DOI: 10.1006/jmbi.2000.3866. Effects of side-chain characteristics on stability and oligomerization state of a de Novo -designed model coiled-coil: 20 amino acid substitutions in position “d” 1 1Edited by P. E. Wright

Effects of side-chain characteristics on stability and oligomerization state of a de Novo -designed model coiled-coil: 20 amino acid substitutions in position “d” 1 1Edited by P. E. Wright

10.1006/jmbi.2000.3866

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Tripet, B., Wagschal, K., Lavigne, P., Mant, C. T., & Hodges, R. S. (2000). Effects of side-chain characteristics on stability and oligomerization state of a de Novo -designed model coiled-coil: 20 amino acid substitutions in position âdâ 1 1Edited by P. E. Wright. Journal of Molecular Biology, 300(2), 377â402.

Authors 5

Brian Tripet (first)
Kurt Wagschal (additional)
Pierre Lavigne (additional)
Colin T. Mant (additional)
Robert S. Hodges (additional)

References 69 Referenced 224

10.1016/0003-2697(69)90172-9 / Annu. Biochem. / Measurements of protein concentration with interference optics by Babul (1969)
10.1021/bi00052a024 / Biochemistry / Destabilizing effects of replacing a surface lysine of cytochrome c with aromatic amino acids by Bowler (1993)
10.1073/pnas.88.10.4195 / Proc. Natl Acad. Sci. USA / The protein-folding problem by Behe (1991)
10.1021/bi00713a027 / Biochemistry / Determination of the helix and β form of proteins in aqueous solution by circular dichroism by Chen (1974)
{'key': '10.1006/jmbi.2000.3866_BIB5', 'series-title': 'A Manual of Methods for the Analytical Ultracentrifuge', 'first-page': '1', 'author': 'Chervenka', 'year': '1969'} / A Manual of Methods for the Analytical Ultracentrifuge by Chervenka (1969)
10.1002/prot.340070102 / Proteins: Struct. Funct. Genet. / α-Helical coiled coils and bundles by Cohen (1990)
{'key': '10.1006/jmbi.2000.3866_BIB7', 'series-title': 'Proteins, Amino Acids, and Peptides as Ions and Dipolar Ions', 'first-page': '370', 'author': 'Cohn', 'year': '1943'} / Proteins, Amino Acids, and Peptides as Ions and Dipolar Ions by Cohn (1943)
10.1002/bip.360300703 / Biopolymers / The effect of conformation on the CD of interacting helices by Cooper (1990)
10.1107/S0365110X53001964 / Acta Crystallog. / The packing of α-helices by Crick (1953)
10.1146/annurev.bi.60.070191.004051 / Annu. Rev. Biochem. / Denatured states of proteins by Dill (1991)
10.1038/319199a0 / Nature / Solvation energy in protein folding and binding by Eisenberg (1986)
10.1021/bi00227a002 / Biochemistry / Designed coiled-coil proteins by Engel (1991)
10.1126/science.1553543 / Science / Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect by Eriksson (1992)
{'key': '10.1006/jmbi.2000.3866_BIB13', 'first-page': '369', 'article-title': 'Hydrophobic parameters π of amino acid side-chains from the partioning of N-acetyl-amino-acid-amides', 'volume': '18', 'author': 'Fauchere', 'year': '1983', 'journal-title': 'Eur. J. Med. Chem.'} / Eur. J. Med. Chem. / Hydrophobic parameters π of amino acid side-chains from the partioning of N-acetyl-amino-acid-amides by Fauchere (1983)
10.1038/nsb1296-1002 / Nature Struct. Biol. / Crystal structures of a single coiled-coil peptide in two oligomeric states reveal the basis for structural polymorphism by Gonzalez (1996)
10.1038/nsb0696-510 / Nature Struct. Biol. / An engineered allosteric switch in leucine-zipper oligomerization by Gonzalez (1996)
10.1038/nsb1296-1011 / Nature Struct. Biol. / Buried polar residues and structural specificity in the GCN4 leucine zipper by Gonzalez (1996)
10.1021/bi00140a005 / Biochemistry / Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease by Green (1992)
10.1126/science.8248779 / Science / A switch between two, three, and four-stranded coiled coils in GCN4 leucine zipper mutants by Harbury (1993)
10.1101/SQB.1973.037.01.040 / Cold Spring Harbor Symp. Quant. Biol. / Tropomyosin by Hodges (1972)
10.1016/S0021-9258(19)69951-5 / J. Biol. Chem. / Synthetic model for two-stranded α-helical coiled-coils. Design, synthesis, and characterization of an 86-residue analog of tropomyosin by Hodges (1981)
{'key': '10.1006/jmbi.2000.3866_BIB21', 'first-page': '123', 'article-title': 'Synthetic model proteins', 'volume': '3', 'author': 'Hodges', 'year': '1990', 'journal-title': 'Peptide Res.'} / Peptide Res. / Synthetic model proteins by Hodges (1990)
10.1126/science.2147779 / Science / Sequence requirements for coiled-coils by Hu (1990)
10.1021/bi00437a058 / Biochemistry / Energetics of complementary side-chain packing in a protein hydrophobic core by Kellis (1989)
10.1038/333784a0 / Nature / Contribution of hydrophobic interactions to protein stability by Kellis (1988)
10.1006/jmbi.1997.0930 / J. Mol. Biol. / Salt effects on protein stability by Kohn (1997)
10.1006/jmbi.1998.2125 / J. Mol. Biol. / Orientation, positional, additivity, and oligomerization-state effects of interhelical ion pairs in α-helical coiled-coils by Kohn (1998)
10.1016/S0021-9258(18)90686-1 / J. Biol. Chem. / Synthesis of a model protein of defined secondary and quaternary structure; effect of chain length on the stabilization and formation of two-stranded α-helical coiled-coils by Lau (1984)
10.1038/339031a0 / Nature / Alternative packing arrangements in the hydrophobic core of λ repressor by Lim (1989)
10.1021/bi00027a013 / Biochemistry / A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil by Lumb (1995)
10.1126/science.252.5009.1162 / Science / Predicting coiled coils from protein sequences by Lupas (1991)
10.1016/S0021-9673(97)00767-X / J. Chromatog. sect. A / Effect of mobile phase on the oligomerization state of alpha-helical coiled-coil peptides during high-performance size-exclusion chromatography by Mant (1997)
10.1038/334406a0 / Nature / Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile3 by Matsumura (1988)
10.1016/S0022-2836(75)80119-7 / J. Mol. Biol. / Tropomyosin coiled-coil interactions by McLachlan (1975)
10.1126/science.1615324 / Science / Probing protein stability with unnatural amino acids by Mendel (1992)
10.1021/bi971424h / Biochemistry / Leucine is the most stabilizing aliphatic amino acid in the d position of a dimeric leucine zipper coiled coil by Moitra (1997)
10.1093/protein/9.4.353 / Protein Eng. / The relative positions of alanine residues in the hydrophobic core control the formation of two-stranded or four-stranded alpha-helical coiled-coils by Monera (1996)
10.1016/S0021-9258(19)36502-0 / J. Biol. Chem. / Comparison of anti-parallel and parallel two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization by Monera (1993)
10.1002/pro.5560041020 / Protein Sci. / Denaturant m values and heat capacity changes by Myers (1995)
10.1002/pro.5560070206 / Protein Sci. / An interaction-based analysis of calcium-induced conformational changes in Ca2+ sensor proteins by Nelson (1998)
10.1126/science.1948029 / Science / X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil by O’Shea (1991)
{'key': '10.1006/jmbi.2000.3866_BIB42', 'first-page': '658', 'article-title': 'Peptide “Velcro”', 'volume': '3', 'author': 'O’Shea', 'year': '1993', 'journal-title': 'Curr. Biol.'} / Curr. Biol. / Peptide “Velcro” by O’Shea (1993)
10.1016/0076-6879(86)31045-0 / Methods Enzymol. / Determination and analysis of urea and guanidine hydrochloride denaturation curves by Pace (1986)
10.1021/bi00125a013 / Biochemistry / Urea denaturation of bamase by Pace (1992)
10.1096/fasebj.10.1.8566551 / FASEB J. / Forces contributing to the conformational stability of proteins by Pace (1996)
10.1016/0022-2836(87)90358-5 / J. Mol. Biol. / Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes by Ponder (1987)
10.1126/science.2787053 / Science / Influence of interior packing and hydrophobicity on the stability of a protein by Sandberg (1989)
10.1002/bip.1981.360200921 / Biopolymers / Mutations and protein stability by Schellman (1981)
10.1038/342296a0 / Nature / Capping and alpha-helix stability by Serrano (1989)
10.1038/326563a0 / Nature / Tests of the helix dipole model for stabilization of α-helices by Shoemaker (1987)
10.1017/S0033583500004674 / Quart. Rev. Biophys. / Mutational studies of protein structures and their stabilities by Shortle (1992)
10.1016/0959-440X(93)90204-X / Curr. Opin. Struct. Biol. / Denatured states of proteins and their roles in folding and stability by Shortle (1993)
10.1016/S0021-9258(18)83544-X / J. Biol. Chem. / Probing the determinants of protein folding and stability with amino acid substitutions by Shortle (1989)
10.1002/prot.340010113 / Protein: Struct. Funct. Genet. / Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation by Shortle (1986)
10.1021/bi00429a003 / Biochemistry / Residual structure in large fragments of staphylococcal nuclease by Shortle (1989)
10.1021/bi00487a007 / Biochemistry / Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease by Shortle (1990)
10.1002/pro.5560051007 / Protein Sci. / Surface point mutations that significantly alter the structure and stability of a protein’s denatured state by Smith (1996)
10.1021/bi00152a015 / Biochemisty / Effect of trifluoroethanol on protein secondary structure by Sönnichsen (1992)
10.1006/jmbi.1998.2284 / J. Mol. Biol. / De novo design of a model peptide sequence to examine the effects of single amino acid substitutions in the hydrophobic core on both stability and oligomerization state of coiled-coils by Wagschal (1999)
10.1110/ps.8.11.2312 / Protein Sci. / The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils by Wagschal (1999)
{'key': '10.1006/jmbi.2000.3866_BIB61', 'first-page': '121', 'article-title': 'SEQSEE', 'volume': '10', 'author': 'Wishart', 'year': '1994', 'journal-title': 'Comp. Appl. Biosci.'} / Comp. Appl. Biosci. / SEQSEE by Wishart (1994)
10.1016/0301-4622(95)00131-X / Biophys. Chem. / Investigation of electrostatic interactions in two-stranded coiled-coils through residue shuffling by Yu (1996)
10.1006/jmbi.1996.0030 / J. Mol. Biol. / Ion pairs significantly stabilize coiled-coils in the absence of electrolyte by Yu (1996)
10.1021/bi00140a008 / Biochemistry / Synthetic model proteins by Zhou (1992)
10.1016/S0021-9258(18)45932-7 / J. Biol. Chem. / Synthetic model proteins. Positional effects of interchain hydrophobic interactions on stability of two-stranded α-helical coiled-coils by Zhou (1992)
10.2174/0929866501666220424135225 / Protein Peptide Letters / α-Helical propensities of amino acids in the hydrophobic face of an amphipathic α-helix by Zhou (1994)
10.1111/j.1399-3011.1992.tb00290.x / Int. J. Peptide Protein Res. / Design, synthesis and structural characterisation of model heterodimeric coiled-coil proteins by Zhu (1992)
10.1002/pro.5560020310 / Protein Sci. / Packing and hydrophobicity effects on protein folding and stability by Zhu (1993)
10.1016/S0959-440X(97)80056-5 / Curr. Opin. Struct. Biol. / Predicting coiled-coil regions in proteins by Lupas (1997)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 3:24 p.m.)
Deposited	2 years, 5 months ago (April 3, 2023, 8:51 p.m.)
Indexed	1 month, 2 weeks ago (July 20, 2025, 6:51 p.m.)
Issued	25 years, 2 months ago (July 1, 2000)
Published	25 years, 2 months ago (July 1, 2000)
Published Print	25 years, 2 months ago (July 1, 2000)

Funders 0

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BibTeX

@article{Tripet_2000, title={Effects of side-chain characteristics on stability and oligomerization state of a de Novo -designed model coiled-coil: 20 amino acid substitutions in position “d” 1 1Edited by P. E. Wright}, volume={300}, ISSN={0022-2836}, url={http://dx.doi.org/10.1006/jmbi.2000.3866}, DOI={10.1006/jmbi.2000.3866}, number={2}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Tripet, Brian and Wagschal, Kurt and Lavigne, Pierre and Mant, Colin T. and Hodges, Robert S.}, year={2000}, month=jul, pages={377–402} }

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      "article-title": "Destabilizing effects of replacing a surface lysine of cytochrome c with aromatic amino acids",
      "volume": "32",
      "author": "Bowler",
      "year": "1993",
      "journal-title": "Biochemistry"
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      "article-title": "The protein-folding problem",
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      "author": "Behe",
      "year": "1991",
      "journal-title": "Proc. Natl Acad. Sci. USA"
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      "first-page": "3350",
      "DOI": "10.1021/bi00713a027",
      "article-title": "Determination of the helix and \u03b2 form of proteins in aqueous solution by circular dichroism",
      "volume": "13",
      "author": "Chen",
      "year": "1974",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB5",
      "series-title": "A Manual of Methods for the Analytical Ultracentrifuge",
      "first-page": "1",
      "author": "Chervenka",
      "year": "1969"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1002/prot.340070102",
      "article-title": "\u03b1-Helical coiled coils and bundles",
      "volume": "7",
      "author": "Cohen",
      "year": "1990",
      "journal-title": "Proteins: Struct. Funct. Genet."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB7",
      "series-title": "Proteins, Amino Acids, and Peptides as Ions and Dipolar Ions",
      "first-page": "370",
      "author": "Cohn",
      "year": "1943"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "657",
      "DOI": "10.1002/bip.360300703",
      "article-title": "The effect of conformation on the CD of interacting helices",
      "volume": "30",
      "author": "Cooper",
      "year": "1990",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1107/S0365110X53001964",
      "article-title": "The packing of \u03b1-helices",
      "volume": "6",
      "author": "Crick",
      "year": "1953",
      "journal-title": "Acta Crystallog."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "795",
      "DOI": "10.1146/annurev.bi.60.070191.004051",
      "article-title": "Denatured states of proteins",
      "volume": "60",
      "author": "Dill",
      "year": "1991",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1038/319199a0",
      "article-title": "Solvation energy in protein folding and binding",
      "volume": "319",
      "author": "Eisenberg",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "3161",
      "DOI": "10.1021/bi00227a002",
      "article-title": "Designed coiled-coil proteins",
      "volume": "30",
      "author": "Engel",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1126/science.1553543",
      "article-title": "Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect",
      "volume": "255",
      "author": "Eriksson",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB13",
      "first-page": "369",
      "article-title": "Hydrophobic parameters \u03c0 of amino acid side-chains from the partioning of N-acetyl-amino-acid-amides",
      "volume": "18",
      "author": "Fauchere",
      "year": "1983",
      "journal-title": "Eur. J. Med. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1002",
      "DOI": "10.1038/nsb1296-1002",
      "article-title": "Crystal structures of a single coiled-coil peptide in two oligomeric states reveal the basis for structural polymorphism",
      "volume": "3",
      "author": "Gonzalez",
      "year": "1996",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "510",
      "DOI": "10.1038/nsb0696-510",
      "article-title": "An engineered allosteric switch in leucine-zipper oligomerization",
      "volume": "3",
      "author": "Gonzalez",
      "year": "1996",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1011",
      "DOI": "10.1038/nsb1296-1011",
      "article-title": "Buried polar residues and structural specificity in the GCN4 leucine zipper",
      "volume": "3",
      "author": "Gonzalez",
      "year": "1996",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "5717",
      "DOI": "10.1021/bi00140a005",
      "article-title": "Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease",
      "volume": "31",
      "author": "Green",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1401",
      "DOI": "10.1126/science.8248779",
      "article-title": "A switch between two, three, and four-stranded coiled coils in GCN4 leucine zipper mutants",
      "volume": "262",
      "author": "Harbury",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1101/SQB.1973.037.01.040",
      "article-title": "Tropomyosin",
      "volume": "37",
      "author": "Hodges",
      "year": "1972",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB20",
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      "first-page": "1214",
      "DOI": "10.1016/S0021-9258(19)69951-5",
      "article-title": "Synthetic model for two-stranded \u03b1-helical coiled-coils. Design, synthesis, and characterization of an 86-residue analog of tropomyosin",
      "volume": "256",
      "author": "Hodges",
      "year": "1981",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB21",
      "first-page": "123",
      "article-title": "Synthetic model proteins",
      "volume": "3",
      "author": "Hodges",
      "year": "1990",
      "journal-title": "Peptide Res."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "1400",
      "DOI": "10.1126/science.2147779",
      "article-title": "Sequence requirements for coiled-coils",
      "volume": "250",
      "author": "Hu",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "4914",
      "DOI": "10.1021/bi00437a058",
      "article-title": "Energetics of complementary side-chain packing in a protein hydrophobic core",
      "volume": "28",
      "author": "Kellis",
      "year": "1989",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "784",
      "DOI": "10.1038/333784a0",
      "article-title": "Contribution of hydrophobic interactions to protein stability",
      "volume": "333",
      "author": "Kellis",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1039",
      "DOI": "10.1006/jmbi.1997.0930",
      "article-title": "Salt effects on protein stability",
      "volume": "267",
      "author": "Kohn",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "993",
      "DOI": "10.1006/jmbi.1998.2125",
      "article-title": "Orientation, positional, additivity, and oligomerization-state effects of interhelical ion pairs in \u03b1-helical coiled-coils",
      "volume": "283",
      "author": "Kohn",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "13253",
      "DOI": "10.1016/S0021-9258(18)90686-1",
      "article-title": "Synthesis of a model protein of defined secondary and quaternary structure; effect of chain length on the stabilization and formation of two-stranded \u03b1-helical coiled-coils",
      "volume": "259",
      "author": "Lau",
      "year": "1984",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1038/339031a0",
      "article-title": "Alternative packing arrangements in the hydrophobic core of \u03bb repressor",
      "volume": "339",
      "author": "Lim",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "8642",
      "DOI": "10.1021/bi00027a013",
      "article-title": "A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil",
      "volume": "34",
      "author": "Lumb",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1162",
      "DOI": "10.1126/science.252.5009.1162",
      "article-title": "Predicting coiled coils from protein sequences",
      "volume": "252",
      "author": "Lupas",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/S0021-9673(97)00767-X",
      "article-title": "Effect of mobile phase on the oligomerization state of alpha-helical coiled-coil peptides during high-performance size-exclusion chromatography",
      "volume": "791",
      "author": "Mant",
      "year": "1997",
      "journal-title": "J. Chromatog. sect. A"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "406",
      "DOI": "10.1038/334406a0",
      "article-title": "Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile3",
      "volume": "334",
      "author": "Matsumura",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1016/S0022-2836(75)80119-7",
      "article-title": "Tropomyosin coiled-coil interactions",
      "volume": "98",
      "author": "McLachlan",
      "year": "1975",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "1798",
      "DOI": "10.1126/science.1615324",
      "article-title": "Probing protein stability with unnatural amino acids",
      "volume": "256",
      "author": "Mendel",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "12567",
      "DOI": "10.1021/bi971424h",
      "article-title": "Leucine is the most stabilizing aliphatic amino acid in the d position of a dimeric leucine zipper coiled coil",
      "volume": "36",
      "author": "Moitra",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1093/protein/9.4.353",
      "article-title": "The relative positions of alanine residues in the hydrophobic core control the formation of two-stranded or four-stranded alpha-helical coiled-coils",
      "volume": "9",
      "author": "Monera",
      "year": "1996",
      "journal-title": "Protein Eng."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "19218",
      "DOI": "10.1016/S0021-9258(19)36502-0",
      "article-title": "Comparison of anti-parallel and parallel two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization",
      "volume": "268",
      "author": "Monera",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "2138",
      "DOI": "10.1002/pro.5560041020",
      "article-title": "Denaturant m values and heat capacity changes",
      "volume": "4",
      "author": "Myers",
      "year": "1995",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "270",
      "DOI": "10.1002/pro.5560070206",
      "article-title": "An interaction-based analysis of calcium-induced conformational changes in Ca2+ sensor proteins",
      "volume": "7",
      "author": "Nelson",
      "year": "1998",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "539",
      "DOI": "10.1126/science.1948029",
      "article-title": "X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil",
      "volume": "254",
      "author": "O\u2019Shea",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB42",
      "first-page": "658",
      "article-title": "Peptide \u201cVelcro\u201d",
      "volume": "3",
      "author": "O\u2019Shea",
      "year": "1993",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1016/0076-6879(86)31045-0",
      "article-title": "Determination and analysis of urea and guanidine hydrochloride denaturation curves",
      "volume": "131",
      "author": "Pace",
      "year": "1986",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "2728",
      "DOI": "10.1021/bi00125a013",
      "article-title": "Urea denaturation of bamase",
      "volume": "31",
      "author": "Pace",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1096/fasebj.10.1.8566551",
      "article-title": "Forces contributing to the conformational stability of proteins",
      "volume": "10",
      "author": "Pace",
      "year": "1996",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "775",
      "DOI": "10.1016/0022-2836(87)90358-5",
      "article-title": "Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes",
      "volume": "193",
      "author": "Ponder",
      "year": "1987",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "54",
      "DOI": "10.1126/science.2787053",
      "article-title": "Influence of interior packing and hydrophobicity on the stability of a protein",
      "volume": "245",
      "author": "Sandberg",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "1989",
      "DOI": "10.1002/bip.1981.360200921",
      "article-title": "Mutations and protein stability",
      "volume": "20",
      "author": "Schellman",
      "year": "1981",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "296",
      "DOI": "10.1038/342296a0",
      "article-title": "Capping and alpha-helix stability",
      "volume": "342",
      "author": "Serrano",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1038/326563a0",
      "article-title": "Tests of the helix dipole model for stabilization of \u03b1-helices",
      "volume": "326",
      "author": "Shoemaker",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "205",
      "DOI": "10.1017/S0033583500004674",
      "article-title": "Mutational studies of protein structures and their stabilities",
      "volume": "25",
      "author": "Shortle",
      "year": "1992",
      "journal-title": "Quart. Rev. Biophys."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "66",
      "DOI": "10.1016/0959-440X(93)90204-X",
      "article-title": "Denatured states of proteins and their roles in folding and stability",
      "volume": "3",
      "author": "Shortle",
      "year": "1993",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "5315",
      "DOI": "10.1016/S0021-9258(18)83544-X",
      "article-title": "Probing the determinants of protein folding and stability with amino acid substitutions",
      "volume": "264",
      "author": "Shortle",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1002/prot.340010113",
      "article-title": "Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation",
      "volume": "1",
      "author": "Shortle",
      "year": "1986",
      "journal-title": "Protein: Struct. Funct. Genet."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "936",
      "DOI": "10.1021/bi00429a003",
      "article-title": "Residual structure in large fragments of staphylococcal nuclease",
      "volume": "28",
      "author": "Shortle",
      "year": "1989",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "8033",
      "DOI": "10.1021/bi00487a007",
      "article-title": "Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease",
      "volume": "29",
      "author": "Shortle",
      "year": "1990",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "2009",
      "DOI": "10.1002/pro.5560051007",
      "article-title": "Surface point mutations that significantly alter the structure and stability of a protein\u2019s denatured state",
      "volume": "5",
      "author": "Smith",
      "year": "1996",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "8790",
      "DOI": "10.1021/bi00152a015",
      "article-title": "Effect of trifluoroethanol on protein secondary structure",
      "volume": "31",
      "author": "S\u00f6nnichsen",
      "year": "1992",
      "journal-title": "Biochemisty"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "785",
      "DOI": "10.1006/jmbi.1998.2284",
      "article-title": "De novo design of a model peptide sequence to examine the effects of single amino acid substitutions in the hydrophobic core on both stability and oligomerization state of coiled-coils",
      "volume": "285",
      "author": "Wagschal",
      "year": "1999",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "2312",
      "DOI": "10.1110/ps.8.11.2312",
      "article-title": "The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils",
      "volume": "8",
      "author": "Wagschal",
      "year": "1999",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB61",
      "first-page": "121",
      "article-title": "SEQSEE",
      "volume": "10",
      "author": "Wishart",
      "year": "1994",
      "journal-title": "Comp. Appl. Biosci."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1016/0301-4622(95)00131-X",
      "article-title": "Investigation of electrostatic interactions in two-stranded coiled-coils through residue shuffling",
      "volume": "59",
      "author": "Yu",
      "year": "1996",
      "journal-title": "Biophys. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "367",
      "DOI": "10.1006/jmbi.1996.0030",
      "article-title": "Ion pairs significantly stabilize coiled-coils in the absence of electrolyte",
      "volume": "255",
      "author": "Yu",
      "year": "1996",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "5739",
      "DOI": "10.1021/bi00140a008",
      "article-title": "Synthetic model proteins",
      "volume": "31",
      "author": "Zhou",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "2664",
      "DOI": "10.1016/S0021-9258(18)45932-7",
      "article-title": "Synthetic model proteins. Positional effects of interchain hydrophobic interactions on stability of two-stranded \u03b1-helical coiled-coils",
      "volume": "267",
      "author": "Zhou",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "114",
      "DOI": "10.2174/0929866501666220424135225",
      "article-title": "\u03b1-Helical propensities of amino acids in the hydrophobic face of an amphipathic \u03b1-helix",
      "volume": "1",
      "author": "Zhou",
      "year": "1994",
      "journal-title": "Protein Peptide Letters"
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB67",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1111/j.1399-3011.1992.tb00290.x",
      "article-title": "Design, synthesis and structural characterisation of model heterodimeric coiled-coil proteins",
      "volume": "40",
      "author": "Zhu",
      "year": "1992",
      "journal-title": "Int. J. Peptide Protein Res."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB68",
      "doi-asserted-by": "crossref",
      "first-page": "383",
      "DOI": "10.1002/pro.5560020310",
      "article-title": "Packing and hydrophobicity effects on protein folding and stability",
      "volume": "2",
      "author": "Zhu",
      "year": "1993",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1006/jmbi.2000.3866_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "388",
      "DOI": "10.1016/S0959-440X(97)80056-5",
      "article-title": "Predicting coiled-coil regions in proteins",
      "volume": "7",
      "author": "Lupas",
      "year": "1997",
      "journal-title": "Curr. Opin. Struct. Biol."
    }
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