Developmental Regulation of the β-Globin Gene Locus
10.1007/3-540-27310-7_8
Crossref book-chapter
Springer-Verlag
Progress in Molecular and Subcellular Biology (297)
Bibliography

Chakalova, L., Carter, D., Debrand, E., Goyenechea, B., Horton, A., Miles, J., Osborne, C., & Fraser, P. (n.d.). Developmental Regulation of the β-Globin Gene Locus. Epigenetics and Chromatin, 183–206.

Authors 8
  1. Lyubomira Chakalova (first)
  2. David Carter (additional)
  3. Emmanuel Debrand (additional)
  4. Beatriz Goyenechea (additional)
  5. Alice Horton (additional)
  6. Joanne Miles (additional)
  7. Cameron Osborne (additional)
  8. Peter Fraser (additional)
References 111 Referenced 21
  1. Ahmad K, Henikoff S (2002a) Histone H3 variants specify modes of chromatin assembly. Proc Natl Acad Sci USA 99(Suppl 4):16477–16484 (10.1073/pnas.172403699) / Proc Natl Acad Sci USA by K. Ahmad (2002)
  2. Ahmad K, Henikoff S (2002b) The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell 9(6):1191–1200 (10.1016/S1097-2765(02)00542-7) / Mol Cell by K. Ahmad (2002)
  3. Alami R, Bender MA, Feng YQ, Fiering SN, Hug BA, Ley TJ, Groudine M, Bouhassira EE (2000) Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression. Genomics 63(3):417–424 (10.1006/geno.1999.6104) / Genomics by R. Alami (2000)
  4. Antoniou M, deBoer E, Habets G, Grosveld F (1988) The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J 7(2):377–384 (10.1002/j.1460-2075.1988.tb02824.x) / EMBO J by M. Antoniou (1988)
  5. Ashe HL, Monks J, Wijgerde M, Fraser P, Proudfoot NJ (1997) Intergenic transcription and transinduction of the human beta-globin locus. Genes Dev 11(19):2494–2509 (10.1101/gad.11.19.2494) / Genes Dev by H.L. Ashe (1997)
  6. Behringer RR, Hammer RE, Brinster RL, Palmiter RD, Townes TM (1987) Two 3′ sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci USA 84(20):7056–7060 (10.1073/pnas.84.20.7056) / Proc Natl Acad Sci USA by R.R. Behringer (1987)
  7. Bell AC, Felsenfeld G (1999) Stopped at the border: boundaries and insulators. Curr Opin Genet Dev 9(2):191–198 (10.1016/S0959-437X(99)80029-X) / Curr Opin Genet Dev by A.C. Bell (1999)
  8. Bender MA, Reik A, Close J, Telling A, Epner E, Fiering S, Hardison R, Groudine M (1998) Description and targeted deletion of 5′ hypersensitive site 5 and 6 of the mouse beta-globin locus control region. Blood 92(11):4394–4403 (10.1182/blood.V92.11.4394) / Blood by M.A. Bender (1998)
  9. Bender MA, Roach JN, Halow J, Close J, Alami R, Bouhassira EE, Groudine M, Fiering SN (2001) Targeted deletion of 5′HS1 and 5′HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood 98(7):2022–2027 (10.1182/blood.V98.7.2022) / Blood by M.A. Bender (2001)
  10. Blom van Assendelft G, Hanscombe O, Grosveld F, Greaves DR (1989) The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner. Cell 56(6):969–977 (10.1016/0092-8674(89)90630-2) / Cell by G. Blom Assendelft van (1989)
  11. Brotherton TW, Chui DH, Gauldie J, Patterson M (1979) Hemoglobin ontogeny during normal mouse fetal development. Proc Natl Acad Sci USA 76(6):2853–2857 (10.1073/pnas.76.6.2853) / Proc Natl Acad Sci USA by T.W. Brotherton (1979)
  12. Brown KE, Amoils S, Horn JM, Buckle VJ, Higgs DR, Merkenschlager M, Fisher AG (2001) Expression of alpha-and beta-globin genes occurs within different nuclear domains in haemopoietic cells. Nat Cell Biol 3(6):602–606 (10.1038/35078577) / Nat Cell Biol by K.E. Brown (2001)
  13. Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (1999) Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci USA 96(9):5129–5134 (10.1073/pnas.96.9.5129) / Proc Natl Acad Sci USA by M. Bulger (1999)
  14. Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (2000) Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Proc Natl Acad Sci USA 97(26):14560–14565 (10.1073/pnas.97.26.14560) / Proc Natl Acad Sci USA by M. Bulger (2000)
  15. Bulger M, Schubeler D, Bender MA, Hamilton J, Farrell CM, Hardison RC, Groudine M (2003) A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol 23(15):5234–5244 (10.1128/MCB.23.15.5234-5244.2003) / Mol Cell Biol by M. Bulger (2003)
  16. Bungert J, Dave U, Lim KC, Lieuw KH, Shavit JA, Liu Q, Engel JD (1995) Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4. Genes Dev 9(24):3083–3096 (10.1101/gad.9.24.3083) / Genes Dev by J. Bungert (1995)
  17. Bungert J, Tanimoto K, Patel S, Liu Q, Fear M, Engel JD (1999) Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription. Mol Cell Biol 19(4):3062–3072 (10.1128/MCB.19.4.3062) / Mol Cell Biol by J. Bungert (1999)
  18. Carter D, Chakalova L, Osborne CS, Dai YF, Fraser P (2002) Long-range chromatin regulatory interactions in vivo. Nat Genet 32(4):623–626 (10.1038/ng1051) / Nat Genet by D. Carter (2002)
  19. Chada K, Magram J, Costantini F (1986) An embryonic pattern of expression of a human fetal globin gene in transgenic mice. Nature 319(6055):685–689 (10.1038/319685a0) / Nature by K. Chada (1986)
  20. Collins FS, Weissman SM (1984) The molecular genetics of human hemoglobin. Prog Nucleic Acid Res Mol Biol 31:315–462 (10.1016/S0079-6603(08)60382-7) / Prog Nucleic Acid Res Mol Biol by F.S. Collins (1984)
  21. Collis P, Antoniou M, Grosveld F (1990) Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J 9(1):233–240 (10.1002/j.1460-2075.1990.tb08100.x) / EMBO J by P. Collis (1990)
  22. Curtin P, Pirastu M, Kan YW, Gobert-Jones JA, Stephens AD, Lehmann H (1985) A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia. J Clin Invest 76(4):1554–1558 (10.1172/JCI112136) / J Clin Invest by P. Curtin (1985)
  23. Curtin PT, Kan YW (1988) The inactive beta globin gene on a gamma delta beta thalassemia chromosome has a normal structure and functions normally in vitro. Blood 71(3):766–770 (10.1182/blood.V71.3.766.766) / Blood by P.T. Curtin (1988)
  24. Dekker J, Rippe K, Dekker M, Kleckner N (2002) Capturing chromosome conformation. Science 295(5558):1306–1311 (10.1126/science.1067799) / Science by J. Dekker (2002)
  25. Dillon N, Trimborn T, Strouboulis J, Fraser P, Grosveld F (1997) The effect of distance on long-range chromatin interactions. Mol Cell 1(1):131–139 (10.1016/S1097-2765(00)80014-3) / Mol Cell by N. Dillon (1997)
  26. Dimitrova DS, Gilbert DM (1999) The spatial position and replication timing of chromosomal domains are both established in early G1 phase. Mol Cell 4(6):983–993 (10.1016/S1097-2765(00)80227-0) / Mol Cell by D.S. Dimitrova (1999)
  27. Driscoll MC, Dobkin CS, Alter BP (1989) Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ beta-globin gene activation-region hypersensitive sites. Proc Natl Acad Sci USA 86(19):7470–7474 (10.1073/pnas.86.19.7470) / Proc Natl Acad Sci USA by M.C. Driscoll (1989)
  28. Ellis J, Tan-Un KC, Harper A, Michalovich D, Yannoutsos N, Philipsen S, Grosveld F (1996) A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region. EMBO J 15(3):562–568 (10.1002/j.1460-2075.1996.tb00388.x) / EMBO J by J. Ellis (1996)
  29. Enver T, Raich N, Ebens AJ, Papayannopoulou T, Costantini F, Stamatoyannopoulos G (1990) Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature 344(6264):309–313 (10.1038/344309a0) / Nature by T. Enver (1990)
  30. Epner E, Reik A, Cimbora D, Telling A, Bender MA, Fiering S, Enver T, Martin DI, Kennedy M, Keller G, Groudine M (1998) The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol Cell 2(4):447–455 (10.1016/S1097-2765(00)80144-6) / Mol Cell by E. Epner (1998)
  31. Farrell CM, West AG, Felsenfeld G (2002) Conserved CTCF insulator elements flank the mouse and human beta-globin loci. Mol Cell Biol 22(11):3820–3831 (10.1128/MCB.22.11.3820-3831.2002) / Mol Cell Biol by C.M. Farrell (2002)
  32. Farrell CM, Grinberg A, Huang SP, Chen D, Pichel JG, Westphal H, Felsenfeld G (2000) A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta-globin locus. Proc Natl Acad Sci USA 97(26):14554–14559 (10.1073/pnas.97.26.14554) / Proc Natl Acad Sci USA by C.M. Farrell (2000)
  33. Felsenfeld G (1993) Chromatin structure and the expression of globin-encoding genes. Gene 135(1–2):119–124 (10.1016/0378-1119(93)90056-9) / Gene by G. Felsenfeld (1993)
  34. Festenstein R, Tolaini M, Corbella P, Mamalaki C, Parrington J, Fox M, Miliou A, Jones M, Kioussis D (1996) Locus control region function and heterochromatin-induced position effect variegation. Science 271(5252):1123–1125 (10.1126/science.271.5252.1123) / Science by R. Festenstein (1996)
  35. Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ, Groudine M (1995) Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev 9(18):2203–2213 (10.1101/gad.9.18.2203) / Genes Dev by S. Fiering (1995)
  36. Forrester WC, Thompson C, Elder JT, Groudine M (1986) A developmentally stable chromatin structure in the human beta-globin gene cluster. Proc Natl Acad Sci USA 83(5):1359–1363 (10.1073/pnas.83.5.1359) / Proc Natl Acad Sci USA by W.C. Forrester (1986)
  37. Forrester WC, Takegawa S, Papayannopoulou T, Stamatoyannopoulos G, Groudine M (1987) Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res 15(24):10159–10177 (10.1093/nar/15.24.10159) / Nucleic Acids Res by W.C. Forrester (1987)
  38. Forrester WC, Epner E, Driscoll MC, Enver T, Brice M, Papayannopoulou T, Groudine M (1990) A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev 4(10):1637–1649 (10.1101/gad.4.10.1637) / Genes Dev by W.C. Forrester (1990)
  39. Forsberg EC, Downs KM, Christensen HM, Im H, Nuzzi PA, Bresnick EH (2000) Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain. Proc Natl Acad Sci USA 97(26):14494–14499 (10.1073/pnas.97.26.14494) / Proc Natl Acad Sci USA by E.C. Forsberg (2000)
  40. Fraser P, Grosveld F (1998) Locus control regions, chromatin activation and transcription. Curr Opin Cell Biol 10(3):361–365 (10.1016/S0955-0674(98)80012-4) / Curr Opin Cell Biol by P. Fraser (1998)
  41. Fraser P, Hurst J, Collis P, Grosveld F (1990) DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression. Nucleic Acids Res 18(12):3503–3508 (10.1093/nar/18.12.3503) / Nucleic Acids Res by P. Fraser (1990)
  42. Fraser P, Pruzina S, Antoniou M, Grosveld F (1993) Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes. Genes Dev 7(1):106–113 (10.1101/gad.7.1.106) / Genes Dev by P. Fraser (1993)
  43. Fraser P, Gribnau J, Trimborn T (1998) Mechanisms of developmental regulation in globin loci. Curr Opin Hematol 5(2):139–144 (10.1097/00062752-199803000-00009) / Curr Opin Hematol by P. Fraser (1998)
  44. Friend C, Patuleia MC, de Harven E (1966) Erythrocytic maturation in vitro of murine (Friend) virus-induced leukemic cells. Natl Cancer Inst Monogr 22:505–522 / Natl Cancer Inst Monogr by C. Friend (1966)
  45. Furukawa T, Navas PA, Josephson BM, Peterson KR, Papayannopoulou T, Stamatoy-annopoulos G (1995) Coexpression of epsilon, G gamma and A gamma globin mRNA in embryonic red blood cells from a single copy beta-YAC transgenic mouse. Blood Cells Mol Dis 21(2):168–178 (10.1006/bcmd.1995.0019) / Blood Cells Mol Dis by T. Furukawa (1995)
  46. Goodwin AJ, McInerney JM, Glander MA, Pomerantz O, Lowrey CH (2001) In vivo formation of a human beta-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and Sp1. J Biol Chem 276(29):26883–26892 (10.1074/jbc.M008410200) / J Biol Chem by A.J. Goodwin (2001)
  47. Gribnau J, Diderich K, Pruzina S, Calzolari R, Fraser P (2000) Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus. Mol Cell 5(2):377–386 (10.1016/S1097-2765(00)80432-3) / Mol Cell by J. Gribnau (2000)
  48. Grosveld F, van Assendelft GB, Greaves DR, Kollias G (1987) Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51(6):975–985 (10.1016/0092-8674(87)90584-8) / Cell by F. Grosveld (1987)
  49. Hanscombe O, Whyatt D, Fraser P, Yannoutsos N, Greaves D, Dillon N, Grosveld F (1991) Importance of globin gene order for correct developmental expression. Genes Dev 5(8):1387–1394 (10.1101/gad.5.8.1387) / Genes Dev by O. Hanscombe (1991)
  50. Harteveld CL, Osborne CS, Peters M, van der Werf S, Plug R, Fraser P, Giordano PC (2003) Novel 112 kb (epsilon G gamma A gamma) delta beta-thalassaemia deletion in a Dutch family. Br J Haematol 122(5):855–858 (10.1046/j.1365-2141.2003.04505.x) / Br J Haematol by C.L. Harteveld (2003)
  51. Hebbes TR, Clayton AL, Thorne AW, Crane-Robinson C (1994) Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain. EMBO J 13(8):1823–1830 (10.1002/j.1460-2075.1994.tb06451.x) / EMBO J by T.R. Hebbes (1994)
  52. Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ (1996) Analysis of mice containing a targeted deletion of beta-globin locus control region 5′ hypersensitive site 3. Mol Cell Biol 16(6):2906–2912 (10.1128/MCB.16.6.2906) / Mol Cell Biol by B.A. Hug (1996)
  53. Hunt JA (1974) Rate of synthesis and half-life of globin messenger ribonucleic acid. Rate of synthesis of globin messenger ribonucleic acid calculated from data of cell haemoglobin content. Biochem J 138(3):499–510 (10.1042/bj1380499) / Biochem J by J.A. Hunt (1974)
  54. Imaizumi T, Diggelmann H, Scherrer K (1973) Demonstration of globin messenger sequences in giant nuclear precursors of messenger RNA of avian erythroblasts. Proc Natl Acad Sci USA 70(4):1122–1126 (10.1073/pnas.70.4.1122) / Proc Natl Acad Sci USA by T. Imaizumi (1973)
  55. Jackson JD, Petrykowska H, Philipsen S, Miller W, Hardison R (1996) Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3. J Biol Chem 271(20):11871–11878 (10.1074/jbc.271.20.11871) / J Biol Chem by J.D. Jackson (1996)
  56. Kioussis D, Festenstein R (1997) Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals. Curr Opin Genet Dev 7(5):614–619 (10.1016/S0959-437X(97)80008-1) / Curr Opin Genet Dev by D. Kioussis (1997)
  57. Kioussis D, Vanin E, deLange T, Flavell RA, Grosveld F (1983) Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature 306(5944):662–666 (10.1038/306662a0) / Nature by D. Kioussis (1983)
  58. Kmita M, Duboule D (2003) Organizing axes in time and space; 25 years of colinear tinkering. Science 301(5631):331–333 (10.1126/science.1085753) / Science by M. Kmita (2003)
  59. Kollias G, Wrighton N, Hurst J, Grosveld F (1986) Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns. Cell 46(1):89–94 (10.1016/0092-8674(86)90862-7) / Cell by G. Kollias (1986)
  60. Kollias G, Hurst J, deBoer E, Grosveld F (1987) The human beta-globin gene contains a downstream developmental specific enhancer. Nucleic Acids Res 15(14):5739–5747 (10.1093/nar/15.14.5739) / Nucleic Acids Res by G. Kollias (1987)
  61. Kong S, Bohl D, Li C, Tuan D (1997) Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene. Mol Cell Biol 17(7):3955–3965 (10.1128/MCB.17.7.3955) / Mol Cell Biol by S. Kong (1997)
  62. Kulozik AE, Yarwood N, Jones RW (1988) The Corfu delta beta zero thalassemia: a small deletion acts at a distance to selectively abolish beta globin gene expression. Blood 71(2):457–462 (10.1182/blood.V71.2.457.457) / Blood by A.E. Kulozik (1988)
  63. Leach KM, Nightingale K, Igarashi K, Levings PP, Engel JD, Becker PB, Bungert J (2001) Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly. Mol Cell Biol 21(8):2629–2640 (10.1128/MCB.21.8.2629-2640.2001) / Mol Cell Biol by K.M. Leach (2001)
  64. Litt MD, Simpson M, Gaszner M, Allis CD, Felsenfeld G (2001a) Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 293(5539):2453–2455 (10.1126/science.1064413) / Science by M.D. Litt (2001)
  65. Litt MD, Simpson M, Recillas-Targa F, Prioleau MN, Felsenfeld G (2001b) Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J 20(9):2224–2235 (10.1093/emboj/20.9.2224) / EMBO J by M.D. Litt (2001)
  66. Long Q, Bengra C, Li C, Kutlar F, Tuan D (1998) A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5′ boundary area of the human beta-globin locus control region. Genomics 54(3):542–555 (10.1006/geno.1998.5608) / Genomics by Q. Long (1998)
  67. Mahy NL, Perry PE, Gilchrist S, Baldock RA, Bickmore WA (2002a) Spatial organization of active and inactive genes and noncoding DNA within chromosome territories. J Cell Biol 157(4):579–589 (10.1083/jcb.200111071) / J Cell Biol by N.L. Mahy (2002)
  68. Mahy NL, Perry PE, Bickmore WA (2002b) Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. J Cell Biol 159(5):753–763 (10.1083/jcb.200207115) / J Cell Biol by N.L. Mahy (2002)
  69. Marks PA, Rifkind RA (1978) Erythroleukemic differentiation. Annu Rev Biochem 47:419–448 (10.1146/annurev.bi.47.070178.002223) / Annu Rev Biochem by P.A. Marks (1978)
  70. McKittrick E, Gafken PR, Ahmad K, Henikoff S (2004) Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci USA 101(6):1525–1530 (10.1073/pnas.0308092100) / Proc Natl Acad Sci USA by E. McKittrick (2004)
  71. Milot E, Strouboulis J, Trimborn T, Wijgerde M, de Boer E, Langeveld A, Tan-Un K, Vergeer W, Yannoutsos N, Grosveld F, Fraser P (1996) Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell 87(1):105–114 (10.1016/S0092-8674(00)81327-6) / Cell by E. Milot (1996)
  72. Moon AM, Ley TJ (1991) Functional properties of the beta-globin locus control region in K562 erythroleukemia cells. Blood 77(10):2272–2284 (10.1182/blood.V77.10.2272.2272) / Blood by A.M. Moon (1991)
  73. Mutskov VJ, Farrell CM, Wade PA, Wolffe AP, Felsenfeld G (2002) The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev 16(12):1540–1554 (10.1101/gad.988502) / Genes Dev by V.J. Mutskov (2002)
  74. Navas PA, Peterson KR, Li Q, Skarpidi E, Rohde A, Shaw SE, Clegg CH, Asano H, Stamatoyannopoulos G (1998) Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion. Mol Cell Biol 18(7):4188–4196 (10.1128/MCB.18.7.4188) / Mol Cell Biol by P.A. Navas (1998)
  75. Navas PA, Peterson KR, Li Q, McArthur M, Stamatoyannopoulos G (2001) The 5′HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis. J Mol Biol 312(1):17–26 (10.1006/jmbi.2001.4939) / J Mol Biol by P.A. Navas (2001)
  76. Navas PA, Swank RA, Yu M, Peterson KR, Stamatoyannopoulos G (2003) Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes. Hum Mol Genet 12(22):2941–2948 (10.1093/hmg/ddg319) / Hum Mol Genet by P.A. Navas (2003)
  77. Orphanides G, Reinberg D (2000) RNA polymerase II elongation through chromatin. Nature 407(6803):471–475 (10.1038/35035000) / Nature by G. Orphanides (2000)
  78. Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W (2003) The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet 35(2):190–194 (10.1038/ng1244) / Nat Genet by R.J. Palstra (2003)
  79. Peterson KR, Clegg CH, Huxley C, Josephson BM, Haugen HS, Furukawa T, Stamatoyannopoulos G (1993) Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc Natl Acad Sci USA 90(16):7593–7597 (10.1073/pnas.90.16.7593) / Proc Natl Acad Sci USA by K.R. Peterson (1993)
  80. Peterson KR, Clegg CH, Navas PA, Norton EJ, Kimbrough TG, Stamatoyannopoulos G (1996) Effect of deletion of 5′HS3 or 5′HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice. Proc Natl Acad Sci USA 93(13):6605–6609 (10.1073/pnas.93.13.6605) / Proc Natl Acad Sci USA by K.R. Peterson (1996)
  81. Philipsen S, Talbot D, Fraser P, Grosveld F (1990) The beta-globin dominant control region: hypersensitive site 2. EMBO J 9(7):2159–2167 (10.1002/j.1460-2075.1990.tb07385.x) / EMBO J by S. Philipsen (1990)
  82. Pikaart MJ, Recillas-Targa F, Felsenfeld G (1998) Loss of transcriptional activity of a trans-gene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev 12(18):2852–2862 (10.1101/gad.12.18.2852) / Genes Dev by M.J. Pikaart (1998)
  83. Plant KE, Routledge SJ, Proudfoot NJ (2001) Intergenic transcription in the human beta-globin gene cluster. Mol Cell Biol 21(19):6507–6514 (10.1128/MCB.21.19.6507-6514.2001) / Mol Cell Biol by K.E. Plant (2001)
  84. Pope SH, Fibach E, Sun J, Chin K, Rodgers GP (2000) Two-phase liquid culture system models normal human adult erythropoiesis at the molecular level. Eur J Haematol 64(5):292–303 (10.1034/j.1600-0609.2000.90032.x) / Eur J Haematol by S.H. Pope (2000)
  85. Prioleau MN, Nony P, Simpson M, Felsenfeld G (1999) An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J 18(14):4035–4048 (10.1093/emboj/18.14.4035) / EMBO J by M.N. Prioleau (1999)
  86. Pruzina S, Hanscombe O, Whyatt D, Grosveld F, Philipsen S (1991) Hypersensitive site 4 of the human beta globin locus control region. Nucleic Acids Res 19(7):1413–1419 (10.1093/nar/19.7.1413) / Nucleic Acids Res by S. Pruzina (1991)
  87. Ragoczy T, Telling A, Sawado T, Groudine M, Kosak ST (2003) A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements. Chromosome Res 11(5):513–525 (10.1023/A:1024939130361) / Chromosome Res by T. Ragoczy (2003)
  88. Recillas-Targa F, Pikaart MJ, Burgess-Beusse B, Bell AC, Litt MD, West AG, Gaszner M, Felsenfeld G (2002) Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci USA 99(10):6883–6888 (10.1073/pnas.102179399) / Proc Natl Acad Sci USA by F. Recillas-Targa (2002)
  89. Reik A, Telling A, Zitnik G, Cimbora D, Epner E, Groudine M (1998) The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol Cell Biol 18(10):5992–6000 (10.1128/MCB.18.10.5992) / Mol Cell Biol by A. Reik (1998)
  90. Routledge SJ, Proudfoot NJ (2002) Definition of transcriptional promoters in the human beta globin locus control region. J Mol Biol 323(4):601–611 (10.1016/S0022-2836(02)01011-2) / J Mol Biol by S.J. Routledge (2002)
  91. Ryan TM, Behringer RR, Townes TM, Palmiter RD, Brinster RL (1989) High-level erythroid expression of human alpha-globin genes in transgenic mice. Proc Natl Acad Sci USA 86(1):37–41 (10.1073/pnas.86.1.37) / Proc Natl Acad Sci USA by T.M. Ryan (1989)
  92. Saveliev A, Everett C, Sharpe T, Webster Z, Festenstein R (2003) DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing. Nature 422(6934):909–913 (10.1038/nature01596) / Nature by A. Saveliev (2003)
  93. Schubeler, Francastel C, Cimbora DM, Reik A, Martin DI, Groudine M et al (2000) Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. Genes Dev 14(8):940–950 (10.1101/gad.14.8.940) / Genes Dev by Schubeler (2000)
  94. Smith RD, Yu J, Seale RL (1984) Chromatin structure of the beta-globin gene family in murine erythroleukemia cells. Biochemistry 23(4):785–790 (10.1021/bi00299a031) / Biochemistry by R.D. Smith (1984)
  95. Stamatoyannopoulos G, Grosveld F (2001) Hemoglobin switching. In: Stamatoyannopoulos G, Majerus PW, Perlmutter RM, Varmus H (eds) The molecular basis of blood diseases. Saunders, Philadelphia, pp 135–182 / The molecular basis of blood diseases by G. Stamatoyannopoulos (2001)
  96. Strauss EC, Orkin SH (1992) In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region. Proc Natl Acad Sci USA 89(13):5809–5813 (10.1073/pnas.89.13.5809) / Proc Natl Acad Sci USA by E.C. Strauss (1992)
  97. Strouboulis J, Dillon N, Grosveld F (1992) Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice. Genes Dev 6(10):1857–1864 (10.1101/gad.6.10.1857) / Genes Dev by J. Strouboulis (1992)
  98. Studitsky VM, Walter W, Kireeva M, Kashlev M, Felsenfeld G (2004) Chromatin remodeling by RNA polymerases. Trends Biochem Sci 29(3):127–135 (10.1016/j.tibs.2004.01.003) / Trends Biochem Sci by V.M. Studitsky (2004)
  99. Talbot D, Philipsen S, Fraser P, Grosveld F (1990) Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J 9(7):2169–2177 (10.1002/j.1460-2075.1990.tb07386.x) / EMBO J by D. Talbot (1990)
  100. Tanimoto K, Liu Q, Bungert J, Engel JD (1999) Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice. Nature 398(6725):344–348 (10.1038/18698) / Nature by K. Tanimoto (1999)
  101. Thomson I, Gilchrist S, Bickmore WA, Chubb JR (2004) The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1. Curr Biol 14(2):166–172 (10.1016/j.cub.2003.12.024) / Curr Biol by I. Thomson (2004)
  102. Tolhuis B, Palstra RJ, Splinter E, Grosveld F, de Laat W (2002) Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell 10(6):1453–1465 (10.1016/S1097-2765(02)00781-5) / Mol Cell by B. Tolhuis (2002)
  103. Townes TM, Lingrel JB, Chen HY, Brinster RL, Palmiter RD (1985) Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J 4(7):1715–1723 (10.1002/j.1460-2075.1985.tb03841.x) / EMBO J by T.M. Townes (1985)
  104. Trimborn T, Gribnau J, Grosveld F, Fraser P (1999) Mechanisms of developmental control of transcription in the murine alpha-and beta-globin loci. Genes Dev 13(1):112–124 (10.1101/gad.13.1.112) / Genes Dev by T. Trimborn (1999)
  105. Tuan D, Solomon W, Li Q, London IM (1985) The ‘beta-like-globin’ gene domain in human erythroid cells. Proc Natl Acad Sci USA 82(19):6384–6388 (10.1073/pnas.82.19.6384) / Proc Natl Acad Sci USA by D. Tuan (1985)
  106. Tuan D, Solomon WB, London IM, Lee DP (1989) An erythroid-specific, developmental-stage-independent enhancer far upstream of the human ‘beta-like globin’ genes. Proc Natl Acad Sci USA 86(8):2554–2558 (10.1073/pnas.86.8.2554) / Proc Natl Acad Sci USA by D. Tuan (1989)
  107. Tuan D, Kong S, Hu K (1992) Transcription of the hypersensitive site HS2 enhancer in erythroid cells. Proc Natl Acad Sci USA 89(23):11219–11223 (10.1073/pnas.89.23.11219) / Proc Natl Acad Sci USA by D. Tuan (1992)
  108. Van der Ploeg LH, Konings A, Oort M, Roos D, Bernini L, Flavell RA (1980) Gamma-beta-thalassaemia studies showing that deletion of the gamma-and delta-genes influences beta-globin gene expression in man. Nature 283(5748):637–642 (10.1038/283637a0) / Nature by L.H. Ploeg Van der (1980)
  109. Wijgerde M, Grosveld F, Fraser P (1995) Transcription complex stability and chromatin dynamics in vivo. Nature 377(6546):209–213 (10.1038/377209a0) / Nature by M. Wijgerde (1995)
  110. Wojda U, Noel P, Miller JL (2002) Fetal and adult hemoglobin production during adult erythropoiesis: coordinate expression correlates with cell proliferation. Blood 99(8):3005–3013 (10.1182/blood.V99.8.3005) / Blood by U. Wojda (2002)
  111. Wright S, Rosenthal A, Flavell R, Grosveld F (1984) DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell 38(1):265–273 (10.1016/0092-8674(84)90548-8) / Cell by S. Wright (1984)
Dates
Type When
Created 19 years, 11 months ago (Sept. 1, 2005, 6:53 p.m.)
Deposited 2 years, 3 months ago (May 4, 2023, 6:15 a.m.)
Indexed 11 months, 2 weeks ago (Sept. 4, 2024, 8:40 a.m.)
Funders 0

None

@inbook{Chakalova, title={Developmental Regulation of the β-Globin Gene Locus}, ISBN={3540233725}, url={http://dx.doi.org/10.1007/3-540-27310-7_8}, DOI={10.1007/3-540-27310-7_8}, booktitle={Epigenetics and Chromatin}, publisher={Springer-Verlag}, author={Chakalova, Lyubomira and Carter, David and Debrand, Emmanuel and Goyenechea, Beatriz and Horton, Alice and Miles, Joanne and Osborne, Cameron and Fraser, Peter}, pages={183–206} }