DOI: 10.1006/jmbi.2001.4869. Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor 1 1Edited by I. A. Wilson

Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor 1 1Edited by I. A. Wilson

10.1006/jmbi.2001.4869

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Groll, M., Koguchi, Y., Huber, R., & Kohno, J. (2001). Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor 1 1Edited by I. A. Wilson. Journal of Molecular Biology, 311(3), 543â548.

Authors 4

Michael Groll (first)
Yutaka Koguchi (additional)
Robert Huber (additional)
Jun Kohno (additional)

References 36 Referenced 152

10.1146/annurev.biophys.28.1.295 / Annu. Rev. Biophys. Biomol. Struct. / The proteasome by Bochtler (1999)
10.1146/annurev.bi.65.070196.004101 / Annu. Rev. Biochem. / Structure and functions of the 20 S and 26 S proteasomes by Coux (1996)
10.1146/annurev.biochem.67.1.425 / Annu. Rev. Biochem. / The ubiquitin system by Hershko (1998)
10.1146/annurev.biochem.68.1.1015 / Annu. Rev. Biochem. / The 26 S proteasome by Voges (1999)
10.1038/12043 / Nature Cell Biol. / The base of the proteasome regulatory particle exhibits chaperone-like activity by Braun (1999)
10.1016/S0092-8674(00)81603-7 / Cell / A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3 by Glickman (1998)
10.1038/386463a0 / Nature / Structure of 20 S proteasome from yeast at 2.4 Å resolution by Groll (1997)
10.1126/science.7725097 / Science / Crystal structure of the 20 S proteasome from the archaeon T. acidophilum at 3.4 Å resolution by Löwe (1995)
10.1073/pnas.95.21.12504 / Proc. Natl Acad. Sci. USA / Cleavage motifs of the yeast 20 S proteasome beta subunits deduced from digests of enolase 1 by Nussbaum (1998)
10.1111/j.1432-1033.1992.tb17249.x / Eur. J. Biochem. / Biochemical properties of the proteasome from Thermoplasma acidophilum by Dahlmann (1992)
10.1016/S0021-9258(17)41897-7 / J. Biol. Chem. / Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome by Chu-Ping (1994)
10.1016/S0021-9258(19)89473-5 / J. Biol. Chem. / Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits by Hoffman (1994)
10.1038/378416a0 / Nature / A protein catalytic framework with an N-terminal nucleophile is capable of self-activation by Brannigan (1995)
10.1016/S0092-8674(00)80171-3 / Cell / Autocatalytic subunit processing couples active site formation in the 20 S proteasome to completion of assembly by Chen (1996)
10.1006/jmbi.1998.1818 / J. Mol. Biol. / Conformational constraints for protein self-cleavage in the proteasome by Ditzel (1998)
10.1002/j.1460-2075.1996.tb01081.x / EMBO J. / Analysis of mammalian 20 S proteasome biogenesis by Schmidtke (1996)
10.1038/382468a0 / Nature / Autocatalytic processing of the 20 S proteasome by Seemuller (1996)
10.1073/pnas.96.20.10976 / Proc. Natl Acad. Sci. USA / The catalytic sites of 20 S proteasomes and their role in subunit maturation by Groll (1999)
10.1074/jbc.272.40.25200 / J. Biol. Chem. / The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing by Heinemeyer (1997)
10.1016/0167-5699(96)10051-7 / Immunol. Today / Peptide antigen production by the proteasome by Groettrup (1996)
10.1038/sj.gt.3300724 / Gene Ther. / The proteasome system by Kloetzel (1998)
10.7164/antibiotics.53.105 / J. Antibiot. (Tokyo) / TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities by Koguchi (2000)
10.1021/jo991375+ / J. Org. Chem. / Structures of TMC-95A-D by Kohno (2000)
10.1038/80992 / Nature Struct. Biol. / A gated channel into the proteasome core particle by Groll (2000)
10.1021/ja993588m / J. Am. Chem. Soc. / Crystal structure of epoxomicin by Groll (2000)
10.1016/S1074-5521(98)90169-7 / Chem. Biol. / Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes by Bogyo (1998)
10.1073/pnas.96.10.5418 / Proc. Natl Acad. Sci. USA / Bivalency as a principle for proteasome inhibition by Loidl (1999)
10.1073/pnas.96.18.10403 / Proc. Natl Acad. Sci. USA / Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity by Meng (1999)
10.1126/science.7732382 / Science / Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin by Fenteany (1995)
10.1016/S0092-8674(94)90462-6 / Cell / Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules by Rock (1994)
10.1016/S1074-5521(99)80036-2 / Chem. Biol. / Bifunctional inhibitors of the trypsin-like activity of eukaryotic proteasomes by Loidl (1999)
{'key': '10.1006/jmbi.2001.4869_BIB32', 'series-title': 'Mosfilm User Guide, Mosfilm Version 5.2', 'author': 'Lesslie', 'year': '1994'} / Mosfilm User Guide, Mosfilm Version 5.2 by Lesslie (1994)
{'key': '10.1006/jmbi.2001.4869_BIB33', 'series-title': 'X-PLOR Version 3.1. A System for X-ray Crystallography and NMR', 'author': 'Brunger', 'year': '1992'} / X-PLOR Version 3.1. A System for X-ray Crystallography and NMR by Brunger (1992)
{'key': '10.1006/jmbi.2001.4869_BIB34', 'series-title': 'Improvement of a programm for molecular graphics and manipulation of electron densities and its application for protein structure determination', 'author': 'Turk', 'year': '1992'} / Improvement of a programm for molecular graphics and manipulation of electron densities and its application for protein structure determination by Turk (1992)
10.1107/S0021889878013308 / J. Appl. Crystallog. / A graphic model building and refinement system for macromolecules by Jones (1978)
10.1107/S0108767391001071 / Acta. Crystallog. sect. A / Accurate bond and angles parameters for X-ray protein structure refinement by Engh (1991)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 11:51 a.m.)
Deposited	4 years, 4 months ago (May 2, 2021, 11:01 p.m.)
Indexed	1 month, 2 weeks ago (July 19, 2025, 11:52 p.m.)
Issued	24 years, 1 month ago (Aug. 1, 2001)
Published	24 years, 1 month ago (Aug. 1, 2001)
Published Print	24 years, 1 month ago (Aug. 1, 2001)

Funders 0

None

BibTeX

@article{Groll_2001, title={Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor 1 1Edited by I. A. Wilson}, volume={311}, ISSN={0022-2836}, url={http://dx.doi.org/10.1006/jmbi.2001.4869}, DOI={10.1006/jmbi.2001.4869}, number={3}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Groll, Michael and Koguchi, Yutaka and Huber, Robert and Kohno, Jun}, year={2001}, month=aug, pages={543–548} }

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      "author": "Voges",
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      "author": "Braun",
      "year": "1999",
      "journal-title": "Nature Cell Biol."
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      "journal-title": "Nature"
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      "volume": "268",
      "author": "L\u00f6we",
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      "article-title": "Cleavage motifs of the yeast 20 S proteasome beta subunits deduced from digests of enolase 1",
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      "author": "Nussbaum",
      "year": "1998",
      "journal-title": "Proc. Natl Acad. Sci. USA"
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      "author": "Hoffman",
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      "journal-title": "Nature"
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      "article-title": "Autocatalytic subunit processing couples active site formation in the 20 S proteasome to completion of assembly",
      "volume": "86",
      "author": "Chen",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1187",
      "DOI": "10.1006/jmbi.1998.1818",
      "article-title": "Conformational constraints for protein self-cleavage in the proteasome",
      "volume": "279",
      "author": "Ditzel",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "6887",
      "DOI": "10.1002/j.1460-2075.1996.tb01081.x",
      "article-title": "Analysis of mammalian 20 S proteasome biogenesis",
      "volume": "15",
      "author": "Schmidtke",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB17",
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      "first-page": "468",
      "DOI": "10.1038/382468a0",
      "article-title": "Autocatalytic processing of the 20 S proteasome",
      "volume": "382",
      "author": "Seemuller",
      "year": "1996",
      "journal-title": "Nature"
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      "first-page": "10976",
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      "volume": "96",
      "author": "Groll",
      "year": "1999",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
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      "volume": "272",
      "author": "Heinemeyer",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB20",
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      "first-page": "429",
      "DOI": "10.1016/0167-5699(96)10051-7",
      "article-title": "Peptide antigen production by the proteasome",
      "volume": "17",
      "author": "Groettrup",
      "year": "1996",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB21",
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      "first-page": "1297",
      "DOI": "10.1038/sj.gt.3300724",
      "article-title": "The proteasome system",
      "volume": "5",
      "author": "Kloetzel",
      "year": "1998",
      "journal-title": "Gene Ther."
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    {
      "key": "10.1006/jmbi.2001.4869_BIB22",
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      "first-page": "105",
      "DOI": "10.7164/antibiotics.53.105",
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      "volume": "53",
      "author": "Koguchi",
      "year": "2000",
      "journal-title": "J. Antibiot. (Tokyo)"
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB23",
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      "first-page": "990",
      "DOI": "10.1021/jo991375+",
      "article-title": "Structures of TMC-95A-D",
      "volume": "65",
      "author": "Kohno",
      "year": "2000",
      "journal-title": "J. Org. Chem."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1062",
      "DOI": "10.1038/80992",
      "article-title": "A gated channel into the proteasome core particle",
      "volume": "7",
      "author": "Groll",
      "year": "2000",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1237",
      "DOI": "10.1021/ja993588m",
      "article-title": "Crystal structure of epoxomicin",
      "volume": "122",
      "author": "Groll",
      "year": "2000",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB26",
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      "first-page": "307",
      "DOI": "10.1016/S1074-5521(98)90169-7",
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      "volume": "5",
      "author": "Bogyo",
      "year": "1998",
      "journal-title": "Chem. Biol."
    },
    {
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      "first-page": "5418",
      "DOI": "10.1073/pnas.96.10.5418",
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      "author": "Loidl",
      "year": "1999",
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      "author": "Meng",
      "year": "1999",
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      "volume": "78",
      "author": "Rock",
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      "journal-title": "Cell"
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      "volume": "6",
      "author": "Loidl",
      "year": "1999",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "10.1006/jmbi.2001.4869_BIB32",
      "series-title": "Mosfilm User Guide, Mosfilm Version 5.2",
      "author": "Lesslie",
      "year": "1994"
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      "key": "10.1006/jmbi.2001.4869_BIB33",
      "series-title": "X-PLOR Version 3.1. A System for X-ray Crystallography and NMR",
      "author": "Brunger",
      "year": "1992"
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      "series-title": "Improvement of a programm for molecular graphics and manipulation of electron densities and its application for protein structure determination",
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      "DOI": "10.1107/S0021889878013308",
      "article-title": "A graphic model building and refinement system for macromolecules",
      "volume": "11",
      "author": "Jones",
      "year": "1978",
      "journal-title": "J. Appl. Crystallog."
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