DOI: 10.1007/bf02533198. Intracerebrally injected monohydroxy and other C<sub>24</sub> steroid acids as demyelinating agents in the guinea pig

Intracerebrally injected monohydroxy and other C24 steroid acids as demyelinating agents in the guinea pig

10.1007/bf02533198

Crossref journal-article

Wiley

Lipids (311)

Abstract

AbstractSodium salts of lithocholic acid (3α‐hydroxy‐5β‐cholanoic acid), 5β‐cholanoic acid, Δ5‐cholenoic acid and 3‐keto‐5β‐cholanoic acid injected intracerebrally into guinea pigs in doses of 1 mg or higher produced periventricular demyelination. 24‐14C‐sodium lithocholate was rapidly released from the brain (only traces remained 2 hr after injection) if injected in quantities ranging from 2 μg to 5 mg. This rapid elimination is believed to account for the relatively high dose of lithocholate required for producing demyelination, and may also account for the limited demyelinating capacity of the other acids injected intracerebrally.

Bibliography

Mujtaba Naqvi, S. H., Herndon, B. L., Del Rosario, L., & Nicholas, H. J. (1970). Intracerebrally injected monohydroxy and other C24 steroid acids as demyelinating agents in the guinea pig. Lipids, 5(12), 964â969. Portico.

Authors 4

S. H. Mujtaba Naqvi (first)
B. L. Herndon (additional)
L. Del Rosario (additional)
H. J. Nicholas (additional)

References 13 Referenced 14

10.1212/WNL.14.6.549
{'key': 'e_1_2_1_3_1', 'first-page': '828', 'volume': '9', 'author': 'Weil A.', 'year': '1930', 'journal-title': 'Arch. Path.'} / Arch. Path. by Weil A. (1930)
10.1016/S0022-2275(20)42655-0
10.1007/BF02532752
10.1016/0005-2760(67)90173-7
{'key': 'e_1_2_1_7_1', 'first-page': '986', 'volume': '63', 'author': 'Norman A.', 'year': '1964', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. by Norman A. (1964)
10.1111/j.1471-4159.1959.tb13172.x
10.1111/j.1471-4159.1966.tb09861.x
10.1016/0039-128X(66)91018-X
10.1016/0039-128X(67)90043-8
10.1016/0039-128X(66)90099-7
10.1016/S0039-128X(68)80102-3
10.1016/S0039-128X(70)80115-5

Dates

Type	When
Created	18 years, 9 months ago (Nov. 22, 2006, 1 a.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 7:16 p.m.)
Indexed	1 month ago (July 28, 2025, 5:13 p.m.)
Issued	54 years, 9 months ago (Dec. 1, 1970)
Published	54 years, 9 months ago (Dec. 1, 1970)
Published Online	54 years, 9 months ago (Dec. 1, 1970)
Published Print	54 years, 9 months ago (Dec. 1, 1970)

Funders 0

None

BibTeX

@article{Mujtaba_Naqvi_1970, title={Intracerebrally injected monohydroxy and other C24 steroid acids as demyelinating agents in the guinea pig}, volume={5}, ISSN={1558-9307}, url={http://dx.doi.org/10.1007/bf02533198}, DOI={10.1007/bf02533198}, number={12}, journal={Lipids}, publisher={Wiley}, author={Mujtaba Naqvi, S. H. and Herndon, B. L. and Del Rosario, L. and Nicholas, H. J.}, year={1970}, month=dec, pages={964–969} }

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