DOI: 10.1007/bf02907789. The primary structure of noxiustoxin: A K+ channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann

The primary structure of noxiustoxin: A K+ channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann

10.1007/bf02907789

Crossref journal-article

Springer Science and Business Media LLC

Carlsberg Research Communications (297)

Bibliography

Domingos Possani, L., Martin, B. M., & Svendsen, I. (1982). The primary structure of noxiustoxin: A K+ channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann. Carlsberg Research Communications, 47(5), 285â289.

Authors 3

Lourival Domingos Possani (first)
Brian M. Martin (additional)
IB Svendsen (additional)

References 22 Referenced 128

Babin, D.R., D.D. Watt, S.M. Goos &R.V. Mlejnek: Amino acid sequences of neurotoxic protein variants from the venom ofCentruroides sculpturatus Ewing. Arch. Biochem. Biophys. 164, 694–706 (1974) (10.1016/0003-9861(74)90082-4) / Arch. Biochem. Biophys. by D.R. Babin (1974)
Biedermann, K., U. Montali, B. Martin, I. Svendsen &M. Ottesen: The amino acid sequence of proteinase A inhibitor 3 from baker's yeast. Carlsberg Res. Commun. 45, 225–235 (1980) (10.1007/BF02906176) / Carlsberg Res. Commun. by K. Biedermann (1980)
Cahalan, M.D.: Modification of sodium channel gating by scorpion venom. J. Physiol. London 244, 511–534 (1975) (10.1113/jphysiol.1975.sp010810) / J. Physiol. London by M.D. Cahalan (1975)
Carbone, E., E. Wanke, G. Prestipino, L.D. Possani &A. Maelicke: Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature, London 296, 90–91 (1982) (10.1038/296090a0) / Nature, London by E. Carbone (1982)
Carbone, E., G. Prestipino, E. Wanke, L.D. Possani & A. Maelicke: Selective action of scorpion neurotoxins on the ionic currents of the squid giant axon. Proceedings from the 7th World Congress on Animal, Plant and Microbial Toxins, Brisbane, Australia, July (1982) to be published by Toxicon (10.1016/0041-0101(83)90154-X)
Catterall, W.A.: Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Ann. Rev. Pharmacol. Toxicol. 20, 15–43 (1980) (10.1146/annurev.pa.20.040180.000311) / Ann. Rev. Pharmacol. Toxicol. by W.A. Catterall (1980)
Couraud, F., E. Jover, J.M. Dubois &H. Rochat: Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel. Toxicon 20, 9–16 (1982) (10.1016/0041-0101(82)90138-6) / Toxicon by F. Couraud (1982)
Couraud, F., H. Rochat &S. Lissitzky: Binding of scorpion neurotoxins to chick embryonic heart cells in culture and relationship to calcium uptake and membrane potential. Biochemistry 19, 457–462 (1980) (10.1021/bi00544a009) / Biochemistry by F. Couraud (1980)
Edman, P. &G. Begg: A protein sequenator. Eur. J. Biochem. 1, 80–91 (1967) (10.1111/j.1432-1033.1967.tb00047.x) / Eur. J. Biochem. by P. Edman (1967)
Gillespie, J.I. &H. Meves: The effect of scorpion venoms on the sodium currents of the squid giant axon. J. Physiol. London 308, 479–499 (1980) (10.1113/jphysiol.1980.sp013484) / J. Physiol. London by J.I. Gillespie (1980)
Jover, E., F. Couraud &H. Rochat: Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes. Biochem. Biophys. Res. Commun. 95, 1607–1614 (1980) (10.1016/S0006-291X(80)80082-9) / Biochem. Biophys. Res. Commun. by E. Jover (1980)
Kopeyan, C., G. Martinez, S. Lissitzky, F. Miranda &H. Rochat: Disulphide bonds of toxin II of the scorpionAndroctonus australis Hector. Eur. J. Biochem. 47, 483–489 (1974) (10.1111/j.1432-1033.1974.tb03716.x) / Eur. J. Biochem. by C. Kopeyan (1974)
Krueger, B.K., M. Blaustein &R.W. Ratzlaff: Sodium channels in presynaptic nerve terminals. Regulation by neurotoxin. J. Gen. Physiol. 76, 287–313 (1980) (10.1085/jgp.76.3.287) / J. Gen. Physiol. by B.K. Krueger (1980)
Martin, B., I. Svendsen &M. Ottesen: Use of carboxypeptidase Y for carboxy-terminal sequence determination in proteins. Carlsberg Res. Commun. 42, 99–102 (1977) (10.1007/BF02906488) / Carlsberg Res. Commun. by B. Martin (1977)
Nonner, W.: Effects ofLeiurus scorpion venom on the “gating” current in myelinated nerve. Adv. in Cytopharmacol. 3, 345–352 (1979) / Adv. in Cytopharmacol by W. Nonner (1979)
Penke, B., R. Ferenczi &K. Kovács: A new acid hydrolysis method for determining tryptophan in peptides and proteins. Anal. Biochem. 60, 45–50 (1974) (10.1016/0003-2697(74)90129-8) / Anal. Biochem. by B. Penke (1974)
Possani, L.D., M.A.R. Dent, B.M. Martin, A. Maelicke &I. Svendsen: The amino terminal sequence of several toxins from the venom of the Mexican scorpionCentruroides noxius Hoffmann. Carlsberg Res. Commun. 46, 207–214 (1981) (10.1007/BF02906498) / Carlsberg Res. Commun. by L.D. Possani (1981)
Possani, L.D., B.M. Martin, J. Mochca-Morales &I. Svendsen: Purification and chemical characterization of the major toxins from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello. Carlsberg Res. Commun. 46, 195–205 (1981) (10.1007/BF02906497) / Carlsberg Res. Commun. by L.D. Possani (1981)
Reisfeld, R.A., U.J. Lewis &D.E. Williams: Disk electrophoresis of basic proteins and peptides on polyacrylamide gels. Nature, London 195, 281–283 (1962) (10.1038/195281a0) / Nature, London by R.A. Reisfeld (1962)
Rochat, H (ed.): Proceedings of the 4th European Symposium on Animal, Plant and Microbial Toxins. Marseille (France) June 1981, published in Toxicon, 20 (1) 1–367 (1982)
Rochat, H., P. Bernard &F. Couraud: Scorpion toxins: Chemistry and mode of action. Adv. Cytopharm. 3, 325–334 (1979) / Adv. Cytopharm. by H. Rochat (1979)
Tarr, G.E., J.F. Beecher, M. Bell &D.J. McKean: Polyquaternary amines prevent peptide loss from sequenators. Anal. Biochem. 84, 622–627 (1978) (10.1016/0003-2697(78)90086-6) / Anal. Biochem. by G.E. Tarr (1978)

Dates

Type	When
Created	17 years, 3 months ago (May 17, 2008, 2:31 a.m.)
Deposited	6 years, 3 months ago (May 22, 2019, 6:01 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 12:58 a.m.)
Issued	42 years, 11 months ago (Sept. 1, 1982)
Published	42 years, 11 months ago (Sept. 1, 1982)
Published Print	42 years, 11 months ago (Sept. 1, 1982)

Funders 0

None

BibTeX

@article{Domingos_Possani_1982, title={The primary structure of noxiustoxin: A K+ channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann}, volume={47}, ISSN={0105-1938}, url={http://dx.doi.org/10.1007/bf02907789}, DOI={10.1007/bf02907789}, number={5}, journal={Carlsberg Research Communications}, publisher={Springer Science and Business Media LLC}, author={Domingos Possani, Lourival and Martin, Brian M. and Svendsen, IB}, year={1982}, month=sep, pages={285–289} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:58:05Z",
    "timestamp": 1754110685543
  },
  "reference-count": 22,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1982,
            9,
            1
          ]
        ],
        "date-time": "1982-09-01T00:00:00Z",
        "timestamp": 399686400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1982,
        9
      ]
    ]
  },
  "DOI": "10.1007/bf02907789",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        5,
        17
      ]
    ],
    "date-time": "2008-05-17T06:31:15Z",
    "timestamp": 1211005875000
  },
  "page": "285-289",
  "source": "Crossref",
  "is-referenced-by-count": 128,
  "title": "The primary structure of noxiustoxin: A K+ channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann",
  "prefix": "10.1007",
  "volume": "47",
  "author": [
    {
      "given": "Lourival",
      "family": "Domingos Possani",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Brian M.",
      "family": "Martin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "IB",
      "family": "Svendsen",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF02907789_CR1",
      "doi-asserted-by": "crossref",
      "first-page": "694",
      "DOI": "10.1016/0003-9861(74)90082-4",
      "volume": "164",
      "author": "D.R. Babin",
      "year": "1974",
      "unstructured": "Babin, D.R., D.D. Watt, S.M. Goos &R.V. Mlejnek: Amino acid sequences of neurotoxic protein variants from the venom ofCentruroides sculpturatus Ewing. Arch. Biochem. Biophys. 164, 694\u2013706 (1974)",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "BF02907789_CR2",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1007/BF02906176",
      "volume": "45",
      "author": "K. Biedermann",
      "year": "1980",
      "unstructured": "Biedermann, K., U. Montali, B. Martin, I. Svendsen &M. Ottesen: The amino acid sequence of proteinase A inhibitor 3 from baker's yeast. Carlsberg Res. Commun. 45, 225\u2013235 (1980)",
      "journal-title": "Carlsberg Res. Commun."
    },
    {
      "key": "BF02907789_CR3",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1113/jphysiol.1975.sp010810",
      "volume": "244",
      "author": "M.D. Cahalan",
      "year": "1975",
      "unstructured": "Cahalan, M.D.: Modification of sodium channel gating by scorpion venom. J. Physiol. London 244, 511\u2013534 (1975)",
      "journal-title": "J. Physiol. London"
    },
    {
      "key": "BF02907789_CR4",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1038/296090a0",
      "volume": "296",
      "author": "E. Carbone",
      "year": "1982",
      "unstructured": "Carbone, E., E. Wanke, G. Prestipino, L.D. Possani &A. Maelicke: Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature, London 296, 90\u201391 (1982)",
      "journal-title": "Nature, London"
    },
    {
      "key": "BF02907789_CR5",
      "doi-asserted-by": "crossref",
      "unstructured": "Carbone, E., G. Prestipino, E. Wanke, L.D. Possani & A. Maelicke: Selective action of scorpion neurotoxins on the ionic currents of the squid giant axon. Proceedings from the 7th World Congress on Animal, Plant and Microbial Toxins, Brisbane, Australia, July (1982) to be published by Toxicon",
      "DOI": "10.1016/0041-0101(83)90154-X"
    },
    {
      "key": "BF02907789_CR6",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1146/annurev.pa.20.040180.000311",
      "volume": "20",
      "author": "W.A. Catterall",
      "year": "1980",
      "unstructured": "Catterall, W.A.: Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Ann. Rev. Pharmacol. Toxicol. 20, 15\u201343 (1980)",
      "journal-title": "Ann. Rev. Pharmacol. Toxicol."
    },
    {
      "key": "BF02907789_CR7",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1016/0041-0101(82)90138-6",
      "volume": "20",
      "author": "F. Couraud",
      "year": "1982",
      "unstructured": "Couraud, F., E. Jover, J.M. Dubois &H. Rochat: Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel. Toxicon 20, 9\u201316 (1982)",
      "journal-title": "Toxicon"
    },
    {
      "key": "BF02907789_CR8",
      "doi-asserted-by": "crossref",
      "first-page": "457",
      "DOI": "10.1021/bi00544a009",
      "volume": "19",
      "author": "F. Couraud",
      "year": "1980",
      "unstructured": "Couraud, F., H. Rochat &S. Lissitzky: Binding of scorpion neurotoxins to chick embryonic heart cells in culture and relationship to calcium uptake and membrane potential. Biochemistry 19, 457\u2013462 (1980)",
      "journal-title": "Biochemistry"
    },
    {
      "key": "BF02907789_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "80",
      "DOI": "10.1111/j.1432-1033.1967.tb00047.x",
      "volume": "1",
      "author": "P. Edman",
      "year": "1967",
      "unstructured": "Edman, P. &G. Begg: A protein sequenator. Eur. J. Biochem. 1, 80\u201391 (1967)",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "BF02907789_CR10",
      "doi-asserted-by": "crossref",
      "first-page": "479",
      "DOI": "10.1113/jphysiol.1980.sp013484",
      "volume": "308",
      "author": "J.I. Gillespie",
      "year": "1980",
      "unstructured": "Gillespie, J.I. &H. Meves: The effect of scorpion venoms on the sodium currents of the squid giant axon. J. Physiol. London 308, 479\u2013499 (1980)",
      "journal-title": "J. Physiol. London"
    },
    {
      "key": "BF02907789_CR11",
      "doi-asserted-by": "crossref",
      "first-page": "1607",
      "DOI": "10.1016/S0006-291X(80)80082-9",
      "volume": "95",
      "author": "E. Jover",
      "year": "1980",
      "unstructured": "Jover, E., F. Couraud &H. Rochat: Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes. Biochem. Biophys. Res. Commun. 95, 1607\u20131614 (1980)",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "BF02907789_CR12",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1111/j.1432-1033.1974.tb03716.x",
      "volume": "47",
      "author": "C. Kopeyan",
      "year": "1974",
      "unstructured": "Kopeyan, C., G. Martinez, S. Lissitzky, F. Miranda &H. Rochat: Disulphide bonds of toxin II of the scorpionAndroctonus australis Hector. Eur. J. Biochem. 47, 483\u2013489 (1974)",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "BF02907789_CR13",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1085/jgp.76.3.287",
      "volume": "76",
      "author": "B.K. Krueger",
      "year": "1980",
      "unstructured": "Krueger, B.K., M. Blaustein &R.W. Ratzlaff: Sodium channels in presynaptic nerve terminals. Regulation by neurotoxin. J. Gen. Physiol. 76, 287\u2013313 (1980)",
      "journal-title": "J. Gen. Physiol."
    },
    {
      "key": "BF02907789_CR14",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1007/BF02906488",
      "volume": "42",
      "author": "B. Martin",
      "year": "1977",
      "unstructured": "Martin, B., I. Svendsen &M. Ottesen: Use of carboxypeptidase Y for carboxy-terminal sequence determination in proteins. Carlsberg Res. Commun. 42, 99\u2013102 (1977)",
      "journal-title": "Carlsberg Res. Commun."
    },
    {
      "key": "BF02907789_CR15",
      "first-page": "345",
      "volume": "3",
      "author": "W. Nonner",
      "year": "1979",
      "unstructured": "Nonner, W.: Effects ofLeiurus scorpion venom on the \u201cgating\u201d current in myelinated nerve. Adv. in Cytopharmacol. 3, 345\u2013352 (1979)",
      "journal-title": "Adv. in Cytopharmacol"
    },
    {
      "key": "BF02907789_CR16",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/0003-2697(74)90129-8",
      "volume": "60",
      "author": "B. Penke",
      "year": "1974",
      "unstructured": "Penke, B., R. Ferenczi &K. Kov\u00e1cs: A new acid hydrolysis method for determining tryptophan in peptides and proteins. Anal. Biochem. 60, 45\u201350 (1974)",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "BF02907789_CR17",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1007/BF02906498",
      "volume": "46",
      "author": "L.D. Possani",
      "year": "1981",
      "unstructured": "Possani, L.D., M.A.R. Dent, B.M. Martin, A. Maelicke &I. Svendsen: The amino terminal sequence of several toxins from the venom of the Mexican scorpionCentruroides noxius Hoffmann. Carlsberg Res. Commun. 46, 207\u2013214 (1981)",
      "journal-title": "Carlsberg Res. Commun."
    },
    {
      "key": "BF02907789_CR18",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1007/BF02906497",
      "volume": "46",
      "author": "L.D. Possani",
      "year": "1981",
      "unstructured": "Possani, L.D., B.M. Martin, J. Mochca-Morales &I. Svendsen: Purification and chemical characterization of the major toxins from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello. Carlsberg Res. Commun. 46, 195\u2013205 (1981)",
      "journal-title": "Carlsberg Res. Commun."
    },
    {
      "key": "BF02907789_CR19",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1038/195281a0",
      "volume": "195",
      "author": "R.A. Reisfeld",
      "year": "1962",
      "unstructured": "Reisfeld, R.A., U.J. Lewis &D.E. Williams: Disk electrophoresis of basic proteins and peptides on polyacrylamide gels. Nature, London 195, 281\u2013283 (1962)",
      "journal-title": "Nature, London"
    },
    {
      "key": "BF02907789_CR20",
      "unstructured": "Rochat, H (ed.): Proceedings of the 4th European Symposium on Animal, Plant and Microbial Toxins. Marseille (France) June 1981, published in Toxicon, 20 (1) 1\u2013367 (1982)"
    },
    {
      "key": "BF02907789_CR21",
      "first-page": "325",
      "volume": "3",
      "author": "H. Rochat",
      "year": "1979",
      "unstructured": "Rochat, H., P. Bernard &F. Couraud: Scorpion toxins: Chemistry and mode of action. Adv. Cytopharm. 3, 325\u2013334 (1979)",
      "journal-title": "Adv. Cytopharm."
    },
    {
      "key": "BF02907789_CR22",
      "doi-asserted-by": "crossref",
      "first-page": "622",
      "DOI": "10.1016/0003-2697(78)90086-6",
      "volume": "84",
      "author": "G.E. Tarr",
      "year": "1978",
      "unstructured": "Tarr, G.E., J.F. Beecher, M. Bell &D.J. McKean: Polyquaternary amines prevent peptide loss from sequenators. Anal. Biochem. 84, 622\u2013627 (1978)",
      "journal-title": "Anal. Biochem."
    }
  ],
  "container-title": "Carlsberg Research Communications",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://link.springer.com/content/pdf/10.1007/BF02907789.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://link.springer.com/article/10.1007/BF02907789/fulltext.html",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://link.springer.com/content/pdf/10.1007/BF02907789",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        5,
        22
      ]
    ],
    "date-time": "2019-05-22T22:01:46Z",
    "timestamp": 1558562506000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://link.springer.com/10.1007/BF02907789"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1982,
        9
      ]
    ]
  },
  "references-count": 22,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1982,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "BF02907789"
  ],
  "URL": "http://dx.doi.org/10.1007/BF02907789",
  "relation": {},
  "ISSN": [
    "0105-1938"
  ],
  "subject": [],
  "container-title-short": "Carlsberg Res. Commun.",
  "published": {
    "date-parts": [
      [
        1982,
        9
      ]
    ]
  }
}