DOI: 10.1007/bf00373474. Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture

Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture

10.1007/bf00373474

Crossref journal-article

Springer Science and Business Media LLC

Bioprocess Engineering (297)

Bibliography

Miller, W. M., Wilke, C. R., & Blanch, H. W. (1988). Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture. Bioprocess Engineering, 3(3), 113â122.

Authors 3

W. M. Miller (first)
C. R. Wilke (additional)
H. W. Blanch (additional)

References 21 Referenced 109

Eigenbrodt, E.; Fister, P.; Reinacher, M.: New perspectives on carbohydrate metabolism in tumor cells. In: Beitner, R. (Ed.): Regulation of carbohydrate metabolism vol. 2, pp. 141?179. Boca Raton, FL: CRC Press 1985 / Regulation of carbohydrate metabolism vol. 2 by E. Eigenbrodt (1985)
McKeehan, W. L.: Glutaminolysis in animal cells. In: Morgan, M. J. (Ed.): Carbohydrate metabolism in cultured cells, pp. 111?150. New York: Plenum Press 1986 (10.1007/978-1-4684-7679-8_4) / Carbohydrate metabolism in cultured cells by W. L. McKeehan (1986)
Butler, M.; Spier, R. E.: The effects of glutamine utilisation and ammonia production on the growth of BHK cells in microcarrier cultures. J. Biotechnol. 1 (1984) 187?196 (10.1016/0168-1656(84)90004-X) / J. Biotechnol. by M. Butler (1984)
Glacken, M. W.; Fleischaker, R. J.; Sinskey, A. J.: Reduction of waste product excretion via nutrient control: possible stategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol. Bioeng. 28 (1986) 1376?1389 (10.1002/bit.260280912) / Biotechnol. Bioeng. by M. W. Glacken (1986)
Miller, W. M.; Wilke, C. R.; Blanch, H. W.: The transient responses of hybridoma cells to nutrient additions in continuous culture: II. glutamine pulse and step changes. Submitted to Biotechnol. Bioeng. 1987
Zielke, H. R.; Ozand, P- T.; Tildon, J- T.; Sevdalian, D. A.; Cornblath, M.: Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts. J. Cell. Physio. 95 (1978) 41?48 (10.1002/jcp.1040950106) / J. Cell. Physio. by H. R. Zielke (1978)
Miller, W. M.; Blanch, H. W.; Wilke, C. R.: A kinetic analysis of hybridoma growth and metabolism in bath and continuous suspension culture: effect of nutrient concentration, dilution rate and pH. Biotechnol. Bioeng. in press 1987 (10.1002/bit.260320803)
Miller, W. M.; Wilke, C. R.: Blanch, H. W.: The transient responses of hybridoma cells to nutrient additions in continuous culture: I. glucose pulse and step changes. submitted to Biotechnol. Bioeng. 1987
Ryan, W. L.; Cardin, C.: Amino acids and ammonia of fetal calf serum during storage. Proc. Soc. Exp. Biol. Med. 123 (1966) 27?30 (10.3181/00379727-123-31393) / Proc. Soc. Exp. Biol. Med. by W. L. Ryan (1966)
Visek, W. J.; Kolodny, G. M.; Gross, P. R.: Ammonia effects in cultures of normal and transformed 3T3 cells. J. Cell. Physiol. 80 (1972) 373?382 (10.1002/jcp.1040800308) / J. Cell. Physiol. by W. J. Visek (1972)
Reuveny, S.; Velez, D.; Macmillan, J. D.; Miller, L.: Factors affecting cell growth and monoclonal antibody production in stirred reactors. J. Immunol. Methods 86 (1986) 53?59 (10.1016/0022-1759(86)90264-4) / J. Immunol. Methods by S. Reuveny (1986)
Taya, M.; Mano, T.; Kobayashi, T.: Kinetic expression for huma cell growth in a suspension culture system. J. Ferment. Technol. 64 (1986) 347?350 (10.1016/0385-6380(86)90130-5) / J. Ferment. Technol. by M. Taya (1986)
Iio, M.; Moriyama, A.; Murakami, H.: Effects on cell proliferation of metabolites produced by cultured cells and their removal from culture in defined media. In: Murakami, H.; Yamane, I.; Barnes, D. W.; Mather, J. P.; Hayashi, I; Sato, G. H. (Eds.): Growth and differentiation of cells in defined environment, pp. 437?442. Tokyo: Kodansha and Berlin: Springer 1985 / Growth and differentiation of cells in defined environment by M. Iio (1985)
Eagle, H.: The effect of environmental pH on the growth of normal and malignant cells. J. Cell. Physiol. 82 (1973) 1?8 (10.1002/jcp.1040820102) / J. Cell. Physiol. by H. Eagle (1973)
Miller, W. M.; Wilke, C. R.; Blanch, H. W.: Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture. Submitted to Bioprocess Engr. 1987 (10.1007/BF00373473)
Miller, W. M.; Wilke, C. R.; Blanch, H. W.: The effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J. Cell. Physiol. 132 (1987) 524?530 (10.1002/jcp.1041320315) / J. Cell. Physiol. by W. M. Miller (1987)
Miller, W. M.: Ph. D. thesis. Berkeley, CA: University of California 1987 / Ph. D. thesis by W. M. Miller (1987)
Ardawi, M. S. M.; Newsholme, E. A.: Glutamine metabolism in lymphoid tissues. In: Häussinger, D.; Sies, H. (Eds.): Glutamine metabolism in mammalian tissues, pp. 235?246. Berlin; Heidelberg New York: Springer 1984 (10.1007/978-3-642-69754-8_15) / Glutamine metabolism in mammalian tissues by M. S. M. Ardawi (1984)
Williamson, J. R.; Cooper, R. H.: Regulation of the citric acid cycle in mammalian systems. FEBS Lett. 117 (1980) K73-K85 (10.1016/0014-5793(80)80572-2) / FEBS Lett. by J. R. Williamson (1980)
Zimber, A.; Topping, D. C.: Metabolic effects of ammonia on ascites tumor cells and mouse spleen cells in vitro. Fed. Proc. Fed. Am. Soc. Exp. Biol. 29 (1970) 428Abs / Fed. Proc. Fed. Am. Soc. Exp. Biol. by A. Zimber (1970)
Zielke, H. R.; Sumbilla, C. M.; Sevdalian, D. A.; Hawkins, R. L.; Ozand, P- T.: Lactate: a major product of glutamamine metabolism by human diploid fibroblasts. J. Cell. Physiol. 104 (1980) 433?441 (10.1002/jcp.1041040316) / J. Cell. Physiol. by H. R. Zielke (1980)

Dates

Type	When
Created	20 years, 9 months ago (Nov. 15, 2004, 4:28 p.m.)
Deposited	5 years, 4 months ago (April 3, 2020, 11:10 p.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:27 p.m.)
Issued	37 years, 7 months ago (Jan. 1, 1988)
Published	37 years, 7 months ago (Jan. 1, 1988)
Published Print	37 years, 7 months ago (Jan. 1, 1988)

Funders 0

None

BibTeX

@article{Miller_1988, title={Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture}, volume={3}, ISSN={1615-7605}, url={http://dx.doi.org/10.1007/bf00373474}, DOI={10.1007/bf00373474}, number={3}, journal={Bioprocess Engineering}, publisher={Springer Science and Business Media LLC}, author={Miller, W. M. and Wilke, C. R. and Blanch, H. W.}, year={1988}, pages={113–122} }

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