DOI: 10.1006/taap.1996.8086. P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity

P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity

10.1006/taap.1996.8086

Crossref journal-article

Elsevier BV

Toxicology and Applied Pharmacology (78)

Bibliography

Lankas, G. R., Cartwright, M. E., & Umbenhauer, D. (1997). P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity. Toxicology and Applied Pharmacology, 143(2), 357â365.

Authors 3

George R. Lankas (first)
Mark E. Cartwright (additional)
Diane Umbenhauer (additional)

References 27 Referenced 160

10.1021/ja00404a040 / J. Am. Chem. Soc. / Avermectins. Structure determination by Albers-Schonberg (1981)
10.1016/S0021-9258(19)74226-4 / J. Biol. Chem. / Targeted disruption of the mousemdr1bmdr by Altuvia (1993)
10.2307/3283936 / J. Parasitol. / The mechanism of action of avermectins inCaenorhabditis elegans: by Arena (1995)
{'key': '10.1006/taap.1996.8086_TO968086C4', 'first-page': '485', 'article-title': 'Energy-dependent reduced drug binding as a mechanism of vinca alkaloid resistance in leukemic lymphoblasts', 'volume': '24', 'author': 'Beck', 'year': '1983', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Energy-dependent reduced drug binding as a mechanism of vinca alkaloid resistance in leukemic lymphoblasts by Beck (1983)
10.1016/0006-2952(87)90198-5 / Biochem. Pharmacol. / The cell biology of multiple drug resistance by Beck (1987)
{'key': '10.1006/taap.1996.8086_TO968086C6', 'series-title': 'Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells', 'author': 'Beck', 'year': '1991'} / Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells by Beck (1991)
10.1016/0092-8674(86)90595-7 / Cell / Internal duplication and homology with bacterial transport proteins in themdr1 by Chen (1986)
10.1128/MCB.9.9.3808 / Mol. Cell. Biol. / Structure and expression of the humanMDR by Chin (1989)
{'key': '10.1006/taap.1996.8086_TO968086C9', 'series-title': 'Ivermectin and Abamectin', 'article-title': 'Metabolism and tissue residues', 'author': 'Chiu', 'year': '1989'} / Ivermectin and Abamectin / Metabolism and tissue residues by Chiu (1989)
10.1073/pnas.86.2.695 / Proc. Natl. Acad. Sci. USA / Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood–brain barrier sites by Cordon-Cardo (1989)
10.1016/S0140-6736(94)91625-X / Lancet / Ivermectin for spasticity in spinal-cord injury by Costa (1994)
10.1128/MCB.9.3.1346 / Mol. Cell. Biol. / The three mouse multidrug resistance (mdr by Croop (1989)
{'key': '10.1006/taap.1996.8086_TO968086C13', 'first-page': '156', 'article-title': 'P-glycoprotein and multidrug resistance in cancer chemotherapy', 'volume': '16', 'author': 'Deuchars', 'year': '1989', 'journal-title': 'Semin. Oncol.'} / Semin. Oncol. / P-glycoprotein and multidrug resistance in cancer chemotherapy by Deuchars (1989)
10.1128/MCB.7.11.4075 / Mol. Cell. Biol. / Simultaneous expression of two P-glycoprotein genes in drug sensitive Chinese hamster ovary cells by Endicott (1987)
10.1146/annurev.bi.58.070189.001033 / Annu. Rev. Biochem. / The biochemistry of P-glycoprotein-mediated multidrug resistance by Endicott (1989)
{'key': '10.1006/taap.1996.8086_TO968086C16', 'series-title': 'Ivermectin and Abamectin', 'first-page': '131', 'article-title': 'Chemistry', 'author': 'Fisher', 'year': '1989'} / Ivermectin and Abamectin / Chemistry by Fisher (1989)
10.1200/JCO.1987.5.9.1452 / J. Clin. Oncol. / P-glycoprotein in human sarcoma: Evidence for multidrug resistance by Gerlach (1987)
10.1093/jnci/81.2.116 / J. Natl. Cancer Inst. / Expression of a multidrug resistance gene in human cancers by Goldstein (1989)
10.1146/annurev.bi.62.070193.002125 / Annu. Rev. Biochem. / Biochemistry of multidrug resistance mediated by the multidrug transporter by Gottesman (1993)
10.1016/0092-8674(86)90594-5 / Cell / Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins by Gros (1986)
10.1038/227680a0 / Nature / Cleavage of structural proteins during the assembly of the head of bacteriophage T4 by Laemmli (1970)
{'key': '10.1006/taap.1996.8086_TO968086C22', 'series-title': 'Ivermectin and Abamectin', 'first-page': '131', 'article-title': 'Toxicology', 'author': 'Lankas', 'year': '1989'} / Ivermectin and Abamectin / Toxicology by Lankas (1989)
10.1016/S0889-8588(18)30097-2 / Hematol. Oncol. Clin. NA / MDR expression in normal tissues—Pharmacological implications for the clinical use of P-glycoprotein inhibitors by Lum (1995)
MECTIZAN Program Notes, Issue 12, 1994, MECTIZAN Donation Program, One Copenhill, Atlanta, GA
10.1016/0092-8674(94)90212-7 / Cell / Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs by Schinkel (1994)
10.1172/JCI118214 / J. Clin. Invest. / Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A by Schinkel (1995)
10.1073/pnas.84.21.7735 / Proc. Natl. Acad. Sci. USA / Cellular localization of the multidrug resistance gene product in normal human tissues by Thiebaut (1989)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 6:01 p.m.)
Deposited	4 years, 4 months ago (May 3, 2021, 2:35 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:14 a.m.)
Issued	28 years, 5 months ago (April 1, 1997)
Published	28 years, 5 months ago (April 1, 1997)
Published Print	28 years, 5 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Lankas_1997, title={P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity}, volume={143}, ISSN={0041-008X}, url={http://dx.doi.org/10.1006/taap.1996.8086}, DOI={10.1006/taap.1996.8086}, number={2}, journal={Toxicology and Applied Pharmacology}, publisher={Elsevier BV}, author={Lankas, George R. and Cartwright, Mark E. and Umbenhauer, Diane}, year={1997}, month=apr, pages={357–365} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:14:07Z",
    "timestamp": 1754108047787
  },
  "reference-count": 27,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1997,
            4,
            1
          ]
        ],
        "date-time": "1997-04-01T00:00:00Z",
        "timestamp": 859852800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        4
      ]
    ]
  },
  "DOI": "10.1006/taap.1996.8086",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        18
      ]
    ],
    "date-time": "2002-09-18T22:01:25Z",
    "timestamp": 1032386485000
  },
  "page": "357-365",
  "source": "Crossref",
  "is-referenced-by-count": 160,
  "title": "P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity",
  "prefix": "10.1006",
  "volume": "143",
  "author": [
    {
      "given": "George R.",
      "family": "Lankas",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Mark E.",
      "family": "Cartwright",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Diane",
      "family": "Umbenhauer",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/taap.1996.8086_TO968086C1",
      "doi-asserted-by": "crossref",
      "first-page": "4216",
      "DOI": "10.1021/ja00404a040",
      "article-title": "Avermectins. Structure determination",
      "volume": "103",
      "author": "Albers-Schonberg",
      "year": "1981",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C2",
      "doi-asserted-by": "crossref",
      "first-page": "27127",
      "DOI": "10.1016/S0021-9258(19)74226-4",
      "article-title": "Targeted disruption of the mousemdr1bmdr",
      "volume": "268",
      "author": "Altuvia",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C3",
      "doi-asserted-by": "crossref",
      "first-page": "286",
      "DOI": "10.2307/3283936",
      "article-title": "The mechanism of action of avermectins inCaenorhabditis elegans:",
      "volume": "81",
      "author": "Arena",
      "year": "1995",
      "journal-title": "J. Parasitol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C4",
      "first-page": "485",
      "article-title": "Energy-dependent reduced drug binding as a mechanism of vinca alkaloid resistance in leukemic lymphoblasts",
      "volume": "24",
      "author": "Beck",
      "year": "1983",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C5",
      "doi-asserted-by": "crossref",
      "first-page": "2879",
      "DOI": "10.1016/0006-2952(87)90198-5",
      "article-title": "The cell biology of multiple drug resistance",
      "volume": "36",
      "author": "Beck",
      "year": "1987",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C6",
      "series-title": "Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells",
      "author": "Beck",
      "year": "1991"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C7",
      "doi-asserted-by": "crossref",
      "first-page": "381",
      "DOI": "10.1016/0092-8674(86)90595-7",
      "article-title": "Internal duplication and homology with bacterial transport proteins in themdr1",
      "volume": "47",
      "author": "Chen",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C8",
      "doi-asserted-by": "crossref",
      "first-page": "3808",
      "DOI": "10.1128/MCB.9.9.3808",
      "article-title": "Structure and expression of the humanMDR",
      "volume": "9",
      "author": "Chin",
      "year": "1989",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C9",
      "series-title": "Ivermectin and Abamectin",
      "article-title": "Metabolism and tissue residues",
      "author": "Chiu",
      "year": "1989"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C10",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1073/pnas.86.2.695",
      "article-title": "Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood\u2013brain barrier sites",
      "volume": "86",
      "author": "Cordon-Cardo",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C11",
      "doi-asserted-by": "crossref",
      "first-page": "739",
      "DOI": "10.1016/S0140-6736(94)91625-X",
      "article-title": "Ivermectin for spasticity in spinal-cord injury",
      "volume": "343",
      "author": "Costa",
      "year": "1994",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C12",
      "doi-asserted-by": "crossref",
      "first-page": "1346",
      "DOI": "10.1128/MCB.9.3.1346",
      "article-title": "The three mouse multidrug resistance (mdr",
      "volume": "9",
      "author": "Croop",
      "year": "1989",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C13",
      "first-page": "156",
      "article-title": "P-glycoprotein and multidrug resistance in cancer chemotherapy",
      "volume": "16",
      "author": "Deuchars",
      "year": "1989",
      "journal-title": "Semin. Oncol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C14",
      "doi-asserted-by": "crossref",
      "first-page": "4075",
      "DOI": "10.1128/MCB.7.11.4075",
      "article-title": "Simultaneous expression of two P-glycoprotein genes in drug sensitive Chinese hamster ovary cells",
      "volume": "7",
      "author": "Endicott",
      "year": "1987",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C15",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1146/annurev.bi.58.070189.001033",
      "article-title": "The biochemistry of P-glycoprotein-mediated multidrug resistance",
      "volume": "58",
      "author": "Endicott",
      "year": "1989",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C16",
      "series-title": "Ivermectin and Abamectin",
      "first-page": "131",
      "article-title": "Chemistry",
      "author": "Fisher",
      "year": "1989"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C17",
      "doi-asserted-by": "crossref",
      "first-page": "1452",
      "DOI": "10.1200/JCO.1987.5.9.1452",
      "article-title": "P-glycoprotein in human sarcoma: Evidence for multidrug resistance",
      "volume": "5",
      "author": "Gerlach",
      "year": "1987",
      "journal-title": "J. Clin. Oncol."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C18",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1093/jnci/81.2.116",
      "article-title": "Expression of a multidrug resistance gene in human cancers",
      "volume": "81",
      "author": "Goldstein",
      "year": "1989",
      "journal-title": "J. Natl. Cancer Inst."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C19",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1146/annurev.bi.62.070193.002125",
      "article-title": "Biochemistry of multidrug resistance mediated by the multidrug transporter",
      "volume": "62",
      "author": "Gottesman",
      "year": "1993",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C20",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1016/0092-8674(86)90594-5",
      "article-title": "Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins",
      "volume": "47",
      "author": "Gros",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C21",
      "doi-asserted-by": "crossref",
      "first-page": "680",
      "DOI": "10.1038/227680a0",
      "article-title": "Cleavage of structural proteins during the assembly of the head of bacteriophage T4",
      "volume": "227",
      "author": "Laemmli",
      "year": "1970",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C22",
      "series-title": "Ivermectin and Abamectin",
      "first-page": "131",
      "article-title": "Toxicology",
      "author": "Lankas",
      "year": "1989"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C23",
      "doi-asserted-by": "crossref",
      "first-page": "319",
      "DOI": "10.1016/S0889-8588(18)30097-2",
      "article-title": "MDR expression in normal tissues\u2014Pharmacological implications for the clinical use of P-glycoprotein inhibitors",
      "volume": "9",
      "author": "Lum",
      "year": "1995",
      "journal-title": "Hematol. Oncol. Clin. NA"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C24",
      "unstructured": "MECTIZAN Program Notes, Issue 12, 1994, MECTIZAN Donation Program, One Copenhill, Atlanta, GA"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C25",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1016/0092-8674(94)90212-7",
      "article-title": "Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood\u2013brain barrier and to increased sensitivity to drugs",
      "volume": "77",
      "author": "Schinkel",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C26",
      "doi-asserted-by": "crossref",
      "first-page": "1698",
      "DOI": "10.1172/JCI118214",
      "article-title": "Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A",
      "volume": "96",
      "author": "Schinkel",
      "year": "1995",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1006/taap.1996.8086_TO968086C27",
      "doi-asserted-by": "crossref",
      "first-page": "7735",
      "DOI": "10.1073/pnas.84.21.7735",
      "article-title": "Cellular localization of the multidrug resistance gene product in normal human tissues",
      "volume": "84",
      "author": "Thiebaut",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    }
  ],
  "container-title": "Toxicology and Applied Pharmacology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0041008X96980862?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0041008X96980862?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        3
      ]
    ],
    "date-time": "2021-05-03T06:35:38Z",
    "timestamp": 1620023738000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0041008X96980862"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        4
      ]
    ]
  },
  "references-count": 27,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1997,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S0041008X96980862"
  ],
  "URL": "http://dx.doi.org/10.1006/taap.1996.8086",
  "relation": {},
  "ISSN": [
    "0041-008X"
  ],
  "subject": [],
  "container-title-short": "Toxicology and Applied Pharmacology",
  "published": {
    "date-parts": [
      [
        1997,
        4
      ]
    ]
  }
}