DOI: 10.1006/jmbi.1998.2208. Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

10.1006/jmbi.1998.2208

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Ding, J., Das, K., Hsiou, Y., Sarafianos, S. G., Clark, A. D., Jacobo-Molina, A., Tantillo, C., Hughes, S. H., & Arnold, E. (1998). Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Ã resolution. Journal of Molecular Biology, 284(4), 1095â1111.

Authors 9

Jianping Ding (first)
Kalyan Das (additional)
Yu Hsiou (additional)
Stefan G Sarafianos (additional)
Arthur D Clark (additional)
Alfredo Jacobo-Molina (additional)
Chris Tantillo (additional)
Stephen H Hughes (additional)
Edward Arnold (additional)

References 92 Referenced 274

10.1093/nar/16.21.9909 / Nucl. Acids Res. / A sequence motif in many polymerases by Argos (1988)
10.1038/357085a0 / Nature / Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations by Arnold (1992)
{'key': '10.1006/jmbi.1998.2208_BIB3', 'first-page': '29', 'article-title': 'Targeting HIV reverse transcriptase for anti-AIDS drug design', 'volume': '13', 'author': 'Arnold', 'year': '1996', 'journal-title': 'Drug Des. Discov.'} / Drug Des. Discov. / Targeting HIV reverse transcriptase for anti-AIDS drug design by Arnold (1996)
10.1016/S0079-6603(08)60041-0 / Prog. Nucl. Acid Res. Mol. Biol. / Interaction of retroviral reverse transcriptase with template-primer duplexes during replication by Arts (1998)
10.1016/0014-5793(96)00747-8 / FEBS Letters / Mutational studies of human immunodeficiency virus type 1 reverse transcriptase by Bakhanashvili (1996)
10.1016/S0021-9258(18)46899-8 / J. Biol. Chem. / Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase by Beard (1994)
10.1074/jbc.270.33.19516 / J. Biol. Chem. / Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain by Bebenek (1995)
10.1038/nsb0397-194 / Nature Struct. Biol. / A minor groove binding track in reverse transcriptase by Bebenek (1997)
10.1128/JVI.66.2.1031-1039.1992 / J. Virol. / Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1 by Boyer (1992)
10.1128/AAC.42.2.447 / Antimicrob. Agents Chemother. / A mutation at position 190 of HIV-1 RT interacts with mutations at positions 74 and 75 via the template-primer by Boyer (1998)
{'key': '10.1006/jmbi.1998.2208_BIB11', 'first-page': '472', 'article-title': 'The free R value', 'volume': '355', 'author': 'Brunger', 'year': '1992', 'journal-title': 'Nature'} / Nature / The free R value by Brunger (1992)
{'key': '10.1006/jmbi.1998.2208_BIB12', 'series-title': 'X-PLOR Manual Version 3.1: A System for X-ray Crystallography and NMR', 'author': 'Brunger', 'year': '1993'} / X-PLOR Manual Version 3.1: A System for X-ray Crystallography and NMR by Brunger (1993)
10.1126/science.3892686 / Science / Aromatic-aromatic interaction by Burley (1985)
10.1016/0263-7855(87)80010-3 / J. Mol. Graph. / Ribbon models of macromolecules by Carson (1987)
10.1126/science.276.5314.960 / Science / Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection by Cavert (1997)
10.1093/nar/23.5.803 / Nucl. Acids Res. / Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1 by Chao (1995)
10.1016/0076-6879(95)62017-6 / Methods Enzymol. / Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors and an antibody Fab fragment by Clark (1995)
{'key': '10.1006/jmbi.1998.2208_BIB18', 'first-page': '34', 'article-title': 'dmmulti', 'volume': 'vol. 31', 'author': 'Cowtan', 'year': '1994'} / dmmulti by Cowtan (1994)
10.1006/jmbi.1996.0698 / J. Mol. Biol. / Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant by Das (1996)
10.1016/0006-2952(94)90001-9 / Biochem. Pharmacol. / HIV resistance to reverse transcriptase inhibitors by De Clercq (1994)
10.1128/CMR.8.2.200 / Clin. Microbiol. Rev. / Antiviral therapy of human immunodeficiency virus infections by De Clercq (1995)
10.1128/CMR.10.4.674 / Clin. Microbiol. Rev. / In search of a selective antiviral chemotherapy by De Clercq (1997)
10.1093/protein/3.6.461 / Protein Eng. / An attempt to unify the structure of polymerases by Delarue (1990)
{'key': '10.1006/jmbi.1998.2208_BIB24', 'series-title': 'From First Map to Final Model', 'first-page': '95', 'article-title': 'Using MIRmodelmask procedure to improve the map interpretability and reduce model bias in the structure determination of HIV-1 RT/DNA/Fab complex', 'author': 'Ding', 'year': '1994'} / From First Map to Final Model / Using MIRmodelmask procedure to improve the map interpretability and reduce model bias in the structure determination of HIV-1 RT/DNA/Fab complex by Ding (1994)
10.1038/nsb0595-407 / Nature Struct. Biol. / Structure of HIV-1 RT/TIBO R 86183 reveals similarity in the binding of diverse nonnucleoside inhibitors by Ding (1995)
10.1016/S0969-2126(01)00168-X / Structure / Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibitor α-APA R 95845 at 2.8 Å resolution by Ding (1995)
{'key': '10.1006/jmbi.1998.2208_BIB27', 'series-title': 'Structure Based Drug Design', 'first-page': '41', 'article-title': 'A review of HIV-1 RT structural studies and implications for drug design', 'author': 'Ding', 'year': '1997'} / Structure Based Drug Design / A review of HIV-1 RT structural studies and implications for drug design by Ding (1997)
10.1002/(SICI)1097-0282(1997)44:2<125::AID-BIP2>3.0.CO;2-X / Biopolymers / Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer by Ding (1997)
10.1038/34593 / Nature / Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution by Doublié (1998)
{'key': '10.1006/jmbi.1998.2208_BIB30', 'series-title': 'Retroviruses', 'first-page': '637', 'article-title': 'Immunological and pharmacological approaches to the control of retroviral infections', 'author': 'Emini', 'year': '1997'} / Retroviruses / Immunological and pharmacological approaches to the control of retroviral infections by Emini (1997)
10.1038/nsb0495-303 / Nature Struct. Biol. / Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors by Esnouf (1995)
10.1073/pnas.94.8.3984 / Proc. Natl Acad. Sci. USA / Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor by Esnouf (1997)
10.1128/AAC.37.6.1390 / Antimicrob. Agents Chemother. / The same mutation that encodes low-level human immunodeficiency virus type-1 resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine confers high-level resistance to the (−) enantiomer of 2′,3′-dideoxy-3′-thiacytidine by Gao (1993)
10.1006/jmbi.1998.1624 / J. Mol. Biol. / Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase by Gao (1998)
10.1016/S0969-2126(01)00223-4 / Structure / Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase by Georgiadis (1995)
10.1021/bi952773j / Biochemistry / Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization by Ghosh (1996)
10.1128/JVI.66.12.7128-7135.1992 / J. Virol. / Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine by Gu (1992)
10.1006/jmbi.1996.0707 / J. Mol. Biol. / A model for the mechanism of polymerase translocation by Guajardo (1997)
10.1016/0076-6879(85)14029-2 / Methods Enzymol. / Multiwire area X-ray diffractometers by Hamlin (1985)
10.1016/S0969-2126(97)00261-X / Structure / Structure of the RNA-dependent RNA polymerase of poliovirus by Hansen (1997)
10.1021/jm960056x / J. Med. Chem. / Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors by Hopkins (1996)
10.1128/JVI.66.5.3179-3182.1992 / J. Virol. / The reverse transcriptase of HIV-1 by Hostomsky (1992)
10.1016/0076-6879(85)14030-9 / Methods Enzymol. / Software for a diffractometer with multiwire area detector by Howard (1985)
10.1016/S0969-2126(96)00091-3 / Structure / Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution by Hsiou (1996)
10.1016/0022-2836(91)90271-7 / J. Mol. Biol. / π-π interactions by Hunter (1991)
10.1021/bi00240a001 / Biochemistry / HIV reverse transcriptase structure-function relationships by Jacobo-Molina (1991)
10.1073/pnas.88.23.10895 / Proc. Natl Acad. Sci. USA / Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract X-rays to 3.5 Å resolution by Jacobo-Molina (1991)
10.1073/pnas.90.13.6320 / Proc. Natl Acad. Sci. USA / Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA by Jacobo-Molina (1993)
10.1016/S0021-9258(18)47218-3 / J. Biol. Chem. / Mutating the “primer grip” of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization by Jacques (1994)
10.1073/pnas.83.20.7648 / Proc. Natl Acad. Sci. USA / Computer analysis of retroviral pol genes by Johnson (1986)
10.1107/S0108767390010224 / Acta Crystallog. sect. A / Improved methods for building protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1093/nar/12.18.7269 / Nucl. Acids Res. / Primary structural comparison of RNA-dependent polymerases from plant, animal, and bacterial viruses by Kamer (1984)
10.1021/bi960364x / Biochemistry / Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase by Kaushik (1996)
10.1128/AAC.40.7.1711 / Antimicrob. Agents Chemother. / The nucleoside analog-resistant E89G mutant of HIV-1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors by Kew (1996)
10.1016/S0969-2126(97)00169-X / Structure / Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 Å resolution by Kiefer (1997)
10.1073/pnas.93.1.34 / Proc. Natl Acad. Sci. USA by Kleim (1996)
{'key': '10.1006/jmbi.1998.2208_BIB57', 'series-title': 'From First Map to Final Model', 'first-page': '59', 'article-title': 'Halloween, masks and bones', 'author': 'Kleywegt', 'year': '1994'} / From First Map to Final Model / Halloween, masks and bones by Kleywegt (1994)
10.1126/science.1377403 / Science / Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor by Kohlstaedt (1992)
{'key': '10.1006/jmbi.1998.2208_BIB59', 'series-title': 'Reverse Transcriptase', 'first-page': '205', 'article-title': 'Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance', 'author': 'Larder', 'year': '1993'} / Reverse Transcriptase / Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance by Larder (1993)
10.1038/327716a0 / Nature / Site-specific mutagenesis of AIDS virus reverse transcriptase by Larder (1987)
10.1073/pnas.86.13.4803 / Proc. Natl Acad. Sci. USA / Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity by Larder (1989)
10.1126/science.7542804 / Science / Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy by Larder (1995)
10.1107/S0021889892009944 / J. Appl. Crystallog. / PROCHECK by Laskowski (1993)
10.1002/j.1460-2075.1991.tb04960.x / EMBO J. / Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase by Le Grice (1991)
10.1107/S0365110X52002161 / Acta Crystallog. / Traitement statistique des erreurs dans la determination des structures cristallines by Luzzati (1952)
10.1016/0022-2836(68)90205-2 / J. Mol. Biol. / Solvent content of protein crystals by Matthews (1968)
{'key': '10.1006/jmbi.1998.2208_BIB67', 'series-title': 'XDISPLAY Program', 'author': 'Minor', 'year': '1993'} / XDISPLAY Program by Minor (1993)
{'key': '10.1006/jmbi.1998.2208_BIB68', 'first-page': '55', 'article-title': 'Processing of X-ray diffraction data collected in oscillation mode', 'volume': '276', 'author': 'Otwinowski', 'year': '1996', 'journal-title': 'Methods Enzymol.'} / Methods Enzymol. / Processing of X-ray diffraction data collected in oscillation mode by Otwinowski (1996)
10.1074/jbc.272.17.11157 / J. Biol. Chem. / Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function by Palaniappan (1997)
10.1021/bi00016a006 / Biochemistry / Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase by Patel (1995)
10.1126/science.7516580 / Science / Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP by Pelletier (1994)
10.1021/bi952955d / Biochemistry / Crystal structures of human DNA polymerase β complexed with DNA by Pelletier (1996)
10.1038/387188a0 / Nature / Decay characteristics of HIV-1-infected compartments during combination therapy by Perelson (1997)
10.1002/j.1460-2075.1989.tb08565.x / EMBO J. / Identification of four conserved motifs among the RNA-dependent polymerase encoding elements by Poch (1989)
10.1038/nsb0495-293 / Nature Struct. Biol. / High resolution structures of HIV-1 RT from four RT-inhibitor complexes by Ren (1995)
10.1016/S0969-2126(01)00226-X / Structure / The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO by Ren (1995)
10.1073/pnas.92.17.8046 / Proc. Natl Acad. Sci. USA / Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors by Rittinger (1995)
10.1016/S0969-2126(94)00116-2 / Structure / Cryocrystallography by Rodgers (1994)
10.1073/pnas.92.4.1222 / Proc. Natl Acad. Sci. USA / The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1 by Rodgers (1995)
{'key': '10.1006/jmbi.1998.2208_BIB80', 'series-title': 'Anti-Infectives: Recent Advances in Chemistry and Structure Activity Relationships', 'first-page': '328', 'article-title': 'Current perspectives on mechanisms of HIV-1 reverse transcriptase inhibition by nonnucleoside inhibitors', 'author': 'Sarafianos', 'year': '1997'} / Anti-Infectives: Recent Advances in Chemistry and Structure Activity Relationships / Current perspectives on mechanisms of HIV-1 reverse transcriptase inhibition by nonnucleoside inhibitors by Sarafianos (1997)
10.1128/AAC.37.4.875 / Antimicrob. Agents Chemother / Characterization of human immunodeficiency virus resistant to oxathiolane-cytosine nucleosides by Schinazi (1993)
10.1073/pnas.91.9.3911 / Proc. Natl Acad. Sci. USA / Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1 by Smerdon (1994)
10.1002/pro.5560041026 / Protein Sci. / Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors by Smith (1995)
10.1126/science.7532321 / Science / Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors by Spence (1995)
10.1021/bi952058+ / Biochemistry / HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors by Spence (1996)
10.1006/jmbi.1994.1665 / J. Mol. Biol. / Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase by Tantillo (1994)
{'key': '10.1006/jmbi.1998.2208_BIB87', 'series-title': 'Retroviruses', 'first-page': '121', 'article-title': 'Reverse transcription and the generation of retroviral DNA', 'author': 'Telesnitsky', 'year': '1997'} / Retroviruses / Reverse transcription and the generation of retroviral DNA by Telesnitsky (1997)
10.1107/S0021889890005568 / J. Appl. Crystallog. / Mounting of crystals for macromolecular crystallography in a free-standing thin film by Teng (1990)
10.1073/pnas.90.12.5653 / Proc. Natl Acad. Sci. USA / Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase by Tisdale (1993)
10.1016/0076-6879(85)15009-3 / Methods Enzymol. / Resolution of phase ambiguity in macromolecular crystallography by Wang (1985)
10.1146/annurev.cb.08.110192.001423 / Annu. Rev. Cell Biol. / Retroviral reverse transcription and integration by Whitcomb (1992)
10.1002/j.1460-2075.1990.tb07536.x / EMBO J. / Origin and evolution of retroelements based upon their reverse transcriptase sequences by Xiong (1990)

Dates

Type	When
Created	22 years, 10 months ago (Oct. 7, 2002, 12:21 p.m.)
Deposited	4 years, 3 months ago (May 3, 2021, 3:22 a.m.)
Indexed	2 days, 19 hours ago (Aug. 28, 2025, 8:18 a.m.)
Issued	26 years, 8 months ago (Dec. 1, 1998)
Published	26 years, 8 months ago (Dec. 1, 1998)
Published Print	26 years, 8 months ago (Dec. 1, 1998)

Funders 0

None

BibTeX

@article{Ding_1998, title={Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution}, volume={284}, ISSN={0022-2836}, url={http://dx.doi.org/10.1006/jmbi.1998.2208}, DOI={10.1006/jmbi.1998.2208}, number={4}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Ding, Jianping and Das, Kalyan and Hsiou, Yu and Sarafianos, Stefan G and Clark, Arthur D and Jacobo-Molina, Alfredo and Tantillo, Chris and Hughes, Stephen H and Arnold, Edward}, year={1998}, month=dec, pages={1095–1111} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        28
      ]
    ],
    "date-time": "2025-08-28T12:18:06Z",
    "timestamp": 1756383486776
  },
  "reference-count": 92,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            12,
            1
          ]
        ],
        "date-time": "1998-12-01T00:00:00Z",
        "timestamp": 912470400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        12
      ]
    ]
  },
  "DOI": "10.1006/jmbi.1998.2208",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        10,
        7
      ]
    ],
    "date-time": "2002-10-07T16:21:31Z",
    "timestamp": 1034007691000
  },
  "page": "1095-1111",
  "source": "Crossref",
  "is-referenced-by-count": 274,
  "title": "Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 \u00c5 resolution",
  "prefix": "10.1006",
  "volume": "284",
  "author": [
    {
      "given": "Jianping",
      "family": "Ding",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Kalyan",
      "family": "Das",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yu",
      "family": "Hsiou",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stefan G",
      "family": "Sarafianos",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "suffix": "Jr",
      "given": "Arthur D",
      "family": "Clark",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alfredo",
      "family": "Jacobo-Molina",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Chris",
      "family": "Tantillo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stephen H",
      "family": "Hughes",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Edward",
      "family": "Arnold",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/jmbi.1998.2208_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "9909",
      "DOI": "10.1093/nar/16.21.9909",
      "article-title": "A sequence motif in many polymerases",
      "volume": "16",
      "author": "Argos",
      "year": "1988",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1038/357085a0",
      "article-title": "Structure of HIV-1 reverse transcriptase/DNA complex at 7 \u00c5 resolution showing active site locations",
      "volume": "357",
      "author": "Arnold",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB3",
      "first-page": "29",
      "article-title": "Targeting HIV reverse transcriptase for anti-AIDS drug design",
      "volume": "13",
      "author": "Arnold",
      "year": "1996",
      "journal-title": "Drug Des. Discov."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "339",
      "DOI": "10.1016/S0079-6603(08)60041-0",
      "article-title": "Interaction of retroviral reverse transcriptase with template-primer duplexes during replication",
      "volume": "58",
      "author": "Arts",
      "year": "1998",
      "journal-title": "Prog. Nucl. Acid Res. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1016/0014-5793(96)00747-8",
      "article-title": "Mutational studies of human immunodeficiency virus type 1 reverse transcriptase",
      "volume": "391",
      "author": "Bakhanashvili",
      "year": "1996",
      "journal-title": "FEBS Letters"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "28091",
      "DOI": "10.1016/S0021-9258(18)46899-8",
      "article-title": "Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase",
      "volume": "269",
      "author": "Beard",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "19516",
      "DOI": "10.1074/jbc.270.33.19516",
      "article-title": "Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain",
      "volume": "270",
      "author": "Bebenek",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "194",
      "DOI": "10.1038/nsb0397-194",
      "article-title": "A minor groove binding track in reverse transcriptase",
      "volume": "4",
      "author": "Bebenek",
      "year": "1997",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "1031",
      "DOI": "10.1128/JVI.66.2.1031-1039.1992",
      "article-title": "Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1",
      "volume": "66",
      "author": "Boyer",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1128/AAC.42.2.447",
      "article-title": "A mutation at position 190 of HIV-1 RT interacts with mutations at positions 74 and 75 via the template-primer",
      "volume": "42",
      "author": "Boyer",
      "year": "1998",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB11",
      "first-page": "472",
      "article-title": "The free R value",
      "volume": "355",
      "author": "Brunger",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB12",
      "series-title": "X-PLOR Manual Version 3.1: A System for X-ray Crystallography and NMR",
      "author": "Brunger",
      "year": "1993"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "23",
      "DOI": "10.1126/science.3892686",
      "article-title": "Aromatic-aromatic interaction",
      "volume": "229",
      "author": "Burley",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1016/0263-7855(87)80010-3",
      "article-title": "Ribbon models of macromolecules",
      "volume": "5",
      "author": "Carson",
      "year": "1987",
      "journal-title": "J. Mol. Graph."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "960",
      "DOI": "10.1126/science.276.5314.960",
      "article-title": "Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection",
      "volume": "276",
      "author": "Cavert",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "803",
      "DOI": "10.1093/nar/23.5.803",
      "article-title": "Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1",
      "volume": "23",
      "author": "Chao",
      "year": "1995",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1016/0076-6879(95)62017-6",
      "article-title": "Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors and an antibody Fab fragment",
      "volume": "262",
      "author": "Clark",
      "year": "1995",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB18",
      "first-page": "34",
      "article-title": "dmmulti",
      "volume": "vol. 31",
      "author": "Cowtan",
      "year": "1994"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1085",
      "DOI": "10.1006/jmbi.1996.0698",
      "article-title": "Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant",
      "volume": "264",
      "author": "Das",
      "year": "1996",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "155",
      "DOI": "10.1016/0006-2952(94)90001-9",
      "article-title": "HIV resistance to reverse transcriptase inhibitors",
      "volume": "47",
      "author": "De Clercq",
      "year": "1994",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.1128/CMR.8.2.200",
      "article-title": "Antiviral therapy of human immunodeficiency virus infections",
      "volume": "8",
      "author": "De Clercq",
      "year": "1995",
      "journal-title": "Clin. Microbiol. Rev."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "674",
      "DOI": "10.1128/CMR.10.4.674",
      "article-title": "In search of a selective antiviral chemotherapy",
      "volume": "10",
      "author": "De Clercq",
      "year": "1997",
      "journal-title": "Clin. Microbiol. Rev."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1093/protein/3.6.461",
      "article-title": "An attempt to unify the structure of polymerases",
      "volume": "6",
      "author": "Delarue",
      "year": "1990",
      "journal-title": "Protein Eng."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB24",
      "series-title": "From First Map to Final Model",
      "first-page": "95",
      "article-title": "Using MIRmodelmask procedure to improve the map interpretability and reduce model bias in the structure determination of HIV-1 RT/DNA/Fab complex",
      "author": "Ding",
      "year": "1994"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "407",
      "DOI": "10.1038/nsb0595-407",
      "article-title": "Structure of HIV-1 RT/TIBO R 86183 reveals similarity in the binding of diverse nonnucleoside inhibitors",
      "volume": "2",
      "author": "Ding",
      "year": "1995",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1016/S0969-2126(01)00168-X",
      "article-title": "Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibitor \u03b1-APA R 95845 at 2.8 \u00c5 resolution",
      "volume": "3",
      "author": "Ding",
      "year": "1995",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB27",
      "series-title": "Structure Based Drug Design",
      "first-page": "41",
      "article-title": "A review of HIV-1 RT structural studies and implications for drug design",
      "author": "Ding",
      "year": "1997"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1002/(SICI)1097-0282(1997)44:2<125::AID-BIP2>3.0.CO;2-X",
      "article-title": "Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer",
      "volume": "44",
      "author": "Ding",
      "year": "1997",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1038/34593",
      "article-title": "Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 \u00c5 resolution",
      "volume": "391",
      "author": "Doubli\u00e9",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB30",
      "series-title": "Retroviruses",
      "first-page": "637",
      "article-title": "Immunological and pharmacological approaches to the control of retroviral infections",
      "author": "Emini",
      "year": "1997"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1038/nsb0495-303",
      "article-title": "Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors",
      "volume": "2",
      "author": "Esnouf",
      "year": "1995",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "3984",
      "DOI": "10.1073/pnas.94.8.3984",
      "article-title": "Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor",
      "volume": "94",
      "author": "Esnouf",
      "year": "1997",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1390",
      "DOI": "10.1128/AAC.37.6.1390",
      "article-title": "The same mutation that encodes low-level human immunodeficiency virus type-1 resistance to 2\u2032,3\u2032-dideoxyinosine and 2\u2032,3\u2032-dideoxycytidine confers high-level resistance to the (\u2212) enantiomer of 2\u2032,3\u2032-dideoxy-3\u2032-thiacytidine",
      "volume": "37",
      "author": "Gao",
      "year": "1993",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "559",
      "DOI": "10.1006/jmbi.1998.1624",
      "article-title": "Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase",
      "volume": "277",
      "author": "Gao",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "879",
      "DOI": "10.1016/S0969-2126(01)00223-4",
      "article-title": "Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase",
      "volume": "3",
      "author": "Georgiadis",
      "year": "1995",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "8553",
      "DOI": "10.1021/bi952773j",
      "article-title": "Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization",
      "volume": "35",
      "author": "Ghosh",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "7128",
      "DOI": "10.1128/JVI.66.12.7128-7135.1992",
      "article-title": "Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2\u2032,3\u2032-dideoxyinosine and 2\u2032,3\u2032-dideoxycytidine",
      "volume": "66",
      "author": "Gu",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "8",
      "DOI": "10.1006/jmbi.1996.0707",
      "article-title": "A model for the mechanism of polymerase translocation",
      "volume": "265",
      "author": "Guajardo",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "416",
      "DOI": "10.1016/0076-6879(85)14029-2",
      "article-title": "Multiwire area X-ray diffractometers",
      "volume": "114",
      "author": "Hamlin",
      "year": "1985",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1109",
      "DOI": "10.1016/S0969-2126(97)00261-X",
      "article-title": "Structure of the RNA-dependent RNA polymerase of poliovirus",
      "volume": "5",
      "author": "Hansen",
      "year": "1997",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1589",
      "DOI": "10.1021/jm960056x",
      "article-title": "Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors",
      "volume": "39",
      "author": "Hopkins",
      "year": "1996",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "3179",
      "DOI": "10.1128/JVI.66.5.3179-3182.1992",
      "article-title": "The reverse transcriptase of HIV-1",
      "volume": "66",
      "author": "Hostomsky",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "452",
      "DOI": "10.1016/0076-6879(85)14030-9",
      "article-title": "Software for a diffractometer with multiwire area detector",
      "volume": "114",
      "author": "Howard",
      "year": "1985",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "853",
      "DOI": "10.1016/S0969-2126(96)00091-3",
      "article-title": "Structure of unliganded HIV-1 reverse transcriptase at 2.7 \u00c5 resolution",
      "volume": "4",
      "author": "Hsiou",
      "year": "1996",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "837",
      "DOI": "10.1016/0022-2836(91)90271-7",
      "article-title": "\u03c0-\u03c0 interactions",
      "volume": "218",
      "author": "Hunter",
      "year": "1991",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "6351",
      "DOI": "10.1021/bi00240a001",
      "article-title": "HIV reverse transcriptase structure-function relationships",
      "volume": "30",
      "author": "Jacobo-Molina",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "10895",
      "DOI": "10.1073/pnas.88.23.10895",
      "article-title": "Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract X-rays to 3.5 \u00c5 resolution",
      "volume": "88",
      "author": "Jacobo-Molina",
      "year": "1991",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "6320",
      "DOI": "10.1073/pnas.90.13.6320",
      "article-title": "Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 \u00c5 resolution shows bent DNA",
      "volume": "90",
      "author": "Jacobo-Molina",
      "year": "1993",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "26472",
      "DOI": "10.1016/S0021-9258(18)47218-3",
      "article-title": "Mutating the \u201cprimer grip\u201d of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization",
      "volume": "269",
      "author": "Jacques",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "7648",
      "DOI": "10.1073/pnas.83.20.7648",
      "article-title": "Computer analysis of retroviral pol genes",
      "volume": "83",
      "author": "Johnson",
      "year": "1986",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "article-title": "Improved methods for building protein models in electron density maps and the location of errors in these models",
      "volume": "47",
      "author": "Jones",
      "year": "1991",
      "journal-title": "Acta Crystallog. sect. A"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "7269",
      "DOI": "10.1093/nar/12.18.7269",
      "article-title": "Primary structural comparison of RNA-dependent polymerases from plant, animal, and bacterial viruses",
      "volume": "12",
      "author": "Kamer",
      "year": "1984",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "11536",
      "DOI": "10.1021/bi960364x",
      "article-title": "Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase",
      "volume": "35",
      "author": "Kaushik",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "1711",
      "DOI": "10.1128/AAC.40.7.1711",
      "article-title": "The nucleoside analog-resistant E89G mutant of HIV-1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors",
      "volume": "40",
      "author": "Kew",
      "year": "1996",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1016/S0969-2126(97)00169-X",
      "article-title": "Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 \u00c5 resolution",
      "volume": "5",
      "author": "Kiefer",
      "year": "1997",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "34",
      "DOI": "10.1073/pnas.93.1.34",
      "volume": "93",
      "author": "Kleim",
      "year": "1996",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB57",
      "series-title": "From First Map to Final Model",
      "first-page": "59",
      "article-title": "Halloween, masks and bones",
      "author": "Kleywegt",
      "year": "1994"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "1783",
      "DOI": "10.1126/science.1377403",
      "article-title": "Crystal structure at 3.5 \u00c5 resolution of HIV-1 reverse transcriptase complexed with an inhibitor",
      "volume": "256",
      "author": "Kohlstaedt",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB59",
      "series-title": "Reverse Transcriptase",
      "first-page": "205",
      "article-title": "Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance",
      "author": "Larder",
      "year": "1993"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "716",
      "DOI": "10.1038/327716a0",
      "article-title": "Site-specific mutagenesis of AIDS virus reverse transcriptase",
      "volume": "327",
      "author": "Larder",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "4803",
      "DOI": "10.1073/pnas.86.13.4803",
      "article-title": "Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity",
      "volume": "86",
      "author": "Larder",
      "year": "1989",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "696",
      "DOI": "10.1126/science.7542804",
      "article-title": "Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy",
      "volume": "269",
      "author": "Larder",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1107/S0021889892009944",
      "article-title": "PROCHECK",
      "volume": "26",
      "author": "Laskowski",
      "year": "1993",
      "journal-title": "J. Appl. Crystallog."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "3905",
      "DOI": "10.1002/j.1460-2075.1991.tb04960.x",
      "article-title": "Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase",
      "volume": "10",
      "author": "Le Grice",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "802",
      "DOI": "10.1107/S0365110X52002161",
      "article-title": "Traitement statistique des erreurs dans la determination des structures cristallines",
      "volume": "5",
      "author": "Luzzati",
      "year": "1952",
      "journal-title": "Acta Crystallog."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1016/0022-2836(68)90205-2",
      "article-title": "Solvent content of protein crystals",
      "volume": "33",
      "author": "Matthews",
      "year": "1968",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB67",
      "series-title": "XDISPLAY Program",
      "author": "Minor",
      "year": "1993"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB68",
      "first-page": "55",
      "article-title": "Processing of X-ray diffraction data collected in oscillation mode",
      "volume": "276",
      "author": "Otwinowski",
      "year": "1996",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "11157",
      "DOI": "10.1074/jbc.272.17.11157",
      "article-title": "Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function",
      "volume": "272",
      "author": "Palaniappan",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "5351",
      "DOI": "10.1021/bi00016a006",
      "article-title": "Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase",
      "volume": "34",
      "author": "Patel",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "1891",
      "DOI": "10.1126/science.7516580",
      "article-title": "Structures of ternary complexes of rat DNA polymerase \u03b2, a DNA template-primer, and ddCTP",
      "volume": "264",
      "author": "Pelletier",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "12742",
      "DOI": "10.1021/bi952955d",
      "article-title": "Crystal structures of human DNA polymerase \u03b2 complexed with DNA",
      "volume": "35",
      "author": "Pelletier",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1038/387188a0",
      "article-title": "Decay characteristics of HIV-1-infected compartments during combination therapy",
      "volume": "387",
      "author": "Perelson",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB74",
      "doi-asserted-by": "crossref",
      "first-page": "3867",
      "DOI": "10.1002/j.1460-2075.1989.tb08565.x",
      "article-title": "Identification of four conserved motifs among the RNA-dependent polymerase encoding elements",
      "volume": "8",
      "author": "Poch",
      "year": "1989",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1038/nsb0495-293",
      "article-title": "High resolution structures of HIV-1 RT from four RT-inhibitor complexes",
      "volume": "2",
      "author": "Ren",
      "year": "1995",
      "journal-title": "Nature Struct. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB76",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.1016/S0969-2126(01)00226-X",
      "article-title": "The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO",
      "volume": "3",
      "author": "Ren",
      "year": "1995",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB77",
      "doi-asserted-by": "crossref",
      "first-page": "8046",
      "DOI": "10.1073/pnas.92.17.8046",
      "article-title": "Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors",
      "volume": "92",
      "author": "Rittinger",
      "year": "1995",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB78",
      "doi-asserted-by": "crossref",
      "first-page": "1135",
      "DOI": "10.1016/S0969-2126(94)00116-2",
      "article-title": "Cryocrystallography",
      "volume": "2",
      "author": "Rodgers",
      "year": "1994",
      "journal-title": "Structure"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB79",
      "doi-asserted-by": "crossref",
      "first-page": "1222",
      "DOI": "10.1073/pnas.92.4.1222",
      "article-title": "The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1",
      "volume": "92",
      "author": "Rodgers",
      "year": "1995",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB80",
      "series-title": "Anti-Infectives: Recent Advances in Chemistry and Structure Activity Relationships",
      "first-page": "328",
      "article-title": "Current perspectives on mechanisms of HIV-1 reverse transcriptase inhibition by nonnucleoside inhibitors",
      "author": "Sarafianos",
      "year": "1997"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB81",
      "doi-asserted-by": "crossref",
      "first-page": "875",
      "DOI": "10.1128/AAC.37.4.875",
      "article-title": "Characterization of human immunodeficiency virus resistant to oxathiolane-cytosine nucleosides",
      "volume": "37",
      "author": "Schinazi",
      "year": "1993",
      "journal-title": "Antimicrob. Agents Chemother"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB82",
      "doi-asserted-by": "crossref",
      "first-page": "3911",
      "DOI": "10.1073/pnas.91.9.3911",
      "article-title": "Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1",
      "volume": "91",
      "author": "Smerdon",
      "year": "1994",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB83",
      "doi-asserted-by": "crossref",
      "first-page": "2203",
      "DOI": "10.1002/pro.5560041026",
      "article-title": "Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors",
      "volume": "4",
      "author": "Smith",
      "year": "1995",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB84",
      "doi-asserted-by": "crossref",
      "first-page": "988",
      "DOI": "10.1126/science.7532321",
      "article-title": "Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors",
      "volume": "267",
      "author": "Spence",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB85",
      "doi-asserted-by": "crossref",
      "first-page": "1054",
      "DOI": "10.1021/bi952058+",
      "article-title": "HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors",
      "volume": "35",
      "author": "Spence",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB86",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1006/jmbi.1994.1665",
      "article-title": "Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase",
      "volume": "243",
      "author": "Tantillo",
      "year": "1994",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB87",
      "series-title": "Retroviruses",
      "first-page": "121",
      "article-title": "Reverse transcription and the generation of retroviral DNA",
      "author": "Telesnitsky",
      "year": "1997"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB88",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1107/S0021889890005568",
      "article-title": "Mounting of crystals for macromolecular crystallography in a free-standing thin film",
      "volume": "24",
      "author": "Teng",
      "year": "1990",
      "journal-title": "J. Appl. Crystallog."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB89",
      "doi-asserted-by": "crossref",
      "first-page": "5653",
      "DOI": "10.1073/pnas.90.12.5653",
      "article-title": "Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3\u2032-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase",
      "volume": "90",
      "author": "Tisdale",
      "year": "1993",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB90",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1016/0076-6879(85)15009-3",
      "article-title": "Resolution of phase ambiguity in macromolecular crystallography",
      "volume": "115",
      "author": "Wang",
      "year": "1985",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB91",
      "doi-asserted-by": "crossref",
      "first-page": "275",
      "DOI": "10.1146/annurev.cb.08.110192.001423",
      "article-title": "Retroviral reverse transcription and integration",
      "volume": "8",
      "author": "Whitcomb",
      "year": "1992",
      "journal-title": "Annu. Rev. Cell Biol."
    },
    {
      "key": "10.1006/jmbi.1998.2208_BIB92",
      "doi-asserted-by": "crossref",
      "first-page": "3353",
      "DOI": "10.1002/j.1460-2075.1990.tb07536.x",
      "article-title": "Origin and evolution of retroelements based upon their reverse transcriptase sequences",
      "volume": "9",
      "author": "Xiong",
      "year": "1990",
      "journal-title": "EMBO J."
    }
  ],
  "container-title": "Journal of Molecular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283698922082?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283698922082?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        3
      ]
    ],
    "date-time": "2021-05-03T07:22:46Z",
    "timestamp": 1620026566000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022283698922082"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        12
      ]
    ]
  },
  "references-count": 92,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1998,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022283698922082"
  ],
  "URL": "http://dx.doi.org/10.1006/jmbi.1998.2208",
  "relation": {},
  "ISSN": [
    "0022-2836"
  ],
  "subject": [],
  "container-title-short": "Journal of Molecular Biology",
  "published": {
    "date-parts": [
      [
        1998,
        12
      ]
    ]
  }
}