Crossref journal-article
Elsevier BV
Seminars in Immunology (78)
Bibliography

Zinkernagel, R. M. (2000). Localization dose and time of antigens determine immune reactivity. Seminars in Immunology, 12(3), 163–171.

Authors 1
  1. Rolf M. Zinkernagel (first)
References 67 Referenced 163
  1. 10.1111/j.1600-065X.1991.tb00601.x / Immunol Rev / T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease by Zinkernagel (1991)
  2. {'key': '10.1006/smim.2000.0253_RF2', 'article-title': 'Antigen localisation regulates immune responses in a dose and time-dependent fashion: a geographical view of immune reactivity', 'volume': '156', 'author': 'Zinkenagel', 'year': '1997', 'journal-title': 'Immunol Rev'} / Immunol Rev / Antigen localisation regulates immune responses in a dose and time-dependent fashion: a geographical view of immune reactivity by Zinkenagel (1997)
  3. 10.1126/science.81.2099.298 / Science / A filterable virus recovered from white mice by Traub (1935)
  4. 10.1038/172603a0 / Nature / Actively aquired tolerance of foreign cells by Billingham (1953)
  5. {'key': '10.1006/smim.2000.0253_RF5', 'article-title': 'Infectious immunological tolerance', 'volume': '21', 'author': 'Gershon', 'year': '1971', 'journal-title': 'Immunology'} / Immunology / Infectious immunological tolerance by Gershon (1971)
  6. {'key': '10.1006/smim.2000.0253_RF6', 'article-title': 'Towards a network theory of the immune system', 'volume': '125C', 'author': 'Jerne', 'year': '1974', 'journal-title': 'Ann Immunol (Paris)'} / Ann Immunol (Paris) / Towards a network theory of the immune system by Jerne (1974)
  7. {'key': '10.1006/smim.2000.0253_RF7', 'article-title': 'A theory of self–nonself discrimination', 'volume': '169', 'author': 'Bretscher', 'year': '1970', 'journal-title': 'Science'} / Science / A theory of self–nonself discrimination by Bretscher (1970)
  8. 10.1126/science.271.5256.1723 / Science / Neonatal tolerance revisited: turning on newborn T cells with dendritic cells [see comments] by Ridge (1996)
  9. 10.1126/science.271.5256.1726 / Science / Induction of protective CTL responses in newborn mice by a murine retrovirus [see comments] by Sarzotti (1996)
  10. 10.1126/science.271.5256.1728 / Science / Induction of TH1 and TH2 immunity in neonatal mice [see comments] by Forsthuber (1996)
  11. 10.1038/icb.1975.3 / Aust J Exp Biol Med Sci / A new analysis of allogeneic interactions by Lafferty (1975)
  12. 10.1126/science.2113314 / Science / A cell culture model for T lymphocyte clonal anergy by Schwartz (1990)
  13. 10.1084/jem.184.1.1 / J Exp Med / Models of T cell anergy: is there a common molecular mechanism? [comment] by Schwartz (1996)
  14. 10.1146/annurev.iy.12.040194.005015 / Annu Rev Immunol / Tolerance, danger, and the extended family by Matzinger (1994)
  15. 10.1126/science.271.5246.173 / Science / Immunology taught by viruses by Zinkernagel (1996)
  16. {'key': '10.1006/smim.2000.0253_RF16', 'article-title': 'The influence of virus structure on antibody responses and virus serotype formation', 'volume': '12', 'author': 'Bachmann', 'year': '1996', 'journal-title': 'Immunol Today'} / Immunol Today / The influence of virus structure on antibody responses and virus serotype formation by Bachmann (1996)
  17. 10.1084/jem.185.12.2157 / J Exp Med / On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (alylaly) and spleenless (Hox11(−)/−) mutant mice by Karrer (1997)
  18. 10.1084/jem.188.8.1493 / J Exp Med / Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue by Ludewig (1998)
  19. 10.1016/0092-8674(91)90164-T / Cell / Ablation of “tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice by Ohashi (1991)
  20. 10.1073/pnas.96.5.2233 / Proc Natl Acad Sci USA / Immune surveillance against a solid tumor fails because of immunological ignorance by Ochsenbein (1999)
  21. 10.1016/0092-8674(90)90420-J / Cell / Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity by Webb (1990)
  22. {'key': '10.1006/smim.2000.0253_RF22', 'article-title': 'Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells [published erratum appears in Nature 1993 Jul 15, 364(6434):262]', 'volume': '362', 'author': 'Moskophidis', 'year': '1993', 'journal-title': 'Nature'} / Nature / Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells [published erratum appears in Nature 1993 Jul 15, 364(6434):262] by Moskophidis (1993)
  23. 10.1038/2001 / Nat Med / Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection by Ehl (1998)
  24. 10.1084/jem.143.6.1429 / J Exp Med / Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen by Möller (1976)
  25. 10.1159/000228405 / Int Arch Allergy / Experimental studies on the pathogenesis of contact eczema in the guinea-pig by Frey (1957)
  26. 10.1016/S0065-2776(08)60501-5 / Adv Immunol / Immunological memory by Mackay (1993)
  27. 10.1073/pnas.94.2.640 / Proc Natl Acad Sci USA / Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without “memory T cells"? by Bachmann (1997)
  28. 10.1073/pnas.93.18.9716 / Proc Natl Acad Sci USA / On the role of antigen in maintaining cytotoxic T-cell memory by Kundig (1996)
  29. 10.1016/S0167-5699(99)01474-7 / Immunol Today / Distribution of activated T cells migrating through the body: a matter of life and death by Westermann (1999)
  30. 10.1126/science.7761853 / Science / Fibroblasts as efficient antigen-presenting cells in lymphoid organs by Kundig (1995)
  31. 10.1084/jem.186.5.645 / J Exp Med / Self antigens expressed by solid tumors do not efficiently stimulate naive or activated T cells: implications for immunotherapy by Speiser (1997)
  32. 10.4049/jimmunol.161.5.2187 / J Immunol / Tumor-infiltrating lymphocytes exhibiting high ex vivo cytolytic activity fail to prevent murine melanoma tumor growth in vivo by Prevost-Blondel (1998)
  33. 10.1093/infdis/125.5.520 / J Infect Dis / A model in mice for the pathogenesis and treatment of rabies by Baer (1972)
  34. {'key': '10.1006/smim.2000.0253_RF34', 'article-title': 'Protection against influenza virus encephalitis by adoptive lymphocyte transfer', 'volume': '232', 'author': 'Stavenson', 'year': '1997', 'journal-title': 'Virology'} / Virology / Protection against influenza virus encephalitis by adoptive lymphocyte transfer by Stavenson (1997)
  35. 10.1073/pnas.96.17.9769 / Proc Natl Acad Sci USA / T cell ignorance in mice to Born disease virus can be overcome by peripheral expression of the viral nucleoprotein by Hausmann (1999)
  36. 10.1084/jem.114.1.111 / J Exp Med / The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins by Weigle (1961)
  37. 10.4049/jimmunol.57.2.179 / J Immunol / Isoallergic encephalomyelitis and radiculitis in guinea pigs after one injection of brain and mycobacteria in water-in-oil emulsion by Freund (1947)
  38. 10.1002/eji.1830230834 / Eur J Immunol / T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides by Kyburz (1993)
  39. 10.1084/jem.182.1.261 / J Exp Med / T cell priming versus T cell tolerance induced by synthetic peptides by Aichele (1995)
  40. {'key': '10.1006/smim.2000.0253_RF40', 'article-title': 'Activation versus tolerance: a decision made by T helper cells', 'volume': '54 Pt 2', 'author': 'Guerder', 'year': '1989', 'journal-title': 'Cold Spring Harb Symp Quant Biol'} / Cold Spring Harb Symp Quant Biol / Activation versus tolerance: a decision made by T helper cells by Guerder (1989)
  41. 10.1084/jem.187.5.763 / J Exp Med / Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+T cells to cause immunopathology by Ehl (1998)
  42. 10.1084/jem.186.2.229 / J Exp Med / Antigenic cancer cells grow progressively in immune hosts without evidence of T cell exhaustion or systemic anergy by Wick (1997)
  43. 10.1126/science.8248784 / Science / The influence of antigen organization on B cell responsiveness by Bachmann (1993)
  44. 10.1002/eji.1830251236 / Eur J Immunol / T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction? by Bachmann (1995)
  45. {'key': '10.1006/smim.2000.0253_RF45', 'article-title': 'T- and B-cell recognition of hepatitis B viral antigens', 'volume': '9', 'author': 'Millch', 'year': '1988', 'journal-title': 'Immunol Today'} / Immunol Today / T- and B-cell recognition of hepatitis B viral antigens by Millch (1988)
  46. 10.1073/pnas.73.10.3671 / Proc Natl Acad Sci USA / Molecular determinants of immunogenicity: the immunon model of immune response by Dintzis (1976)
  47. 10.4049/jimmunol.143.4.1239 / J Immunol / The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence by Dintzis (1989)
  48. 10.1084/jem.185.10.1785 / J Exp Med / Role repetitive antigen patterns for induction of antibodies against antibodies by Fehr (1997)
  49. {'key': '10.1006/smim.2000.0253_RF49', 'article-title': 'Virus induced autoantibody response to a transgenic viral antigen', 'volume': '344', 'author': 'Zinkernagel', 'year': '1990', 'journal-title': 'Nature'} / Nature / Virus induced autoantibody response to a transgenic viral antigen by Zinkernagel (1990)
  50. {'key': '10.1006/smim.2000.0253_RF50', 'article-title': 'Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes', 'volume': '337', 'author': 'Namazee', 'year': '1989', 'journal-title': 'Nature'} / Nature / Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes by Namazee (1989)
  51. 10.1038/342385a0 / Nature / Induction of self-tolerance in mature peripheral B lymphocytes [see comments] by Goodnow (1989)
  52. 10.1016/0092-8674(89)90044-5 / Cell / Acquisition of immunologic self-tolerance by Schwartz (1989)
  53. 10.1016/S0092-8674(05)80055-8 / Cell / Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy by Schwartz (1992)
  54. 10.1002/eji.1830201204 / Eur J Immunol / Analysis of the kinetics of antiviral memory T help in vivo: characterization of short-lived cross-reactive T help by Roost (1990)
  55. {'key': '10.1006/smim.2000.0253_RF55', 'article-title': 'Living grafts of endocrine glands', 'volume': '39', 'author': 'Stone', 'year': '1933', 'journal-title': 'Calif West Med'} / Calif West Med / Living grafts of endocrine glands by Stone (1933)
  56. {'key': '10.1006/smim.2000.0253_RF56', 'article-title': 'Acceptance of phenotypically differing cultured skin in man and mice', 'volume': '5', 'author': 'Summerlin', 'year': '1973', 'journal-title': 'Transplant Proc'} / Transplant Proc / Acceptance of phenotypically differing cultured skin in man and mice by Summerlin (1973)
  57. {'key': '10.1006/smim.2000.0253_RF57', 'article-title': 'Immunobiology of tissue transplantation: a return to the passenger leukocyte concept', 'volume': '1:143-73', 'author': 'Lafferty', 'year': '1983', 'journal-title': 'Annu Rev Immunol'} / Annu Rev Immunol / Immunobiology of tissue transplantation: a return to the passenger leukocyte concept by Lafferty (1983)
  58. 10.1016/S0167-5699(98)01301-2 / Immunol Today / Cross-presentation: a general mechanism for CTL immunity and tolerance by Carbone (1998)
  59. {'key': '10.1006/smim.2000.0253_RF59', 'article-title': 'Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen [see comments]', 'volume': '368', 'author': 'Sigal', 'year': '1999', 'journal-title': 'Nature'} / Nature / Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen [see comments] by Sigal (1999)
  60. {'key': '10.1006/smim.2000.0253_RF60', 'article-title': 'Autoaggression and tumor rejection: it takes more than self-specific T-cell activation', 'volume': '169:263-72', 'author': 'Ganss', 'year': '1999', 'journal-title': 'Immunol Rev'} / Immunol Rev / Autoaggression and tumor rejection: it takes more than self-specific T-cell activation by Ganss (1999)
  61. {'key': '10.1006/smim.2000.0253_RF61', 'article-title': 'Peripheral T-cell tolerance: the contribution of permissive T-cell migration into parenchymal tissues of the neonate', 'volume': '169:255-61', 'author': 'Alferink', 'year': '1999', 'journal-title': 'Immunol Rev'} / Immunol Rev / Peripheral T-cell tolerance: the contribution of permissive T-cell migration into parenchymal tissues of the neonate by Alferink (1999)
  62. 10.1038/30989 / Nature / A conditioned dendritic cell can be a temporal bridge between a CD4+T- helper and a T-killer cell by Ridge (1998)
  63. 10.1038/30996 / Nature / Help for cytotoxic-T-cell responses is mediated by CD-40 signalling by Bennett (1998)
  64. 10.1084/jem.183.5.2209 / J Exp Med / CD40–CD40 ligand interactions are critical in T–B cooperation but not for other anti-viral CD4+T cell functions by Oxenius (1996)
  65. 10.1038/nm0598supp-525 / Nat Med / Cancer vaccines by Pardoll (1998)
  66. 10.1038/325192b0 / Nature / Antigen recognition. Class discriminiation in the world of immunology by Bevan (1987)
  67. 10.1038/32183 / Nature / Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs by Albert (1998)
Dates
Type When
Created 22 years, 11 months ago (Sept. 18, 2002, 5:19 p.m.)
Deposited 2 years, 4 months ago (April 3, 2023, 7:24 p.m.)
Indexed 4 months, 3 weeks ago (April 8, 2025, 7:28 p.m.)
Issued 25 years, 2 months ago (June 1, 2000)
Published 25 years, 2 months ago (June 1, 2000)
Published Print 25 years, 2 months ago (June 1, 2000)
Funders 0

None

@article{Zinkernagel_2000, title={Localization dose and time of antigens determine immune reactivity}, volume={12}, ISSN={1044-5323}, url={http://dx.doi.org/10.1006/smim.2000.0253}, DOI={10.1006/smim.2000.0253}, number={3}, journal={Seminars in Immunology}, publisher={Elsevier BV}, author={Zinkernagel, Rolf M.}, year={2000}, month=jun, pages={163–171} }