DOI: 10.1006/jmbi.2000.3738. A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht

10.1006/jmbi.2000.3738

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

ChÃ¨ne, P., Fuchs, J., Bohn, J., GarcÄ±Ìa-EcheverrÄ±Ìa, C., Furet, P., & Fabbro, D. (2000). A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht. Journal of Molecular Biology, 299(1), 245â253.

Authors 6

Patrick Chène (first)
Jean Fuchs (additional)
Jacqueline Bohn (additional)
Carlos Garcı́a-Echeverrı́a (additional)
Pascal Furet (additional)
Doriano Fabbro (additional)

References 33 Referenced 124

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10.1038/sj.onc.1201018 / Oncogene / Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2 by Blaydes (1997)
{'key': '10.1006/jmbi.2000.3738_BIB4', 'first-page': '2141', 'article-title': 'Identification of novel mdm2 binding peptides by phage display', 'volume': '13', 'author': 'Bottger', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Identification of novel mdm2 binding peptides by phage display by Bottger (1996)
10.1016/S0960-9822(06)00374-5 / Curr. Biol. / Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo by Bottger (1997)
10.1042/bj3220019 / Biochem. J. / Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis by Chandler (1997)
10.1128/MCB.13.7.4107 / Mol. Cell. Biol. / Mapping of the p53 and mdm-2 interaction domains by Chen (1993)
10.1073/pnas.95.1.195 / Proc. Natl Acad. Sci. USA / Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage by Chen (1998)
10.1101/gad.12.15.2434 / Genes Dev. / E1A signaling to p53 involves the p19(ARF) tumor suppressor by de Stanchina (1998)
10.1128/MCB.10.11.5772 / Mol. Cell. Biol. / p53 functions as a cell cycle control protein in osteosarcomas by Diller (1990)
10.1016/0092-8674(93)90500-P / Cell / WAF1, a potential mediator of p53 tumor suppression by el-Deiry (1993)
10.1093/jnci/86.17.1297 / J. Natl Cancer Inst. / MDM2 gene amplification and transcript levels in human sarcomas by Florenes (1994)
10.1128/MCB.18.12.7288 / Mol. Cell. Biol. / Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6 by Freedman (1998)
10.1038/387296a0 / Nature / Mdm2 promotes the rapid degradation of p53 by Haupt (1997)
10.1093/emboj/18.1.22 / EMBO J. / Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 by Honda (1999)
10.1038/387299a0 / Nature / Regulation of p53 stability by Mdm2 by Kubbutat (1997)
10.1126/science.274.5289.948 / Science / Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain by Kussie (1996)
10.1006/excr.1999.4433 / Exp. Cell. Res. / An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs by Lain (1999)
10.1016/S0968-0004(97)01119-5 / Trends Biochem. Sci. / MDM2-arbiter of p53’s destruction by Lane (1997)
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{'key': '10.1006/jmbi.2000.3738_BIB23', 'first-page': '343', 'article-title': 'The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation', 'volume': '1237', 'author': 'Momand', 'year': '1992', 'journal-title': 'Cell'} / Cell / The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation by Momand (1992)
10.1038/376037a0 / Nature / Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis by Nicholson (1995)
{'key': '10.1006/jmbi.2000.3738_BIB25', 'first-page': '4285', 'article-title': 'Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents', 'volume': '57', 'author': 'O’Connor', 'year': '1997', 'journal-title': 'Cancer Res.'} / Cancer Res. / Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents by O’Connor (1997)
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Dates

Type	When
Created	22 years, 11 months ago (Sept. 18, 2002, 3:24 p.m.)
Deposited	5 years, 8 months ago (Dec. 16, 2019, 4:46 a.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:12 a.m.)
Issued	25 years, 4 months ago (May 1, 2000)
Published	25 years, 4 months ago (May 1, 2000)
Published Print	25 years, 4 months ago (May 1, 2000)

Funders 0

None

BibTeX

@article{Ch_ne_2000, title={A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht}, volume={299}, ISSN={0022-2836}, url={http://dx.doi.org/10.1006/jmbi.2000.3738}, DOI={10.1006/jmbi.2000.3738}, number={1}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Chène, Patrick and Fuchs, Jean and Bohn, Jacqueline and Garcı́a-Echeverrı́a, Carlos and Furet, Pascal and Fabbro, Doriano}, year={2000}, month=may, pages={245–253} }

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