DOI: 10.1007/bf00166596. On Ohta's hypothesis: Most amino acid substitutions are deleterious

On Ohta's hypothesis: Most amino acid substitutions are deleterious

10.1007/bf00166596

Crossref journal-article

Springer Science and Business Media LLC

Journal of Molecular Evolution (297)

Bibliography

Gillespie, J. H. (1995). On Ohtaâs hypothesis: Most amino acid substitutions are deleterious. Journal of Molecular Evolution, 40(1), 64â69.

Authors 1

John H. Gillespie (first)

References 24 Referenced 32

Aquadro CF (1993) Molecular population genetics of Drosophila. In: Oakeshott JG, Whitten M (eds) Molecular approaches to pure and applied entomology. Springer-Verlag, New York, pp 222?266 (10.1007/978-1-4613-9217-0_6) / Molecular approaches to pure and applied entomology by CF Aquadro (1993)
Fisher RA (1958) The genetical theory of natural selection. Dover, New York / The genetical theory of natural selection by RA Fisher (1958)
Gillespie JH (1984) Molecular evolution over the mutational landscape. Evolution 38:1116?1129 (10.1111/j.1558-5646.1984.tb00380.x) / Evolution by JH Gillespie (1984)
Gillespie JH (1991) The causes of molecular evolution. Oxford Univ Press, New York / The causes of molecular evolution by JH Gillespie (1991)
Gillespie JH (1994) Substitution processes in molecular evolution. III. Deleterious alleles. Genetics (in press) (10.2307/2410370)
Glick N (1978) Breaking records and breaking boards. Am Math Monthly 85:2?26 (10.1080/00029890.1978.11994501) / Am Math Monthly by N Glick (1978)
Kimura M (1968) Evolutionary rate at the molecular level. Nature 217:624?626 (10.1038/217624a0) / Nature by M Kimura (1968)
Kimura M (1979) Model of effectively neutral mutations in which selective constraint is incorporated. Proc Natl Acad Sci USA 76: 3440?3444 (10.1073/pnas.76.7.3440) / Proc Natl Acad Sci USA by M Kimura (1979)
Kimura M (1983) The neutral allele theory of molecular evolution. Cambridge University Press, Cambridge. (10.1017/CBO9780511623486) / The neutral allele theory of molecular evolution by M Kimura (1983)
Kimura M, Ohta T (1971) Protein polymorphism as a phase of molecular evolution. Nature 229:467?469 (10.1038/229467a0) / Nature by M Kimura (1971)
Kingman JFC (1978) A simple model for the balance between selection and mutation. J Appl Prob 15:1?12 (10.2307/3213231) / J Appl Prob by JFC Kingman (1978)
Kohne DE (1970) Evolution of higher-organism DNA. Q Rev Biophys 3:327?375 (10.1017/S0033583500004765) / Q Rev Biophys by DE Kohne (1970)
Laird CD, McConaughy BL, McCarthy BJ (1969) Rate of fixation of nucleotide substitutions in evolution. Nature 224:149?154 (10.1038/224149a0) / Nature by CD Laird (1969)
Mayo O (1970) Fixation of new mutants. Nature 227:860 (10.1038/227860a0) / Nature by O Mayo (1970)
Nevo E, Beiles A, Ben-Shlomo R (1984) The evolutionary significance of genetic diversity: ecological, demographic and life history correlates. In: Mani GS (ed) Evolutionary dynamics of genetic diversity. Springer-Verlag, Berlin, pp 13?213 (10.1007/978-3-642-51588-0_2) / Evolutionary dynamics of genetic diversity by E Nevo (1984)
Ohta T (1972) Evolutionary rate of cistrons and DNA divergence. J Mol Evol 1:150?157 (10.1007/BF01659161) / J Mol Evol by T Ohta (1972)
Ohta T (1977) Extension of the neutral mutation drift hypothesis. In: Kimura M (ed) Molecular evolution and polymorphism. National Institute of Genetics, Mishima, pp 148?167 / Molecular evolution and polymorphism by T Ohta (1977)
Ohta T (1992) The nearly neutral theory of molecular evolution. Annu Rev Ecol Syst 23:263?286 (10.1146/annurev.es.23.110192.001403) / Annu Rev Ecol Syst by T Ohta (1992)
Ohta T, Kimura M (1971) On the constancy of the evolutionary rate of cistrons. J Mol Evol 1:18?25 (10.1007/BF01659391) / J Mol Evol by T Ohta (1971)
Ohta T, Tachida H (1990) Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution. Genetics 126:219?229 (10.1093/genetics/126.1.219) / Genetics by T Ohta (1990)
Robertson A (1967) The nature of quantitative genetic variation. In: Brink A (ed) Heritage from Mendel. University of Wisconsin Press, Madison, pp 265?280 / Heritage from Mendel by A Robertson (1967)
Tachida H (1991) A study on a nearly neutral mutation model in finite populations. Genetics 128:183?192 (10.1093/genetics/128.1.183) / Genetics by H Tachida (1991)
Watterson GA (1975) On the number of segregating sites in genetic models without recombination. Theor Popul Biol 7:256?276 (10.1016/0040-5809(75)90020-9) / Theor Popul Biol by GA Watterson (1975)
Zuckerkandl E, Pauling L (1965) Evolutionary divergence and convergence in proteins. In: Bryson V, Vogel HJ (eds) Evolving genes and proteins. Academic Press, New York, pp 97?166 (10.1016/B978-1-4832-2734-4.50017-6) / Evolving genes and proteins by E Zuckerkandl (1965)

Dates

Type	When
Created	20 years, 9 months ago (Nov. 8, 2004, 7:43 a.m.)
Deposited	4 years, 2 months ago (June 27, 2021, 6:16 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 8:59 a.m.)
Issued	30 years, 8 months ago (Jan. 1, 1995)
Published	30 years, 8 months ago (Jan. 1, 1995)
Published Print	30 years, 8 months ago (Jan. 1, 1995)

Funders 0

None

BibTeX

@article{Gillespie_1995, title={On Ohta’s hypothesis: Most amino acid substitutions are deleterious}, volume={40}, ISSN={1432-1432}, url={http://dx.doi.org/10.1007/bf00166596}, DOI={10.1007/bf00166596}, number={1}, journal={Journal of Molecular Evolution}, publisher={Springer Science and Business Media LLC}, author={Gillespie, John H.}, year={1995}, month=jan, pages={64–69} }

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