DOI: 10.1007/bf02244232. A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena

A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena

10.1007/bf02244232

Crossref journal-article

Springer Science and Business Media LLC

Psychopharmacology (297)

Bibliography

File, S. E., & Hitchcott, P. K. (1990). A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena. Psychopharmacology, 101(4), 525â532.

Authors 2

Sandra E. File (first)
Paul K. Hitchcott (additional)

References 42 Referenced 52

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Baldwin HA, File SE (1989) Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety. Psychopharmacology 97:424–426 (10.1007/BF00439464) / Psychopharmacology by HA Baldwin (1989)
Baldwin HA, Hitchcott PK, File SE (1990) The use of flumazenil in prevention of diazepam dependence in the rat. Hum Psychopharmacol 5:57–61 (10.1002/hup.470050109) / Hum Psychopharmacol by HA Baldwin (1990)
Emmett-Oglesby MW, Spencer D, Lewis M, Elmesallamy F, Lal H (1983) Anxiogenic aspects of diazepam withdrawal can be detected in animals. Eur J Pharmacol 92:127–130 (10.1016/0014-2999(83)90117-6) / Eur J Pharmacol by MW Emmett-Oglesby (1983)
Emmett-Oglesby MW, Mathis DA, Lal H (1987) Diazepam tolerance and withdrawal assessed in an animal model of subjective drug effects. Drug Dev Res 11:145–156 (10.1002/ddr.430110302) / Drug Dev Res by MW Emmett-Oglesby (1987)
File SE (1984) Behavioural pharmacology of benzodiazepines. Prog Neuropsychopharm Biol Psychiatry 8:19–31 (10.1016/0278-5846(84)90132-5) / Prog Neuropsychopharm Biol Psychiatry by SE File (1984)
File SE (1985) Tolerance to the behavioral actions of benzodiazepines. Neurosci Biobehav Rev 9:113–121 (10.1016/0149-7634(85)90037-5) / Neurosci Biobehav Rev by SE File (1985)
File SE (1989) Chronic diazepam treatment: effect of dose on development of tolerance and incidence of withdrawal in an animal test of anxiety. Hum Psychopharmacol 4:59–63 (10.1002/hup.470040111) / Hum Psychopharmacol by SE File (1989)
File SE (1990a) The history of benzodiazepine dependence: a review of animal studies. Neurosci Biobehav Rev 14:135–146 (10.1016/S0149-7634(05)80214-3) / Neurosci Biobehav Rev by SE File (1990)
File SE (1990b) One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze. Psychopharmacology 100:281–282 (10.1007/BF02244419) / Psychopharmacology by SE File (1990)
File SE, Pellow S (1985a) Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal? Pharmacol Biochem Behav 23:33–36 (10.1016/0091-3057(85)90126-1) / Pharmacol Biochem Behav by SE File (1985)
File SE, Pellow S (1985b) Does the benzodiazepine antagonist Ro 15-1788 reverse the actions of picrotoxin and pentylenetetrazole on social and exploratory behaviour? Arch Int Pharmacodyn Ther 277:272–279 / Arch Int Pharmacodyn Ther by SE File (1985)
File SE, Pellow S (1986) Intrinsic actions of the benzodiazepine receptor antagonist, Ro 15-1788. Psychopharmacology 88:1–11 (10.1007/BF00310505) / Psychopharmacology by SE File (1986)
File SE, Baldwin HA, Arnako K (1987) Anxiogenic effects from benzodiazepine withdrawal are linked to the development of tolerance. Brain Res Bull 19:607–610 (10.1016/0361-9230(87)90079-7) / Brain Res Bull by SE File (1987)
File SE, Baldwin HA, Hitchcott PK (1989) The effect of flumazenil on levels of anxiety in rats after one week of chronic diazepam treatment. Neurosci Lett S36:S63
File SE, Mabbutt PS, Hitchcott PK (1990) Characterisation and explanation of the phenomenon of “one-trial tolerance” to the anxiolytic effect of chloridazepoxide. Psychopharmacology (in press) (10.1007/BF02245751)
Gallager DW, Heninger K, Heninger G (1986) Periodic benzodiazepine administration prevents benzodiazepine withdrawal symptoms in primates. Eur J Pharmacol 132:31–38 (10.1016/0014-2999(86)90005-1) / Eur J Pharmacol by DW Gallager (1986)
Gallaher EJ, Henauer SA, Jacques CJ, Hollister LE (1986) Benzodiazepine-dependence in mice after ingestion of drug containing food pellets. J Pharmacol Exp Ther 237:462–467 / J Pharmacol Exp Ther by EJ Gallaher (1986)
Grant SJ, Galloway MP, Mayor R, Fenerty JP, Finkelstein MF, Roth RH, Redmond DE (1985) Precipitated diazepam withdrawal elevates noradrenergic metabolism in primate brain. Eur J Pharmacol 107:127–132 (10.1016/0014-2999(85)90050-0) / Eur J Pharmacol by SJ Grant (1985)
Harris CM, Idemudia SO, Benjamin D, Bhadra S, Lal H (1988) Withdrawal from ingested diazepam produces a pentylenetetrazol-like stimulus in rats. Drug Dev Res 12:71–76 (10.1002/ddr.430120107) / Drug Dev Res by CM Harris (1988)
Hitchcott PK, File SE, Little HJ, Nutt DJ (1989) Diazepam withdrawal: decreased seizure threshold and increased anxiety reversed by FG 7142 and flumazenil. Soc Neurosci Abstr 15:414 / Soc Neurosci Abstr by PK Hitchcott (1989)
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Idemudia SO, Lal H (1989) Pentylenetetrazole-like stimulus is produced in rats during withdrawal from ingested chlordiazepoxide. Drug Dev Res 16:23–29 (10.1002/ddr.430160104) / Drug Dev Res by SO Idemudia (1989)
Kunchandy J, Kulkarni SK (1986) Reversal by alpha-2 agonists of diazepam hyperactivity in rats. Psychopharmacology 90:198–202 (10.1007/BF00181241) / Psychopharmacology by J Kunchandy (1986)
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Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149–167 (10.1016/0165-0270(85)90031-7) / J Neurosci Methods by S Pellow (1985)
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Dates

Type	When
Created	19 years, 9 months ago (Nov. 14, 2005, 4:46 p.m.)
Deposited	5 years, 4 months ago (April 10, 2020, 5:54 p.m.)
Indexed	1 week, 3 days ago (Aug. 20, 2025, 9:23 a.m.)
Issued	35 years ago (Aug. 1, 1990)
Published	35 years ago (Aug. 1, 1990)
Published Print	35 years ago (Aug. 1, 1990)

Funders 0

None

BibTeX

@article{File_1990, title={A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena}, volume={101}, ISSN={1432-2072}, url={http://dx.doi.org/10.1007/bf02244232}, DOI={10.1007/bf02244232}, number={4}, journal={Psychopharmacology}, publisher={Springer Science and Business Media LLC}, author={File, Sandra E. and Hitchcott, Paul K.}, year={1990}, month=aug, pages={525–532} }

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