DOI: 10.1006/jmbi.2000.4474. ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information

ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information

10.1006/jmbi.2000.4474

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Armon, A., Graur, D., & Ben-Tal, N. (2001). ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information. Journal of Molecular Biology, 307(1), 447â463.

Authors 3

Aharon Armon (first)
Dan Graur (additional)
Nir Ben-Tal (additional)

References 59 Referenced 417

10.1093/nar/28.1.235 / Nucl. Acids Res. / The protein data bank by Berman (2000)
10.1038/4136 / Nature Struct. Biol. / 100,000 protein structures for the biologist by Sali (1998)
10.1016/S0969-2126(98)00029-X / Structure / Marrying structure and genomics by Rost (1998)
{'key': '10.1006/jmbi.2000.4474_BIB4', 'series-title': 'Introduction to Protein Structure', 'author': 'Branden', 'year': '1999'} / Introduction to Protein Structure by Branden (1999)
10.1006/jmbi.1998.1843 / J. Mol. Biol. / Anatomy of hot spots in protein interfaces by Bogan (1998)
10.1016/0300-9084(94)90172-4 / Biochimie / Protein interaction sites obtained vis homology. The site of complexation of electron transfer portions of cytochrome c revealed by mapping amino acid substitution onto three-dimensional protein surfaces by Meyer (1994)
10.1006/jmbi.1997.1198 / J. Mol. Biol. / Correlated mutations contain information about protein-protein interaction by Pazos (1997)
10.1126/science.286.5438.295 / Science / Evolutionary conserved pathways of energetic connectivity in protein families by Lockless (1999)
10.1016/S0968-0004(00)01631-5 / Trends Biochem. Sci. / On the conservation of protein sequences in evolution by Kisters-Woike (2000)
10.1006/jmbi.2000.4092 / J. Mol. Biol. / A fast method to predict protein interaction sites from sequences by Gallet (2000)
10.1006/jmbi.1996.0167 / J. Mol. Biol. / An evolutionary trace method defines binding surfaces common to protein families by Lichtarge (1996)
10.1073/pnas.93.15.7507 / Proc. Natl Acad. Sci. USA / Evolutionarily conserved G-alpha-beta-gamma binding surfaces support a model of the G protein-receptor complex by Lichtarge (1996)
10.1006/jmbi.1997.1395 / J. Mol. Biol. / Identification of functional surfaces of the zinc binding domains of intracellular receptors by Lichtarge (1997)
10.1007/BF02603120 / J. Mol. Evol. / Progressive sequence alignment as a prerequisite to correct phylogenetic trees by Feng (1987)
{'key': '10.1006/jmbi.2000.4474_BIB15', 'first-page': '151', 'article-title': 'Fast and sensitive multiple sequence alignments on a microcomputer', 'volume': '5', 'author': 'Higgins', 'year': '1989', 'journal-title': 'Comput. Appl. Biosci.'} / Comput. Appl. Biosci. / Fast and sensitive multiple sequence alignments on a microcomputer by Higgins (1989)
{'key': '10.1006/jmbi.2000.4474_BIB16', 'series-title': 'Fundamentals of Molecular Evolution', 'author': 'Graur', 'year': '2000'} / Fundamentals of Molecular Evolution by Graur (2000)
10.1016/S0076-6879(96)66026-1 / Methods Enzymol. / Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods by Felsenstein (1996)
10.1007/BF01732340 / J. Mol. Evol. / Two types of amino acid substitutions in protein evolution by Miyata (1979)
10.1038/385595a0 / Nature / Three-dimensional structure of the tyrosine kinase c-Src by Xu (1997)
10.1038/385602a0 / Nature / Crystal structure of the Src family tyrosine kinase Hck by Sicheri (1997)
10.1016/0092-8674(93)90405-F / Cell / Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain by Waksman (1993)
10.1016/0092-8674(93)90404-E / Cell / SH2 domains recognize specific phosphopeptide sequences by Songyang (1993)
10.1016/S1097-2765(00)80269-5 / Mol. Cell / Structural basis for specificity switching of the Src SH2 domain by Kimber (2000)
10.1016/S0092-8674(00)80105-1 / Cell / Peptide-surface association by Harrison (1996)
10.1038/4873 / Nature Struct. Biol. / The surprisingly flexible PTB domain by Siegal (1999)
10.1016/S0959-440X(99)00031-7 / Curr. Opin. Struct. Biol. / Diversity in recognition by PTB domains by Forman-Kay (1999)
10.1093/nar/22.22.4673 / Nucl. Acids. Res. / CLUSTAL W by Thompson (1994)
{'key': '10.1006/jmbi.2000.4474_BIB28', 'first-page': '406', 'article-title': 'The neighbor-joining method', 'volume': '4', 'author': 'Saitou', 'year': '1987', 'journal-title': 'Mol. Biol. Evol.'} / Mol. Biol. Evol. / The neighbor-joining method by Saitou (1987)
10.1093/nar/28.1.263 / Nucl. Acids Res. / The Pfam protein families database by Bateman (2000)
10.1128/MCB.16.11.6229 / Mol. Cell. Biol. / The phosphotyrosine interaction domains of X11 and FE65 binf to distinct sites on YENPTY motif of amyloid precursor protein by Borg (1996)
10.1093/emboj/16.20.6141 / EMBO J. / Sequence-specific recognition of the internalization motif of the Alzheimer amyloid precursor protein by the X11 PTB domain by Zhang (1997)
10.1074/jbc.270.31.18205 / J. Biol. Chem. / Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine by Trub (1995)
10.1074/jbc.270.46.27407 / J. Biol. Chem. / PTB domains of IRS-1 and SHC have distinct but overlapping binding specificities by Wolf (1995)
10.1126/science.7527937 / Science / An alternative to SH2 domains for binding tyrosine-phosphorylated proteins by Kavanaugh (1994)
10.1038/378584a0 / Nature / Structure and lignad recognition of the phosphoytrosine binding domain of SHC by Zhou (1995)
10.1016/S0092-8674(00)81236-2 / Cell / Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor by Eck (1996)
10.1038/nsb0496-388 / Nature Struct. Biol. / Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain by Zhou (1996)
10.1074/jbc.273.15.9179 / J. Biol. Chem. / The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein LNX by Dho (1998)
10.1128/MCB.19.7.5179 / Mol. Cell. Biol. / The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids by Howell (1999)
10.1038/4185 / Nature Struct. Biol. / Structure of a numb PTB domain-peptide complex suggests a basis for diverse binding specifity by Li (1998)
10.1016/0092-8674(95)90347-X / Cell / A phosphotyrosine interaction domain by Bork (1995)
10.1021/bi982974y / Biochemistry / Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding by Bradshaw (1999)
10.1007/PL00006218 / J. Mol. Evol. / Theoretical method for evaluating the relative importance of positive selection and neutral drift from observed base changes by Otsuka (1997)
10.1093/nar/24.1.201 / Nucl. Acids Res. / The HSSP database of protein structure-sequence alignments by Schneider (1996)
{'key': '10.1006/jmbi.2000.4474_BIB45', 'first-page': '345', 'article-title': 'A model of evolutionary change in proteins', 'volume': 'vol.5', 'author': 'Dayhoff', 'year': '1978'} / A model of evolutionary change in proteins by Dayhoff (1978)
10.1038/4878 / Nature Struct. Biol. / Structural genomics by Montelione (1999)
10.1016/0022-2836(81)90087-5 / J. Mol. Biol. / Identification of common molecular subsequences by Smith (1981)
10.1093/nar/28.1.45 / Nucl. Acids Res. / The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 by Bairoch (2000)
10.1006/geno.1996.0614 / Genomics / Sensitivity and selectivity in protein similarity searches by Shpaer (1996)
10.1006/jmbi.1997.1525 / J. Mol. Biol. / Empirical statistical estimates for sequence similarity searches by Pearson (1998)
{'key': '10.1006/jmbi.2000.4474_BIB51', 'series-title': 'Biological Sequence Analysis Probabilistic Models of Proteins and Nucleic Acids', 'author': 'Durbin', 'year': '1998'} / Biological Sequence Analysis Probabilistic Models of Proteins and Nucleic Acids by Durbin (1998)
10.2307/2412116 / Syst. Zool. / Toward defining the course of evolution by Fitch (1971)
10.1126/science.185.4154.862 / Science / Amino acid difference formula to help explain protein evolution by Grantham (1974)
{'key': '10.1006/jmbi.2000.4474_BIB54', 'series-title': 'Introduction to Protein Structure', 'author': 'Schulz', 'year': '1979'} / Introduction to Protein Structure by Schulz (1979)
10.1016/S0968-0004(00)89080-5 / Trends. Biochem. Sci. / RASMOL by Sayle (1995)
10.1002/prot.340110407 / Proteins: Struct. Funct. Genet / Protein folding and association by Nicholls (1991)
10.1016/0022-2836(73)90011-9 / J. Mol. Biol. / Environment and exposure to solvent of protein atoms. Lysozyme and insulin by Shrake (1973)
{'key': '10.1006/jmbi.2000.4474_BIB58', 'first-page': 'A174', 'article-title': 'A new vertex algorithm to calculate solvent accessible surface area', 'volume': '61', 'author': 'Sridharan', 'year': '1992', 'journal-title': 'Biophys. J.'} / Biophys. J. / A new vertex algorithm to calculate solvent accessible surface area by Sridharan (1992)
10.1002/pro.5560071126 / Protein Sci. / HOMSTRAD by Mizuguchi (1998)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 11:24 a.m.)
Deposited	6 years, 3 months ago (May 8, 2019, 12:20 a.m.)
Indexed	2 weeks, 2 days ago (Aug. 21, 2025, 1:03 p.m.)
Issued	24 years, 6 months ago (March 1, 2001)
Published	24 years, 6 months ago (March 1, 2001)
Published Print	24 years, 6 months ago (March 1, 2001)

Funders 0

None

BibTeX

@article{Armon_2001, title={ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information}, volume={307}, ISSN={0022-2836}, url={http://dx.doi.org/10.1006/jmbi.2000.4474}, DOI={10.1006/jmbi.2000.4474}, number={1}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Armon, Aharon and Graur, Dan and Ben-Tal, Nir}, year={2001}, month=mar, pages={447–463} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        21
      ]
    ],
    "date-time": "2025-08-21T17:03:29Z",
    "timestamp": 1755795809167
  },
  "reference-count": 59,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            3,
            1
          ]
        ],
        "date-time": "2001-03-01T00:00:00Z",
        "timestamp": 983404800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        3
      ]
    ]
  },
  "DOI": "10.1006/jmbi.2000.4474",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        18
      ]
    ],
    "date-time": "2002-09-18T15:24:54Z",
    "timestamp": 1032362694000
  },
  "page": "447-463",
  "source": "Crossref",
  "is-referenced-by-count": 417,
  "title": "ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information",
  "prefix": "10.1006",
  "volume": "307",
  "author": [
    {
      "given": "Aharon",
      "family": "Armon",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Dan",
      "family": "Graur",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nir",
      "family": "Ben-Tal",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/jmbi.2000.4474_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1093/nar/28.1.235",
      "article-title": "The protein data bank",
      "volume": "28",
      "author": "Berman",
      "year": "2000",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "1029",
      "DOI": "10.1038/4136",
      "article-title": "100,000 protein structures for the biologist",
      "volume": "5",
      "author": "Sali",
      "year": "1998",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1016/S0969-2126(98)00029-X",
      "article-title": "Marrying structure and genomics",
      "volume": "6",
      "author": "Rost",
      "year": "1998",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB4",
      "series-title": "Introduction to Protein Structure",
      "author": "Branden",
      "year": "1999"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1006/jmbi.1998.1843",
      "article-title": "Anatomy of hot spots in protein interfaces",
      "volume": "280",
      "author": "Bogan",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "480",
      "DOI": "10.1016/0300-9084(94)90172-4",
      "article-title": "Protein interaction sites obtained vis homology. The site of complexation of electron transfer portions of cytochrome c revealed by mapping amino acid substitution onto three-dimensional protein surfaces",
      "volume": "76",
      "author": "Meyer",
      "year": "1994",
      "journal-title": "Biochimie"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1006/jmbi.1997.1198",
      "article-title": "Correlated mutations contain information about protein-protein interaction",
      "volume": "271",
      "author": "Pazos",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1126/science.286.5438.295",
      "article-title": "Evolutionary conserved pathways of energetic connectivity in protein families",
      "volume": "286",
      "author": "Lockless",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "419",
      "DOI": "10.1016/S0968-0004(00)01631-5",
      "article-title": "On the conservation of protein sequences in evolution",
      "volume": "25",
      "author": "Kisters-Woike",
      "year": "2000",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "917",
      "DOI": "10.1006/jmbi.2000.4092",
      "article-title": "A fast method to predict protein interaction sites from sequences",
      "volume": "302",
      "author": "Gallet",
      "year": "2000",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "342",
      "DOI": "10.1006/jmbi.1996.0167",
      "article-title": "An evolutionary trace method defines binding surfaces common to protein families",
      "volume": "257",
      "author": "Lichtarge",
      "year": "1996",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "7507",
      "DOI": "10.1073/pnas.93.15.7507",
      "article-title": "Evolutionarily conserved G-alpha-beta-gamma binding surfaces support a model of the G protein-receptor complex",
      "volume": "93",
      "author": "Lichtarge",
      "year": "1996",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1006/jmbi.1997.1395",
      "article-title": "Identification of functional surfaces of the zinc binding domains of intracellular receptors",
      "volume": "274",
      "author": "Lichtarge",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1007/BF02603120",
      "article-title": "Progressive sequence alignment as a prerequisite to correct phylogenetic trees",
      "volume": "25",
      "author": "Feng",
      "year": "1987",
      "journal-title": "J. Mol. Evol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB15",
      "first-page": "151",
      "article-title": "Fast and sensitive multiple sequence alignments on a microcomputer",
      "volume": "5",
      "author": "Higgins",
      "year": "1989",
      "journal-title": "Comput. Appl. Biosci."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB16",
      "series-title": "Fundamentals of Molecular Evolution",
      "author": "Graur",
      "year": "2000"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "418",
      "DOI": "10.1016/S0076-6879(96)66026-1",
      "article-title": "Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods",
      "volume": "266",
      "author": "Felsenstein",
      "year": "1996",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "219",
      "DOI": "10.1007/BF01732340",
      "article-title": "Two types of amino acid substitutions in protein evolution",
      "volume": "12",
      "author": "Miyata",
      "year": "1979",
      "journal-title": "J. Mol. Evol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1038/385595a0",
      "article-title": "Three-dimensional structure of the tyrosine kinase c-Src",
      "volume": "385",
      "author": "Xu",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "602",
      "DOI": "10.1038/385602a0",
      "article-title": "Crystal structure of the Src family tyrosine kinase Hck",
      "volume": "385",
      "author": "Sicheri",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1016/0092-8674(93)90405-F",
      "article-title": "Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain",
      "volume": "72",
      "author": "Waksman",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1016/0092-8674(93)90404-E",
      "article-title": "SH2 domains recognize specific phosphopeptide sequences",
      "volume": "72",
      "author": "Songyang",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1043",
      "DOI": "10.1016/S1097-2765(00)80269-5",
      "article-title": "Structural basis for specificity switching of the Src SH2 domain",
      "volume": "5",
      "author": "Kimber",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "341",
      "DOI": "10.1016/S0092-8674(00)80105-1",
      "article-title": "Peptide-surface association",
      "volume": "86",
      "author": "Harrison",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1038/4873",
      "article-title": "The surprisingly flexible PTB domain",
      "volume": "6",
      "author": "Siegal",
      "year": "1999",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "690",
      "DOI": "10.1016/S0959-440X(99)00031-7",
      "article-title": "Diversity in recognition by PTB domains",
      "volume": "9",
      "author": "Forman-Kay",
      "year": "1999",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "4673",
      "DOI": "10.1093/nar/22.22.4673",
      "article-title": "CLUSTAL W",
      "volume": "22",
      "author": "Thompson",
      "year": "1994",
      "journal-title": "Nucl. Acids. Res."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB28",
      "first-page": "406",
      "article-title": "The neighbor-joining method",
      "volume": "4",
      "author": "Saitou",
      "year": "1987",
      "journal-title": "Mol. Biol. Evol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1093/nar/28.1.263",
      "article-title": "The Pfam protein families database",
      "volume": "28",
      "author": "Bateman",
      "year": "2000",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "6229",
      "DOI": "10.1128/MCB.16.11.6229",
      "article-title": "The phosphotyrosine interaction domains of X11 and FE65 binf to distinct sites on YENPTY motif of amyloid precursor protein",
      "volume": "16",
      "author": "Borg",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "6141",
      "DOI": "10.1093/emboj/16.20.6141",
      "article-title": "Sequence-specific recognition of the internalization motif of the Alzheimer amyloid precursor protein by the X11 PTB domain",
      "volume": "16",
      "author": "Zhang",
      "year": "1997",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "18205",
      "DOI": "10.1074/jbc.270.31.18205",
      "article-title": "Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine",
      "volume": "270",
      "author": "Trub",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "27407",
      "DOI": "10.1074/jbc.270.46.27407",
      "article-title": "PTB domains of IRS-1 and SHC have distinct but overlapping binding specificities",
      "volume": "270",
      "author": "Wolf",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1862",
      "DOI": "10.1126/science.7527937",
      "article-title": "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins",
      "volume": "266",
      "author": "Kavanaugh",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "584",
      "DOI": "10.1038/378584a0",
      "article-title": "Structure and lignad recognition of the phosphoytrosine binding domain of SHC",
      "volume": "378",
      "author": "Zhou",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1016/S0092-8674(00)81236-2",
      "article-title": "Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor",
      "volume": "85",
      "author": "Eck",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "388",
      "DOI": "10.1038/nsb0496-388",
      "article-title": "Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain",
      "volume": "3",
      "author": "Zhou",
      "year": "1996",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "9179",
      "DOI": "10.1074/jbc.273.15.9179",
      "article-title": "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein LNX",
      "volume": "273",
      "author": "Dho",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "5179",
      "DOI": "10.1128/MCB.19.7.5179",
      "article-title": "The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids",
      "volume": "19",
      "author": "Howell",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1075",
      "DOI": "10.1038/4185",
      "article-title": "Structure of a numb PTB domain-peptide complex suggests a basis for diverse binding specifity",
      "volume": "5",
      "author": "Li",
      "year": "1998",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "693",
      "DOI": "10.1016/0092-8674(95)90347-X",
      "article-title": "A phosphotyrosine interaction domain",
      "volume": "80",
      "author": "Bork",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "5147",
      "DOI": "10.1021/bi982974y",
      "article-title": "Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding",
      "volume": "38",
      "author": "Bradshaw",
      "year": "1999",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1007/PL00006218",
      "article-title": "Theoretical method for evaluating the relative importance of positive selection and neutral drift from observed base changes",
      "volume": "45",
      "author": "Otsuka",
      "year": "1997",
      "journal-title": "J. Mol. Evol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1093/nar/24.1.201",
      "article-title": "The HSSP database of protein structure-sequence alignments",
      "volume": "24",
      "author": "Schneider",
      "year": "1996",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB45",
      "first-page": "345",
      "article-title": "A model of evolutionary change in proteins",
      "volume": "vol.5",
      "author": "Dayhoff",
      "year": "1978"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1038/4878",
      "article-title": "Structural genomics",
      "volume": "6",
      "author": "Montelione",
      "year": "1999",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1016/0022-2836(81)90087-5",
      "article-title": "Identification of common molecular subsequences",
      "volume": "147",
      "author": "Smith",
      "year": "1981",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1093/nar/28.1.45",
      "article-title": "The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000",
      "volume": "28",
      "author": "Bairoch",
      "year": "2000",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1006/geno.1996.0614",
      "article-title": "Sensitivity and selectivity in protein similarity searches",
      "volume": "38",
      "author": "Shpaer",
      "year": "1996",
      "journal-title": "Genomics"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.1006/jmbi.1997.1525",
      "article-title": "Empirical statistical estimates for sequence similarity searches",
      "volume": "276",
      "author": "Pearson",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB51",
      "series-title": "Biological Sequence Analysis Probabilistic Models of Proteins and Nucleic Acids",
      "author": "Durbin",
      "year": "1998"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "406",
      "DOI": "10.2307/2412116",
      "article-title": "Toward defining the course of evolution",
      "volume": "20",
      "author": "Fitch",
      "year": "1971",
      "journal-title": "Syst. Zool."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "862",
      "DOI": "10.1126/science.185.4154.862",
      "article-title": "Amino acid difference formula to help explain protein evolution",
      "volume": "185",
      "author": "Grantham",
      "year": "1974",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB54",
      "series-title": "Introduction to Protein Structure",
      "author": "Schulz",
      "year": "1979"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "374",
      "DOI": "10.1016/S0968-0004(00)89080-5",
      "article-title": "RASMOL",
      "volume": "20",
      "author": "Sayle",
      "year": "1995",
      "journal-title": "Trends. Biochem. Sci."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1002/prot.340110407",
      "article-title": "Protein folding and association",
      "volume": "11",
      "author": "Nicholls",
      "year": "1991",
      "journal-title": "Proteins: Struct. Funct. Genet"
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1016/0022-2836(73)90011-9",
      "article-title": "Environment and exposure to solvent of protein atoms. Lysozyme and insulin",
      "volume": "79",
      "author": "Shrake",
      "year": "1973",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB58",
      "first-page": "A174",
      "article-title": "A new vertex algorithm to calculate solvent accessible surface area",
      "volume": "61",
      "author": "Sridharan",
      "year": "1992",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1006/jmbi.2000.4474_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "2469",
      "DOI": "10.1002/pro.5560071126",
      "article-title": "HOMSTRAD",
      "volume": "7",
      "author": "Mizuguchi",
      "year": "1998",
      "journal-title": "Protein Sci."
    }
  ],
  "container-title": "Journal of Molecular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283600944747?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283600944747?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        5,
        8
      ]
    ],
    "date-time": "2019-05-08T04:20:40Z",
    "timestamp": 1557289240000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022283600944747"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        3
      ]
    ]
  },
  "references-count": 59,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2001,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022283600944747"
  ],
  "URL": "http://dx.doi.org/10.1006/jmbi.2000.4474",
  "relation": {},
  "ISSN": [
    "0022-2836"
  ],
  "subject": [],
  "container-title-short": "Journal of Molecular Biology",
  "published": {
    "date-parts": [
      [
        2001,
        3
      ]
    ]
  }
}