DOI: 10.1006/taap.2000.9073. Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model

Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model

10.1006/taap.2000.9073

Crossref journal-article

Elsevier BV

Toxicology and Applied Pharmacology (78)

Bibliography

Brenneman, K. A., Wong, B. A., Buccellato, M. A., Costa, E. R., Gross, E. A., & Dorman, D. C. (2000). Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model. Toxicology and Applied Pharmacology, 169(3), 238â248.

Authors 6

Karrie A. Brenneman (first)
Brian A. Wong (additional)
Matthew A. Buccellato (additional)
Elisabeth R. Costa (additional)
Elizabeth A. Gross (additional)
David C. Dorman (additional)

References 40 Referenced 154

Agency for Toxic Substances and Disease Registry. 1999. Toxicological Profile For Hydrogen Sulfide, pp. 11–47. 65–69. U. S. Department of Commerce, Springfield, VA.
{'key': '10.1006/taap.2000.9073_RF2', 'first-page': '161', 'article-title': 'Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese', 'volume': '20', 'author': 'Andersen', 'year': '1999', 'journal-title': 'Neurotoxicology.'} / Neurotoxicology. / Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese by Andersen (1999)
{'key': '10.1006/taap.2000.9073_RF3', 'first-page': '339', 'article-title': 'Role of manganese in dystonia', 'volume': '14', 'author': 'Barbeau', 'year': '1976', 'journal-title': 'Adv. Neurol.'} / Adv. Neurol. / Role of manganese in dystonia by Barbeau (1976)
{'key': '10.1006/taap.2000.9073_RF4', 'first-page': '477', 'article-title': 'Manganese-induced developmental neurotoxicity in the CD rat: Is oxidative damage a mechanism of action?', 'volume': '20', 'author': 'Brenneman', 'year': '1999', 'journal-title': 'Neurotoxicology.'} / Neurotoxicology. / Manganese-induced developmental neurotoxicity in the CD rat: Is oxidative damage a mechanism of action? by Brenneman (1999)
10.1177/019262330002800213 / Toxicol. Pathol. / Olfactory neuron loss in adult male CD rats following subchronic inhalation exposure to low levels of hydrogen sulfide by Brenneman (2000)
10.1016/0041-008X(84)90295-3 / Toxicol. Appl. Pharmacol. / Respiratory tract lesions induced by sensory irritants at the RD50 concentration by Buckley (1984)
10.1080/15298668391405959 / Am. Ind. Hyg. Assoc. J. / The flow-past chamber: An improved nose-only exposure system for rodents by Cannon (1983)
10.1289/ehp.98106s1191 / Environ. Health Perspect. / Methylcyclopentadienyl manganese tricarbonyl: Health risk uncertainties and research directions by Davis (1998)
{'key': '10.1006/taap.2000.9073_RF9', 'first-page': '451', 'article-title': 'The physiopathological significance of manganese in brain: Its relation to schizophrenia and neurodegenerative disorders', 'volume': '8', 'author': 'Donaldson', 'year': '1987', 'journal-title': 'Neurotoxicology'} / Neurotoxicology / The physiopathological significance of manganese in brain: Its relation to schizophrenia and neurodegenerative disorders by Donaldson (1987)
10.1111/j.1600-0773.1990.tb00711.x / Pharmacol. Toxicol. / Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse by Ghantous (1990)
10.1006/faat.1997.2306 / Fundam. Appl. Toxicol. / Accumulation of manganese in rat brain following intranasal administration by Gianutsos (1997)
{'key': '10.1006/taap.2000.9073_RF12', 'first-page': '83', 'article-title': 'Comparative morphometry of the nasal cavity in rats and mice', 'volume': '135', 'author': 'Gross', 'year': '1982', 'journal-title': 'J. Anat.'} / J. Anat. / Comparative morphometry of the nasal cavity in rats and mice by Gross (1982)
10.1006/taap.1999.8639 / Toxicol. Appl. Pharmacol. / Transport of manganese via the olfactory pathway in rats: Dosage dependency of the uptake and subcellular distribution of the metal in the olfactory epithelium and brain by Henriksson (1999)
10.1006/taap.1997.8206 / Toxicol. Appl. Pharmacol. / Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages by Kimbell (1997)
10.1016/S0163-1047(86)90506-6 / Behav. Neural Biol. / Unilateral olfactory conditioning in 6-day-old rat pups by Kucharski (1986)
{'key': '10.1006/taap.2000.9073_RF16', 'first-page': '36', 'article-title': 'Retention of vapors and gases in the human nose and lung', 'volume': '1', 'author': 'Landahl', 'year': '1950', 'journal-title': 'AMA Arch. Ind. Hyg.'} / AMA Arch. Ind. Hyg. / Retention of vapors and gases in the human nose and lung by Landahl (1950)
{'key': '10.1006/taap.2000.9073_RF17', 'series-title': 'Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses', 'first-page': '119', 'article-title': 'Mucosa of the nasal cavity and paranasal sinuses', 'author': 'Lang', 'year': '1989'} / Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses / Mucosa of the nasal cavity and paranasal sinuses by Lang (1989)
{'key': '10.1006/taap.2000.9073_RF18', 'first-page': '1107', 'article-title': 'Nasal lesions in rats exposed to hydrogen sulfide for four hours', 'volume': '49', 'author': 'Lopez', 'year': '1988', 'journal-title': 'Am. J. Vet. Res.'} / Am. J. Vet. Res. / Nasal lesions in rats exposed to hydrogen sulfide for four hours by Lopez (1988)
10.1177/0192623391019004-103 / Toxicol. Pathol. / Approaches to identification and recording of nasal lesions in toxicology studies by Morgan (1991)
National Research Council, 1996, Guide for the Care and Use of Laboratory Animals, National Academic Press, Washington, D.C.
{'key': '10.1006/taap.2000.9073_RF21', 'first-page': '510', 'article-title': 'Manganese encephalopathy: Utility of early magnetic resonance imaging', 'volume': '50', 'author': 'Nelson', 'year': '1993', 'journal-title': 'Br. J. Indust. Med.'} / Br. J. Indust. Med. / Manganese encephalopathy: Utility of early magnetic resonance imaging by Nelson (1993)
10.1002/mrm.1910400515 / Magn. Reson. Med. / In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging by Pautler (1998)
{'key': '10.1006/taap.2000.9073_RF23', 'series-title': 'Nasal tumors in animals and man, Vol. I, Anatomy, Physiology, and Epidemiology', 'first-page': '1', 'article-title': 'Comparative anatomy and physiology of the nasal cavity', 'author': 'Proctor', 'year': '1983'} / Nasal tumors in animals and man, Vol. I, Anatomy, Physiology, and Epidemiology / Comparative anatomy and physiology of the nasal cavity by Proctor (1983)
10.1111/j.1471-4159.1993.tb02153.x / J. Neurochem. / Rapid uptake of manganese (II) across the blood-brain barrier by Rabin (1993)
10.3109/03602539308993975 / Drug Metab. Rev. / Drug metabolism in the nasal cavity: Relevance to toxicology by Reed (1993)
10.1007/s002040050380 / Arch. Toxicol. / Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats by Roels (1997)
10.1002/etc.5620140318 / Environ. Toxicol. Chem. / Uptake, distribution and elimination of 54manganese (II) in the brown trout (Salmo trutta) by Rouleau (1995)
{'key': '10.1006/taap.2000.9073_RF28', 'series-title': 'Nasal Tumors in Animals and Man, Vol. III, Experimental Nasal Carcinogenesis', 'first-page': '1', 'article-title': 'Nasal airway anatomy and inhalation deposition in experimental animals and people', 'author': 'Schreider', 'year': '1983'} / Nasal Tumors in Animals and Man, Vol. III, Experimental Nasal Carcinogenesis / Nasal airway anatomy and inhalation deposition in experimental animals and people by Schreider (1983)
10.1016/0021-9681(66)90094-4 / J. Chron. Dis. / Essential trace metals in man: Manganese, a study in homeostasis by Schroeder (1966)
{'key': '10.1006/taap.2000.9073_RF30', 'series-title': 'Principles of Neural Science', 'first-page': '126', 'article-title': 'Biochemical control mechanisms in synaptic transmission', 'author': 'Schwartz', 'year': '1981'} / Principles of Neural Science / Biochemical control mechanisms in synaptic transmission by Schwartz (1981)
{'key': '10.1006/taap.2000.9073_RF31', 'series-title': 'Applied Biopharmaceutics and Pharmacokinetics', 'first-page': '51', 'article-title': 'Multicompartment models', 'author': 'Shargel', 'year': '1985'} / Applied Biopharmaceutics and Pharmacokinetics / Multicompartment models by Shargel (1985)
10.1212/WNL.45.6.1199 / Neurology / MRI and PET studies of manganese-intoxicated monkeys by Shinotoh (1995)
10.1016/0006-8993(94)90959-8 / Brain Res. / Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia by Sloot (1994)
10.1016/S0361-9230(97)00330-4 / Brain Res. Bull. / Manganese transport in the neural circuit of rat CNS by Takeda (1998)
{'key': '10.1006/taap.2000.9073_RF35', 'first-page': '181', 'article-title': 'Uptake of metals in the brain via olfactory pathways', 'volume': '20', 'author': 'Tjälve', 'year': '1999', 'journal-title': 'Neurotoxicology.'} / Neurotoxicology. / Uptake of metals in the brain via olfactory pathways by Tjälve (1999)
10.1111/j.1600-0773.1996.tb00021.x / Pharmacol. Toxicol. / Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats by Tjälve (1996)
10.1111/j.1600-0773.1995.tb01909.x / Pharmacol. Toxicol. / Uptake and transport of manganese in primary and secondary olfactory neurones in pike by Tjälve (1995)
10.1006/taap.1999.8874 / Toxicol. Appl. Pharmacol. / Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure by Vitarella (2000)
{'key': '10.1006/taap.2000.9073_RF39', 'series-title': 'Molecular Neurobiology of the Olfactory System', 'first-page': '217', 'article-title': 'Axoplasmic transport in olfactory receptor neurons', 'author': 'Weiss', 'year': '1988'} / Molecular Neurobiology of the Olfactory System / Axoplasmic transport in olfactory receptor neurons by Weiss (1988)
{'key': '10.1006/taap.2000.9073_RF40', 'first-page': '248', 'article-title': 'Kinetics of inhaled 54MnCl2 aerosols: Influence of inhaled concentration', 'volume': '2', 'author': 'Wieczorek', 'year': '1989', 'journal-title': 'Polish J. Occup. Med.'} / Polish J. Occup. Med. / Kinetics of inhaled 54MnCl2 aerosols: Influence of inhaled concentration by Wieczorek (1989)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 6:01 p.m.)
Deposited	6 years, 3 months ago (May 8, 2019, 5:58 a.m.)
Indexed	5 months ago (March 27, 2025, 4:16 a.m.)
Issued	24 years, 9 months ago (Dec. 1, 2000)
Published	24 years, 9 months ago (Dec. 1, 2000)
Published Print	24 years, 9 months ago (Dec. 1, 2000)

Funders 0

None

BibTeX

@article{Brenneman_2000, title={Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model}, volume={169}, ISSN={0041-008X}, url={http://dx.doi.org/10.1006/taap.2000.9073}, DOI={10.1006/taap.2000.9073}, number={3}, journal={Toxicology and Applied Pharmacology}, publisher={Elsevier BV}, author={Brenneman, Karrie A. and Wong, Brian A. and Buccellato, Matthew A. and Costa, Elisabeth R. and Gross, Elizabeth A. and Dorman, David C.}, year={2000}, month=dec, pages={238–248} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        3,
        27
      ]
    ],
    "date-time": "2025-03-27T08:16:21Z",
    "timestamp": 1743063381973
  },
  "reference-count": 40,
  "publisher": "Elsevier BV",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            12,
            1
          ]
        ],
        "date-time": "2000-12-01T00:00:00Z",
        "timestamp": 975628800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        12
      ]
    ]
  },
  "DOI": "10.1006/taap.2000.9073",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        18
      ]
    ],
    "date-time": "2002-09-18T22:01:25Z",
    "timestamp": 1032386485000
  },
  "page": "238-248",
  "source": "Crossref",
  "is-referenced-by-count": 154,
  "title": "Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model",
  "prefix": "10.1006",
  "volume": "169",
  "author": [
    {
      "given": "Karrie A.",
      "family": "Brenneman",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Brian A.",
      "family": "Wong",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Matthew A.",
      "family": "Buccellato",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Elisabeth R.",
      "family": "Costa",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Elizabeth A.",
      "family": "Gross",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David C.",
      "family": "Dorman",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/taap.2000.9073_RF1",
      "unstructured": "Agency for Toxic Substances and Disease Registry. 1999. Toxicological Profile For Hydrogen Sulfide, pp. 11\u201347. 65\u201369. U. S. Department of Commerce, Springfield, VA."
    },
    {
      "key": "10.1006/taap.2000.9073_RF2",
      "first-page": "161",
      "article-title": "Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese",
      "volume": "20",
      "author": "Andersen",
      "year": "1999",
      "journal-title": "Neurotoxicology."
    },
    {
      "key": "10.1006/taap.2000.9073_RF3",
      "first-page": "339",
      "article-title": "Role of manganese in dystonia",
      "volume": "14",
      "author": "Barbeau",
      "year": "1976",
      "journal-title": "Adv. Neurol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF4",
      "first-page": "477",
      "article-title": "Manganese-induced developmental neurotoxicity in the CD rat: Is oxidative damage a mechanism of action?",
      "volume": "20",
      "author": "Brenneman",
      "year": "1999",
      "journal-title": "Neurotoxicology."
    },
    {
      "key": "10.1006/taap.2000.9073_RF5",
      "doi-asserted-by": "crossref",
      "first-page": "326",
      "DOI": "10.1177/019262330002800213",
      "article-title": "Olfactory neuron loss in adult male CD rats following subchronic inhalation exposure to low levels of hydrogen sulfide",
      "volume": "28",
      "author": "Brenneman",
      "year": "2000",
      "journal-title": "Toxicol. Pathol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF6",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/0041-008X(84)90295-3",
      "article-title": "Respiratory tract lesions induced by sensory irritants at the RD50 concentration",
      "volume": "74",
      "author": "Buckley",
      "year": "1984",
      "journal-title": "Toxicol. Appl. Pharmacol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF7",
      "doi-asserted-by": "crossref",
      "first-page": "923",
      "DOI": "10.1080/15298668391405959",
      "article-title": "The flow-past chamber: An improved nose-only exposure system for rodents",
      "volume": "44",
      "author": "Cannon",
      "year": "1983",
      "journal-title": "Am. Ind. Hyg. Assoc. J."
    },
    {
      "key": "10.1006/taap.2000.9073_RF8",
      "doi-asserted-by": "crossref",
      "first-page": "191",
      "DOI": "10.1289/ehp.98106s1191",
      "article-title": "Methylcyclopentadienyl manganese tricarbonyl: Health risk uncertainties and research directions",
      "volume": "106",
      "author": "Davis",
      "year": "1998",
      "journal-title": "Environ. Health Perspect."
    },
    {
      "key": "10.1006/taap.2000.9073_RF9",
      "first-page": "451",
      "article-title": "The physiopathological significance of manganese in brain: Its relation to schizophrenia and neurodegenerative disorders",
      "volume": "8",
      "author": "Donaldson",
      "year": "1987",
      "journal-title": "Neurotoxicology"
    },
    {
      "key": "10.1006/taap.2000.9073_RF10",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1111/j.1600-0773.1990.tb00711.x",
      "article-title": "Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse",
      "volume": "66",
      "author": "Ghantous",
      "year": "1990",
      "journal-title": "Pharmacol. Toxicol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF11",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1006/faat.1997.2306",
      "article-title": "Accumulation of manganese in rat brain following intranasal administration",
      "volume": "37",
      "author": "Gianutsos",
      "year": "1997",
      "journal-title": "Fundam. Appl. Toxicol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF12",
      "first-page": "83",
      "article-title": "Comparative morphometry of the nasal cavity in rats and mice",
      "volume": "135",
      "author": "Gross",
      "year": "1982",
      "journal-title": "J. Anat."
    },
    {
      "key": "10.1006/taap.2000.9073_RF13",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1006/taap.1999.8639",
      "article-title": "Transport of manganese via the olfactory pathway in rats: Dosage dependency of the uptake and subcellular distribution of the metal in the olfactory epithelium and brain",
      "volume": "156",
      "author": "Henriksson",
      "year": "1999",
      "journal-title": "Toxicol. Appl. Pharmacol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF14",
      "doi-asserted-by": "crossref",
      "first-page": "388",
      "DOI": "10.1006/taap.1997.8206",
      "article-title": "Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages",
      "volume": "145",
      "author": "Kimbell",
      "year": "1997",
      "journal-title": "Toxicol. Appl. Pharmacol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF15",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1016/S0163-1047(86)90506-6",
      "article-title": "Unilateral olfactory conditioning in 6-day-old rat pups",
      "volume": "46",
      "author": "Kucharski",
      "year": "1986",
      "journal-title": "Behav. Neural Biol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF16",
      "first-page": "36",
      "article-title": "Retention of vapors and gases in the human nose and lung",
      "volume": "1",
      "author": "Landahl",
      "year": "1950",
      "journal-title": "AMA Arch. Ind. Hyg."
    },
    {
      "key": "10.1006/taap.2000.9073_RF17",
      "series-title": "Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses",
      "first-page": "119",
      "article-title": "Mucosa of the nasal cavity and paranasal sinuses",
      "author": "Lang",
      "year": "1989"
    },
    {
      "key": "10.1006/taap.2000.9073_RF18",
      "first-page": "1107",
      "article-title": "Nasal lesions in rats exposed to hydrogen sulfide for four hours",
      "volume": "49",
      "author": "Lopez",
      "year": "1988",
      "journal-title": "Am. J. Vet. Res."
    },
    {
      "key": "10.1006/taap.2000.9073_RF19",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1177/0192623391019004-103",
      "article-title": "Approaches to identification and recording of nasal lesions in toxicology studies",
      "volume": "19",
      "author": "Morgan",
      "year": "1991",
      "journal-title": "Toxicol. Pathol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF20",
      "unstructured": "National Research Council, 1996, Guide for the Care and Use of Laboratory Animals, National Academic Press, Washington, D.C."
    },
    {
      "key": "10.1006/taap.2000.9073_RF21",
      "first-page": "510",
      "article-title": "Manganese encephalopathy: Utility of early magnetic resonance imaging",
      "volume": "50",
      "author": "Nelson",
      "year": "1993",
      "journal-title": "Br. J. Indust. Med."
    },
    {
      "key": "10.1006/taap.2000.9073_RF22",
      "doi-asserted-by": "crossref",
      "first-page": "740",
      "DOI": "10.1002/mrm.1910400515",
      "article-title": "In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging",
      "volume": "40",
      "author": "Pautler",
      "year": "1998",
      "journal-title": "Magn. Reson. Med."
    },
    {
      "key": "10.1006/taap.2000.9073_RF23",
      "series-title": "Nasal tumors in animals and man, Vol. I, Anatomy, Physiology, and Epidemiology",
      "first-page": "1",
      "article-title": "Comparative anatomy and physiology of the nasal cavity",
      "author": "Proctor",
      "year": "1983"
    },
    {
      "key": "10.1006/taap.2000.9073_RF24",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1111/j.1471-4159.1993.tb02153.x",
      "article-title": "Rapid uptake of manganese (II) across the blood-brain barrier",
      "volume": "61",
      "author": "Rabin",
      "year": "1993",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1006/taap.2000.9073_RF25",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.3109/03602539308993975",
      "article-title": "Drug metabolism in the nasal cavity: Relevance to toxicology",
      "volume": "25",
      "author": "Reed",
      "year": "1993",
      "journal-title": "Drug Metab. Rev."
    },
    {
      "key": "10.1006/taap.2000.9073_RF26",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1007/s002040050380",
      "article-title": "Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats",
      "volume": "71",
      "author": "Roels",
      "year": "1997",
      "journal-title": "Arch. Toxicol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF27",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1002/etc.5620140318",
      "article-title": "Uptake, distribution and elimination of 54manganese (II) in the brown trout (Salmo trutta)",
      "volume": "14",
      "author": "Rouleau",
      "year": "1995",
      "journal-title": "Environ. Toxicol. Chem."
    },
    {
      "key": "10.1006/taap.2000.9073_RF28",
      "series-title": "Nasal Tumors in Animals and Man, Vol. III, Experimental Nasal Carcinogenesis",
      "first-page": "1",
      "article-title": "Nasal airway anatomy and inhalation deposition in experimental animals and people",
      "author": "Schreider",
      "year": "1983"
    },
    {
      "key": "10.1006/taap.2000.9073_RF29",
      "doi-asserted-by": "crossref",
      "first-page": "545",
      "DOI": "10.1016/0021-9681(66)90094-4",
      "article-title": "Essential trace metals in man: Manganese, a study in homeostasis",
      "volume": "19",
      "author": "Schroeder",
      "year": "1966",
      "journal-title": "J. Chron. Dis."
    },
    {
      "key": "10.1006/taap.2000.9073_RF30",
      "series-title": "Principles of Neural Science",
      "first-page": "126",
      "article-title": "Biochemical control mechanisms in synaptic transmission",
      "author": "Schwartz",
      "year": "1981"
    },
    {
      "key": "10.1006/taap.2000.9073_RF31",
      "series-title": "Applied Biopharmaceutics and Pharmacokinetics",
      "first-page": "51",
      "article-title": "Multicompartment models",
      "author": "Shargel",
      "year": "1985"
    },
    {
      "key": "10.1006/taap.2000.9073_RF32",
      "doi-asserted-by": "crossref",
      "first-page": "1199",
      "DOI": "10.1212/WNL.45.6.1199",
      "article-title": "MRI and PET studies of manganese-intoxicated monkeys",
      "volume": "45",
      "author": "Shinotoh",
      "year": "1995",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1006/taap.2000.9073_RF33",
      "doi-asserted-by": "crossref",
      "first-page": "124",
      "DOI": "10.1016/0006-8993(94)90959-8",
      "article-title": "Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia",
      "volume": "657",
      "author": "Sloot",
      "year": "1994",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1006/taap.2000.9073_RF34",
      "doi-asserted-by": "crossref",
      "first-page": "149",
      "DOI": "10.1016/S0361-9230(97)00330-4",
      "article-title": "Manganese transport in the neural circuit of rat CNS",
      "volume": "45",
      "author": "Takeda",
      "year": "1998",
      "journal-title": "Brain Res. Bull."
    },
    {
      "key": "10.1006/taap.2000.9073_RF35",
      "first-page": "181",
      "article-title": "Uptake of metals in the brain via olfactory pathways",
      "volume": "20",
      "author": "Tj\u00e4lve",
      "year": "1999",
      "journal-title": "Neurotoxicology."
    },
    {
      "key": "10.1006/taap.2000.9073_RF36",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1111/j.1600-0773.1996.tb00021.x",
      "article-title": "Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats",
      "volume": "79",
      "author": "Tj\u00e4lve",
      "year": "1996",
      "journal-title": "Pharmacol. Toxicol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF37",
      "doi-asserted-by": "crossref",
      "first-page": "23",
      "DOI": "10.1111/j.1600-0773.1995.tb01909.x",
      "article-title": "Uptake and transport of manganese in primary and secondary olfactory neurones in pike",
      "volume": "77",
      "author": "Tj\u00e4lve",
      "year": "1995",
      "journal-title": "Pharmacol. Toxicol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF38",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1006/taap.1999.8874",
      "article-title": "Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure",
      "volume": "163",
      "author": "Vitarella",
      "year": "2000",
      "journal-title": "Toxicol. Appl. Pharmacol."
    },
    {
      "key": "10.1006/taap.2000.9073_RF39",
      "series-title": "Molecular Neurobiology of the Olfactory System",
      "first-page": "217",
      "article-title": "Axoplasmic transport in olfactory receptor neurons",
      "author": "Weiss",
      "year": "1988"
    },
    {
      "key": "10.1006/taap.2000.9073_RF40",
      "first-page": "248",
      "article-title": "Kinetics of inhaled 54MnCl2 aerosols: Influence of inhaled concentration",
      "volume": "2",
      "author": "Wieczorek",
      "year": "1989",
      "journal-title": "Polish J. Occup. Med."
    }
  ],
  "container-title": "Toxicology and Applied Pharmacology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0041008X00990732?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0041008X00990732?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        5,
        8
      ]
    ],
    "date-time": "2019-05-08T09:58:06Z",
    "timestamp": 1557309486000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0041008X00990732"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        12
      ]
    ]
  },
  "references-count": 40,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          2000,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "S0041008X00990732"
  ],
  "URL": "http://dx.doi.org/10.1006/taap.2000.9073",
  "relation": {},
  "ISSN": [
    "0041-008X"
  ],
  "subject": [],
  "container-title-short": "Toxicology and Applied Pharmacology",
  "published": {
    "date-parts": [
      [
        2000,
        12
      ]
    ]
  }
}