Crossref book-chapter
Humana Press
Methods in Molecular Biology (297)
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Loo, D. T. (2010). In Situ Detection of Apoptosis by the TUNEL Assay: An Overview of Techniques. DNA Damage Detection In Situ, Ex Vivo, and In Vivo, 3–13.

Authors 1
  1. Deryk T. Loo (first)
References 29 Referenced 197
  1. Kerr, J.F.R., Wyllie, A.H., and Currie, A.R. (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 26, 239–57. (10.1038/bjc.1972.33) / Br J Cancer by JFR Kerr (1972)
  2. Wyllie, A.H. (1980) Cell death: The significance of apoptosis, in Int. Rev. Cytol, (Bourne, G.H., Danielli, F.J., and Jeon, K.W., eds.) Academic Press, New York, NY, vol. 68, pp. 251–306. (10.1016/S0074-7696(08)62312-8)
  3. Bremer, E., van Dam, G., Kroesen, B.J., de Leij, L., and Helfrich, W. (2006) Targeted induction of apoptosis for cancer therapy: Current progress and prospects Trends Mol Med 12, 382–93. (10.1016/j.molmed.2006.06.002) / Trends Mol Med by E Bremer (2006)
  4. Ashkenazi, A. (2008) Targeting the extrinsic apoptosis pathway in cancer Cytokine Growth Factor Rev 19, 325–31. (10.1016/j.cytogfr.2008.04.001) / Cytokine Growth Factor Rev by A Ashkenazi (2008)
  5. Plummer, R., Attard, G., Pacey, S., Li, L., Razak, A., Perrett, R., Barrett, M., Judson, I., Kaye, S., Fox, N.L., Halpern, W., Corey, A., Calvert, H., and de Bono, J. (2007) Phase I and pharmacokinetic study of lexatumumab in patients with advanced cancers Clin Cancer Res 13, 6187–94. (10.1158/1078-0432.CCR-07-0950) / Clin Cancer Res by R Plummer (2007)
  6. Hotte, S.J., Hirte, H.W., Chen, E.X., Siu, L.L., Le, L.H., Corey, A., Iacobucci, A., MacLean, M., Lo, L., Fox., N.L., and Oza, A.M. (2008) A Phase I study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies Clin Cancer Res 14, 3450–55. (10.1158/1078-0432.CCR-07-1416) / Clin Cancer Res by SJ Hotte (2008)
  7. Arends, M.J., Morris, R.G., and Wyllie, A.H. (1990) Apoptosis: the role of the endonuclease Am J Pathol 136, 593–608. / Am J Pathol by MJ Arends (1990)
  8. Bortner, C.D., Oldenburg, N.B.E., and Cidlowski, J.A. (1995) The role of DNA fragmentation in apoptosis Trends Cell Biol 5, 21–6. (10.1016/S0962-8924(00)88932-1) / Trends Cell Biol by CD Bortner (1995)
  9. Loo, D.T. and Rillema, J.R. (1998) Measurement of cell death, in Methods in Cell Biol (Mather, J.P. and Barnes, D., eds.), Academic Press, San Diego, CA, vol. 57, pp. 251–64.
  10. Gavrieli, Y., Sherman, Y., and Ben-Sannon, S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation J Cell Biol 119, 493–501. (10.1083/jcb.119.3.493) / J Cell Biol by Y Gavrieli (1992)
  11. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. (1993) Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays Cancer Res 53, 1945–51. / Cancer Res by W Gorczyca (1993)
  12. Watanabe, M., Hitomi, M., van der Wee, K., Rothenberg, F., Fisher, S.A., Zucker, R., Svoboda, K.K.H., Goldsmith, E.C., Heiskanen, K.M., and Nieminen, A.-L. (2002) The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs Microsc Microanal 8, 375–91. (10.1017/S1431927602010346) / Microsc Microanal by M Watanabe (2002)
  13. Huerta, S., Goulet, E.J., Huerta-Yepez, S, and Livingston, E.H. (2007) Screening and detection of apoptosis J Surg Res 139, 143–56. (10.1016/j.jss.2006.07.034) / J Surg Res by S Huerta (2007)
  14. Ansari, B., Coates, P.J., Greenstein, B.D., and Hall, P.A. (1993) In situ end-labeling detects DNA strand breaks in apoptosis and other physiological and pathological states J Pathol 170, 1–8. (10.1002/path.1711700102) / J Pathol by B Ansari (1993)
  15. Didenko, V.V. and Hornsby, P.J. (1996) Presence of double-strand breaks with single-base 3’ overhangs in cells undergoing apoptosis but not necrosis J Cell Biol 135, 1369–76. (10.1083/jcb.135.5.1369) / J Cell Biol by VV Didenko (1996)
  16. Kanoh, M., Takemura, G., Misao, J., Hayakawa, Y., Aoyama, T., Nishigaki, K., Noda, T., Fujiwara, T., Fukuda, K., Minatoguchi, S., and Fujiwara, H. (1999) Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair Circulation 99, 2757–64. (10.1161/01.CIR.99.21.2757) / Circulation by M Kanoh (1999)
  17. Sloop, G.D., Roa, J.C., Delgado, A.G., Balart, J.T., Hines III, M.O., and Hill, J.M. (1999) Histologic sectioning produces TUNEL reactivity: a potential cause of false-positive staining Arch Pathol Lab Med 123, 529–32. (10.5858/1999-123-0529-HSPTR) / Arch Pathol Lab Med by GD Sloop (1999)
  18. Jerome, K.R., Vallan, C., and Jaggi, R. (2000) The TUNEL assay in the diagnosis of graft-versus-host disease: caveats for interpretation Pathology 32, 186–90. (10.1080/713688927) / Pathology by KR Jerome (2000)
  19. Kockx, M.M., Muhring, J., Knaapen, M.W., and de Meyer, G.R. (1998) RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis Am J Pathol 152, 885–88. / Am J Pathol by MM Kockx (1998)
  20. Whiteside, G., Cougnon, N., Hunt, S.P., and Munglani, R. (1998) An improved method for detection of apoptosis in tissue sections and cell culture, using the TUNEL technique combined with Hoechst stain Brain Res Prot 2, 160–4. (10.1016/S1385-299X(97)00032-9) / Brain Res Prot by G Whiteside (1998)
  21. Hughes, S.E. (2003) Detection of apoptosis using in situ markers for DNA strand breaks in the failing human heart. Fact or epiphenomenon? J Pathol 201, 181–86. (10.1002/path.1447) / J Pathol by SE Hughes (2003)
  22. Gal, I., Varga, T., Szilagyi, I., Balazs, M., Schlammadinger, J., and Szabo Jr., G. (2000) Protease-elicited TUNEL positivity of non-apoptotic fixed cells J Histochem Cytochem 48, 963–69. (10.1177/002215540004800709) / J Histochem Cytochem by I Gal (2000)
  23. Kishimoto, H., Surh, C.D., and Sprent, J. (1995) Upregulation of surface markers on dying thymocytes J Exp Med 181, 649–55. (10.1084/jem.181.2.649) / J Exp Med by H Kishimoto (1995)
  24. Christina, M., Angelika, H.L., Bernd, P., and Martina, P. (2006) Simultaneous detection of a cell surface antigen and apoptosis by microwave-sensitized TUNEL assay on paraffin sections J Immunol Methods 316, 163–6. (10.1016/j.jim.2006.08.013) / J Immunol Methods by M Christina (2006)
  25. Furukawa, H., Oshima, K., Tung, T., Cui, G., Laks, H., and Sen, L. (2008) Overexpressed exogenous IL-4 and IL-10 paradoxically regulate allogeneic T-cell and cardiac myocytes apotosis through FAS/FASL pathway Transplantation 85, 437–46. (10.1097/TP.0b013e31816026e7) / Transplantation by H Furukawa (2008)
  26. Kuge, Y., Kume, N., Ishino, S., Takai, N., Ogawa, Y., Mukai, T., Minami, M., Shiomi, M., and Saji, H. (2008) Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits Biol Pharm Bull 31, 1475–82. (10.1248/bpb.31.1475) / Biol Pharm Bull by Y Kuge (2008)
  27. Hewitson, T.D., Bisucci, T., and Darby, I.A. (2006) Histochemical localization of apoptosis with in situ labeling of fragmented DNA Methods Mol Biol 326, 227–34. / Methods Mol Biol by TD Hewitson (2006)
  28. Darzynkiewicz, Z., Galkowski, D., and Zhao, H. (2008) Analysis of apoptosis by cytometry using TUNEL assay Methods 44, 250–4. (10.1016/j.ymeth.2007.11.008) / Methods by Z Darzynkiewicz (2008)
  29. Loo, D. T. 2002. TUNEL assay. An overview of techniques, in: In Situ Detection of DNA Damage, Methods in Molecular Biol., Humana Press, ed. V. Didenko, Vol. 203 :pp. 21–30, Figure 1.
Dates
Type When
Created 14 years, 9 months ago (Nov. 5, 2010, 2:34 p.m.)
Deposited 3 years, 9 months ago (Nov. 12, 2021, 10:29 p.m.)
Indexed 5 hours, 6 minutes ago (Aug. 29, 2025, 6 a.m.)
Issued 14 years, 10 months ago (Oct. 15, 2010)
Published 14 years, 10 months ago (Oct. 15, 2010)
Published Online 14 years, 10 months ago (Oct. 15, 2010)
Published Print 14 years, 7 months ago (Jan. 1, 2011)
Funders 0

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@inbook{Loo_2010, title={In Situ Detection of Apoptosis by the TUNEL Assay: An Overview of Techniques}, ISBN={9781603274098}, ISSN={1940-6029}, url={http://dx.doi.org/10.1007/978-1-60327-409-8_1}, DOI={10.1007/978-1-60327-409-8_1}, booktitle={DNA Damage Detection In Situ, Ex Vivo, and In Vivo}, publisher={Humana Press}, author={Loo, Deryk T.}, year={2010}, month=oct, pages={3–13} }