Immunotherapeutic advances in the treatment of gram‐negative bacterial sepsis
10.1007/bf01656407
Crossref journal-article
Wiley
World Journal of Surgery (311)
Abstract

AbstractGram‐negative bacterial sepsis with the frequent sequelae of shock, multi‐system organ failure, and death represents one of the most severe infections that can occur in the surgical patient. Fatality in most series has paralleled the presence and severity of underlying host disease processes, polymicrobial bacteremia, shock, and lack of early appropriate antimicrobial therapy. Even patients with no underlying disease state have a significant mortality (10–20%). Therapy of gram‐negative bacterial sepsis and shock at present consists of antimicrobial agents, hemodynamic monitoring, aggressive fluid resuscitation, and metabolic support. The use of these treatment modalities in concert has reduced, but not eliminated, the severe consequences that may ensue. Administration of antibody directed against the comon core lipopolysaccharide antigen of gramnegative microorganisms to patients with gram‐negative sepsis represents a means by which the morbidity and mortality of this disease process may be further reduced. This is supported by a large body of experimental evidence, as well as several preliminary clinical studies. It is necessary to determine how the clinical efficacy of such antibody preparations can be maximized. This will entail rigorously controlled studies in which the timing of antibody administration and dose utilized can be correlated with clinical efficacy. Should such antibody preparations continue to prove efficacious as an additive form of therapy, it may be possible to identify high‐risk groups of patients who would benefit from antibody prophylaxis.

Bibliography

Dunn, D. L. (1987). Immunotherapeutic advances in the treatment of gram‐negative bacterial sepsis. World Journal of Surgery, 11(2), 233–240. Portico.

Authors 1
  1. David L. Dunn (first)
References 135 Referenced 18
  1. 10.1016/0002-9343(80)90101-1
  2. 10.1093/infdis/132.3.316
  3. {'key': 'e_1_2_1_4_1', 'first-page': '507', 'volume-title': 'Hospital Infections', 'author': 'Steere A.C.', 'year': '1979'} / Hospital Infections by Steere A.C. (1979)
  4. {'key': 'e_1_2_1_5_1', 'first-page': '135', 'article-title': 'Gram‐negative bacteremia', 'volume': '19', 'author': 'McCabe W.R.', 'year': '1974', 'journal-title': 'Adv. Intern. Med.'} / Adv. Intern. Med. / Gram‐negative bacteremia by McCabe W.R. (1974)
  5. 10.1093/infdis/122.5.419
  6. 10.1093/infdis/136.Supplement.S151
  7. 10.1093/infdis/124.3.239
  8. 10.1016/0002-9343(80)90102-3
  9. {'key': 'e_1_2_1_10_1', 'first-page': '78', 'article-title': 'Gram‐negative pathogens in septicaemic infections', 'volume': '31', 'author': 'Young L.S.', 'year': '1982', 'journal-title': 'Scand. J. Infect. Dis.'} / Scand. J. Infect. Dis. / Gram‐negative pathogens in septicaemic infections by Young L.S. (1982)
  10. 10.1001/archinte.1971.00310130124022
  11. 10.1093/clinids/5.4.629
  12. 10.1097/00005792-196907000-00003
  13. 10.1001/archinte.1962.03620240029006
  14. 10.1001/archinte.1978.03630370022013
  15. {'key': 'e_1_2_1_16_1', 'first-page': '267', 'article-title': 'Factors affecting mortality of patients with bacteremia', 'volume': '137', 'author': 'Kluge R.M.', 'year': '1973', 'journal-title': 'Surg. Gynecol. Obstet.'} / Surg. Gynecol. Obstet. / Factors affecting mortality of patients with bacteremia by Kluge R.M. (1973)
  16. 10.1016/0002-9343(77)90876-2
  17. 10.1001/archinte.1968.03640050028006
  18. 10.7326/0003-4819-56-2-207
  19. 10.1016/0002-9343(65)90118-X
  20. 10.1093/infdis/150.6.808
  21. 10.1016/S0140-6736(78)90979-0
  22. {'key': 'e_1_2_1_23_1', 'first-page': '286', 'article-title': 'Branched chain metabolic support: A prospective, randomized, double‐blind trial in surgical stress', 'volume': '199', 'author': 'Cerra F.B.', 'year': '1984', 'journal-title': 'Surgery'} / Surgery / Branched chain metabolic support: A prospective, randomized, double‐blind trial in surgical stress by Cerra F.B. (1984)
  23. 10.1056/NEJM197703312961301
  24. 10.3109/10408367909147137
  25. 10.1097/00000658-197609000-00011
  26. 10.1056/NEJM197106032842206
  27. 10.7326/0003-4819-81-1-36
  28. 10.1056/NEJM198108203050810
  29. 10.1056/NEJM198411013111801
  30. {'key': 'e_1_2_1_31_1', 'first-page': '1', 'volume-title': 'Bacterial Outer Membranes: Biogenesis and Function', 'author': 'Inouye M.', 'year': '1979'} / Bacterial Outer Membranes: Biogenesis and Function by Inouye M. (1979)
  31. 10.1128/br.38.1.87-110.1974
  32. 10.1093/infdis/128.Supplement_1.S9
  33. {'key': 'e_1_2_1_34_1', 'first-page': '319', 'volume-title': 'Bacterial Outer Membranes: Biogenesis and Function', 'author': 'Konisky J.', 'year': '1979'} / Bacterial Outer Membranes: Biogenesis and Function by Konisky J. (1979)
  34. {'key': 'e_1_2_1_35_1', 'first-page': '15', 'volume-title': 'Bacterial Outer Membranes: Biogenesis and Function', 'author': 'Osborn M.J.', 'year': '1979'} / Bacterial Outer Membranes: Biogenesis and Function by Osborn M.J. (1979)
  35. 10.1093/infdis/128.Supplement_1.S17
  36. {'key': 'e_1_2_1_37_1', 'first-page': '508', 'article-title': 'Possible reasons for the inefficiency of gram‐negative bacterial vaccines', 'volume': '5', 'author': 'Wardlaw A.C.', 'year': '1972', 'journal-title': 'Prog. Immunobiol. Standard'} / Prog. Immunobiol. Standard / Possible reasons for the inefficiency of gram‐negative bacterial vaccines by Wardlaw A.C. (1972)
  37. 10.1128/br.30.1.192-255.1966
  38. 10.1111/j.1749-6632.1966.tb52376.x
  39. 10.1111/j.1432-1033.1970.tb01092.x
  40. 10.1111/j.1432-1033.1970.tb00297.x
  41. 10.1128/br.41.3.667-710.1977
  42. {'key': 'e_1_2_1_43_1', 'first-page': '239', 'article-title': 'Newer aspects of the chemistry and biology of bacterial lipopolysaccharide with special reference to their lipid A component', 'volume': '14', 'author': 'Galanos C.', 'year': '1977', 'journal-title': 'Int. Rev. Biochem.'} / Int. Rev. Biochem. / Newer aspects of the chemistry and biology of bacterial lipopolysaccharide with special reference to their lipid A component by Galanos C. (1977)
  43. 10.1111/j.1432-1033.1969.tb19618.x
  44. 10.1128/iai.45.1.293-296.1984
  45. {'key': 'e_1_2_1_46_1', 'first-page': 'S8', 'article-title': 'Bacterial endotoxins: Chemical structure, biological activity and role in septicemia', 'volume': '31', 'author': 'Rietschel E.T.H.', 'year': '1982', 'journal-title': 'Scand. J. Infect. Dis.'} / Scand. J. Infect. Dis. / Bacterial endotoxins: Chemical structure, biological activity and role in septicemia by Rietschel E.T.H. (1982)
  46. 10.1111/j.1432-1033.1969.tb19618.x
  47. 10.1016/S0021-9258(18)97405-3
  48. 10.1128/jb.135.2.687-702.1978
  49. 10.1111/j.1432-1033.1973.tb02861.x
  50. 10.1128/jb.126.1.467-477.1976
  51. 10.1128/iai.45.3.544-549.1984
  52. 10.1126/science.145.3634.783
  53. 10.1128/jb.144.2.630-640.1980
  54. 10.1111/j.1432-1033.1980.tb04635.x
  55. 10.1128/iai.41.1.74-82.1983
  56. 10.4049/jimmunol.100.2.292
  57. 10.1016/0019-2791(75)90045-2
  58. {'key': 'e_1_2_1_59_1', 'first-page': '298', 'article-title': 'Bacterial endotoxins and host immune responses', 'volume': '28', 'author': 'Morrison D.C.', 'year': '1979', 'journal-title': 'Adv. Immunol.'} / Adv. Immunol. / Bacterial endotoxins and host immune responses by Morrison D.C. (1979)
  59. {'key': 'e_1_2_1_60_1', 'first-page': '981', 'article-title': 'Comparison of canine responses toEscherichia coli organisms and endotoxin', 'volume': '23', 'author': 'Hinshaw L.B.', 'year': '1968', 'journal-title': 'Surg. Gynecol. Obstet.'} / Surg. Gynecol. Obstet. / Comparison of canine responses toEscherichia coli organisms and endotoxin by Hinshaw L.B. (1968)
  60. 10.1128/iai.27.3.798-803.1980
  61. 10.1084/jem.118.4.619
  62. 10.1084/jem.115.1.131
  63. 10.1111/j.1749-6632.1966.tb52403.x
  64. 10.1084/jem.121.5.751
  65. 10.1111/j.1749-6632.1966.tb52402.x
  66. 10.1111/j.1749-6632.1966.tb52404.x
  67. 10.4049/jimmunol.108.2.505
  68. 10.1093/infdis/128.Supplement_1.S157
  69. 10.1001/archsurg.1985.01390250044007
  70. 10.4049/jimmunol.132.5.2590
  71. 10.1084/jem.118.4.565
  72. {'key': 'e_1_2_1_73_1', 'first-page': '204', 'article-title': 'Immunofluorescent localization of bacterial antigen in pyelonephritis: I. The use of antisera against the common enterobacterial antigen in experimental renal lesions', 'volume': '70', 'author': 'Aoki S.', 'year': '1967', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. / Immunofluorescent localization of bacterial antigen in pyelonephritis: I. The use of antisera against the common enterobacterial antigen in experimental renal lesions by Aoki S. (1967)
  73. 10.1128/iai.7.3.386-392.1973
  74. 10.1128/iai.17.1.9-15.1977
  75. 10.1128/iai.23.3.758-763.1979
  76. 10.1128/iai.10.6.1195-1201.1974
  77. 10.1128/iai.48.2.597-600.1985
  78. 10.1128/iai.35.2.639-646.1982
  79. 10.1128/iai.35.2.647-653.1982
  80. 10.1093/infdis/144.4.319
  81. 10.1007/BF01953765
  82. 10.1093/infdis/136.Supplement.S161
  83. 10.1128/iai.17.1.16-20.1977
  84. 10.1111/j.1432-1033.1971.tb19661.x
  85. 10.1084/jem.118.3.425
  86. 10.1128/iai.8.2.173-177.1973
  87. 10.1128/iai.15.1.34-49.1977
  88. 10.1093/infdis/136.Supplement.S167
  89. {'key': 'e_1_2_1_90_1', 'first-page': '212', 'article-title': 'Immunotherapy of gram‐negative bacterial sepsis: Enhanced survival in a guinea pig model by use of rabbit antiserum toEscherichia coli J‐5', 'volume': '92', 'author': 'Dunn D.L.', 'year': '1982', 'journal-title': 'Surgery'} / Surgery / Immunotherapy of gram‐negative bacterial sepsis: Enhanced survival in a guinea pig model by use of rabbit antiserum toEscherichia coli J‐5 by Dunn D.L. (1982)
  90. {'key': 'e_1_2_1_91_1', 'first-page': '440', 'article-title': 'Anti‐core endotoxin F(ab′)2 equine immunoglobulin fragments protect against lethal effects of gram‐negative bacterial sepsis', 'volume': '96', 'author': 'Dunn D.L.', 'year': '1984', 'journal-title': 'Surgery'} / Surgery / Anti‐core endotoxin F(ab′)2 equine immunoglobulin fragments protect against lethal effects of gram‐negative bacterial sepsis by Dunn D.L. (1984)
  91. 10.1093/infdis/147.1.57
  92. 10.1093/infdis/128.Supplement_1.S284
  93. 10.1093/infdis/137.1.7
  94. {'key': 'e_1_2_1_95_1', 'first-page': '101', 'article-title': 'Prevention of lethalPseudomonas bacteremia with epimerase‐deficientE. coli antiserum', 'volume': '88', 'author': 'Ziegler E.J.', 'year': '1975', 'journal-title': 'Trans. Assoc. Am. Physicians'} / Trans. Assoc. Am. Physicians / Prevention of lethalPseudomonas bacteremia with epimerase‐deficientE. coli antiserum by Ziegler E.J. (1975)
  95. 10.1172/JCI108164
  96. 10.1093/infdis/136.Supplement.S174
  97. 10.1016/0022-4804(83)90099-9
  98. 10.1016/0022-4804(85)90041-1
  99. {'key': 'e_1_2_1_100_1', 'first-page': '433', 'article-title': 'Treatment ofE. coli andKlebsiella bacteremia in agranulocytic animals with antiserum to a UDP‐gal‐epimerasedeficient mutant', 'volume': '111', 'author': 'Ziegler E.J.', 'year': '1973', 'journal-title': 'Infect. Immun.'} / Infect. Immun. / Treatment ofE. coli andKlebsiella bacteremia in agranulocytic animals with antiserum to a UDP‐gal‐epimerasedeficient mutant by Ziegler E.J. (1973)
  100. 10.4049/jimmunol.108.3.601
  101. {'key': 'e_1_2_1_102_1', 'first-page': '141', 'volume-title': 'Immunotherapy', 'author': 'Helting T.B.', 'year': '1981'} / Immunotherapy by Helting T.B. (1981)
  102. 10.1093/infdis/151.6.995
  103. 10.3181/00379727-158-40231
  104. 10.1099/00221287-94-1-107
  105. 10.1099/00222615-14-4-381
  106. 10.1007/BF01666916
  107. 10.1128/jb.98.3.979-991.1969
  108. 10.1093/infdis/144.6.599
  109. 10.1093/infdis/142.3.421
  110. {'key': 'e_1_2_1_111_1', 'first-page': '241', 'article-title': 'Effect of aerosol immunization with Re 595Salmonella minnesota on lung bactericidal activity againstSerratia marcescens, Enterobacter cloacae, andPseudomonas aeruginosa', 'volume': '116', 'author': 'LaForce F.M.', 'year': '1977', 'journal-title': 'Am. Rev. Respir. Dis.'} / Am. Rev. Respir. Dis. / Effect of aerosol immunization with Re 595Salmonella minnesota on lung bactericidal activity againstSerratia marcescens, Enterobacter cloacae, andPseudomonas aeruginosa by LaForce F.M. (1977)
  111. 10.1007/BF01927729
  112. 10.1093/infdis/142.4.532
  113. 10.1093/infdis/135.6.965
  114. 10.1128/iai.33.3.784-787.1981
  115. {'key': 'e_1_2_1_116_1', 'first-page': '142', 'article-title': 'Monoclonal antibodies protect against lethal effects of gram‐negative bacterial sepsis', 'volume': '32', 'author': 'Dunn D.L.', 'year': '1983', 'journal-title': 'Surg. Forum'} / Surg. Forum / Monoclonal antibodies protect against lethal effects of gram‐negative bacterial sepsis by Dunn D.L. (1983)
  116. {'key': 'e_1_2_1_117_1', 'first-page': '283', 'article-title': 'Efficacy of type‐specific and cross‐reactive murine monoclonal antibodies directed against endotoxin during experimental sepsis', 'volume': '98', 'author': 'Dunn D.L.', 'year': '1985', 'journal-title': 'Surgery'} / Surgery / Efficacy of type‐specific and cross‐reactive murine monoclonal antibodies directed against endotoxin during experimental sepsis by Dunn D.L. (1985)
  117. Dunn D.L. Ewald D.C. Chandan N. Cerra F.B.:A single murine monoclonal antibody provides cross‐genera protection during murine gram‐negative sepsis. Arch. Surg. (in press).
  118. {'key': 'e_1_2_1_119_1', 'first-page': '522A', 'article-title': 'Monoclonal antibody directed against the “core” glycolipid of enterobacterial endotoxin', 'volume': '30', 'author': 'Young L.S.', 'year': '1982', 'journal-title': 'Clin. Res.'} / Clin. Res. / Monoclonal antibody directed against the “core” glycolipid of enterobacterial endotoxin by Young L.S. (1982)
  119. 10.1128/iai.46.3.677-681.1984
  120. 10.1128/iai.45.3.631-636.1984
  121. {'key': 'e_1_2_1_122_1', 'first-page': '1682', 'article-title': 'Murine monoclonal antibodies against gram‐negative bacterial core‐glycolipid: Criteria for cross‐genera reactivity', 'volume': '43', 'author': 'Bogard W.C.', 'year': '1984', 'journal-title': 'Fed. Proc.'} / Fed. Proc. / Murine monoclonal antibodies against gram‐negative bacterial core‐glycolipid: Criteria for cross‐genera reactivity by Bogard W.C. (1984)
  122. 10.1093/infdis/151.6.1005
  123. 10.1073/pnas.82.6.1790
  124. 10.1093/infdis/133.1.37
  125. 10.1016/0002-9343(84)90292-4
  126. 10.1172/JCI111150
  127. 10.1056/NEJM197208102870601
  128. 10.1093/infdis/151.6.988
  129. {'key': 'e_1_2_1_130_1', 'first-page': '107', 'article-title': 'Potential use of shared antigens for immunization against gram‐negative bacillary infections', 'volume': '47', 'author': 'McCabe W.R.', 'year': '1980', 'journal-title': 'Prog. Clin. Biol. Res.'} / Prog. Clin. Biol. Res. / Potential use of shared antigens for immunization against gram‐negative bacillary infections by McCabe W.R. (1980)
  130. 10.1016/0002-9343(81)90789-0
  131. {'key': 'e_1_2_1_132_1', 'first-page': '253', 'article-title': 'Clinical trial of core glycolipid antibody in gram‐negative bacteremia', 'volume': '91', 'author': 'Ziegler E.J.', 'year': '1978', 'journal-title': 'Trans. Assoc. Am. Physicians'} / Trans. Assoc. Am. Physicians / Clinical trial of core glycolipid antibody in gram‐negative bacteremia by Ziegler E.J. (1978)
  132. 10.1056/NEJM198211113072001
  133. 10.1016/S0140-6736(84)92324-9
  134. {'key': 'e_1_2_1_135_1', 'first-page': '40', 'article-title': 'Ineffectiveness of single‐dose human antiserum to core glycolipid (E. coli J5) for prophylaxis of bacteremic, gram‐negative infections in patients with prolonged neutropenia', 'volume': '113', 'author': 'McCutchan J.A.', 'year': '1983', 'journal-title': 'Schweiz. Med. Wochenschr.'} / Schweiz. Med. Wochenschr. / Ineffectiveness of single‐dose human antiserum to core glycolipid (E. coli J5) for prophylaxis of bacteremic, gram‐negative infections in patients with prolonged neutropenia by McCutchan J.A. (1983)
  135. 10.1016/S0140-6736(85)90176-X
Dates
Type When
Created 20 years, 3 months ago (May 9, 2005, 9:47 a.m.)
Deposited 1 year, 8 months ago (Dec. 27, 2023, 12:48 p.m.)
Indexed 1 year, 8 months ago (Dec. 27, 2023, 7:01 p.m.)
Issued 38 years, 4 months ago (April 1, 1987)
Published 38 years, 4 months ago (April 1, 1987)
Published Online 38 years, 4 months ago (April 1, 1987)
Published Print 38 years, 4 months ago (April 1, 1987)
Funders 1
  1. National Institutes of Health 10.13039/100000002

    Region: Americas

    gov (National government)

    Labels3
    1. Institutos Nacionales de la Salud
    2. US National Institutes of Health
    3. NIH
    Awards1
    1. GM 32414

@article{Dunn_1987, title={Immunotherapeutic advances in the treatment of gram‐negative bacterial sepsis}, volume={11}, ISSN={1432-2323}, url={http://dx.doi.org/10.1007/bf01656407}, DOI={10.1007/bf01656407}, number={2}, journal={World Journal of Surgery}, publisher={Wiley}, author={Dunn, David L.}, year={1987}, month=apr, pages={233–240} }