DOI: 10.1006/jsbi.1998.3990. The Sodium Channel Has Four Domains Surrounding a Central Pore

The Sodium Channel Has Four Domains Surrounding a Central Pore

10.1006/jsbi.1998.3990

Crossref journal-article

Elsevier BV

Journal of Structural Biology (78)

Bibliography

Sato, C., Sato, M., Iwasaki, A., Doi, T., & Engel, A. (1998). The Sodium Channel Has Four Domains Surrounding a Central Pore. Journal of Structural Biology, 121(3), 314â325.

Authors 5

Chikara Sato (first)
Masahiko Sato (additional)
Akio Iwasaki (additional)
Takeshi Doi (additional)
Andreas Engel (additional)

References 70 Referenced 38

10.1146/annurev.ph.51.030189.002055 / Annu. Rev. Physiol. / Classes of calcium channels in vertebrate cells by Bean (1989)
10.1111/j.1365-2818.1986.tb04669.x / J. Microsc. / Reconstitution of molecule images analysed by correspondence analysis, A tool for structural interpretation by Bretaudiere (1986)
10.1126/science.2493160 / Science / A family of putative potassium channel genes in Drosophila by Butler (1989)
10.1016/0166-2236(86)90004-4 / Trends Neurosci. / Voltage-dependent gating of sodium channels: Correlating structure and function by Catterall (1986)
10.1126/science.2459775 / Science / Structure and function of voltage-sensitive ion channels by Catterall (1988)
10.1085/jgp.98.1.197 / J. Gen. Physiol. / Steady-state gating of batrachotoxin-modified sodium channels. Variability and electrolyte-dependent modulation by Chabala (1991)
10.1016/0896-6273(94)90271-2 / Neuron / Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation by Chahine (1994)
10.1016/S0006-3495(92)81809-X / Biophys. J. / Atomic scale structure and functional models of voltage-gated potassium channels by Durell (1992)
10.1083/jcb.97.6.1834 / J. Cell Biol. / Molecular morphology of the tetrodotoxin-binding sodium channel protein fromElectrophorus electricus by Ellisman (1983)
10.1111/j.1365-2818.1988.tb04602.x / J. Microsc. / Classification of images of biomolecular assemblies. A study of ribosomes and ribosomal subunits of Escherichia coli by Frank (1988)
10.1016/S0304-3991(78)80038-2 / Ultramicroscopy / Reconstruction of glutamine synthetase using computer averaging by Frank (1978)
10.1126/science.7313694 / Science / Computer averaging of electron micrographs of 40S ribosomal subunits by Frank (1981)
10.1038/340642a0 / Nature / A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning by Frech (1989)
10.1073/pnas.84.1.308 / Proc. Natl. Acad. Sci. USA / Topographical localization of the C-terminal region of the voltage- dependent sodium channel fromElectrophorus electricus by Gordon (1987)
10.1073/pnas.83.2.508 / Proc. Natl. Acad. Sci. USA / Molecular model of the action potential sodium channel by Guy (1986)
10.1038/356441a0 / Nature / Calcium channel characteristics conferred on the sodium channel by single mutations by Heinemann (1992)
{'key': '10.1006/jsbi.1998.3990_SB983990RF17', 'series-title': 'Ionic Channels of Excitable Membranes', 'author': 'Hille', 'year': '1992'} / Ionic Channels of Excitable Membranes by Hille (1992)
10.1113/jphysiol.1952.sp004764 / J. Physiol. / A quantitative description of membrane current and its application to conduction and excitation in nerve by Hodgkin (1952)
10.1111/j.1749-6632.1983.tb22191.x / Ann. N.Y. Acad. Sci. / Preparation of monomeric Fab′-horseradish peroxidase conjugate using thiol groups in the hinge and its evaluation in enzyme immunoassay and immunohistochemical staining by Ishikawa (1983)
10.1016/0092-8674(92)90280-P / Cell / Tracing the roots of ion channels by Jan (1992)
10.1016/0006-291X(87)90949-1 / Biochem. Biophys. Res. Commun. / Multiple oligosaccharide chains in the voltage sensitive Na channel fromElectrophorus electricus by James (1987)
10.1126/science.6289442 / Science / Molecular Biology of learning: Modulation of transmitter release by Kandel (1982)
10.1016/0014-5793(88)80614-8 / FEBS Lett. / Primary structure of rat brain sodium channel III deduced from the cDNA sequence by Kayano (1988)
10.1016/0014-5793(93)80009-J / FEBS Lett. / Structural determinants of ion selectivity in brain calcium channel by Kim (1993)
10.1016/0022-2836(82)90515-0 / J. Mol. Biol. / A simple method for displaying the hydropathic character of a protein by Kyte (1982)
10.1038/227680a0 / Nature (London) / Cleavage of structural proteins during the assembly of the head of bacteriophage T4 by Laemmli (1970)
10.1016/S0960-9822(94)00026-6 / Current Biol. / Images of purified shaker potassium channels by Li (1994)
10.1016/S0896-6273(00)80357-8 / Neuron / Gated access to the pore of a voltage-dependent K+ by Liu (1997)
10.1016/S0076-6879(74)34094-3 / Methods Enzymol. / Immunoaffinity chromatography of proteins by Livingston (1974)
10.1038/350232a0 / Nature / Determination of the subunit stoichiometry of a voltage-activated potassium channel by MacKinnon (1991)
10.1126/science.2218530 / Science / Mutations affecting TEA blockade and ion permeation in voltage-activated K+ by MacKinnon (1990)
10.1038/340230a0 / Nature / Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel by Mikami (1989)
10.1021/bi00271a032 / Biochemistry / Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein fromElectrophorus electricus by Miller (1983)
10.1038/350398a0 / Nature / Primary structure and functional expression from complementary DNA of a brain calcium channel by Mori (1991)
10.1016/0006-291X(92)90676-C / Biochem. Biophys. Res. Commun. / Photolabeled sites with a tetrodotoxin derivative in the domain III and IV of the electroplax sodium channel by Nakayama (1992)
10.1016/0005-2736(93)90390-L / Biochim. Biophys. Acta / A topographical study of the electroplax sodium channel with site-directed antibodies by Nakayama (1993)
10.1038/312121a0 / Nature / Primary structure ofElectrophorus electricus by Noda (1984)
10.1038/320188a0 / Nature / Existence of distinct sodium channel messenger RNAs in rat brain by Noda (1986)
10.1016/0003-2697(83)90703-0 / Anal. Biochem. / Silver stain for detecting 10-femtogram quantities of protein after polyacrylamide Gel electrophoresis by Ohsawa (1983)
10.1016/0092-8674(91)90374-8 / Cell / Identification of a mutation in the gene causing hyperkalemic periodic paralysis by Ptacek (1991)
10.1007/BF01561134 / Eur. Biophys. J. / Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating by Pusch (1991)
10.1038/newbio229177a0 / Nature New Biol. / Sodium conductance activation without inactivation in pronase-perfused axons by Rojas (1971)
10.1016/S0006-291X(05)80775-2 / Biochem. Biophys. Res. Commun. / Primary structure of squid sodium channel deduced from the complementary DNA sequence by Sato (1992)
10.1016/0006-291X(92)90868-L / Biochem. Biophys. Res. Commun. / Proposed tertiary structure of the sodium channel by Sato (1992)
10.1007/BF00235397 / J. Membr. Biol. / Sodium channel functioning based on an octagonal structure model by Sato (1995)
10.1111/j.1365-2818.1982.tb00405.x / J. Microsc. / The correlation averaging of a regularly arranged bacterial cell envelope protein by Saxton (1982)
10.1006/jsbi.1996.0035 / J. Struct. Biol. / Semper: Distortion, compensation, selective averaging, 3-d reconstitution, and transfer function correlation in a highly programmable system by Saxton (1996)
Schirmer, T. General and specific porins from bacterial outer membranes, J. Struct. Biol.
10.1016/0003-2697(85)90442-7 / Anal. Biochem. / Measurement of protein using bicinchoninic acid by Smith (1985)
10.1074/jbc.272.4.2389 / J. Biol. Chem. / Purification, visualization, and biophysical characterization of Kv1.3 tetramers by Spencer (1997)
10.1038/339597a0 / Nature / Structural parts involved in activation and inactivation of the sodium channel by Stühmer (1989)
10.1038/328313a0 / Nature / Primary structure of the receptor for calcium channel blockers from skeletal muscle by Tanabe (1987)
10.1016/S0021-9258(19)38613-2 / J. Biol. Chem. / Molecular localization of ion selectivity sites within the pore of a human L- type cardiac calcium channel by Tang (1993)
10.1126/science.2441471 / Science / Sequence of a probable potassium channel component encoded at Shaker Locus of Drosophila by Tempel (1987)
10.1038/332837a0 / Nature / Cloning of a probable potassium channel gene from mouse brain by Tempel (1988)
10.1016/0014-5793(91)81159-6 / FEBS Lett. / Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II by Terlau (1991)
10.1073/pnas.86.24.10161 / Proc. Natl. Acad. Sci. USA / Localization of the receptor site for α-scorpion toxins by antibody mapping: Implications for sodium channel topology by Thomsen (1989)
10.1073/pnas.76.9.4350 / Proc. Natl. Acad. Sci. USA / Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets, procedure and some applications by Towbin (1979)
10.1016/0896-6273(89)90113-X / Neuron / Primary structure and functional expression of a mammalian skeletal muscle sodium channel by Trimmer (1989)
10.1146/annurev.ph.45.030183.002013 / Annu. Rev. Physiol. / Calcium channels in excitable cell membranes by Tsien (1983)
10.1038/nsb0197-39 / Nature Struct. Biol. / Projection structure of a gap junction membrane channel at 7 Å resolution by Unger (1997)
10.1016/0304-3991(87)90225-7 / Ultramicroscopy / A new resolution criterion based on spectral signal-to-noise ratios by Unser (1987)
Unwin, N. The nicotinic acetylcholine receptor of the Torpedo electric ray, J. Struct. Biol.
10.1016/0304-3991(84)90066-4 / Ultramicroscopy / Multivariate statistical classification of noisy images (randomly oriented biological macromolecules) by van Heel (1984)
10.1126/science.2458625 / Science / Identification of an intracellular peptide segment involved in sodium channel inactivation by Vassilev (1988)
10.1038/42512 / Nature / The three-dimensional structure of aquaporin-1 by Walz (1997)
10.1126/science.2333511 / Science / K+ by Wei (1990)
10.1126/science.2000494 / Science / Mutations affecting internal TEA blockade identify the probable pore forming region of a K+ channel by Yellen (1991)
10.1016/0014-5793(89)81488-7 / FEBS Lett. / Potassium channels from NG108–15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs by Yokoyama (1989)
10.2220/biomedres.17.257 / Biomed. Res. / A sensitive enzyme immunoassay specific for salmon calcitonin by Yuuki (1996)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 2:57 p.m.)
Deposited	4 years, 3 months ago (May 2, 2021, 9:24 p.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 2:26 a.m.)
Issued	27 years, 8 months ago (Jan. 1, 1998)
Published	27 years, 8 months ago (Jan. 1, 1998)
Published Print	27 years, 8 months ago (Jan. 1, 1998)

Funders 0

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BibTeX

@article{Sato_1998, title={The Sodium Channel Has Four Domains Surrounding a Central Pore}, volume={121}, ISSN={1047-8477}, url={http://dx.doi.org/10.1006/jsbi.1998.3990}, DOI={10.1006/jsbi.1998.3990}, number={3}, journal={Journal of Structural Biology}, publisher={Elsevier BV}, author={Sato, Chikara and Sato, Masahiko and Iwasaki, Akio and Doi, Takeshi and Engel, Andreas}, year={1998}, pages={314–325} }

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      "author": "Chabala",
      "year": "1991",
      "journal-title": "J. Gen. Physiol."
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      "article-title": "Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation",
      "volume": "12",
      "author": "Chahine",
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      "first-page": "238",
      "DOI": "10.1016/S0006-3495(92)81809-X",
      "article-title": "Atomic scale structure and functional models of voltage-gated potassium channels",
      "volume": "62",
      "author": "Durell",
      "year": "1992",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF9",
      "doi-asserted-by": "crossref",
      "first-page": "1834",
      "DOI": "10.1083/jcb.97.6.1834",
      "article-title": "Molecular morphology of the tetrodotoxin-binding sodium channel protein fromElectrophorus electricus",
      "volume": "97",
      "author": "Ellisman",
      "year": "1983",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF10",
      "doi-asserted-by": "crossref",
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      "volume": "150",
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      "author": "Kandel",
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      "article-title": "Primary structure of rat brain sodium channel III deduced from the cDNA sequence",
      "volume": "228",
      "author": "Kayano",
      "year": "1988",
      "journal-title": "FEBS Lett."
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      "first-page": "145",
      "DOI": "10.1016/0014-5793(93)80009-J",
      "article-title": "Structural determinants of ion selectivity in brain calcium channel",
      "volume": "318",
      "author": "Kim",
      "year": "1993",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF25",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/0022-2836(82)90515-0",
      "article-title": "A simple method for displaying the hydropathic character of a protein",
      "volume": "157",
      "author": "Kyte",
      "year": "1982",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF26",
      "doi-asserted-by": "crossref",
      "first-page": "680",
      "DOI": "10.1038/227680a0",
      "article-title": "Cleavage of structural proteins during the assembly of the head of bacteriophage T4",
      "volume": "227",
      "author": "Laemmli",
      "year": "1970",
      "journal-title": "Nature (London)"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF27",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1016/S0960-9822(94)00026-6",
      "article-title": "Images of purified shaker potassium channels",
      "volume": "4",
      "author": "Li",
      "year": "1994",
      "journal-title": "Current Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF28",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1016/S0896-6273(00)80357-8",
      "article-title": "Gated access to the pore of a voltage-dependent K+",
      "volume": "19",
      "author": "Liu",
      "year": "1997",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF29",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1016/S0076-6879(74)34094-3",
      "article-title": "Immunoaffinity chromatography of proteins",
      "volume": "34",
      "author": "Livingston",
      "year": "1974",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF30",
      "doi-asserted-by": "crossref",
      "first-page": "232",
      "DOI": "10.1038/350232a0",
      "article-title": "Determination of the subunit stoichiometry of a voltage-activated potassium channel",
      "volume": "350",
      "author": "MacKinnon",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF31",
      "doi-asserted-by": "crossref",
      "first-page": "276",
      "DOI": "10.1126/science.2218530",
      "article-title": "Mutations affecting TEA blockade and ion permeation in voltage-activated K+",
      "volume": "250",
      "author": "MacKinnon",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF32",
      "doi-asserted-by": "crossref",
      "first-page": "230",
      "DOI": "10.1038/340230a0",
      "article-title": "Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel",
      "volume": "340",
      "author": "Mikami",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF33",
      "doi-asserted-by": "crossref",
      "first-page": "462",
      "DOI": "10.1021/bi00271a032",
      "article-title": "Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein fromElectrophorus electricus",
      "volume": "22",
      "author": "Miller",
      "year": "1983",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF34",
      "doi-asserted-by": "crossref",
      "first-page": "398",
      "DOI": "10.1038/350398a0",
      "article-title": "Primary structure and functional expression from complementary DNA of a brain calcium channel",
      "volume": "350",
      "author": "Mori",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF35",
      "doi-asserted-by": "crossref",
      "first-page": "900",
      "DOI": "10.1016/0006-291X(92)90676-C",
      "article-title": "Photolabeled sites with a tetrodotoxin derivative in the domain III and IV of the electroplax sodium channel",
      "volume": "184",
      "author": "Nakayama",
      "year": "1992",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF36",
      "doi-asserted-by": "crossref",
      "first-page": "134",
      "DOI": "10.1016/0005-2736(93)90390-L",
      "article-title": "A topographical study of the electroplax sodium channel with site-directed antibodies",
      "volume": "1145",
      "author": "Nakayama",
      "year": "1993",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF37",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1038/312121a0",
      "article-title": "Primary structure ofElectrophorus electricus",
      "volume": "312",
      "author": "Noda",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF38",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1038/320188a0",
      "article-title": "Existence of distinct sodium channel messenger RNAs in rat brain",
      "volume": "320",
      "author": "Noda",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF39",
      "doi-asserted-by": "crossref",
      "first-page": "409",
      "DOI": "10.1016/0003-2697(83)90703-0",
      "article-title": "Silver stain for detecting 10-femtogram quantities of protein after polyacrylamide Gel electrophoresis",
      "volume": "135",
      "author": "Ohsawa",
      "year": "1983",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF40",
      "doi-asserted-by": "crossref",
      "first-page": "1021",
      "DOI": "10.1016/0092-8674(91)90374-8",
      "article-title": "Identification of a mutation in the gene causing hyperkalemic periodic paralysis",
      "volume": "67",
      "author": "Ptacek",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF41",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1007/BF01561134",
      "article-title": "Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating",
      "volume": "20",
      "author": "Pusch",
      "year": "1991",
      "journal-title": "Eur. Biophys. J."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF42",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1038/newbio229177a0",
      "article-title": "Sodium conductance activation without inactivation in pronase-perfused axons",
      "volume": "229",
      "author": "Rojas",
      "year": "1971",
      "journal-title": "Nature New Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF43",
      "doi-asserted-by": "crossref",
      "first-page": "61",
      "DOI": "10.1016/S0006-291X(05)80775-2",
      "article-title": "Primary structure of squid sodium channel deduced from the complementary DNA sequence",
      "volume": "186",
      "author": "Sato",
      "year": "1992",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF44",
      "doi-asserted-by": "crossref",
      "first-page": "1158",
      "DOI": "10.1016/0006-291X(92)90868-L",
      "article-title": "Proposed tertiary structure of the sodium channel",
      "volume": "186",
      "author": "Sato",
      "year": "1992",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF45",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1007/BF00235397",
      "article-title": "Sodium channel functioning based on an octagonal structure model",
      "volume": "147",
      "author": "Sato",
      "year": "1995",
      "journal-title": "J. Membr. Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF46",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1111/j.1365-2818.1982.tb00405.x",
      "article-title": "The correlation averaging of a regularly arranged bacterial cell envelope protein",
      "volume": "127",
      "author": "Saxton",
      "year": "1982",
      "journal-title": "J. Microsc."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF47",
      "doi-asserted-by": "crossref",
      "first-page": "230",
      "DOI": "10.1006/jsbi.1996.0035",
      "article-title": "Semper: Distortion, compensation, selective averaging, 3-d reconstitution, and transfer function correlation in a highly programmable system",
      "volume": "116",
      "author": "Saxton",
      "year": "1996",
      "journal-title": "J. Struct. Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF48",
      "unstructured": "Schirmer, T. General and specific porins from bacterial outer membranes, J. Struct. Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF49",
      "doi-asserted-by": "crossref",
      "first-page": "76",
      "DOI": "10.1016/0003-2697(85)90442-7",
      "article-title": "Measurement of protein using bicinchoninic acid",
      "volume": "150",
      "author": "Smith",
      "year": "1985",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF50",
      "doi-asserted-by": "crossref",
      "first-page": "2389",
      "DOI": "10.1074/jbc.272.4.2389",
      "article-title": "Purification, visualization, and biophysical characterization of Kv1.3 tetramers",
      "volume": "272",
      "author": "Spencer",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF51",
      "doi-asserted-by": "crossref",
      "first-page": "597",
      "DOI": "10.1038/339597a0",
      "article-title": "Structural parts involved in activation and inactivation of the sodium channel",
      "volume": "339",
      "author": "St\u00fchmer",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF52",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1038/328313a0",
      "article-title": "Primary structure of the receptor for calcium channel blockers from skeletal muscle",
      "volume": "328",
      "author": "Tanabe",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF53",
      "doi-asserted-by": "crossref",
      "first-page": "13026",
      "DOI": "10.1016/S0021-9258(19)38613-2",
      "article-title": "Molecular localization of ion selectivity sites within the pore of a human L- type cardiac calcium channel",
      "volume": "268",
      "author": "Tang",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF54",
      "doi-asserted-by": "crossref",
      "first-page": "770",
      "DOI": "10.1126/science.2441471",
      "article-title": "Sequence of a probable potassium channel component encoded at Shaker Locus of Drosophila",
      "volume": "237",
      "author": "Tempel",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF55",
      "doi-asserted-by": "crossref",
      "first-page": "837",
      "DOI": "10.1038/332837a0",
      "article-title": "Cloning of a probable potassium channel gene from mouse brain",
      "volume": "332",
      "author": "Tempel",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF56",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/0014-5793(91)81159-6",
      "article-title": "Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II",
      "volume": "293",
      "author": "Terlau",
      "year": "1991",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF57",
      "doi-asserted-by": "crossref",
      "first-page": "10161",
      "DOI": "10.1073/pnas.86.24.10161",
      "article-title": "Localization of the receptor site for \u03b1-scorpion toxins by antibody mapping: Implications for sodium channel topology",
      "volume": "86",
      "author": "Thomsen",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF58",
      "doi-asserted-by": "crossref",
      "first-page": "4350",
      "DOI": "10.1073/pnas.76.9.4350",
      "article-title": "Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets, procedure and some applications",
      "volume": "76",
      "author": "Towbin",
      "year": "1979",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF59",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1016/0896-6273(89)90113-X",
      "article-title": "Primary structure and functional expression of a mammalian skeletal muscle sodium channel",
      "volume": "3",
      "author": "Trimmer",
      "year": "1989",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF60",
      "doi-asserted-by": "crossref",
      "first-page": "341",
      "DOI": "10.1146/annurev.ph.45.030183.002013",
      "article-title": "Calcium channels in excitable cell membranes",
      "volume": "45",
      "author": "Tsien",
      "year": "1983",
      "journal-title": "Annu. Rev. Physiol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF61",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1038/nsb0197-39",
      "article-title": "Projection structure of a gap junction membrane channel at 7 \u00c5 resolution",
      "volume": "4",
      "author": "Unger",
      "year": "1997",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF62",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1016/0304-3991(87)90225-7",
      "article-title": "A new resolution criterion based on spectral signal-to-noise ratios",
      "volume": "23",
      "author": "Unser",
      "year": "1987",
      "journal-title": "Ultramicroscopy"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF63",
      "unstructured": "Unwin, N. The nicotinic acetylcholine receptor of the Torpedo electric ray, J. Struct. Biol."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF64",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1016/0304-3991(84)90066-4",
      "article-title": "Multivariate statistical classification of noisy images (randomly oriented biological macromolecules)",
      "volume": "13",
      "author": "van Heel",
      "year": "1984",
      "journal-title": "Ultramicroscopy"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF65",
      "doi-asserted-by": "crossref",
      "first-page": "1658",
      "DOI": "10.1126/science.2458625",
      "article-title": "Identification of an intracellular peptide segment involved in sodium channel inactivation",
      "volume": "241",
      "author": "Vassilev",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF66",
      "doi-asserted-by": "crossref",
      "first-page": "624",
      "DOI": "10.1038/42512",
      "article-title": "The three-dimensional structure of aquaporin-1",
      "volume": "387",
      "author": "Walz",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF67",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1126/science.2333511",
      "article-title": "K+",
      "volume": "248",
      "author": "Wei",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF68",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1126/science.2000494",
      "article-title": "Mutations affecting internal TEA blockade identify the probable pore forming region of a K+ channel",
      "volume": "251",
      "author": "Yellen",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF69",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1016/0014-5793(89)81488-7",
      "article-title": "Potassium channels from NG108\u201315 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs",
      "volume": "259",
      "author": "Yokoyama",
      "year": "1989",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/jsbi.1998.3990_SB983990RF70",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.2220/biomedres.17.257",
      "article-title": "A sensitive enzyme immunoassay specific for salmon calcitonin",
      "volume": "17",
      "author": "Yuuki",
      "year": "1996",
      "journal-title": "Biomed. Res."
    }
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