb07093.x) / EMBO J by FE Nargang (1995)
Neupert W (1997) Protein import into mitochondria. Annu Rev Biochem 66:863–917 (10.1146/annurev.biochem.66.1.863) / Annu Rev Biochem by W Neupert (1997)
Ohta S, Schatz G (1984) A purified precursor polypeptide requires a cytosolic protein fraction for import into mitochondria. EMBO J 3:651–657 (10.1002/j.1460-2075.1984.tb01862.x) / EMBO J by S Ohta (1984)
Ohba M, Schatz G (1987) Disruption of the outer membrane restores protein import to trypsin-treated yeast mitochondria. EMBO J 6:2117–2122 (10.1002/j.1460-2075.1987.tb02478.x) / EMBO J by M Ohba (1987)
Ono H, Tubio S (1988) The cytosolic factor required for import of precursors of mitochondrial proteins into mitochondria. J Biol Chem 263:3188–3193 (10.1016/S0021-9258(18)69053-2) / J Biol Chem by H Ono (1988)
Ono H, Tuboi S (1990) Purification and identification of a cytosolic factor required for import of precursors of mitochondrial proteins into mitochondria. Arch Biochem Biophys 280:299–304 (10.1016/0003-9861(90)90333-T) / Arch Biochem Biophys by H Ono (1990)
Pfanner N (2000) Recognizing mitochondrial presequences. Curr Biol 10:412–415 (10.1016/S0960-9822(00)00507-8) / Curr Biol by N Pfanner (2000)
Pfanner N, Neupert W (1985) Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of the ADP/ATP carrier. EMBO J 4:2819–2825 (10.1002/j.1460-2075.1985.tb04009.x) / EMBO J by N Pfanner (1985)
Pfanner N, Neupert W (1986) Transport of F1-ATPase subunit β into mitochondria depends on both a membrane potential and nucleoside triphosphates. FEBS Lett 209:152–156 (10.1016/0014-5793(86)81101-2) / FEBS Lett by N Pfanner (1986)
Pfanner N, Neupert W (1987) Distinct steps in the import of the ADP/ATP carrier into mitochondria. J Biol Chem 262:7528–7536 (10.1016/S0021-9258(18)47598-9) / J Biol Chem by N Pfanner (1987)
Pfanner N, Hoeben P, Tropschug M, Neupert W (1987a) The carboxy terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria. J Biol Chem 262:14851–14854 (10.1016/S0021-9258(18)48101-X) / J Biol Chem by N Pfanner (1987)
Pfanner N, Müller HK, Harmey MA, Neupert W (1987b) Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites. EMBO J 6:3449–3454 (10.1002/j.1460-2075.1987.tb02668.x) / EMBO J by N Pfanner (1987)
Pfanner N, Tropschug M, Neupert W (1987c) Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell 49:815–823 (10.1016/0092-8674(87)90619-2) / Cell by N Pfanner (1987)
Pfanner N, Rassow J, Guiard B, Söllner T, Hartl FU, Neupert W (1990) Energy requirements for unfolding and membrane translocation of precursor proteins during import into mitochondria. J Biol Chem 265:16324–16329 (10.1016/S0021-9258(17)46226-0) / J Biol Chem by N Pfanner (1990)
Pohlmeyer K, Soll J, Steinkamp T, Hinnah S, Wagner R (1997) Isolation and characterization of an amino acid-selective channel protein present in the chloroplastic outer envelope membrane. Proc Natl Acad Sci USA 94:9504–9509 (10.1073/pnas.94.17.9504) / Proc Natl Acad Sci USA by K Pohlmeyer (1997)
Ramage L, Junne T, Hahne K, Lithgow T, Schatz G (1993) Functional cooperation of mitochondrial protein import receptors in yeast. EMBO J 12:4115–4123 (10.1002/j.1460-2075.1993.tb06095.x) / EMBO J by L Ramage (1993)
Rapaport D, Mayer A, Neupert W, Lill R (1998) Cis and trans sites of the TOM complex of mitochondria in unfolding and initial translocation of preproteins. J Biol Chem 273:8806–8813 (10.1074/jbc.273.15.8806) / J Biol Chem by D Rapaport (1998)
Rassow J, Pfanner N (1991) Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space. FEBS Lett 293:85–88 (10.1016/0014-5793(91)81157-4) / FEBS Lett by J Rassow (1991)
Rassow J, Maarse AC, Krainer E, Kübrich M, Müller H, Meijer M, Craig EA, Pfanner N (1994) Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol 127:1547–1556 (10.1083/jcb.127.6.1547) / J Cell Biol by J Rassow (1994)
Rassow J, von Ahsen O, Bömer U, Pfanner N (1997) Molecular chaperones: towards a characterization of the heat-shock protein 70 family. Trends Cell Biol 7:129–133 (10.1016/S0962-8924(96)10056-8) / Trends Cell Biol by J Rassow (1997)
Rassow J, Dekker PJT, van Wilpe S, Meijer M, Soll J (1999) The preprotein translocase of the mitochondrial inner membrane: function and evolution. J Mol Biol 286:105–120 (10.1006/jmbi.1998.2455) / J Mol Biol by J Rassow (1999)
Reid GA, Yonetani T, Schatz G (1982) Import of proteins into mitochondria. Import and maturation of the mitochondrial intermembrane space enzymes cytochrome b 2 and cytochrome c peroxidase in intact yeast cells. J Biol Chem 257:13068–13074 (10.1016/S0021-9258(18)33623-8) / J Biol Chem by GA Reid (1982)
Roise D, Schatz G (1988) Mitochondrial presequences. J Biol Chem 263:4509–4511 (10.1016/S0021-9258(18)68809-X) / J Biol Chem by D Roise (1988)
Rojo EE, Stuart RA, Neupert W (1995) Conservative sorting of Fo-ATPase subunit 9: export from matrix requires delta pH across inner membrane and matrix ATP. EMBO J 14:3445–3451 (10.1002/j.1460-2075.1995.tb07350.x) / EMBO J by EE Rojo (1995)
Rospert S, Junne T, Glick BS, Schatz G (1993) Cloning and disruption of the gene encoding yeast mitochondrial chaperonin 10, the homologue of E. coli groES. FEBS Lett 335:358–360 (10.1016/0014-5793(93)80419-U) / FEBS Lett by S Rospert (1993)
Rüdiger S, Germeroth L, Schneider-Mergener J, Bukau B (1997) Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J 16:1501–1507 (10.1093/emboj/16.7.1501) / EMBO J by S Rüdiger (1997)
Ryan KR, Jensen RE (1993) Mas6p can be cross-linked to an arrested precursor and interacts with other proteins during mitochondrial protein import. J Biol Chem 268:23743–23746 (10.1016/S0021-9258(20)80441-4) / J Biol Chem by KR Ryan (1993)
Ryan KR, Menold MM, Garrett S, Jensen RE (1994a) SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Mol Biol Cell 5:529–538 (10.1091/mbc.5.5.529) / Mol Biol Cell by KR Ryan (1994)
Ryan MT, Hoogenraad NJ, Høj PB (1994b) Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence. FEBS Lett 337:152–156 (10.1016/0014-5793(94)80263-7) / FEBS Lett by MT Ryan (1994)
Ryan KR, Leung RS, Jensen RE (1998) Characterization of the mitochondrial inner membrane translocase complex: the Tim23p hydrophobic domain interacts with Tim17p but not with other Tim23p molecules. Mol Cell Biol 18:178–187 (10.1128/MCB.18.1.178) / Mol Cell Biol by KR Ryan (1998)
Ryan MT, Müller H, Pfanner N (1999) Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane. J Biol Chem 274:20619–20627 (10.1074/jbc.274.29.20619) / J Biol Chem by MT Ryan (1999)
Schatz G (1997) Just follow the acid chain. Nature 388:121–122 (10.1038/40510) / Nature by G Schatz (1997)
Scherer PE, Krieg UC, Hwang ST, Vestweber D, Schatz G (1990) A precursor protein partly translocated into yeast mitochondria is bound to a 70 kD mitochondrial stress protein. EMBO J 9:4315–4322 (10.1002/j.1460-2075.1990.tb07880.x) / EMBO J by PE Scherer (1990)
Scherer PE, Manning-Krieg UC, Jenö P, Schatz G, Horst M (1992) Identification of a 45-kDa protein import site of the yeast mitochondrial inner membrane. Proc Natl Acad Sci USA 89:11930–11934 (10.1073/pnas.89.24.11930) / Proc Natl Acad Sci USA by PE Scherer (1992)
Schleyer M, Neupert W (1985) Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes. Cell 43:339–350 (10.1016/0092-8674(85)90039-X) / Cell by M Schleyer (1985)
Schleyer M, Schmidt B, Neupert W (1982) Requirement of a membrane potential for the postranslational transfer of proteins into mitochondria. Eur J Biochem 125:109–116 (10.1111/j.1432-1033.1982.tb06657.x) / Eur J Biochem by M Schleyer (1982)
Schlossmann J, Dietmeier K, Pfanner N, Neupert W (1994) Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72. J Biol Chem 269:11893–11901 (10.1016/S0021-9258(17)32657-1) / J Biol Chem by J Schlossmann (1994)
Schlossmann J, Lill R, Neupert W, Court DA (1996) Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. J Biol Chem 271:17890–17895 (10.1074/jbc.271.30.17890) / J Biol Chem by J Schlossmann (1996)
Schneider H, Söllner T, Dietmeier K, Eckerskorn C, Lottspeich F Trülzsch B Neupert W, Pfanner N (1991) Targeting of the master receptor MOM19 to mitochondria. Science 254:1659–1662 (10.1126/science.1661031) / Science by H Schneider (1991)
Schneider H-C, Berthold J, Bauer MF, Dietmeier K, Guiard B, Brunner M, Neupert W (1994) Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature 371:768–774 (10.1038/371768a0) / Nature by H-C Schneider (1994)
Schneider HC, Westermann B, Neupert W, Brunner M (1996) The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. EMBO J 15:5796–5803 (10.1002/j.1460-2075.1996.tb00966.x) / EMBO J by HC Schneider (1996)
Segui-Real B, Kispal G, Lill R, Neupert W (1993) Functional independence of the protein translocation machineries in mitochondrial outer and inner membranes: Passage of preproteins through the intermembrane space. EMBO J 12:2211–2218 (10.1002/j.1460-2075.1993.tb05869.x) / EMBO J by B Segui-Real (1993)
Sepuri NB, Schulke N, Pain D (1998) GTP hydrolysis is essential for protein import into the mitochondrial matrix. J Biol Chem 273:1420–1424 (10.1074/jbc.273.3.1420) / J Biol Chem by NB Sepuri (1998)
Sepuri NBV, Gordon DM, Pain D (1998) A GTP-dependent “Push” is generally required for efficient protein translocation across the mitochondrial inner membrane into the matrix. J Biol Chem 273:20941–20950 (10.1074/jbc.273.33.20941) / J Biol Chem by NBV Sepuri (1998)
Simon MS, Peskin CS, Oster GF (1992) What drives the translocation of proteins? Proc Natl Acad Sci USA 89:3770–3774 (10.1073/pnas.89.9.3770) / Proc Natl Acad Sci USA by MS Simon (1992)
Sirrenberg C, Bauer MF, Guiard B, Neupert W, Brunner M (1996) Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature 384:582–585 (10.1038/384582a0) / Nature by C Sirrenberg (1996)
Sirrenberg C, Endres M, Fölsch H, Stuart RA, Neupert W, Brunner M (1998) Carrier protein import into mitochondria mediated by the intermembrane proteins Tim 10/Mrs11 and Tim12/Mrs5. Nature 391:912–915 (10.1038/36136) / Nature by C Sirrenberg (1998)
Smagula C, Douglas MG (1988) Mitochondrial import of the ADP/ATP carrier protein in Saccharomyces cerevisiae. Sequences required for receptor binding and membrane translocation. J Biol Chem 263:6783–6790 (10.1016/S0021-9258(18)68711-3) / J Biol Chem by C Smagula (1988)
Söllner T, Griffiths G, Pfaller R, Pfanner N, Neupert W (1989) MOM19, an import receptor for mitochondrial precursor proteins. Cell 59:1061–1070 (10.1016/0092-8674(89)90762-9) / Cell by T Söllner (1989)
Söllner T, Pfaller R, Griffiths G, Pfanner N, Neupert W (1990) A mitochondrial import receptor for the ATP/ADP carrier. Cell 62:107–115 (10.1016/0092-8674(90)90244-9) / Cell by T Söllner (1990)
Steger HF, Söllner T, Kiebler M, Dietmeier KA, Pfaller R, Trülzsch KS, Tropschug M, Neupert W, Pfanner N (1990) Import of the ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol 111:2353–2363 (10.1083/jcb.111.6.2353) / J Cell Biol by HF Steger (1990)
Steinkamp T, Hill K, Hinnah SC, Wagner R, Rohl T, Pohlmeyer K, Soll J (2000) Identification of the pore-forming region of the outer chloroplast envelope protein OEP16. J Biol Chem 275:11758–11764 (10.1074/jbc.275.16.11758) / J Biol Chem by T Steinkamp (2000)
Suh WC, Burkholder WF, Lu CZ, Zhao X, Gottesman ME, Gross CA (1998) Interaction of the Hsp 70 molecular chaperone, DnaK, with its cochaperone DnaJ. Proc Natl Acad Sci USA 95:15223–15228 (10.1073/pnas.95.26.15223) / Proc Natl Acad Sci USA by WC Suh (1998)
Terada K, Kanazawa M, Yano M, Hanson B, Hoogenraad N, Mori M (1997) Participation of the import receptor Tom20 in protein import into mammalian mitochondria: analyses in vitro and in cultured cells. FEBS Lett 403:309–312 (10.1016/S0014-5793(97)00070-7) / FEBS Lett by K Terada (1997)
Ungermann C, Neupert W, Cyr DM (1994) The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science 266:1250–1253 (10.1126/science.7973708) / Science by C Ungermann (1994)
van Loon AP, Schatz G (1987) Transport of proteins to the mitochondrial intermembrane space: the 'sorting’ domain of the cytochrome c 1 presequence is a stoptransfer sequence specific for the mitochondrial inner membrane. EMBO J 6:2441–2448 (10.1002/j.1460-2075.1987.tb02523.x) / EMBO J by AP Loon van (1987)
van Wilpe S, Ryan MT, Hill K, Maarse AC, Meisinger C, Brix J, Dekker PJ, Moczko M, Wagner R, Meijer M, Guiard B, Hönlinger A, Pfanner N (1999) Tom22 is a multifunctional organiser of the mitochondrial preprotein translocase. Nature 401:485–489 (10.1038/46802) / Nature by S Wilpe van (1999)
Vestweber D, Brunner J, Baker A, Schatz G (1989) A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature 341:205–209 (10.1038/341205a0) / Nature by D Vestweber (1989)
Voisine C, Craig EA, Zufall N, von Ahsen O, Pfanner N, Voos W (1999) The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp 70. Cell 97:1–20 (10.1016/S0092-8674(00)80768-0) / Cell by C Voisine (1999)
von Ahsen O, Voos W, Henninger H, Pfanner N (1995) The mitochondrial protein import machinery. Role of ATP in dissociation of the Hsp70-Mim44 complex. J Biol Chem 270:29848–29853 (10.1074/jbc.270.50.29848) / J Biol Chem by O Ahsen von (1995)
von Heijne G (1986) Mitochondrial targeting sequences may form amphipathic helices. EMBO J 5:1335–1342 (10.1002/j.1460-2075.1986.tb04364.x) / EMBO J by G Heijne von (1986)
von Heijne G, Steppuhn, J, Herrmann RG (1989) Domain structure of mitochondrial and chloroplast targeting peptides. Eur J Biochem 180:535–545 (10.1111/j.1432-1033.1989.tb14679.x) / Eur J Biochem by G Heijne von (1989)
Voos W, Gambill BD, Guiard B, Pfanner N, Craig EA (1993) Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol 123:119–126 (10.1083/jcb.123.1.119) / J Cell Biol by W Voos (1993)
Voos W, Gambill BD, Laloraya S, Ang D, Craig EA, Pfanner N (1994) Mitochondrial GrpE is present in a complex with hsp 70 and preproteins in transit across membranes. Mol Cell Biol 14:6627–6634 (10.1128/MCB.14.10.6627) / Mol Cell Biol by W Voos (1994)
Voos W, von Ahsen O, Müller H, Guiard B, Rassow J, Pfanner N (1996) Differential requirement for the mitochondrial Hsp70-Tim44 complex, in unfolding and translocation of preproteins. EMBO J 15:2668–2677 (10.1002/j.1460-2075.1996.tb00627.x) / EMBO J by W Voos (1996)
Wachter C, Schatz G, Glick BS (1992) Role of ATP in the intramitochondrial sorting of cytochrome c 1 and the adenine nucleotide transproter. EMBO J 11:4787–4794 (10.1002/j.1460-2075.1992.tb05584.x) / EMBO J by C Wachter (1992)
Wachter C, Schatz G, Glick BS (1994) Protein import into mitochondria: the requirement for external ATP is precursor-specific whereas intramitochondrial ATP is universally needed for translocation into the matrix. Mol Biol Cell 5:465–474 (10.1091/mbc.5.4.465) / Mol Biol Cell by C Wachter (1994)
Wallace DC, Murdock DG (1999) Mitochondria and dystonia: the movement disorder connection? Proc Natl Acad Sci USA 96:1817–1819 (10.1073/pnas.96.5.1817) / Proc Natl Acad Sci USA by DC Wallace (1999)
Weiss C, Oppliger W, Vergères G, Demel R, Jeno P, Horst M, de Kruijff B, Schatz G, Azem A (1999) Domain structure and lipid interaction of recombinant yeast Tim44. Proc Natl Acad Sci USA 96:8890–8894 (10.1073/pnas.96.16.8890) / Proc Natl Acad Sci USA by C Weiss (1999)
Zara V, Palmieri F, Mahlke K, Pfanner N (1992) The cleavable presequence is not essential for import and assembly of the phosphate carrier of mammalian mitochondria but enhances the specificity and efficiency of import. J Biol Chem 267:12077–12081 (10.1016/S0021-9258(19)49808-6) / J Biol Chem by V Zara (1992)
Zhu X, Zhao X, Burkholder WF, Gragerov A, Ogata CM, Gottesman ME, Hendrickson WA (1996) Structural analysis of substrate binding by the molecular chaperone DnaK. Science 272:1606–16014 (10.1126/science.272.5268.1606) / Science by X Zhu (1996)

Dates

Type	When
Created	17 years, 8 months ago (Dec. 10, 2007, 12:06 a.m.)
Deposited	4 years ago (Aug. 30, 2021, 4:23 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 12, 2024, 5:22 p.m.)

Funders 0

None

BibTeX

@inbook{Truscott, title={Transport of proteins into mitochondria}, ISBN={9783540414742}, url={http://dx.doi.org/10.1007/bfb0115593}, DOI={10.1007/bfb0115593}, booktitle={Reviews of Physiology, Biochemistry and Pharmacology}, publisher={Springer Berlin Heidelberg}, author={Truscott, K. N. and Pfanner, N. and Voos, W.}, pages={81–136} }

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