DOI: 10.1007/bf02532138. Effects of dietary cholesterol upon bile acid metabolism in guinea pig

Effects of dietary cholesterol upon bile acid metabolism in guinea pig

10.1007/bf02532138

Crossref journal-article

Wiley

Lipids (311)

Abstract

AbstractCholesterol fed guinea pigs develop a hemolytic anemia accompanied by high cholesterol concentrations in the liver, plasma, and red cells. We have studied the bile acid metabolism of guinea pigs fed a diet with or without cholesterol in a search for the factor(s) which prevent adequate control of their body cholesterol pool and, therefore, its pathological consequences. The results show that in the cholesterol fed guinea pig the synthesis (and excretion) of bile acids was at least three times greater than in controls. This is the result of a doubling of the fractional turnover rate and a smaller increase in the pool size. The major increase of the bile acid pool was in the liver. The main bile acid in gall bladder bile and small intestines was chenodeoxycholic acid, with smaller amounts of 7‐ketolithocholic and ursodeoxycholic acids. In the caecum, large intestines, and feces, the major bile acid was lithocholic acid.

Bibliography

Lansma, H., & Ostwald, R. (1974). Effects of dietary cholesterol upon bile acid metabolism in guinea pig. Lipids, 9(10), 731â737. Portico.

Authors 2

Heleni Lansma (first)
Rosemarie Ostwald (additional)

References 25 Referenced 14

10.1016/S0021-9258(18)73656-9
10.1042/bj0910146
Ostwald R. W.Yamanaka M.Light andJ.Kroes Abstracts 0–14 VIII International Congress of Nutrition August 1969 Prague Czechoslovakia.
10.3181/00379727-134-34890
10.1016/S0022-2275(20)38982-3
10.1021/bi00875a040
10.1016/S0022-2275(20)43123-2
{'key': 'e_1_2_1_9_1', 'first-page': '149', 'volume-title': 'Lipid Chromatographic Analysis', 'author': 'Eneroth P.', 'year': '1969'} / Lipid Chromatographic Analysis by Eneroth P. (1969)
10.1021/ac60172a041
10.3181/00379727-130-33722
10.1007/BF02532632
10.1111/j.1748-1716.1957.tb01376.x
10.3891/acta.chem.scand.20-1297
{'key': 'e_1_2_1_15_1', 'first-page': '732', 'volume': '18', 'author': 'Danielsson H.', 'year': '1964', 'journal-title': 'Ibid.'} / Ibid. by Danielsson H. (1964)
{'key': 'e_1_2_1_16_1', 'volume-title': "Masters' degree thesis", 'author': 'Matin C.', 'year': '1972'} / Masters' degree thesis by Matin C. (1972)
10.1126/science.179.4074.702
10.1016/S0022-2275(20)39435-9
10.1016/0021-9150(70)90042-0
10.1093/jn/79.4.523
10.1016/S0022-2275(20)39434-7
10.1172/JCI107145
{'key': 'e_1_2_1_23_1', 'first-page': '7', 'volume': '79', 'author': 'Cooper R.A.', 'year': '1972', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. by Cooper R.A. (1972)
10.1016/S0022-2275(20)39368-8
{'key': 'e_1_2_1_25_1', 'first-page': '705', 'volume': '13', 'author': 'Sardet C.', 'year': '1972', 'journal-title': 'Ibid.'} / Ibid. by Sardet C. (1972)
10.1172/JCI105775

Dates

Type	When
Created	18 years, 9 months ago (Nov. 21, 2006, 6:37 a.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 6:51 p.m.)
Indexed	1 year, 2 months ago (June 14, 2024, 8:31 p.m.)
Issued	50 years, 11 months ago (Oct. 1, 1974)
Published	50 years, 11 months ago (Oct. 1, 1974)
Published Online	50 years, 11 months ago (Oct. 1, 1974)
Published Print	50 years, 11 months ago (Oct. 1, 1974)

Funders 0

None

BibTeX

@article{Lansma_1974, title={Effects of dietary cholesterol upon bile acid metabolism in guinea pig}, volume={9}, ISSN={1558-9307}, url={http://dx.doi.org/10.1007/bf02532138}, DOI={10.1007/bf02532138}, number={10}, journal={Lipids}, publisher={Wiley}, author={Lansma, Heleni and Ostwald, Rosemarie}, year={1974}, month=oct, pages={731–737} }

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