Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons
10.1007/bf01000039
Crossref journal-article
Springer Science and Business Media LLC
Neurochemical Research (297)
Bibliography

Palaiologos, G., Hertz, L., & Schousboe, A. (1989). Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons. Neurochemical Research, 14(4), 359–366.

Authors 3
  1. Georgios Palaiologos (first)
  2. Leif Hertz (additional)
  3. Arne Schousboe (additional)
References 60 Referenced 115
  1. Fonnum, F. 1984. Glutamate: A neurotransmitter in mammalian brain. J. Neurochem. 42:1?11. (10.1111/j.1471-4159.1984.tb09689.x) / J. Neurochem. by F. Fonnum (1984)
  2. Hudson, D. B., Valcana, T., Bean, G., and Timiras, P. S. 1976. Glutamic acid; a strong candidate as the neurotransmitter of cerebellar granule cells. Neurochem. Res. 1:73?81. (10.1007/BF00965633) / Neurochem. Res. by D. B. Hudson (1976)
  3. Stone, T. W. 1979. Glutamate as the neurotransmitter of cerebellar granule cells in the rat: An electrophysiological study. Br. J. Pharmacol. 66:291?296. (10.1111/j.1476-5381.1979.tb13678.x) / Br. J. Pharmacol. by T. W. Stone (1979)
  4. Ito, M. 1984. Glutamate as a neurotransmitter in the cerebellar cortex. Biomed. Res. 5:Suppl:63?66. / Biomed. Res. by M. Ito (1984)
  5. Hertz, L., Kvamme, E., McGeer, E. G., and Schousboe, A. (eds.) 1983. Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Pages 1?800, Vol. 7, Alan R. Liss Inc., New York. / Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology (1983)
  6. Schousboe, A. 1987. An overview of the biochemistry and pharmacology of glutamatergic and GABAergic neurotransmission. Biochem. Soc. Trans. 15:205?208. (10.1042/bst0150205) / Biochem. Soc. Trans. by A. Schousboe (1987)
  7. Hertz, L., and Schousboe, A. 1987. Primary cultures of GABAergic and glutamatergic neurons as model systems to study neurotransmitter functions. Pages 19?31,in Vernadakis, A., Privat, A., Lauder, J. M., Timiras, P. S., and Giacobini, E. (eds.), Model Systems of Development and Aging of the Nervous System. Martinus Nijhoff Publ., Amsterdam. (10.1007/978-1-4613-2037-1_2) / Model Systems of Development and Aging of the Nervous System by L. Hertz (1987)
  8. Kvamme, E. 1983. Glutaminase (PAG). Pages 51?67,in Hertz, L., Kvamme, E., McGeer, E. G., and Schousboe, A. (eds.), Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Vol. 7. Alan R. Liss, Inc., NY. / Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Vol. 7 by E. Kvamme (1983)
  9. Ward, H. K., Thanki, C. M., and Bradford, H. F. 1983. Glutamine and glucose as precursors of transmitter amino acids: ex vivo studies. J. Neurochem. 40:855?860. (10.1111/j.1471-4159.1983.tb08058.x) / J. Neurochem. by H. K. Ward (1983)
  10. Rothstein, J. D., and Tabakoff, B. 1984. Alteration of striatal glutamate release after glutamine synthetase inhibition. J. Neurochem. 43:1438?1446. (10.1111/j.1471-4159.1984.tb05406.x) / J. Neurochem. by J. D. Rothstein (1984)
  11. Ward, H. K., Thanki, C. M., Peterson, D. W., and Bradford, H. F. 1982. Brain glutaminase activity in relation to transmitter glutamate biosynthesis. Biochem. Soc. Trans. 10:369?370. (10.1042/bst0100369) / Biochem. Soc. Trans. by H. K. Ward (1982)
  12. Hamberger, A., Chiang, G. H., Nylen, E. S., Scheff, S. W., and Cotman, C. W. 1979. Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res. 168:513?530. (10.1016/0006-8993(79)90306-8) / Brain Res. by A. Hamberger (1979)
  13. McCarthy, A. D., and Tipton, K. F. 1983. Glutamate dehydrogenase. Pages 19?32,in Hertz, L. Kvamme, E., McGeer, E. G., and Schousboe, A. (eds.), Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Vol. 7. Alan R. Liss, Inc., NY. / Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Vol. 7 by A. D. McCarthy (1983)
  14. Wolf, G., and Schünzel, G. 1987. Glutamate dehydrogenase in aminoacidergic structures of the postnatally developing rat cerebellum. Neurosci. Lett. 78:7?11. (10.1016/0304-3940(87)90552-0) / Neurosci. Lett. by G. Wolf (1987)
  15. Altschuler, R. A., Neises, G. R., Harmison, G. G., Wenthold, R. J., and Fex, J. 1981. Immunocytochemical localization of aspartate aminotransferase immunoreactivity in cochlear nucleus of the guinea pig. Proc. Natl. Acad. Sci. USA 78:6553?6557. (10.1073/pnas.78.10.6553) / Proc. Natl. Acad. Sci. USA by R. A. Altschuler (1981)
  16. Wenthold, R. J., and Altschuler, R. A. 1983. Immunocytochemistry of aspartate aminotransferase and glutaminase. Pages 33?50in Hertz, L., Kvamme, E., McGeer, E. G. and Schousboe, A. (eds.), Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Vol. 7. Alan R. Liss, Inc. NY. / Glutamine, Glutamate and GABA in the Central Nervous System. Neurology and Neurobiology, Vol. 7 by R. J. Wenthold (1983)
  17. Altschuler, R. A., Monaghan, D. T., Haser, W. G., Wenthold, R. J., Curthoys, N. P., and Cotman, C. W. 1985. Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus. Brain Res. 330:225?233. (10.1016/0006-8993(85)90681-X) / Brain Res. by R. A. Altschuler (1985)
  18. Wenthold, R. J., Skaggs, K. K., and Altschuler, R. A. 1986. Immunocytochemical localization of aspartate aminotransferase and glutaminase immunoreactivities in the cerebellum. Brain. Res. 363:371?375. (10.1016/0006-8993(86)91025-5) / Brain. Res. by R. J. Wenthold (1986)
  19. Roberts, E. 1981. Strategies for identifying sources and sites of formation of GABA-precursor or transmitter glutamate in brain. Pages 91?102,in DiChiara, G. and Gessa, G. L. (eds.), Glutamate as a Neurotransmitter. Raven Press, New York. / Glutamate as a Neurotransmitter by E. Roberts (1981)
  20. Drejer, J., Larsson, O. M., and Schousboe, A. 1982. Characterization ofl-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions. Exp. Brain Res. 47:259?269. (10.1007/BF00239385) / Exp. Brain Res. by J. Drejer (1982)
  21. Gallo, V., Ciotti, M. T., Coletti, A., Aloisi, F. and Levi, G. 1982. Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc. Natl. Acad. Sci. USA 79:7919?7923. (10.1073/pnas.79.24.7919) / Proc. Natl. Acad. Sci. USA by V. Gallo (1982)
  22. Schousboe, A., Drejer, J., and Hertz, L. 1985. Comparison of the metabolism of glucose and glutamate in cultured cerebellar granule cells. J. Neurochem. 44 Suppl.:S168. / J. Neurochem. by A. Schousboe (1985)
  23. Drejer, J., Larsson, O. M., Kvamme, E., Svenneby, G., Hertz, L. and Schousboe, A. 1985. Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivo. Neurochem. Res. 10:49?62. (10.1007/BF00964771) / Neurochem. Res. by J. Drejer (1985)
  24. Fonnum, F. 1968. The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guineapig brain. Biochem. J. 106:401?412. (10.1042/bj1060401) / Biochem. J. by F. Fonnum (1968)
  25. Palaiologos, G., Hertz, L., and Schousboe, A. 1988. Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosythesis of transmitter glutamate J. Neurochem. 51:317?320. (10.1111/j.1471-4159.1988.tb04872.x) / J. Neurochem. by G. Palaiologos (1988)
  26. Passarella, S., Barile, M., Atlante, A., and Quagliariello, E. 1984. Oxaloacetate uptake into rat brain mitochondria and reconstruction of the malate/oxaloacetate shuttle. Biochem. Biophys. Res. Commun. 119:1039?1046. (10.1016/0006-291X(84)90879-9) / Biochem. Biophys. Res. Commun. by S. Passarella (1984)
  27. Passarella, S., Atlante, A., Barile, M., and Quagliariello, E. 1987. Anion transport in rat brain mitochondria: Fumarate uptake via the dicarboxylate carrier. Neurochem. Res. 12:255?264. (10.1007/BF00972135) / Neurochem. Res. by S. Passarella (1987)
  28. Meijer, A. J., and van Dam, K. 1974. The metabolic significance of anion transport in mitochondria. Biochim. Biophys. Acta 346:213?244. (10.1016/0304-4173(74)90001-9) / Biochim. Biophys. Acta by A. J. Meijer (1974)
  29. Balcar, V. J., and Johnston, G. A. R. 1972. The structural specificity of high affinity uptake ofl-glutamate andl-aspartate by rat brain slices. J. Neurochem. 19:2657?2666. (10.1111/j.1471-4159.1972.tb01325.x) / J. Neurochem. by V. J. Balcar (1972)
  30. Drejer, J., Larsson, O. M., and Schousboe, A. 1983. Characterization of uptake and release processes ford- andl-aspartate in primary cultures of astrocytes and cerebellar granule cells. Neurochem. Res. 8:231?243. (10.1007/BF00963923) / Neurochem. Res. by J. Drejer (1983)
  31. Wilkin, G. P., Garthwaite, J., and Balazs, R. 1982. Putative acidic amino acid transmitters in the cerebellum. II. Electron microscopic localization of transport sites. Brain Res. 244:69?80. (10.1016/0006-8993(82)90905-2) / Brain Res. by G. P. Wilkin (1982)
  32. Levi, G., Gordon, R. D., Gallo, V., Wilkin, G. P., and Balazs, R. 1982. Putative acidic amino acid transmitters in the cerebellum. I. Depolarization-induced release. Brain Res. 239:425?445. (10.1016/0006-8993(82)90520-0) / Brain Res. by G. Levi (1982)
  33. Meier, E., Drejer, J., and Schousboe, A. 1984. GABA induces functionally active low-affinity GABA receptors on cerebellar granule cells. J. Neurochem. 43:1737?1744. (10.1111/j.1471-4159.1984.tb06102.x) / J. Neurochem. by E. Meier (1984)
  34. Nielsen, E. Ø., Aarslew-Jensen, M., Diemer, N. H., Krogsgaard-Larsen, P. and Schousboe, A. 1989. Baclofen-induced, calcium-dependent stimulation of in vivo release ofd-[3H] aspartate from rat hippocampus monitored by intra-cerebral microdialysis. Neurochem. Res. 1714:421?425. / Neurochem. Res. by E. Ø. Nielsen (1989)
  35. Nichols, R. A., and Nakajama, Y. 1975. Effects of manganese and cobalt on the inhibitory synapse of the crustacean stretch receptor neuron. Brain Res. 86:493?498. (10.1016/0006-8993(75)90902-6) / Brain Res. by R. A. Nichols (1975)
  36. Schousboe, A., Palaiologos, G., and Hertz, L. 1988. Mitochondrial keto acid transport and biosynthesis of transmitter glutamate. Trans. Amer. Soc. Neurochem. 19:199. / Trans. Amer. Soc. Neurochem. by A. Schousboe (1988)
  37. Palaiologos, G., Hertz, L., and Schousboe, A. 1988. Effects of aminooxyacetate or phenylsuccinate on the biosynthesis of neurotransmitter glutamate. Neurochem. Int. 13 Suppl. 1:157. / Neurochem. Int. by G. Palaiologos (1988)
  38. Messer, A. 1977. Maintenance and identification of mouse cerebellar granule cells in monolayer cultures. Brain Res. 130:1?12. (10.1016/0006-8993(77)90838-1) / Brain Res. by A. Messer (1977)
  39. Meier, E., and Schousboe, A. 1982. Diffeences between GABA receptor binding to membranes from cerebellum during postnatal development and from cultured cerebellar granule cells. Dev. Neurosci. 5:546?553. (10.1159/000112716) / Dev. Neurosci. by E. Meier (1982)
  40. Hertz, L., Juurlink, B. H. J., Fosmark, H., and Schousboe, A. 1982. Astrocytes in primary culture. Pages 175?186in Pfeiffer, S. (ed.), Neuroscience Approached through Cell Culture, Vol. 1. CRC Press, Inc. Boca Raton, Fla. / Neuroscience Approached through Cell Culture, Vol. 1 by L. Hertz (1982)
  41. Sensenbrenner, M., Maderspach, K., Latzkowitz, L., and Jaros, G. G. 1978. Neuronal cells from chick embryo cerebral hemispheres cultivated on poly-lysine coated surfaces. Dev. Neurosci. 1:90?101. (10.1159/000112560) / Dev. Neurosci. by M. Sensenbrenner (1978)
  42. Hansen, G. H., Meier, E., and Schousboe, A. 1984. GABA influences the ultrastructure composition of cerebellar granule cells during development in culture. Int. J. Devl. Neurosci. 2:247?257. (10.1016/0736-5748(84)90019-4) / Int. J. Devl. Neurosci. by G. H. Hansen (1984)
  43. Drejer, J., Honore, T., and Schousboe, A. 1987. Exciatory amino acid-induced release of3H-GABA from cultured mouse cerebral cortex interneurons. J. Neurosci. 7:2910?2916. (10.1523/JNEUROSCI.07-09-02910.1987) / J. Neurosci. by J. Drejer (1987)
  44. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265?275. (10.1016/S0021-9258(19)52451-6) / J. Biol. Chem. by O. H. Lowry (1951)
  45. Lowry, O. H., and Passonneau, J. V. 1972. A Flexible System of Enzymatic Analysis. Pages 1?291, Academic Press, NY. / A Flexible System of Enzymatic Analysis by O. H. Lowry (1972)
  46. Lindroth, P., and Mopper, K. 1979. High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluoresence derivatization with O-phthal-dialdehyde. Anal. Chem. 51:1667?1674. (10.1021/ac50047a019) / Anal. Chem. by P. Lindroth (1979)
  47. Yu, A. C. H., Schousboe, A., and Hertz, L. 1984. Influence of pathological concentrations of ammonia on metabolism of14C-labeled glutamate in astrocytes in primary cultures. J. Neurochem. 42:594?597. (10.1111/j.1471-4159.1984.tb02721.x) / J. Neurochem. by A. C. H. Yu (1984)
  48. Kvamme, E., Schousboe, A., Hertz, L., Torgner, I. A., and Svenneby, G. 1985. Developmental change of endogenous glutamate and gamma-glutamyl transferase in cultured cerebral cortical interneurons and cerebellar granule cells, and in mouse cerebral cortex and cerebellum in vivo. Neurochem. Res. 10:993?1008. (10.1007/BF00964635) / Neurochem. Res. by E. Kvamme (1985)
  49. Hogstad, S., Svenneby, G., Torgner, I. A., Kvamme, E., Hertz, L., and Schousboe, A. 1988. Glutaminase in neurons and astrocytes cultured from mouse brain: Kinetic properties and effects of phosphate, glutamate and ammonia. Neurochem. Res. 13:383?388. (10.1007/BF00972489) / Neurochem. Res. by S. Hogstad (1988)
  50. Patel, A. J., Hunt, A., Gordon, R. D., and Balazs, R. 1982. The activities in different neural cell types of certain enzymes associated with the metabolic compartmentation of glutamate. Dev. Brain Res. 4:3?11. (10.1016/0165-3806(82)90091-8) / Dev. Brain Res. by A. J. Patel (1982)
  51. Nicholls, D. G., Sihra, T. S., and Sanchez-Prieto, J. 1987. Calcium-dependent and-independent release of glutamate from synaptosomes monitored by continuous fluorometry. J. Neurochem. 49:50?57. (10.1111/j.1471-4159.1987.tb03393.x) / J. Neurochem. by D. G. Nicholls (1987)
  52. Yu, A. C. H., Schousboe, A., and Hertz, L. 1982. Metabolic fate of14C-labelled glutamate in astrocytes in primary cultures. J. Neurochem. 39:954?960. (10.1111/j.1471-4159.1982.tb11482.x) / J. Neurochem. by A. C. H. Yu (1982)
  53. Kauppinen, R. A., Sihra, T. S., and Nicholls, D. G. 1987. Amioxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates. Biochim. Biophys. Acta 930:173?178. (10.1016/0167-4889(87)90029-2) / Biochim. Biophys. Acta by R. A. Kauppinen (1987)
  54. Norenberg, M. D., and Martinez-Hernandez, A. 1979. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161:303?310. (10.1016/0006-8993(79)90071-4) / Brain Res. by M. D. Norenberg (1979)
  55. Yu, A. C. H., Drejer, J., Hertz, L., and Schousboe, A. 1983. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J. Neurochem. 41:1484?1487. (10.1111/j.1471-4159.1983.tb00849.x) / J. Neurochem. by A. C. H. Yu (1983)
  56. Shank, R. P., Bennett, G. S., Freitag, S. D., Campbell, G. L., and Utter, M. F. 1985. Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res. 329:364?367. (10.1016/0006-8993(85)90552-9) / Brain Res. by R. P. Shank (1985)
  57. Hertz, L., and Schousboe, A. 1988. Metabolism of glutamate and glutamine in neurons and astrocytes in primary cultures. Pages 39?55,in Kvamme, E. (ed.), Glutamine and Glutamate in Mammals, Vol. 2. CRC Press, Inc., Boca Raton, Fla. / Glutamine and Glutamate in Mammals, Vol. 2 by L. Hertz (1988)
  58. Hertz, L., and Schousboe, A. 1986. Role of astrocytes in compartmentation of amino acid and energy metabolism. Pages 179?208in Fedoroff, S. and Vernadakis, A. (eds.), Astrocytes, Vol. 2. Academic Press, NY. (10.1016/B978-0-12-250452-5.50011-5) / Astrocytes, Vol. 2 by L. Hertz (1986)
  59. Yudkoff, M., Nissim, I., Hummeler, K., Medow, M., and Pleasure, D. 1986. Utilization of [15N]-glutamate by cultured astrocytes. Biochem. J. 234:185?192. (10.1042/bj2340185) / Biochem. J. by M. Yudkoff (1986)
  60. Hertz, L., Murthy, C. R. K., Lai, J. C. K., Fitzpatrick, S. M., and Cooper, A. J. L. 1987. Some metabolic effects of ammonia on astrocytes and neurons in primary cultures. Neurochem. Pathol. 6:97?129. (10.1007/BF02833602) / Neurochem. Pathol. by L. Hertz (1987)
Dates
Type When
Created 20 years, 7 months ago (Jan. 18, 2005, 10:40 a.m.)
Deposited 4 years, 2 months ago (July 3, 2021, 11:34 p.m.)
Indexed 1 month, 3 weeks ago (July 14, 2025, 11:39 p.m.)
Issued 36 years, 5 months ago (April 1, 1989)
Published 36 years, 5 months ago (April 1, 1989)
Published Print 36 years, 5 months ago (April 1, 1989)
Funders 0

None

@article{Palaiologos_1989, title={Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons}, volume={14}, ISSN={1573-6903}, url={http://dx.doi.org/10.1007/bf01000039}, DOI={10.1007/bf01000039}, number={4}, journal={Neurochemical Research}, publisher={Springer Science and Business Media LLC}, author={Palaiologos, Georgios and Hertz, Leif and Schousboe, Arne}, year={1989}, month=apr, pages={359–366} }