DOI: 10.1006/viro.2001.1007. HIV-1 Vpr Induces Cell Cycle G2 Arrest in Fission Yeast (Schizosaccharomyces pombe) through a Pathway Involving Regulatory and Catalytic Subunits of PP2A and Acting on Both Wee1 and Cdc25

HIV-1 Vpr Induces Cell Cycle G2 Arrest in Fission Yeast (Schizosaccharomyces pombe) through a Pathway Involving Regulatory and Catalytic Subunits of PP2A and Acting on Both Wee1 and Cdc25

10.1006/viro.2001.1007

Crossref journal-article

Elsevier BV

Virology (78)

Bibliography

Elder, R. T., Yu, M., Chen, M., Zhu, X., Yanagida, M., & Zhao, Y. (2001). HIV-1 Vpr Induces Cell Cycle G2 Arrest in Fission Yeast (Schizosaccharomyces pombe) through a Pathway Involving Regulatory and Catalytic Subunits of PP2A and Acting on Both Wee1 and Cdc25. Virology, 287(2), 359â370.

Authors 6

Robert T. Elder (first)
Min Yu (additional)
Mingzhong Chen (additional)
Xudong Zhu (additional)
Mitsuhiro Yanagida (additional)
Yuqi Zhao (additional)

References 59 Referenced 66

{'key': '10.1006/viro.2001.1007_RF1', 'series-title': 'Experiments with Fission Yeast: A Laboratory Course Manual', 'article-title': 'Nutritional control of entry into stationary phase determined by flow fluorocytometry', 'author': 'Alfa', 'year': '1993'} / Experiments with Fission Yeast: A Laboratory Course Manual / Nutritional control of entry into stationary phase determined by flow fluorocytometry by Alfa (1993)
10.1002/j.1460-2075.1992.tb05179.x / EMBO J. / DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe by al-Khodairy (1992)
10.1128/JVI.70.4.2324-2331.1996 / J. Virol. / Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control by Bartz (1996)
10.1126/science.280.5365.909 / Science / Replication checkpoint enforced by kinases Cds1 and Chk1 by Boddy (1998)
10.1016/S0014-5793(98)00158-6 / FEBS Lett. / A phosphatase activity in Xenopus oocyte extracts preferentially dephosphorylates the MPM-2 epitope by Che (1998)
10.1128/JVI.73.4.3236-3245.1999 / J. Virol. / Mutational analysis of Vpr-induced G2 arrest, nuclear localization and cell death in fission yeast by Chen (1999)
10.1146/annurev.bi.58.070189.002321 / Annu. Rev. Biochem. / The structure and regulation of protein phosphatases by Cohen (1989)
10.1016/S0168-1702(00)00167-2 / Virus Res. / Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint by Elder (2000)
10.1126/science.8036497 / Science / 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast by Ford (1994)
10.1091/mbc.10.4.833 / Mol. Biol. Cell / Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1 by Furnari (1999)
10.1126/science.277.5331.1495 / Science / Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase by Furnari (1997)
10.1038/342039a0 / Nature / Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis by Gould (1989)
10.1007/BF00331307 / Mol. Gen. Genet. / Genetic engineering of Schizosaccharomyces pombe: A system for gene disruption and replacement using the ura4 gene as a selectable marker by Grimm (1988)
10.1128/JVI.69.11.6705-6711.1995 / J. Virol. / Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity by He (1995)
10.1128/JVI.69.10.6304-6313.1995 / J. Virol. / The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle by Jowett (1995)
10.1242/jcs.112.21.3747 / J. Cell. Sci. / Phosphatase 2A and polo kinase, two antagonistic regulators of cdc25 activation and MPF auto-amplification by Karaiskou (1999)
10.1093/genetics/136.3.849 / Genetics / Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe by Keeney (1994)
10.1046/j.1365-2443.1996.02002.x / Genes Cells / The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis by Kinoshita (1996)
10.1016/0092-8674(90)90173-C / Cell / Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle by Kinoshita (1990)
10.1101/gad.7.6.1059 / Genes Dev. / Negative regulation of mitosis by the fission yeast protein phosphatase ppa2 by Kinoshita (1993)
10.1002/j.1460-2075.1991.tb07951.x / EMBO J. / Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: Identification of major phosphorylation sites by Krek (1991)
10.1016/0168-9525(88)90171-0 / Trends Genet. / Cell cycle control genes in fission yeast and mammalian cells by Lee (1988)
10.1016/0092-8674(91)90649-J / Cell / INH, a negative regulator of MPF, is a form of protein phosphatase 2A by Lee (1991)
10.1091/mbc.5.3.323 / Mol. Biol. Cell / Inhibition of cdc2 activation by INH/PP2A by Lee (1994)
10.1038/16488 / Nature / Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein by Lopez-Girona (1999)
10.1016/0092-8674(91)90266-2 / Cell / mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2 by Lundgren (1991)
10.1128/JVI.74.6.2636-2646.2000 / J. Virol. / Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr by Masuda (2000)
10.1126/science.282.5395.1893 / Science / Linkage of ATM to cell cycle regulation by the Chk2 protein kinase by Matsuoka (1998)
10.1016/0378-1119(93)90551-D / Gene / Thiamine-repressible expression vectors pREP and pRIP for fission yeast by Maundrell (1993)
10.1002/j.1460-2075.1992.tb05600.x / EMBO J. / Pyp3 PTPase acts as a mitotic inducer in fission yeast by Millar (1992)
10.1002/j.1460-2075.1991.tb05008.x / EMBO J. / p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast by Millar (1991)
10.1038/374131a0 / Nature / Principles of CDK regulation by Morgan (1995)
10.1128/MCB.20.12.4288-4294.2000 / Mol. Cell. Biol. / Mechanism of caffeine-induced checkpoint override in fission yeast by Moser (2000)
10.1091/mbc.6.1.119 / Mol. Biol. Cell / Cell cycle regulation of a Xenopus Wee1-like kinase by Mueller (1995)
10.1093/genetics/153.4.1561 / Genetics / The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts by Munoz (1999)
10.1002/j.1460-2075.1991.tb04896.x / EMBO J. / Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates by Norbury (1991)
10.1016/S0092-8674(00)80476-6 / Cell / Checkpoint pathways come of age by Nurse (1997)
10.1007/BF00268085 / Mol. Gen. Genet. / Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe by Nurse (1976)
10.1016/S0021-9258(18)53096-9 / J. Biol. Chem. / G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently by O'Connor (1993)
10.1038/sj.onc.1201259 / Oncogene / Protein phosphatase 2A subunit assembly: the catalytic suunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen by Ogris (1997)
10.1016/0092-8674(89)90338-3 / Cell / The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases by Ohkura (1989)
10.1128/JVI.71.5.3961-3971.1997 / J. Virol. / Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard by Poon (1997)
10.1128/JVI.69.11.6859-6864.1995 / J. Virol. / Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B by Re (1995)
10.1016/S0955-0674(98)80118-X / Curr. Opin. Cell. Biol. / Mitotic DNA damage and replication checkpoints in yeast by Rhind (1998)
10.1128/MCB.18.7.3782 / Mol. Cell. Biol. / Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe by Rhind (1998)
10.1128/JVI.69.2.882-888.1995 / J. Virol. / The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection by Rogel (1995)
10.1126/science.277.5331.1497 / Science / Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25 by Sanchez (1997)
10.1126/science.7792600 / Science / A single ataxia telangiectasia gene with a product similar to PI-3 kinase by Savitsky (1995)
10.1128/JVI.71.7.5579-5592.1997 / J. Virol. / Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest by Stewart (1997)
10.1002/j.1460-2075.1993.tb06017.x / EMBO J. / Two distinct mechanisms for negative regulation of the Wee1 protein kinase by Tang (1993)
10.1101/gad.12.2.175 / Genes Dev. / HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection by Vodicka (1998)
10.1126/science.271.5247.353 / Science / rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint by Walworth (1996)
10.1038/26766 / Nature / Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1 by Zeng (1998)
10.1006/viro.1997.8459 / Virology / Cell cycle inhibitory effects of HIV and SIV Vpr and Vpx in the yeast Schizosaccharomyces pombe by Zhang (1997)
10.1128/JVI.70.9.5821-5826.1996 / J. Virol. / Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular functions of fission yeast Schizosaccharomyces pombe by Zhao (1996)
10.2741/zhao / Front. Biosci. / Yeast perspectives on HIV-1 Vpr by Zhao (2000)
10.2144/98253st06 / BioTechniques / Fission yeast expression vectors adapted for positive identification of gene insertion and green fluorescent protein fusion by Zhao (1998)
10.1089/dna.1995.14.359 / DNA Cell. Biol. / Schizosaccharomyces pombe: a model for molecular studies of eukaryotic genes by Zhao (1995)
10.1006/viro.1998.9208 / Virology / Pleiotropic effects of HIV-1 protein R (Vpr) on morphogenesis and cell survival in fission yeast and antagonism by pentoxifylline by Zhao (1998)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 19, 2002, 9 a.m.)
Deposited	4 years, 4 months ago (May 2, 2021, 10:59 p.m.)
Indexed	1 year, 4 months ago (April 7, 2024, 11:56 a.m.)
Issued	24 years ago (Sept. 1, 2001)
Published	24 years ago (Sept. 1, 2001)
Published Print	24 years ago (Sept. 1, 2001)

Funders 0

None

BibTeX

@article{Elder_2001, title={HIV-1 Vpr Induces Cell Cycle G2 Arrest in Fission Yeast (Schizosaccharomyces pombe) through a Pathway Involving Regulatory and Catalytic Subunits of PP2A and Acting on Both Wee1 and Cdc25}, volume={287}, ISSN={0042-6822}, url={http://dx.doi.org/10.1006/viro.2001.1007}, DOI={10.1006/viro.2001.1007}, number={2}, journal={Virology}, publisher={Elsevier BV}, author={Elder, Robert T. and Yu, Min and Chen, Mingzhong and Zhu, Xudong and Yanagida, Mitsuhiro and Zhao, Yuqi}, year={2001}, month=sep, pages={359–370} }

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      "author": "al-Khodairy",
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      "journal-title": "EMBO J."
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      "first-page": "2324",
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      "article-title": "Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control",
      "volume": "70",
      "author": "Bartz",
      "year": "1996",
      "journal-title": "J. Virol."
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    {
      "key": "10.1006/viro.2001.1007_RF4",
      "doi-asserted-by": "crossref",
      "first-page": "909",
      "DOI": "10.1126/science.280.5365.909",
      "article-title": "Replication checkpoint enforced by kinases Cds1 and Chk1",
      "volume": "280",
      "author": "Boddy",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/viro.2001.1007_RF5",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/S0014-5793(98)00158-6",
      "article-title": "A phosphatase activity in Xenopus oocyte extracts preferentially dephosphorylates the MPM-2 epitope",
      "volume": "424",
      "author": "Che",
      "year": "1998",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/viro.2001.1007_RF6",
      "doi-asserted-by": "crossref",
      "first-page": "3236",
      "DOI": "10.1128/JVI.73.4.3236-3245.1999",
      "article-title": "Mutational analysis of Vpr-induced G2 arrest, nuclear localization and cell death in fission yeast",
      "volume": "73",
      "author": "Chen",
      "year": "1999",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF7",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1146/annurev.bi.58.070189.002321",
      "article-title": "The structure and regulation of protein phosphatases",
      "volume": "58",
      "author": "Cohen",
      "year": "1989",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1006/viro.2001.1007_RF8",
      "doi-asserted-by": "crossref",
      "first-page": "161",
      "DOI": "10.1016/S0168-1702(00)00167-2",
      "article-title": "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint",
      "volume": "68",
      "author": "Elder",
      "year": "2000",
      "journal-title": "Virus Res."
    },
    {
      "key": "10.1006/viro.2001.1007_RF9",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1126/science.8036497",
      "article-title": "14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast",
      "volume": "265",
      "author": "Ford",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/viro.2001.1007_RF10",
      "doi-asserted-by": "crossref",
      "first-page": "833",
      "DOI": "10.1091/mbc.10.4.833",
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      "volume": "10",
      "author": "Furnari",
      "year": "1999",
      "journal-title": "Mol. Biol. Cell"
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      "volume": "342",
      "author": "Gould",
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      "volume": "215",
      "author": "Grimm",
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      "volume": "69",
      "author": "He",
      "year": "1995",
      "journal-title": "J. Virol."
    },
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      "key": "10.1006/viro.2001.1007_RF15",
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      "volume": "69",
      "author": "Jowett",
      "year": "1995",
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      "author": "Karaiskou",
      "year": "1999",
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      "volume": "1",
      "author": "Kinoshita",
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      "volume": "63",
      "author": "Kinoshita",
      "year": "1990",
      "journal-title": "Cell"
    },
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      "first-page": "1059",
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      "volume": "7",
      "author": "Kinoshita",
      "year": "1993",
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      "key": "10.1006/viro.2001.1007_RF21",
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      "volume": "10",
      "author": "Krek",
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      "volume": "4",
      "author": "Lee",
      "year": "1988",
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      "key": "10.1006/viro.2001.1007_RF23",
      "doi-asserted-by": "crossref",
      "first-page": "415",
      "DOI": "10.1016/0092-8674(91)90649-J",
      "article-title": "INH, a negative regulator of MPF, is a form of protein phosphatase 2A",
      "volume": "64",
      "author": "Lee",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/viro.2001.1007_RF24",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1091/mbc.5.3.323",
      "article-title": "Inhibition of cdc2 activation by INH/PP2A",
      "volume": "5",
      "author": "Lee",
      "year": "1994",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1006/viro.2001.1007_RF25",
      "doi-asserted-by": "crossref",
      "first-page": "172",
      "DOI": "10.1038/16488",
      "article-title": "Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein",
      "volume": "397",
      "author": "Lopez-Girona",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/viro.2001.1007_RF26",
      "doi-asserted-by": "crossref",
      "first-page": "1111",
      "DOI": "10.1016/0092-8674(91)90266-2",
      "article-title": "mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2",
      "volume": "64",
      "author": "Lundgren",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/viro.2001.1007_RF27",
      "doi-asserted-by": "crossref",
      "first-page": "2636",
      "DOI": "10.1128/JVI.74.6.2636-2646.2000",
      "article-title": "Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr",
      "volume": "74",
      "author": "Masuda",
      "year": "2000",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF28",
      "doi-asserted-by": "crossref",
      "first-page": "1893",
      "DOI": "10.1126/science.282.5395.1893",
      "article-title": "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase",
      "volume": "282",
      "author": "Matsuoka",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/viro.2001.1007_RF29",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/0378-1119(93)90551-D",
      "article-title": "Thiamine-repressible expression vectors pREP and pRIP for fission yeast",
      "volume": "123",
      "author": "Maundrell",
      "year": "1993",
      "journal-title": "Gene"
    },
    {
      "key": "10.1006/viro.2001.1007_RF30",
      "doi-asserted-by": "crossref",
      "first-page": "4933",
      "DOI": "10.1002/j.1460-2075.1992.tb05600.x",
      "article-title": "Pyp3 PTPase acts as a mitotic inducer in fission yeast",
      "volume": "11",
      "author": "Millar",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/viro.2001.1007_RF31",
      "doi-asserted-by": "crossref",
      "first-page": "4301",
      "DOI": "10.1002/j.1460-2075.1991.tb05008.x",
      "article-title": "p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast",
      "volume": "10",
      "author": "Millar",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/viro.2001.1007_RF32",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1038/374131a0",
      "article-title": "Principles of CDK regulation",
      "volume": "374",
      "author": "Morgan",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/viro.2001.1007_RF33",
      "doi-asserted-by": "crossref",
      "first-page": "4288",
      "DOI": "10.1128/MCB.20.12.4288-4294.2000",
      "article-title": "Mechanism of caffeine-induced checkpoint override in fission yeast",
      "volume": "20",
      "author": "Moser",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF34",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1091/mbc.6.1.119",
      "article-title": "Cell cycle regulation of a Xenopus Wee1-like kinase",
      "volume": "6",
      "author": "Mueller",
      "year": "1995",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1006/viro.2001.1007_RF35",
      "doi-asserted-by": "crossref",
      "first-page": "1561",
      "DOI": "10.1093/genetics/153.4.1561",
      "article-title": "The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts",
      "volume": "153",
      "author": "Munoz",
      "year": "1999",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1006/viro.2001.1007_RF36",
      "doi-asserted-by": "crossref",
      "first-page": "3321",
      "DOI": "10.1002/j.1460-2075.1991.tb04896.x",
      "article-title": "Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates",
      "volume": "10",
      "author": "Norbury",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/viro.2001.1007_RF37",
      "doi-asserted-by": "crossref",
      "first-page": "865",
      "DOI": "10.1016/S0092-8674(00)80476-6",
      "article-title": "Checkpoint pathways come of age",
      "volume": "91",
      "author": "Nurse",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/viro.2001.1007_RF38",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1007/BF00268085",
      "article-title": "Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe",
      "volume": "146",
      "author": "Nurse",
      "year": "1976",
      "journal-title": "Mol. Gen. Genet."
    },
    {
      "key": "10.1006/viro.2001.1007_RF39",
      "doi-asserted-by": "crossref",
      "first-page": "8298",
      "DOI": "10.1016/S0021-9258(18)53096-9",
      "article-title": "G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently",
      "volume": "268",
      "author": "O'Connor",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/viro.2001.1007_RF40",
      "doi-asserted-by": "crossref",
      "first-page": "911",
      "DOI": "10.1038/sj.onc.1201259",
      "article-title": "Protein phosphatase 2A subunit assembly: the catalytic suunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen",
      "volume": "15",
      "author": "Ogris",
      "year": "1997",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1006/viro.2001.1007_RF41",
      "doi-asserted-by": "crossref",
      "first-page": "997",
      "DOI": "10.1016/0092-8674(89)90338-3",
      "article-title": "The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases",
      "volume": "57",
      "author": "Ohkura",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/viro.2001.1007_RF42",
      "doi-asserted-by": "crossref",
      "first-page": "3961",
      "DOI": "10.1128/JVI.71.5.3961-3971.1997",
      "article-title": "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard",
      "volume": "71",
      "author": "Poon",
      "year": "1997",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF43",
      "doi-asserted-by": "crossref",
      "first-page": "6859",
      "DOI": "10.1128/JVI.69.11.6859-6864.1995",
      "article-title": "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B",
      "volume": "69",
      "author": "Re",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF44",
      "doi-asserted-by": "crossref",
      "first-page": "749",
      "DOI": "10.1016/S0955-0674(98)80118-X",
      "article-title": "Mitotic DNA damage and replication checkpoints in yeast",
      "volume": "10",
      "author": "Rhind",
      "year": "1998",
      "journal-title": "Curr. Opin. Cell. Biol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF45",
      "doi-asserted-by": "crossref",
      "first-page": "3782",
      "DOI": "10.1128/MCB.18.7.3782",
      "article-title": "Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe",
      "volume": "18",
      "author": "Rhind",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF46",
      "doi-asserted-by": "crossref",
      "first-page": "882",
      "DOI": "10.1128/JVI.69.2.882-888.1995",
      "article-title": "The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection",
      "volume": "69",
      "author": "Rogel",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF47",
      "doi-asserted-by": "crossref",
      "first-page": "1497",
      "DOI": "10.1126/science.277.5331.1497",
      "article-title": "Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25",
      "volume": "277",
      "author": "Sanchez",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/viro.2001.1007_RF48",
      "doi-asserted-by": "crossref",
      "first-page": "1749",
      "DOI": "10.1126/science.7792600",
      "article-title": "A single ataxia telangiectasia gene with a product similar to PI-3 kinase",
      "volume": "268",
      "author": "Savitsky",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/viro.2001.1007_RF49",
      "doi-asserted-by": "crossref",
      "first-page": "5579",
      "DOI": "10.1128/JVI.71.7.5579-5592.1997",
      "article-title": "Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest",
      "volume": "71",
      "author": "Stewart",
      "year": "1997",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF50",
      "doi-asserted-by": "crossref",
      "first-page": "3427",
      "DOI": "10.1002/j.1460-2075.1993.tb06017.x",
      "article-title": "Two distinct mechanisms for negative regulation of the Wee1 protein kinase",
      "volume": "12",
      "author": "Tang",
      "year": "1993",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/viro.2001.1007_RF51",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1101/gad.12.2.175",
      "article-title": "HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection",
      "volume": "12",
      "author": "Vodicka",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1006/viro.2001.1007_RF52",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1126/science.271.5247.353",
      "article-title": "rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint",
      "volume": "271",
      "author": "Walworth",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/viro.2001.1007_RF53",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1038/26766",
      "article-title": "Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1",
      "volume": "395",
      "author": "Zeng",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/viro.2001.1007_RF54",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1006/viro.1997.8459",
      "article-title": "Cell cycle inhibitory effects of HIV and SIV Vpr and Vpx in the yeast Schizosaccharomyces pombe",
      "volume": "230",
      "author": "Zhang",
      "year": "1997",
      "journal-title": "Virology"
    },
    {
      "key": "10.1006/viro.2001.1007_RF55",
      "doi-asserted-by": "crossref",
      "first-page": "5821",
      "DOI": "10.1128/JVI.70.9.5821-5826.1996",
      "article-title": "Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular functions of fission yeast Schizosaccharomyces pombe",
      "volume": "70",
      "author": "Zhao",
      "year": "1996",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF56",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.2741/zhao",
      "article-title": "Yeast perspectives on HIV-1 Vpr",
      "volume": "5",
      "author": "Zhao",
      "year": "2000",
      "journal-title": "Front. Biosci."
    },
    {
      "key": "10.1006/viro.2001.1007_RF57",
      "doi-asserted-by": "crossref",
      "first-page": "438",
      "DOI": "10.2144/98253st06",
      "article-title": "Fission yeast expression vectors adapted for positive identification of gene insertion and green fluorescent protein fusion",
      "volume": "25",
      "author": "Zhao",
      "year": "1998",
      "journal-title": "BioTechniques"
    },
    {
      "key": "10.1006/viro.2001.1007_RF58",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1089/dna.1995.14.359",
      "article-title": "Schizosaccharomyces pombe: a model for molecular studies of eukaryotic genes",
      "volume": "14",
      "author": "Zhao",
      "year": "1995",
      "journal-title": "DNA Cell. Biol."
    },
    {
      "key": "10.1006/viro.2001.1007_RF59",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1006/viro.1998.9208",
      "article-title": "Pleiotropic effects of HIV-1 protein R (Vpr) on morphogenesis and cell survival in fission yeast and antagonism by pentoxifylline",
      "volume": "246",
      "author": "Zhao",
      "year": "1998",
      "journal-title": "Virology"
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