DOI: 10.1006/jmbi.2000.4155. How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways 1 1Edited by J. Thornton

How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways 1 1Edited by J. Thornton

10.1006/jmbi.2000.4155

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

LÃ¼demann, S. K., Lounnas, V., & Wade, R. C. (2000). How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways 1 1Edited by J. Thornton. Journal of Molecular Biology, 303(5), 813â830.

Authors 3

Susanna K. Lüdemann (first)
Valère Lounnas (additional)
Rebecca C. Wade (additional)

References 39 Referenced 129

10.1002/prot.340170408 / Proteins: Struct. Funct. Genet. / Essential dynamics of proteins by Amadei (1993)
10.1016/S0006-3495(97)78161-X / Biophys. J. / Reconstructing potential energy functions from simulated force-induced unbinding processes by Balsera (1997)
10.1006/jmbi.1999.2879 / J. Mol. Biol. / Retinoic acid receptor by Blondel (1999)
10.1021/bi00252a012 / Biochemistry / Electrostatic control of the substrate access channel in cytochrome P450cam by Deprez (1994)
10.1073/pnas.96.23.12987 / Proc. Natl Acad. Sci. USA / Optical detection of cytochrome P450 by sensitizer-linked substrates by Dmochowski (1999)
10.1021/ja973131h / J. Am. Chem. Soc. / Alternate pathways for acetic acid and acetate ion release from acetylcholinesterase by Enyedy (1998)
10.1016/0009-2614(92)85543-J / Chem. Phys. Letters / Conjugate peak refinement by Fischer (1992)
10.1073/pnas.96.15.8384 / Proc. Natl Acad. Sci. USA / A structural snapshot of an intermediate on the streptavidin-biotin dissociation pathway by Freitag (1999)
10.1073/pnas.72.6.2002 / Proc. Natl Acad. Sci. USA / Side-chain torsional potentials and motion of amino acids in proteins by Gelin (1975)
{'key': '10.1006/jmbi.2000.4155_BIB10', 'series-title': 'Bioorganic activation of cytochrome P450cam', 'author': 'Gerber', 'year': '1994'} / Bioorganic activation of cytochrome P450cam by Gerber (1994)
10.1021/jm00145a002 / J. Med. Chem. / A computational procedure for determining energetically favorable binding sites on biologically important macromolecules by Goodford (1985)
10.1096/fasebj.10.2.8641554 / FASEB J. / P450s by Graham-Lorence (1996)
10.1126/science.271.5251.997 / Science / Ligand binding and molecular mechanics calculation of the streptavidin-biotin rupture force by Grubmüller (1996)
10.1016/S0006-3495(97)78202-X / Biophys. J. / Molecular dynamics study of free energy profiles for organic cations in gramicidin A channels by Hao (1997)
10.1021/bi951817l / Biochemistry / Improved binding of cytochrome P450cam substrate analogues designed to fill extra space in the substrate binding pocket by Helms (1996)
10.1016/S0009-2614(99)00183-9 / Chem. Phys. Letters / AN02/DNP- hapten unbinding forces studied by molecular dynamics atmic force microscopy simulations by Heymann (1999)
10.1016/S0006-3495(97)78326-7 / Biophys. J. / Binding pathway of retinal to bacterio-opsin by Isralewitz (1997)
10.1016/S0006-3495(97)78804-0 / Biophys. J. / Molecular dynamics study of unbinding of the avidin-biotin complex by Izrailev (1997)
10.1016/S0006-3495(99)77188-2 / Biophys. J. / Unbinding of retinoic acid from its receptor studied by steered molecular dynamics by Kosztin (1999)
10.1038/nsb0297-140 / Nature Struct. Biol. / The structure of the cytochrome P450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid by Li (1997)
10.1021/bi9622940 / Biochemistry / The exceptionally stable salt-bridges in cytochrome P450cam have functional roles by Lounnas (1997)
10.1016/S0301-4622(98)00237-3 / Biophys. Chem. / Towards molecular dynamics simulation of large proteins with a hydration shell at constant pressure by Lounnas (1999)
10.1006/jmbi.2000.4154 / J. Mol. Biol. / How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms by Lüdemann (2000)
{'key': '10.1006/jmbi.2000.4155_BIB24', 'series-title': 'Twenty-five Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis', 'article-title': 'Cytochrome P450', 'author': 'Mueller', 'year': '1995'} / Twenty-five Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis / Cytochrome P450 by Mueller (1995)
{'key': '10.1006/jmbi.2000.4155_BIB25', 'series-title': 'Cytochrome P450: Structure, Mechanism and Biochemistry', 'author': 'Ortiz de Montellano', 'year': '1995'} / Cytochrome P450: Structure, Mechanism and Biochemistry by Ortiz de Montellano (1995)
10.1063/1.431685 / J. Chem. Phys. / A Monte Carlo method for obtaining the interionic potential of mean force in ionic solution by Patey (1975)
10.1080/07391102.1991.10507906 / J. Biomol. Struct. Dynam. / Analysis of active site motions from a 175 ps molecular dynamics simulation of camphor-bound cytochrome P450cam by Paulsen (1991)
10.1016/S0300-9084(97)82530-8 / Biochimie / A structure-based model for cytochrome P450cam-putidaredoxin interactions by Pochapsky (1996)
10.1021/bi00366a049 / Biochemistry / Crystal structure of substrate-free Pseudomonas putida cytochrome P450cam by Poulos (1986)
10.1016/0022-2836(87)90190-2 / J. Mol. Biol. / High-resolution crystal structure of cytochrome P450cam by Poulos (1987)
10.1021/bi00068a013 / Biochemistry / Inhibitor-induced conformational change in cytochrome P450cam by Raag (1993)
10.1080/08927029308022170 / Mol. Simulat. / Targeted molecular dynamics simulation of conformational change - application to the T-R transition in insulin by Schlitter (1993)
10.1002/jcc.540110806 / J. Comp. Chem. / Argos, a general vectorized molecular dynamics program by Straatsma (1990)
10.1016/0263-7855(90)80070-V / J. Mol. Graph. / What if by Vriend (1990)
10.1021/jm00053a019 / J. Med. Chem. by Wade (1993)
10.1016/S1097-2765(00)80408-6 / Mol. Cell / Mammalian microsomal cytochromeP450 monoxygenase by Williams (2000)
10.1021/ja971226d / J. Am. Chem. Soc. / Molecular dynamics of acetylcholinesterase dimer complexed with tacrine by Wlodek (1997)
10.1002/(SICI)1097-0134(19990501)35:2<262::AID-PROT11>3.0.CO;2-N / Proteins: Struct. Funct. Genet. / Investigating a back door mechanism of actin phosphate release by steered molecular dynamics by Wriggers (1999)
10.1016/S0969-2126(00)00052-6 / Structure / Structural studies on human muscle fatty acid binding protein at 1.4 Å resolution by Young (1994)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 3:24 p.m.)
Deposited	5 years, 8 months ago (Dec. 16, 2019, 6:28 a.m.)
Indexed	1 month, 1 week ago (July 28, 2025, 2:29 a.m.)
Issued	24 years, 10 months ago (Nov. 1, 2000)
Published	24 years, 10 months ago (Nov. 1, 2000)
Published Print	24 years, 10 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{L_demann_2000, title={How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways 1 1Edited by J. Thornton}, volume={303}, ISSN={0022-2836}, url={http://dx.doi.org/10.1006/jmbi.2000.4155}, DOI={10.1006/jmbi.2000.4155}, number={5}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Lüdemann, Susanna K. and Lounnas, Valère and Wade, Rebecca C.}, year={2000}, month=nov, pages={813–830} }

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      "article-title": "Retinoic acid receptor",
      "volume": "291",
      "author": "Blondel",
      "year": "1999",
      "journal-title": "J. Mol. Biol."
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      "article-title": "Electrostatic control of the substrate access channel in cytochrome P450cam",
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      "author": "Deprez",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
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      "first-page": "12987",
      "DOI": "10.1073/pnas.96.23.12987",
      "article-title": "Optical detection of cytochrome P450 by sensitizer-linked substrates",
      "volume": "96",
      "author": "Dmochowski",
      "year": "1999",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "8043",
      "DOI": "10.1021/ja973131h",
      "article-title": "Alternate pathways for acetic acid and acetate ion release from acetylcholinesterase",
      "volume": "120",
      "author": "Enyedy",
      "year": "1998",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.1016/0009-2614(92)85543-J",
      "article-title": "Conjugate peak refinement",
      "volume": "194",
      "author": "Fischer",
      "year": "1992",
      "journal-title": "Chem. Phys. Letters"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "8384",
      "DOI": "10.1073/pnas.96.15.8384",
      "article-title": "A structural snapshot of an intermediate on the streptavidin-biotin dissociation pathway",
      "volume": "96",
      "author": "Freitag",
      "year": "1999",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "2002",
      "DOI": "10.1073/pnas.72.6.2002",
      "article-title": "Side-chain torsional potentials and motion of amino acids in proteins",
      "volume": "72",
      "author": "Gelin",
      "year": "1975",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB10",
      "series-title": "Bioorganic activation of cytochrome P450cam",
      "author": "Gerber",
      "year": "1994"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "849",
      "DOI": "10.1021/jm00145a002",
      "article-title": "A computational procedure for determining energetically favorable binding sites on biologically important macromolecules",
      "volume": "28",
      "author": "Goodford",
      "year": "1985",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "206",
      "DOI": "10.1096/fasebj.10.2.8641554",
      "article-title": "P450s",
      "volume": "10",
      "author": "Graham-Lorence",
      "year": "1996",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "997",
      "DOI": "10.1126/science.271.5251.997",
      "article-title": "Ligand binding and molecular mechanics calculation of the streptavidin-biotin rupture force",
      "volume": "271",
      "author": "Grubm\u00fcller",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1699",
      "DOI": "10.1016/S0006-3495(97)78202-X",
      "article-title": "Molecular dynamics study of free energy profiles for organic cations in gramicidin A channels",
      "volume": "73",
      "author": "Hao",
      "year": "1997",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1485",
      "DOI": "10.1021/bi951817l",
      "article-title": "Improved binding of cytochrome P450cam substrate analogues designed to fill extra space in the substrate binding pocket",
      "volume": "35",
      "author": "Helms",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0009-2614(99)00183-9",
      "article-title": "AN02/DNP- hapten unbinding forces studied by molecular dynamics atmic force microscopy simulations",
      "volume": "303",
      "author": "Heymann",
      "year": "1999",
      "journal-title": "Chem. Phys. Letters"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "2972",
      "DOI": "10.1016/S0006-3495(97)78326-7",
      "article-title": "Binding pathway of retinal to bacterio-opsin",
      "volume": "73",
      "author": "Isralewitz",
      "year": "1997",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1568",
      "DOI": "10.1016/S0006-3495(97)78804-0",
      "article-title": "Molecular dynamics study of unbinding of the avidin-biotin complex",
      "volume": "72",
      "author": "Izrailev",
      "year": "1997",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1016/S0006-3495(99)77188-2",
      "article-title": "Unbinding of retinoic acid from its receptor studied by steered molecular dynamics",
      "volume": "76",
      "author": "Kosztin",
      "year": "1999",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.1038/nsb0297-140",
      "article-title": "The structure of the cytochrome P450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid",
      "volume": "4",
      "author": "Li",
      "year": "1997",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "5402",
      "DOI": "10.1021/bi9622940",
      "article-title": "The exceptionally stable salt-bridges in cytochrome P450cam have functional roles",
      "volume": "36",
      "author": "Lounnas",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0301-4622(98)00237-3",
      "article-title": "Towards molecular dynamics simulation of large proteins with a hydration shell at constant pressure",
      "volume": "78",
      "author": "Lounnas",
      "year": "1999",
      "journal-title": "Biophys. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "797",
      "DOI": "10.1006/jmbi.2000.4154",
      "article-title": "How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms",
      "volume": "303",
      "author": "L\u00fcdemann",
      "year": "2000",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB24",
      "series-title": "Twenty-five Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis",
      "article-title": "Cytochrome P450",
      "author": "Mueller",
      "year": "1995"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB25",
      "series-title": "Cytochrome P450: Structure, Mechanism and Biochemistry",
      "author": "Ortiz de Montellano",
      "year": "1995"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "2334",
      "DOI": "10.1063/1.431685",
      "article-title": "A Monte Carlo method for obtaining the interionic potential of mean force in ionic solution",
      "volume": "63",
      "author": "Patey",
      "year": "1975",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1080/07391102.1991.10507906",
      "article-title": "Analysis of active site motions from a 175 ps molecular dynamics simulation of camphor-bound cytochrome P450cam",
      "volume": "9",
      "author": "Paulsen",
      "year": "1991",
      "journal-title": "J. Biomol. Struct. Dynam."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1016/S0300-9084(97)82530-8",
      "article-title": "A structure-based model for cytochrome P450cam-putidaredoxin interactions",
      "volume": "78",
      "author": "Pochapsky",
      "year": "1996",
      "journal-title": "Biochimie"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "5314",
      "DOI": "10.1021/bi00366a049",
      "article-title": "Crystal structure of substrate-free Pseudomonas putida cytochrome P450cam",
      "volume": "25",
      "author": "Poulos",
      "year": "1986",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "687",
      "DOI": "10.1016/0022-2836(87)90190-2",
      "article-title": "High-resolution crystal structure of cytochrome P450cam",
      "volume": "195",
      "author": "Poulos",
      "year": "1987",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "4571",
      "DOI": "10.1021/bi00068a013",
      "article-title": "Inhibitor-induced conformational change in cytochrome P450cam",
      "volume": "32",
      "author": "Raag",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1080/08927029308022170",
      "article-title": "Targeted molecular dynamics simulation of conformational change - application to the T-R transition in insulin",
      "volume": "10",
      "author": "Schlitter",
      "year": "1993",
      "journal-title": "Mol. Simulat."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "943",
      "DOI": "10.1002/jcc.540110806",
      "article-title": "Argos, a general vectorized molecular dynamics program",
      "volume": "11",
      "author": "Straatsma",
      "year": "1990",
      "journal-title": "J. Comp. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "52",
      "DOI": "10.1016/0263-7855(90)80070-V",
      "article-title": "What if",
      "volume": "8",
      "author": "Vriend",
      "year": "1990",
      "journal-title": "J. Mol. Graph."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "148",
      "DOI": "10.1021/jm00053a019",
      "volume": "36",
      "author": "Wade",
      "year": "1993",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.4155_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1016/S1097-2765(00)80408-6",
      "article-title": "Mammalian microsomal cytochromeP450 monoxygenase",
      "volume": "5",
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