DOI: 10.1006/geno.2002.6780. Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing

Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing

10.1006/geno.2002.6780

Crossref journal-article

Elsevier BV

Genomics (78)

Bibliography

Tabuchi, K., & SÃ¼dhof, T. C. (2002). Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing. Genomics, 79(6), 849â859.

Authors 2

Katsuhiko Tabuchi (first)
Thomas C. Südhof (additional)

References 32 Referenced 240

10.1126/science.1621094 / Science / Neurexins: synaptic cell surface proteins relatedto the α-latrotoxin receptor and laminin by Ushkaryov (1992)
10.1073/pnas.90.14.6410 / Proc. Natl. Acad. Sci. USA / Neurexin IIIα: extensive alternative splicing generates membrane-bound and soluble forms in a novel neurexin by Ushkaryov (1993)
10.1016/S0021-9258(17)32671-6 / J. Biol. Chem. / Conserved domain structure of β-neurexins by Ushkaryov (1994)
10.1016/S0168-9525(97)01324-3 / Trends Genet. / Neurexins: three genes and 1001 products by Missler (1998)
10.1016/S0968-0004(01)01832-1 / Trends Biochem. Sci. / LG/LNS domains: multiple functions—one business end? by Rudenko (2001)
Südhof, T. C.2001. The synaptic cleft and synaptic cell adhesion. In SynapsesW. M. Cowan, T. C. Südhof, and C. F. Stevens, Eds., pp. 177–215. Johns Hopkins University Press, Baltimore, MD, and London, UK.
10.1016/S0092-8674(00)81920-0 / Cell / Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions by Peles (1997)
10.1146/annurev.genet.35.102401.091415 / Annu. Rev. Genet. / Epithelial cell polarity and cell junctions in Drosophila by Tepass (2001)
10.1016/0896-6273(95)90306-2 / Neuron / Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons by Ullrich (1995)
10.1016/S0169-328X(00)00237-0 / Brain Res. Mol. Brain Res. / Differential expression of neurexin mRNA in CA1 and CA3 hippocampal neurons in response to ischemic insult by Sun (2000)
10.1016/S0092-8674(00)80065-3 / Cell / The structure of the ligand-binding domain of neurexin β: regulation of LNS domain function by alternative splicing by Rudenko (1999)
10.1016/S0896-6273(00)80704-7 / Neuron / Neurexins are functional α-latrotoxin receptors by Sugita (1999)
10.1074/jbc.M111231200 / J. Biol. Chem. / Genetic analysis of α-latrotoxin receptors reveals functional interdependence of CIRL/Latrophilin 1 and neurexin 1α by Tobaben (2002)
10.1146/annurev.neuro.24.1.933 / Annu. Rev. Neurosci. / α-latrotoxin and its receptors: neurexins and CIRL latrophilins (CLs) by Südhof (2001)
10.1016/0092-8674(95)90396-8 / Cell / Neuroligin 1: a splice-site specific ligand for β-neurexins by Ichtchenko (1995)
10.1074/jbc.271.5.2676 / J. Biol. Chem. / Structures, alternative splicing, and neurexin binding of multiple neuroligins by Ichtchenko (1996)
10.1073/pnas.96.3.1100 / Proc. Natl Acad. Sci. USA / Neuroligin 1 is a postsynaptic cell-adhesion molecular of excitatory synapses by Song (1999)
10.1016/S0092-8674(00)80877-6 / Cell / Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons by Scheiffele (2000)
10.1083/jcb.200105003 / J. Cell. Biol. / A stoichiometrc complex of neurexins and dystroglycan in brain by Sugita (2001)
10.1038/ng803 / Nat. Genet. / Alternative splicing and genome complexity by Brett (2001)
10.1006/geno.2001.6517 / Genomics / The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at chromosome 7q35 by Nakabayashi (2001)
10.1038/35057062 / Nature (2001)
10.1016/S0092-8674(00)81800-0 / Cell / A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function by Baumgartner (1996)
10.1074/jbc.272.41.26032 / J. Biol. Chem. / Binding properties of neuroligin 1 and neurexin 1β reveal function as heterophilic cell adhesion molecules by Nguyen (1997)
10.1006/geno.1997.4911 / Genomics / Exon-intron organization of the human dystrophin gene by Nobile (1997)
10.1016/0092-8674(88)90383-2 / Cell / The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein by Koenig (1988)
10.1016/S0896-6273(00)81049-1 / Neuron / CASPR2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels by Poliak (1999)
10.1038/ng0295-184 / Nat. Genet. / The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced by Tennyson (1995)
10.1038/ng0493-283 / Nat. Genet. / The structural and functional diversity of dystrophin by Ahn (1993)
10.1074/jbc.273.3.1705 / J. Biol. Chem. / Neurexin Iα is a major α-latrotoxin receptor that cooperates in α-latrotoxin action by Geppert (1998)
10.1126/science.277.5331.1511 / Science / Binding of neuroligins to PSD-95 by Irie (1997)
10.1093/nar/25.17.3389 / Nucleic Acids Res. / Gapped BLAST and PSI-BLAST: a new generation of protein database search programs by Altschul (1997)

Dates

Type	When
Created	22 years, 4 months ago (April 24, 2003, 1:03 p.m.)
Deposited	4 years, 4 months ago (May 3, 2021, 1:23 a.m.)
Indexed	11 hours, 30 minutes ago (Sept. 3, 2025, 6:33 a.m.)
Issued	23 years, 3 months ago (June 1, 2002)
Published	23 years, 3 months ago (June 1, 2002)
Published Print	23 years, 3 months ago (June 1, 2002)

Funders 0

None

BibTeX

@article{Tabuchi_2002, title={Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing}, volume={79}, ISSN={0888-7543}, url={http://dx.doi.org/10.1006/geno.2002.6780}, DOI={10.1006/geno.2002.6780}, number={6}, journal={Genomics}, publisher={Elsevier BV}, author={Tabuchi, Katsuhiko and Südhof, Thomas C.}, year={2002}, month=jun, pages={849–859} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:33:38Z",
    "timestamp": 1756895618258
  },
  "reference-count": 32,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2002,
            6,
            1
          ]
        ],
        "date-time": "2002-06-01T00:00:00Z",
        "timestamp": 1022889600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        6
      ]
    ]
  },
  "DOI": "10.1006/geno.2002.6780",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        4,
        24
      ]
    ],
    "date-time": "2003-04-24T17:03:32Z",
    "timestamp": 1051203812000
  },
  "page": "849-859",
  "source": "Crossref",
  "is-referenced-by-count": 240,
  "title": "Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing",
  "prefix": "10.1006",
  "volume": "79",
  "author": [
    {
      "given": "Katsuhiko",
      "family": "Tabuchi",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Thomas C.",
      "family": "S\u00fcdhof",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/geno.2002.6780_RF1",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1126/science.1621094",
      "article-title": "Neurexins: synaptic cell surface proteins relatedto the \u03b1-latrotoxin receptor and laminin",
      "volume": "257",
      "author": "Ushkaryov",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/geno.2002.6780_RF2",
      "doi-asserted-by": "crossref",
      "first-page": "6410",
      "DOI": "10.1073/pnas.90.14.6410",
      "article-title": "Neurexin III\u03b1: extensive alternative splicing generates membrane-bound and soluble forms in a novel neurexin",
      "volume": "90",
      "author": "Ushkaryov",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/geno.2002.6780_RF3",
      "doi-asserted-by": "crossref",
      "first-page": "11987",
      "DOI": "10.1016/S0021-9258(17)32671-6",
      "article-title": "Conserved domain structure of \u03b2-neurexins",
      "volume": "269",
      "author": "Ushkaryov",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/geno.2002.6780_RF4",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1016/S0168-9525(97)01324-3",
      "article-title": "Neurexins: three genes and 1001 products",
      "volume": "14",
      "author": "Missler",
      "year": "1998",
      "journal-title": "Trends Genet."
    },
    {
      "key": "10.1006/geno.2002.6780_RF5",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1016/S0968-0004(01)01832-1",
      "article-title": "LG/LNS domains: multiple functions\u2014one business end?",
      "volume": "26",
      "author": "Rudenko",
      "year": "2001",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1006/geno.2002.6780_RF6",
      "unstructured": "S\u00fcdhof, T. C.2001. The synaptic cleft and synaptic cell adhesion. In SynapsesW. M. Cowan, T. C. S\u00fcdhof, and C. F. Stevens, Eds., pp. 177\u2013215. Johns Hopkins University Press, Baltimore, MD, and London, UK."
    },
    {
      "key": "10.1006/geno.2002.6780_RF7",
      "doi-asserted-by": "crossref",
      "first-page": "745",
      "DOI": "10.1016/S0092-8674(00)81920-0",
      "article-title": "Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions",
      "volume": "88",
      "author": "Peles",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/geno.2002.6780_RF8",
      "doi-asserted-by": "crossref",
      "first-page": "747",
      "DOI": "10.1146/annurev.genet.35.102401.091415",
      "article-title": "Epithelial cell polarity and cell junctions in Drosophila",
      "volume": "35",
      "author": "Tepass",
      "year": "2001",
      "journal-title": "Annu. Rev. Genet."
    },
    {
      "key": "10.1006/geno.2002.6780_RF9",
      "doi-asserted-by": "crossref",
      "first-page": "497",
      "DOI": "10.1016/0896-6273(95)90306-2",
      "article-title": "Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons",
      "volume": "14",
      "author": "Ullrich",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1006/geno.2002.6780_RF10",
      "doi-asserted-by": "crossref",
      "first-page": "146",
      "DOI": "10.1016/S0169-328X(00)00237-0",
      "article-title": "Differential expression of neurexin mRNA in CA1 and CA3 hippocampal neurons in response to ischemic insult",
      "volume": "84",
      "author": "Sun",
      "year": "2000",
      "journal-title": "Brain Res. Mol. Brain Res."
    },
    {
      "key": "10.1006/geno.2002.6780_RF11",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/S0092-8674(00)80065-3",
      "article-title": "The structure of the ligand-binding domain of neurexin \u03b2: regulation of LNS domain function by alternative splicing",
      "volume": "99",
      "author": "Rudenko",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/geno.2002.6780_RF12",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1016/S0896-6273(00)80704-7",
      "article-title": "Neurexins are functional \u03b1-latrotoxin receptors",
      "volume": "22",
      "author": "Sugita",
      "year": "1999",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1006/geno.2002.6780_RF13",
      "doi-asserted-by": "crossref",
      "first-page": "6359",
      "DOI": "10.1074/jbc.M111231200",
      "article-title": "Genetic analysis of \u03b1-latrotoxin receptors reveals functional interdependence of CIRL/Latrophilin 1 and neurexin 1\u03b1",
      "volume": "277",
      "author": "Tobaben",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/geno.2002.6780_RF14",
      "doi-asserted-by": "crossref",
      "first-page": "933",
      "DOI": "10.1146/annurev.neuro.24.1.933",
      "article-title": "\u03b1-latrotoxin and its receptors: neurexins and CIRL latrophilins (CLs)",
      "volume": "24",
      "author": "S\u00fcdhof",
      "year": "2001",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1006/geno.2002.6780_RF15",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1016/0092-8674(95)90396-8",
      "article-title": "Neuroligin 1: a splice-site specific ligand for \u03b2-neurexins",
      "volume": "81",
      "author": "Ichtchenko",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/geno.2002.6780_RF16",
      "doi-asserted-by": "crossref",
      "first-page": "2676",
      "DOI": "10.1074/jbc.271.5.2676",
      "article-title": "Structures, alternative splicing, and neurexin binding of multiple neuroligins",
      "volume": "271",
      "author": "Ichtchenko",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/geno.2002.6780_RF17",
      "doi-asserted-by": "crossref",
      "first-page": "1100",
      "DOI": "10.1073/pnas.96.3.1100",
      "article-title": "Neuroligin 1 is a postsynaptic cell-adhesion molecular of excitatory synapses",
      "volume": "96",
      "author": "Song",
      "year": "1999",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1006/geno.2002.6780_RF18",
      "doi-asserted-by": "crossref",
      "first-page": "657",
      "DOI": "10.1016/S0092-8674(00)80877-6",
      "article-title": "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons",
      "volume": "101",
      "author": "Scheiffele",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/geno.2002.6780_RF19",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1083/jcb.200105003",
      "article-title": "A stoichiometrc complex of neurexins and dystroglycan in brain",
      "volume": "154",
      "author": "Sugita",
      "year": "2001",
      "journal-title": "J. Cell. Biol."
    },
    {
      "key": "10.1006/geno.2002.6780_RF20",
      "doi-asserted-by": "crossref",
      "first-page": "29",
      "DOI": "10.1038/ng803",
      "article-title": "Alternative splicing and genome complexity",
      "volume": "30",
      "author": "Brett",
      "year": "2001",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/geno.2002.6780_RF21",
      "doi-asserted-by": "crossref",
      "first-page": "108",
      "DOI": "10.1006/geno.2001.6517",
      "article-title": "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at chromosome 7q35",
      "volume": "73",
      "author": "Nakabayashi",
      "year": "2001",
      "journal-title": "Genomics"
    },
    {
      "key": "10.1006/geno.2002.6780_RF22",
      "doi-asserted-by": "crossref",
      "first-page": "860",
      "DOI": "10.1038/35057062",
      "volume": "409",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/geno.2002.6780_RF23",
      "doi-asserted-by": "crossref",
      "first-page": "1059",
      "DOI": "10.1016/S0092-8674(00)81800-0",
      "article-title": "A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function",
      "volume": "87",
      "author": "Baumgartner",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/geno.2002.6780_RF24",
      "doi-asserted-by": "crossref",
      "first-page": "26032",
      "DOI": "10.1074/jbc.272.41.26032",
      "article-title": "Binding properties of neuroligin 1 and neurexin 1\u03b2 reveal function as heterophilic cell adhesion molecules",
      "volume": "272",
      "author": "Nguyen",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/geno.2002.6780_RF25",
      "doi-asserted-by": "crossref",
      "first-page": "421",
      "DOI": "10.1006/geno.1997.4911",
      "article-title": "Exon-intron organization of the human dystrophin gene",
      "volume": "45",
      "author": "Nobile",
      "year": "1997",
      "journal-title": "Genomics"
    },
    {
      "key": "10.1006/geno.2002.6780_RF26",
      "doi-asserted-by": "crossref",
      "first-page": "219",
      "DOI": "10.1016/0092-8674(88)90383-2",
      "article-title": "The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein",
      "volume": "53",
      "author": "Koenig",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/geno.2002.6780_RF27",
      "doi-asserted-by": "crossref",
      "first-page": "1037",
      "DOI": "10.1016/S0896-6273(00)81049-1",
      "article-title": "CASPR2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels",
      "volume": "24",
      "author": "Poliak",
      "year": "1999",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1006/geno.2002.6780_RF28",
      "doi-asserted-by": "crossref",
      "first-page": "184",
      "DOI": "10.1038/ng0295-184",
      "article-title": "The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced",
      "volume": "9",
      "author": "Tennyson",
      "year": "1995",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/geno.2002.6780_RF29",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1038/ng0493-283",
      "article-title": "The structural and functional diversity of dystrophin",
      "volume": "3",
      "author": "Ahn",
      "year": "1993",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1006/geno.2002.6780_RF30",
      "doi-asserted-by": "crossref",
      "first-page": "1705",
      "DOI": "10.1074/jbc.273.3.1705",
      "article-title": "Neurexin I\u03b1 is a major \u03b1-latrotoxin receptor that cooperates in \u03b1-latrotoxin action",
      "volume": "273",
      "author": "Geppert",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/geno.2002.6780_RF31",
      "doi-asserted-by": "crossref",
      "first-page": "1511",
      "DOI": "10.1126/science.277.5331.1511",
      "article-title": "Binding of neuroligins to PSD-95",
      "volume": "277",
      "author": "Irie",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/geno.2002.6780_RF32",
      "doi-asserted-by": "crossref",
      "first-page": "3389",
      "DOI": "10.1093/nar/25.17.3389",
      "article-title": "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs",
      "volume": "25",
      "author": "Altschul",
      "year": "1997",
      "journal-title": "Nucleic Acids Res."
    }
  ],
  "container-title": "Genomics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0888754302967807?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0888754302967807?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        3
      ]
    ],
    "date-time": "2021-05-03T05:23:55Z",
    "timestamp": 1620019435000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0888754302967807"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        6
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2002,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0888754302967807"
  ],
  "URL": "http://dx.doi.org/10.1006/geno.2002.6780",
  "relation": {},
  "ISSN": [
    "0888-7543"
  ],
  "subject": [],
  "container-title-short": "Genomics",
  "published": {
    "date-parts": [
      [
        2002,
        6
      ]
    ]
  }
}