DOI: 10.1006/nbdi.1999.0250. The Role of Copper in Neurodegenerative Disease

The Role of Copper in Neurodegenerative Disease

10.1006/nbdi.1999.0250

Crossref journal-article

Elsevier BV

Neurobiology of Disease (78)

Bibliography

Waggoner, D. J., Bartnikas, T. B., & Gitlin, J. D. (1999). The Role of Copper in Neurodegenerative Disease. Neurobiology of Disease, 6(4), 221â230.

Authors 3

Darrel J. Waggoner (first)
Thomas B. Bartnikas (additional)
Jonathan D. Gitlin (additional)

References 98 Referenced 761

10.1176/jnp.3.4.377 / J. Neuropsychol. Clin. Neurosci. / The psychiatric presentations of Wilson's disease by Akil (1991)
10.1016/0092-8674(94)90346-8 / Cell / The FET3 gene of S. Cerevisiae encodes a multicopper oxidase required for ferrous iron uptake by Askwith (1994)
10.1074/jbc.273.21.12817 / J. Biol. Chem. / Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis by Atwood (1998)
10.1038/364584a0 / Nature / ALS, SOD and peroxynitrite by Beckman (1993)
10.1073/pnas.91.17.8292 / Proc. Natl. Acad. Sci. / Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity by Borchelt (1994)
10.1074/jbc.270.7.3234 / J. Biol. Chem. / Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function by Borchelt (1995)
10.1523/JNEUROSCI.19-03-01018.1999 / J. Neurosci. / A novel pineal night-specific ATPase encoded by the Wilson disease gene by Borjigin (1999)
10.1038/37733 / Nature / The cellular prion protein binds copper in vivo by Brown (1997)
10.1042/bj3340423 / Biochem. J. / Prion protein expression and superoxide dismutase activity by Brown (1998)
10.1073/pnas.94.14.7606 / Proc. Natl. Acad. Sci. USA by Bruijn (1997)
10.1126/science.281.5384.1851 / Science / Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1 by Bruijn (1998)
10.1038/356577a0 / Nature / Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein by Büeler (1992)
10.1038/ng1293-327 / Nat. Genet. / The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene by Bull (1993)
10.1074/jbc.273.37.23625 / J. Biol. Chem. / The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase by Casareno (1998)
10.1038/ng0193-14 / Nat. Genet. / Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein by Chelly (1993)
10.1073/pnas.95.11.6361 / Proc. Natl. Acad. Sci. USA / Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants by Corson (1998)
10.1046/j.1471-4159.1997.69051936.x / J. Neurochem. / Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite by Crow (1997)
10.1002/ana.410410212 / Ann. Neurol. / Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis by Cudkowicz (1997)
{'key': '10.1006/nbdi.1999.0250_RF19', 'series-title': 'The Molecular and Metabolic Basis of Inherited Disease', 'article-title': 'Disorders of copper transport', 'author': 'Culotta', 'year': '1999'} / The Molecular and Metabolic Basis of Inherited Disease / Disorders of copper transport by Culotta (1999)
10.1074/jbc.272.38.23469 / J. Biol. Chem. / The copper chaperone for superoxide dismutase by Culotta (1997)
10.1006/bbrc.1995.2749 / Biochem. Biophys. Res. Commun. / A nonsense mutation of the ceruloplasmin deficiency with diabetes mellitus by Daimon (1995)
10.1126/science.8351519 / Science / Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase by Deng (1993)
10.1001/archpsyc.1989.01810120068011 / Arch. Gen. Psychiatry / Wilson's disease: Psychiatric symptoms in 195 cases by Dening (1989)
10.1002/ana.410320716 / Ann. Neurol. / Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative disease affecting the basal ganglia by Dexter (1992)
10.1074/jbc.272.52.33279 / J. Biol. Chem. / Expression, purification, and metal binding properties of the N-terminal domain from the Wilson disease putative copper-transporting ATPase (ATP7B) by DiDonato (1997)
10.1046/j.1471-4159.1997.69052064.x / J. Neurochem. / Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis by Ferrante (1997)
10.1146/annurev.bi.64.070195.000525 / Annu. Rev. Biochem. / Superoxide radical and superoxide dismutases by Fridovich (1995)
10.1016/S0887-8994(97)00092-1 / Pediatr. Neurol. / Early neuroradiologic evidence of degeneration in Menkes disease by Geller (1997)
10.1126/science.8209258 / Science / Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation by Gurney (1994)
10.1073/pnas.92.7.2539 / Proc. Natl. Acad. Sci. USA / Aceruloplasminemia: Molecular characterization of this disorder of iron metabolism by Harris (1995)
10.1093/qjmed/89.5.355 / Q. J. Med. / Familial dementia due to a frameshift mutation in the caeruloplasmin gene by Harris (1995)
10.1093/ajcn/63.5.836 / Am. J. Clin. Nutr. / Genetic and molecular basis for copper toxicity by Harris (1996)
10.1093/ajcn/67.5.972S / Am. J. Clin. Nutr. / Aceruloplasminemia: An inherited neurodegenerative disease with impaired iron homeostasis by Harris (1998)
10.1016/0014-5793(94)00658-X / FEBS Lett. / The βA4 amyloid precursor protein binding to copper by Hesse (1994)
10.1074/jbc.273.13.7765 / J. Biol. Chem. / Reduced fertility in female mice lacking copper-zinc superoxide dismutase by Ho (1998)
10.1006/bbrc.1995.1233 / Biochem. Biophys. Res. Commun. / Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein by Hornshaw (1995)
10.1111/j.1460-9568.1997.tb01511.x / Eur. J. Neurosci. / The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis by Hottinger (1997)
10.1074/jbc.272.34.21461 / J. Biol. Chem. / Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae by Hung (1997)
10.1016/0021-9975(74)90067-X / J. Comp. Pathol. / A comparison of the biochemical changes induced in mouse brain cuprizone toxicity and by scrapie infection by Kimberlin (1974)
10.1172/JCI118768 / J. Clin. Invest. / Ceruloplasmin gene expression in the murine central nervous system by Klomp (1996)
10.1093/hmg/5.12.1989 / Hum. Mol. Genet. / Expression of the ceruloplasmin gene in the human retina and brain: Implications for a pathogenic model in aceruloplasminemia by Klomp (1996)
10.1074/jbc.273.47.31375 / J. Biol. Chem. / Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases by LaFontaine (1998)
10.1177/088307389701200314 / J. Child. Neurol. / Early magnetic resonance imaging findings in Menkes disease by Leventer (1997)
10.1002/ana.410440510 / Ann. Neurol. / Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis by Liu (1998)
{'key': '10.1006/nbdi.1999.0250_RF45', 'first-page': '663', 'article-title': 'Hereditary caeruloplasmin deficiency, dementia and diabetes mellitus', 'volume': '87', 'author': 'Logan', 'year': '1994', 'journal-title': 'Q. J. Med.'} / Q. J. Med. / Hereditary caeruloplasmin deficiency, dementia and diabetes mellitus by Logan (1994)
10.1074/jbc.272.30.18939 / J. Biol. Chem. / N-terminal domains of human copper-transporting adenosine triphosphatases (the Wilson's and Menkes disease proteins) bind copper selectively in vivo and in vitro with stoichiometry of one copper per metal-binding repeat by Lutsenko (1997)
10.1073/pnas.93.22.12240 / Proc. Natl. Acad. Sci. USA / Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein by Lyons (1996)
10.1210/endo.139.9.6289 / Endocrinology / Ovarian function in superoxide dismutase 1 and 2 knockout mice by Matzuk (1998)
10.1074/jbc.273.40.25545 / J. Biol. Chem. / Reversibility of scrapie inactivation is enhanced by copper by McKenzie (1998)
{'key': '10.1006/nbdi.1999.0250_RF50', 'series-title': 'The Molecular and Genetic Basis of Neurological Disease', 'first-page': '1273', 'article-title': 'Disorders of copper metabolism', 'author': 'Menkes', 'year': '1997'} / The Molecular and Genetic Basis of Neurological Disease / Disorders of copper metabolism by Menkes (1997)
10.1038/ng0193-20 / Nat. Genet. / Isolation of a partial candidate gene for Menkes disease by positional cloning by Mercer (1993)
10.1016/0014-5793(96)01104-0 / FEBS Lett. / Metal-dependent α-helix formation promoted by the glycine-rich octapeptide region of prion protein by Miura (1996)
10.1212/WNL.37.5.761 / Neurology / Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration by Miyajima (1987)
10.1016/0891-5849(95)02178-7 / Free Rad. Biol. Med. / Increased plasma lipid peroxidation in patients with aceruloplasminemia by Miyajima (1996)
10.1212/WNL.50.1.130 / Neurology / Increased very long-chain fatty acids in erythrocyte membranes of patients with aceruloplasminemia by Miyajima (1998)
10.1002/ana.410370515 / Ann. Neurol. / Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a Japanese family by Morita (1995)
10.1126/science.271.5254.1406 / Science / The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) by Multhaup (1996)
10.1021/bi980022m / Biochemistry / Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide by Multhaup (1998)
10.1007/BF02346185 / Hum. Genet. / Hereditary ceruloplasmin deficiency with hemosiderosis by Okamoto (1996)
10.1073/pnas.95.26.15763 / Proc. Natl. Acad. Sci. USA / Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase by Pasinelli (1998)
10.1074/jbc.272.32.20185 / J. Biol. Chem. / A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes by Patel (1997)
10.1016/S0034-5288(18)34168-7 / Res. Vet. Sci. / Clinical and histological observations on cuprizone toxicity and scrapie in mice by Pattison (1971)
10.1074/jbc.273.50.33107 / J. Biol. Chem. / Copper stimulates endocytosis of the prion protein by Pauly (1998)
10.1074/jbc.273.6.3765 / J Biol. Chem. / Functional expression of the Menkes disease protein reveals common biochemical mechanisms among the copper-transporting P-type ATPases by Payne (1998)
10.1073/pnas.95.18.10854 / Proc. Natl. Acad. Sci. USA / Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation by Payne (1998)
10.1002/j.1460-2075.1996.tb00997.x / EMBO J. / Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking by Petris (1996)
10.1093/hmg/7.13.2063 / Hum. Mol. Genet. / A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network by Petris (1998)
10.1093/hmg/3.9.1647 / Hum. Mol. Genet. / Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: Genomic organization, alternative splicing, and structure/function predicting by Petrukhin (1994)
10.1146/annurev.neuro.21.1.479 / Annu. Rev. Neurosci. / Mutant genes in familial Alzheimer's disease and transgenic mice by Price (1998)
10.1126/science.278.5336.245 / Science / Prion diseases and the BSE crisis by Prusiner (1997)
10.1073/pnas.92.7.3024 / Proc. Natl. Acad. Sci. USA / Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: Studies in yeast and neural cells by Rabizadeh (1995)
10.1038/ng0596-43 / Nat. Genet. / Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury by Reaume (1996)
10.1073/pnas.92.3.689 / Proc. Natl. Acad. Sci. USA / Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis by Ripps (1995)
10.1038/362059a0 / Nature / Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis by Rosen (1993)
10.1046/j.1471-4159.1999.0720422.x / J. Neurochem. / The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain by Rothstein (1999)
10.1002/(SICI)1097-4547(19981015)54:2<147::AID-JNR3>3.0.CO;2-E / J. Neurosci. Res. / Ran-2, a glial lineage marker, is a GPI-anchored form of ceruloplasmin by Salzer (1998)
{'key': '10.1006/nbdi.1999.0250_RF77', 'first-page': '5128', 'article-title': 'Mechanisms of copper incorporation during the biosynthesis of human ceruloplasmin', 'volume': '266', 'author': 'Sato', 'year': '1991', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Mechanisms of copper incorporation during the biosynthesis of human ceruloplasmin by Sato (1991)
{'key': '10.1006/nbdi.1999.0250_RF78', 'first-page': 'G311', 'article-title': "Genetic disorders of membrane transport IV. Wilson's disease and Menkes disease", 'volume': '276', 'author': 'Schaefer', 'year': '1999', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Genetic disorders of membrane transport IV. Wilson's disease and Menkes disease by Schaefer (1999)
{'key': '10.1006/nbdi.1999.0250_RF79', 'article-title': 'Hepatocyte-specific localization, copper-dependent trafficking and developmental expression of the Wilson disease protein in the liver', 'author': 'Schaefer', 'year': '1999', 'journal-title': 'Am J Physiol.'} / Am J Physiol. / Hepatocyte-specific localization, copper-dependent trafficking and developmental expression of the Wilson disease protein in the liver by Schaefer (1999)
10.1016/S0962-8924(98)01363-4 / Trends Cell Biol. / The cell biology of beta-amyloid protein and prescinillin in Alzheimer's disease by Selkoe (1998)
10.1212/WNL.47.4_Suppl_2.27S / Neurology / Molecular genetic basis of familial ALS by Siddique (1996)
10.1021/bi972827k / Biochem. / Prion protein selectively binds copper(II) ions by Stockel (1998)
10.1093/hmg/5.1.81 / Hum. Mol. Genet. / Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease by Takahashi (1996)
10.1038/ng1293-344 / Nat. Genet. / The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene by Tanzi (1993)
10.1126/science.278.5339.817 / Science / Delivering copper inside yeast and human cells by Valentine (1997)
10.1038/ng0193-7 / Nat. Genet. / Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase by Vulpe (1993)
10.1038/5979 / Nat. Genet. / Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse by Vulpe (1999)
{'key': '10.1006/nbdi.1999.0250_RF88', 'first-page': '253', 'article-title': "Wilson's disease presenting with features of hepatic dysfunction: A clinical analysis of eighty-seven patients", 'volume': '70', 'author': 'Walshe', 'year': '1989', 'journal-title': 'Q. J. Med.'} / Q. J. Med. / Wilson's disease presenting with features of hepatic dysfunction: A clinical analysis of eighty-seven patients by Walshe (1989)
10.1126/science.271.5248.515 / Science / Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis by Wiedau-Pazos (1996)
10.1038/4553 / Nat. Neurosci. / Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons by Williamson (1999)
10.1016/0896-6273(95)90259-7 / Neuron / An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria by Wong (1995)
10.1016/S0959-4388(98)80123-2 / Curr. Opin. Neurobiol. / The genetic and molecular mechanisms of motor neuron disease by Wong (1998)
10.1006/bbrc.1993.2471 / Biochem. Biophys. Res. Commun. / Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease by Yamaguchi (1993)
10.1016/S0022-510X(98)00015-X / J. Neurol. Sci. / A novel splicing mutation in the ceruloplasmin gene responsible for hereditary ceruloplasmin deficiency with hemosiderosis by Yazaki (1998)
10.1073/pnas.92.7.2632 / Proc. Natl. Acad. Sci. USA / The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake by Yuan (1995)
10.1074/jbc.272.41.25787 / J. Biol. Chem. / Restriction of copper export in Saccharomyces cerevisiae to a late Golgi or post-Golgi compartment in the secretory pathway by Yuan (1997)
10.1073/pnas.93.12.5709 / Proc. Natl. Acad. Sci. USA / A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide by Yim (1996)
10.1038/ng0395-267 / Nat. Genet. / A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis humans by Yoshida (1995)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 11:46 a.m.)
Deposited	5 years, 8 months ago (Dec. 15, 2019, 8:47 p.m.)
Indexed	21 minutes ago (Sept. 6, 2025, 3:09 p.m.)
Issued	26 years, 1 month ago (Aug. 1, 1999)
Published	26 years, 1 month ago (Aug. 1, 1999)
Published Print	26 years, 1 month ago (Aug. 1, 1999)

Funders 0

None

BibTeX

@article{Waggoner_1999, title={The Role of Copper in Neurodegenerative Disease}, volume={6}, ISSN={0969-9961}, url={http://dx.doi.org/10.1006/nbdi.1999.0250}, DOI={10.1006/nbdi.1999.0250}, number={4}, journal={Neurobiology of Disease}, publisher={Elsevier BV}, author={Waggoner, Darrel J. and Bartnikas, Thomas B. and Gitlin, Jonathan D.}, year={1999}, month=aug, pages={221–230} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        6
      ]
    ],
    "date-time": "2025-09-06T19:09:24Z",
    "timestamp": 1757185764152
  },
  "reference-count": 98,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            8,
            1
          ]
        ],
        "date-time": "1999-08-01T00:00:00Z",
        "timestamp": 933465600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        8
      ]
    ]
  },
  "DOI": "10.1006/nbdi.1999.0250",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        18
      ]
    ],
    "date-time": "2002-09-18T15:46:43Z",
    "timestamp": 1032364003000
  },
  "page": "221-230",
  "source": "Crossref",
  "is-referenced-by-count": 761,
  "title": "The Role of Copper in Neurodegenerative Disease",
  "prefix": "10.1006",
  "volume": "6",
  "author": [
    {
      "given": "Darrel J.",
      "family": "Waggoner",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Thomas B.",
      "family": "Bartnikas",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jonathan D.",
      "family": "Gitlin",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/nbdi.1999.0250_RF1",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1176/jnp.3.4.377",
      "article-title": "The psychiatric presentations of Wilson's disease",
      "volume": "3",
      "author": "Akil",
      "year": "1991",
      "journal-title": "J. Neuropsychol. Clin. Neurosci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF2",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1016/0092-8674(94)90346-8",
      "article-title": "The FET3 gene of S. Cerevisiae encodes a multicopper oxidase required for ferrous iron uptake",
      "volume": "76",
      "author": "Askwith",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF3",
      "doi-asserted-by": "crossref",
      "first-page": "12817",
      "DOI": "10.1074/jbc.273.21.12817",
      "article-title": "Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis",
      "volume": "273",
      "author": "Atwood",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF4",
      "doi-asserted-by": "crossref",
      "first-page": "584",
      "DOI": "10.1038/364584a0",
      "article-title": "ALS, SOD and peroxynitrite",
      "volume": "364",
      "author": "Beckman",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF5",
      "doi-asserted-by": "crossref",
      "first-page": "8292",
      "DOI": "10.1073/pnas.91.17.8292",
      "article-title": "Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity",
      "volume": "91",
      "author": "Borchelt",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF6",
      "doi-asserted-by": "crossref",
      "first-page": "3234",
      "DOI": "10.1074/jbc.270.7.3234",
      "article-title": "Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function",
      "volume": "270",
      "author": "Borchelt",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF7",
      "doi-asserted-by": "crossref",
      "first-page": "1018",
      "DOI": "10.1523/JNEUROSCI.19-03-01018.1999",
      "article-title": "A novel pineal night-specific ATPase encoded by the Wilson disease gene",
      "volume": "19",
      "author": "Borjigin",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF8",
      "doi-asserted-by": "crossref",
      "first-page": "684",
      "DOI": "10.1038/37733",
      "article-title": "The cellular prion protein binds copper in vivo",
      "volume": "390",
      "author": "Brown",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF9",
      "doi-asserted-by": "crossref",
      "first-page": "423",
      "DOI": "10.1042/bj3340423",
      "article-title": "Prion protein expression and superoxide dismutase activity",
      "volume": "334",
      "author": "Brown",
      "year": "1998",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF10",
      "doi-asserted-by": "crossref",
      "first-page": "7606",
      "DOI": "10.1073/pnas.94.14.7606",
      "volume": "94",
      "author": "Bruijn",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF11",
      "doi-asserted-by": "crossref",
      "first-page": "1851",
      "DOI": "10.1126/science.281.5384.1851",
      "article-title": "Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1",
      "volume": "281",
      "author": "Bruijn",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF12",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1038/356577a0",
      "article-title": "Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein",
      "volume": "356",
      "author": "B\u00fceler",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF13",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1038/ng1293-327",
      "article-title": "The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene",
      "volume": "5",
      "author": "Bull",
      "year": "1993",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF14",
      "doi-asserted-by": "crossref",
      "first-page": "23625",
      "DOI": "10.1074/jbc.273.37.23625",
      "article-title": "The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase",
      "volume": "273",
      "author": "Casareno",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF15",
      "doi-asserted-by": "crossref",
      "first-page": "14",
      "DOI": "10.1038/ng0193-14",
      "article-title": "Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein",
      "volume": "3",
      "author": "Chelly",
      "year": "1993",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF16",
      "doi-asserted-by": "crossref",
      "first-page": "6301",
      "DOI": "10.1073/pnas.95.11.6361",
      "article-title": "Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants",
      "volume": "95",
      "author": "Corson",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF17",
      "doi-asserted-by": "crossref",
      "first-page": "1936",
      "DOI": "10.1046/j.1471-4159.1997.69051936.x",
      "article-title": "Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite",
      "volume": "69",
      "author": "Crow",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF18",
      "doi-asserted-by": "crossref",
      "first-page": "210",
      "DOI": "10.1002/ana.410410212",
      "article-title": "Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis",
      "volume": "41",
      "author": "Cudkowicz",
      "year": "1997",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF19",
      "series-title": "The Molecular and Metabolic Basis of Inherited Disease",
      "article-title": "Disorders of copper transport",
      "author": "Culotta",
      "year": "1999"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF20",
      "doi-asserted-by": "crossref",
      "first-page": "23469",
      "DOI": "10.1074/jbc.272.38.23469",
      "article-title": "The copper chaperone for superoxide dismutase",
      "volume": "272",
      "author": "Culotta",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF21",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1006/bbrc.1995.2749",
      "article-title": "A nonsense mutation of the ceruloplasmin deficiency with diabetes mellitus",
      "volume": "217",
      "author": "Daimon",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF22",
      "doi-asserted-by": "crossref",
      "first-page": "1047",
      "DOI": "10.1126/science.8351519",
      "article-title": "Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase",
      "volume": "261",
      "author": "Deng",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF23",
      "doi-asserted-by": "crossref",
      "first-page": "1126",
      "DOI": "10.1001/archpsyc.1989.01810120068011",
      "article-title": "Wilson's disease: Psychiatric symptoms in 195 cases",
      "volume": "46",
      "author": "Dening",
      "year": "1989",
      "journal-title": "Arch. Gen. Psychiatry"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF24",
      "doi-asserted-by": "crossref",
      "first-page": "S94",
      "DOI": "10.1002/ana.410320716",
      "article-title": "Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative disease affecting the basal ganglia",
      "volume": "32",
      "author": "Dexter",
      "year": "1992",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF25",
      "doi-asserted-by": "crossref",
      "first-page": "33279",
      "DOI": "10.1074/jbc.272.52.33279",
      "article-title": "Expression, purification, and metal binding properties of the N-terminal domain from the Wilson disease putative copper-transporting ATPase (ATP7B)",
      "volume": "272",
      "author": "DiDonato",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF26",
      "doi-asserted-by": "crossref",
      "first-page": "2064",
      "DOI": "10.1046/j.1471-4159.1997.69052064.x",
      "article-title": "Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis",
      "volume": "69",
      "author": "Ferrante",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF27",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1146/annurev.bi.64.070195.000525",
      "article-title": "Superoxide radical and superoxide dismutases",
      "volume": "64",
      "author": "Fridovich",
      "year": "1995",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF28",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1016/S0887-8994(97)00092-1",
      "article-title": "Early neuroradiologic evidence of degeneration in Menkes disease",
      "volume": "17",
      "author": "Geller",
      "year": "1997",
      "journal-title": "Pediatr. Neurol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF29",
      "doi-asserted-by": "crossref",
      "first-page": "1772",
      "DOI": "10.1126/science.8209258",
      "article-title": "Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation",
      "volume": "264",
      "author": "Gurney",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF30",
      "doi-asserted-by": "crossref",
      "first-page": "2539",
      "DOI": "10.1073/pnas.92.7.2539",
      "article-title": "Aceruloplasminemia: Molecular characterization of this disorder of iron metabolism",
      "volume": "92",
      "author": "Harris",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF31",
      "doi-asserted-by": "crossref",
      "first-page": "355",
      "DOI": "10.1093/qjmed/89.5.355",
      "article-title": "Familial dementia due to a frameshift mutation in the caeruloplasmin gene",
      "volume": "89",
      "author": "Harris",
      "year": "1995",
      "journal-title": "Q. J. Med."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF32",
      "doi-asserted-by": "crossref",
      "first-page": "836S",
      "DOI": "10.1093/ajcn/63.5.836",
      "article-title": "Genetic and molecular basis for copper toxicity",
      "volume": "63",
      "author": "Harris",
      "year": "1996",
      "journal-title": "Am. J. Clin. Nutr."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF33",
      "doi-asserted-by": "crossref",
      "first-page": "972S",
      "DOI": "10.1093/ajcn/67.5.972S",
      "article-title": "Aceruloplasminemia: An inherited neurodegenerative disease with impaired iron homeostasis",
      "volume": "67",
      "author": "Harris",
      "year": "1998",
      "journal-title": "Am. J. Clin. Nutr."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF34",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1016/0014-5793(94)00658-X",
      "article-title": "The \u03b2A4 amyloid precursor protein binding to copper",
      "volume": "349",
      "author": "Hesse",
      "year": "1994",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF35",
      "doi-asserted-by": "crossref",
      "first-page": "7765",
      "DOI": "10.1074/jbc.273.13.7765",
      "article-title": "Reduced fertility in female mice lacking copper-zinc superoxide dismutase",
      "volume": "273",
      "author": "Ho",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF36",
      "doi-asserted-by": "crossref",
      "first-page": "621",
      "DOI": "10.1006/bbrc.1995.1233",
      "article-title": "Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein",
      "volume": "207",
      "author": "Hornshaw",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF37",
      "doi-asserted-by": "crossref",
      "first-page": "1548",
      "DOI": "10.1111/j.1460-9568.1997.tb01511.x",
      "article-title": "The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis",
      "volume": "9",
      "author": "Hottinger",
      "year": "1997",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF38",
      "doi-asserted-by": "crossref",
      "first-page": "21461",
      "DOI": "10.1074/jbc.272.34.21461",
      "article-title": "Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae",
      "volume": "272",
      "author": "Hung",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF39",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1016/0021-9975(74)90067-X",
      "article-title": "A comparison of the biochemical changes induced in mouse brain cuprizone toxicity and by scrapie infection",
      "volume": "84",
      "author": "Kimberlin",
      "year": "1974",
      "journal-title": "J. Comp. Pathol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF40",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1172/JCI118768",
      "article-title": "Ceruloplasmin gene expression in the murine central nervous system",
      "volume": "98",
      "author": "Klomp",
      "year": "1996",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF41",
      "doi-asserted-by": "crossref",
      "first-page": "1989",
      "DOI": "10.1093/hmg/5.12.1989",
      "article-title": "Expression of the ceruloplasmin gene in the human retina and brain: Implications for a pathogenic model in aceruloplasminemia",
      "volume": "5",
      "author": "Klomp",
      "year": "1996",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF42",
      "doi-asserted-by": "crossref",
      "first-page": "31375",
      "DOI": "10.1074/jbc.273.47.31375",
      "article-title": "Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases",
      "volume": "273",
      "author": "LaFontaine",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF43",
      "doi-asserted-by": "crossref",
      "first-page": "222",
      "DOI": "10.1177/088307389701200314",
      "article-title": "Early magnetic resonance imaging findings in Menkes disease",
      "volume": "12",
      "author": "Leventer",
      "year": "1997",
      "journal-title": "J. Child. Neurol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF44",
      "doi-asserted-by": "crossref",
      "first-page": "763",
      "DOI": "10.1002/ana.410440510",
      "article-title": "Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis",
      "volume": "44",
      "author": "Liu",
      "year": "1998",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF45",
      "first-page": "663",
      "article-title": "Hereditary caeruloplasmin deficiency, dementia and diabetes mellitus",
      "volume": "87",
      "author": "Logan",
      "year": "1994",
      "journal-title": "Q. J. Med."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF46",
      "doi-asserted-by": "crossref",
      "first-page": "18939",
      "DOI": "10.1074/jbc.272.30.18939",
      "article-title": "N-terminal domains of human copper-transporting adenosine triphosphatases (the Wilson's and Menkes disease proteins) bind copper selectively in vivo and in vitro with stoichiometry of one copper per metal-binding repeat",
      "volume": "272",
      "author": "Lutsenko",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF47",
      "doi-asserted-by": "crossref",
      "first-page": "12240",
      "DOI": "10.1073/pnas.93.22.12240",
      "article-title": "Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein",
      "volume": "96",
      "author": "Lyons",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF48",
      "doi-asserted-by": "crossref",
      "first-page": "4008",
      "DOI": "10.1210/endo.139.9.6289",
      "article-title": "Ovarian function in superoxide dismutase 1 and 2 knockout mice",
      "volume": "139",
      "author": "Matzuk",
      "year": "1998",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF49",
      "doi-asserted-by": "crossref",
      "first-page": "25545",
      "DOI": "10.1074/jbc.273.40.25545",
      "article-title": "Reversibility of scrapie inactivation is enhanced by copper",
      "volume": "273",
      "author": "McKenzie",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF50",
      "series-title": "The Molecular and Genetic Basis of Neurological Disease",
      "first-page": "1273",
      "article-title": "Disorders of copper metabolism",
      "author": "Menkes",
      "year": "1997"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF51",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1038/ng0193-20",
      "article-title": "Isolation of a partial candidate gene for Menkes disease by positional cloning",
      "volume": "3",
      "author": "Mercer",
      "year": "1993",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF52",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1016/0014-5793(96)01104-0",
      "article-title": "Metal-dependent \u03b1-helix formation promoted by the glycine-rich octapeptide region of prion protein",
      "volume": "396",
      "author": "Miura",
      "year": "1996",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF53",
      "doi-asserted-by": "crossref",
      "first-page": "761",
      "DOI": "10.1212/WNL.37.5.761",
      "article-title": "Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration",
      "volume": "37",
      "author": "Miyajima",
      "year": "1987",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF54",
      "doi-asserted-by": "crossref",
      "first-page": "757",
      "DOI": "10.1016/0891-5849(95)02178-7",
      "article-title": "Increased plasma lipid peroxidation in patients with aceruloplasminemia",
      "volume": "20",
      "author": "Miyajima",
      "year": "1996",
      "journal-title": "Free Rad. Biol. Med."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF55",
      "doi-asserted-by": "crossref",
      "first-page": "130",
      "DOI": "10.1212/WNL.50.1.130",
      "article-title": "Increased very long-chain fatty acids in erythrocyte membranes of patients with aceruloplasminemia",
      "volume": "50",
      "author": "Miyajima",
      "year": "1998",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF56",
      "doi-asserted-by": "crossref",
      "first-page": "646",
      "DOI": "10.1002/ana.410370515",
      "article-title": "Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a Japanese family",
      "volume": "37",
      "author": "Morita",
      "year": "1995",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF57",
      "doi-asserted-by": "crossref",
      "first-page": "1406",
      "DOI": "10.1126/science.271.5254.1406",
      "article-title": "The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)",
      "volume": "271",
      "author": "Multhaup",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF58",
      "doi-asserted-by": "crossref",
      "first-page": "7224",
      "DOI": "10.1021/bi980022m",
      "article-title": "Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide",
      "volume": "37",
      "author": "Multhaup",
      "year": "1998",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF59",
      "doi-asserted-by": "crossref",
      "first-page": "755",
      "DOI": "10.1007/BF02346185",
      "article-title": "Hereditary ceruloplasmin deficiency with hemosiderosis",
      "volume": "97",
      "author": "Okamoto",
      "year": "1996",
      "journal-title": "Hum. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF60",
      "doi-asserted-by": "crossref",
      "first-page": "15763",
      "DOI": "10.1073/pnas.95.26.15763",
      "article-title": "Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase",
      "volume": "95",
      "author": "Pasinelli",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF61",
      "doi-asserted-by": "crossref",
      "first-page": "20185",
      "DOI": "10.1074/jbc.272.32.20185",
      "article-title": "A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes",
      "volume": "272",
      "author": "Patel",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF62",
      "doi-asserted-by": "crossref",
      "first-page": "378",
      "DOI": "10.1016/S0034-5288(18)34168-7",
      "article-title": "Clinical and histological observations on cuprizone toxicity and scrapie in mice",
      "volume": "12",
      "author": "Pattison",
      "year": "1971",
      "journal-title": "Res. Vet. Sci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF63",
      "doi-asserted-by": "crossref",
      "first-page": "33107",
      "DOI": "10.1074/jbc.273.50.33107",
      "article-title": "Copper stimulates endocytosis of the prion protein",
      "volume": "273",
      "author": "Pauly",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF64",
      "doi-asserted-by": "crossref",
      "first-page": "3765",
      "DOI": "10.1074/jbc.273.6.3765",
      "article-title": "Functional expression of the Menkes disease protein reveals common biochemical mechanisms among the copper-transporting P-type ATPases",
      "volume": "273",
      "author": "Payne",
      "year": "1998",
      "journal-title": "J Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF65",
      "doi-asserted-by": "crossref",
      "first-page": "10854",
      "DOI": "10.1073/pnas.95.18.10854",
      "article-title": "Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation",
      "volume": "95",
      "author": "Payne",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF66",
      "doi-asserted-by": "crossref",
      "first-page": "6084",
      "DOI": "10.1002/j.1460-2075.1996.tb00997.x",
      "article-title": "Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking",
      "volume": "15",
      "author": "Petris",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF67",
      "doi-asserted-by": "crossref",
      "first-page": "2063",
      "DOI": "10.1093/hmg/7.13.2063",
      "article-title": "A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network",
      "volume": "7",
      "author": "Petris",
      "year": "1998",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF68",
      "doi-asserted-by": "crossref",
      "first-page": "1647",
      "DOI": "10.1093/hmg/3.9.1647",
      "article-title": "Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: Genomic organization, alternative splicing, and structure/function predicting",
      "volume": "3",
      "author": "Petrukhin",
      "year": "1994",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF69",
      "doi-asserted-by": "crossref",
      "first-page": "479",
      "DOI": "10.1146/annurev.neuro.21.1.479",
      "article-title": "Mutant genes in familial Alzheimer's disease and transgenic mice",
      "volume": "21",
      "author": "Price",
      "year": "1998",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF70",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1126/science.278.5336.245",
      "article-title": "Prion diseases and the BSE crisis",
      "volume": "278",
      "author": "Prusiner",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF71",
      "doi-asserted-by": "crossref",
      "first-page": "3024",
      "DOI": "10.1073/pnas.92.7.3024",
      "article-title": "Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: Studies in yeast and neural cells",
      "volume": "92",
      "author": "Rabizadeh",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF72",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1038/ng0596-43",
      "article-title": "Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury",
      "volume": "13",
      "author": "Reaume",
      "year": "1996",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF73",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1073/pnas.92.3.689",
      "article-title": "Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis",
      "volume": "92",
      "author": "Ripps",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF74",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1038/362059a0",
      "article-title": "Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis",
      "volume": "362",
      "author": "Rosen",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF75",
      "doi-asserted-by": "crossref",
      "first-page": "422",
      "DOI": "10.1046/j.1471-4159.1999.0720422.x",
      "article-title": "The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain",
      "volume": "72",
      "author": "Rothstein",
      "year": "1999",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF76",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1002/(SICI)1097-4547(19981015)54:2<147::AID-JNR3>3.0.CO;2-E",
      "article-title": "Ran-2, a glial lineage marker, is a GPI-anchored form of ceruloplasmin",
      "volume": "54",
      "author": "Salzer",
      "year": "1998",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF77",
      "first-page": "5128",
      "article-title": "Mechanisms of copper incorporation during the biosynthesis of human ceruloplasmin",
      "volume": "266",
      "author": "Sato",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF78",
      "first-page": "G311",
      "article-title": "Genetic disorders of membrane transport IV. Wilson's disease and Menkes disease",
      "volume": "276",
      "author": "Schaefer",
      "year": "1999",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF79",
      "article-title": "Hepatocyte-specific localization, copper-dependent trafficking and developmental expression of the Wilson disease protein in the liver",
      "author": "Schaefer",
      "year": "1999",
      "journal-title": "Am J Physiol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF80",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1016/S0962-8924(98)01363-4",
      "article-title": "The cell biology of beta-amyloid protein and prescinillin in Alzheimer's disease",
      "volume": "8",
      "author": "Selkoe",
      "year": "1998",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF81",
      "doi-asserted-by": "crossref",
      "first-page": "S27",
      "DOI": "10.1212/WNL.47.4_Suppl_2.27S",
      "article-title": "Molecular genetic basis of familial ALS",
      "volume": "47",
      "author": "Siddique",
      "year": "1996",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF82",
      "doi-asserted-by": "crossref",
      "first-page": "7185",
      "DOI": "10.1021/bi972827k",
      "article-title": "Prion protein selectively binds copper(II) ions",
      "volume": "37",
      "author": "Stockel",
      "year": "1998",
      "journal-title": "Biochem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF83",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1093/hmg/5.1.81",
      "article-title": "Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease",
      "volume": "5",
      "author": "Takahashi",
      "year": "1996",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF84",
      "doi-asserted-by": "crossref",
      "first-page": "344",
      "DOI": "10.1038/ng1293-344",
      "article-title": "The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene",
      "volume": "5",
      "author": "Tanzi",
      "year": "1993",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF85",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1126/science.278.5339.817",
      "article-title": "Delivering copper inside yeast and human cells",
      "volume": "278",
      "author": "Valentine",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF86",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1038/ng0193-7",
      "article-title": "Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase",
      "volume": "3",
      "author": "Vulpe",
      "year": "1993",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF87",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1038/5979",
      "article-title": "Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse",
      "volume": "21",
      "author": "Vulpe",
      "year": "1999",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF88",
      "first-page": "253",
      "article-title": "Wilson's disease presenting with features of hepatic dysfunction: A clinical analysis of eighty-seven patients",
      "volume": "70",
      "author": "Walshe",
      "year": "1989",
      "journal-title": "Q. J. Med."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF89",
      "doi-asserted-by": "crossref",
      "first-page": "515",
      "DOI": "10.1126/science.271.5248.515",
      "article-title": "Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis",
      "volume": "271",
      "author": "Wiedau-Pazos",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF90",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1038/4553",
      "article-title": "Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons",
      "volume": "2",
      "author": "Williamson",
      "year": "1999",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF91",
      "doi-asserted-by": "crossref",
      "first-page": "1105",
      "DOI": "10.1016/0896-6273(95)90259-7",
      "article-title": "An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria",
      "volume": "14",
      "author": "Wong",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF92",
      "doi-asserted-by": "crossref",
      "first-page": "791",
      "DOI": "10.1016/S0959-4388(98)80123-2",
      "article-title": "The genetic and molecular mechanisms of motor neuron disease",
      "volume": "8",
      "author": "Wong",
      "year": "1998",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF93",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1006/bbrc.1993.2471",
      "article-title": "Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease",
      "volume": "197",
      "author": "Yamaguchi",
      "year": "1993",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF94",
      "doi-asserted-by": "crossref",
      "first-page": "30",
      "DOI": "10.1016/S0022-510X(98)00015-X",
      "article-title": "A novel splicing mutation in the ceruloplasmin gene responsible for hereditary ceruloplasmin deficiency with hemosiderosis",
      "volume": "156",
      "author": "Yazaki",
      "year": "1998",
      "journal-title": "J. Neurol. Sci."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF95",
      "doi-asserted-by": "crossref",
      "first-page": "2632",
      "DOI": "10.1073/pnas.92.7.2632",
      "article-title": "The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake",
      "volume": "92",
      "author": "Yuan",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF96",
      "doi-asserted-by": "crossref",
      "first-page": "25787",
      "DOI": "10.1074/jbc.272.41.25787",
      "article-title": "Restriction of copper export in Saccharomyces cerevisiae to a late Golgi or post-Golgi compartment in the secretory pathway",
      "volume": "272",
      "author": "Yuan",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF97",
      "doi-asserted-by": "crossref",
      "first-page": "5709",
      "DOI": "10.1073/pnas.93.12.5709",
      "article-title": "A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide",
      "volume": "93",
      "author": "Yim",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/nbdi.1999.0250_RF98",
      "doi-asserted-by": "crossref",
      "first-page": "267",
      "DOI": "10.1038/ng0395-267",
      "article-title": "A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis humans",
      "volume": "9",
      "author": "Yoshida",
      "year": "1995",
      "journal-title": "Nat. Genet."
    }
  ],
  "container-title": "Neurobiology of Disease",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0969996199902504?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0969996199902504?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        12,
        16
      ]
    ],
    "date-time": "2019-12-16T01:47:40Z",
    "timestamp": 1576460860000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0969996199902504"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        8
      ]
    ]
  },
  "references-count": 98,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1999,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S0969996199902504"
  ],
  "URL": "http://dx.doi.org/10.1006/nbdi.1999.0250",
  "relation": {},
  "ISSN": [
    "0969-9961"
  ],
  "subject": [],
  "container-title-short": "Neurobiology of Disease",
  "published": {
    "date-parts": [
      [
        1999,
        8
      ]
    ]
  }
}