DOI: 10.1006/excr.2000.4888. The Ki-67 Protein: Fascinating Forms and an Unknown Function

The Ki-67 Protein: Fascinating Forms and an Unknown Function

10.1006/excr.2000.4888

Crossref journal-article

Elsevier BV

Experimental Cell Research (78)

Bibliography

Endl, E., & Gerdes, J. (2000). The Ki-67 Protein: Fascinating Forms and an Unknown Function. Experimental Cell Research, 257(2), 231â237.

Authors 2

Elmar Endl (first)
Johannes Gerdes (additional)

References 61 Referenced 284

10.1111/j.1365-2184.1996.tb00090.x / Cell Prolif. / Molecular characterization of the gene locus of the human cell proliferation-associated nuclear protein defined by monoclonal antibody Ki-67 by Duchrow (1996)
10.1002/ijc.2910310104 / Int. J. Cancer / Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation by Gerdes (1983)
10.1083/jcb.123.3.513 / J. Cell Biol. / The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins by Schlüter (1993)
{'key': '10.1006/excr.2000.4888_RF4', 'first-page': '867', 'article-title': 'Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67', 'volume': '138', 'author': 'Gerdes', 'year': '1991', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67 by Gerdes (1991)
10.1006/excr.1999.4600 / Exp. Cell Res. / Biochemical characterization of pKi67 with the identification of a mitotic-specific form associated with hyperphosphorylation and altered DNA binding by MacCallum (1999)
10.1002/(SICI)1097-4652(200003)182:3<371::AID-JCP8>3.0.CO;2-J / J. Cell. Physiol. / Post-translational modifications of the Ki-67 protein coincide with two major check points during mitosis by Endl (2000)
10.1126/science.2876518 / Science / Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis by Rogers (1986)
{'key': '10.1006/excr.2000.4888_RF8', 'first-page': '347', 'article-title': 'The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors', 'volume': '20', 'author': 'Hofmann', 'year': '1995', 'journal-title': 'TIBS'} / TIBS / The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors by Hofmann (1995)
10.4049/jimmunol.133.4.1710 / J. Immunol. / Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67 by Gerdes (1984)
10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9 / J. Cell. Physiol. / The Ki-67 protein: From the known and the unknown by Scholzen (2000)
10.1002/hon.2900020406 / Hematol. Oncol. / Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67 by Gerdes (1984)
{'key': '10.1006/excr.2000.4888_RF12', 'first-page': '597', 'article-title': 'Little missed markers and Ki-67', 'volume': '68', 'author': 'Schwarting', 'year': '1993', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Little missed markers and Ki-67 by Schwarting (1993)
10.1002/path.1711540305 / J. Pathol. / The prognostic value of Ki67 immunostaining in non-Hodgkin's lymphoma by Hall (1988)
10.1111/j.1365-2559.1990.tb00788.x / Histopathology / Monoclonal antibody Ki-67: Its use in histopathology by Brown (1990)
10.1159/000020039 / Eur. Urol. / Prognostic value of MIB-1 score, p53, EGFr, mitotic index and papillary status in primary superficial (Stage pTa/T1) bladder cancer: A prospective comparative study by Liukkonen (1999)
10.1038/bjc.1998.515 / Br. J. Cancer / MIB-1 labelling index is an independent prognostic marker in primary breast cancer by Jansen (1998)
10.1128/MCB.9.6.2487 / Mol. Cell Biol. / Sequence requirements for synthetic peptide-mediated translocation to the nucleus by Chelsky (1989)
10.1016/S0960-9822(98)00010-4 / Curr. Biol. / Nuclear import: A tale of two sites by Dingwall (1998)
10.1126/science.281.5374.272 / Science / Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint by Sun (1998)
10.1242/jcs.112.15.2463 / J. Cell Sci. / Chmadrin: A novel Ki-67 antigen-related perichromosomal protein possibly implicated in higher order chromatin structure by Takagi (1999)
{'key': '10.1006/excr.2000.4888_RF21', 'first-page': '697', 'article-title': 'Ki-67 immunoexpression is a robust marker of proliferative cells in the rat', 'volume': '77', 'author': 'Gerlach', 'year': '1997', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Ki-67 immunoexpression is a robust marker of proliferative cells in the rat by Gerlach (1997)
10.1242/jcs.109.1.143 / J. Cell Sci. / The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression by Starborg (1996)
10.1083/jcb.141.4.875 / J. Cell Biol. / Nuclear localization of cyclin B controls mitotic entry after DNA damage by Jin (1998)
10.1007/BF02889998 / Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol. / Cell cycle dependent distribution of the proliferation-associated Ki-67 antigen in human embryonic lung cells by Braun (1988)
10.1242/jcs.92.1.123 / J. Cell Sci. / Ki67 detects a nuclear matrix associated proliferation related antigen I. Intracellular localization during interphase by Verheijen (1989)
{'key': '10.1006/excr.2000.4888_RF26', 'first-page': '1165', 'article-title': 'Cell-cycle-related staining patterns of anti-proliferating cell nuclear antigen monoclonal antibodies: Comparison with BrdUrd labeling and Ki-67 staining', 'volume': '138', 'author': 'van Dierendonck', 'year': '1991', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Cell-cycle-related staining patterns of anti-proliferating cell nuclear antigen monoclonal antibodies: Comparison with BrdUrd labeling and Ki-67 staining by van Dierendonck (1991)
10.1242/jcs.109.6.1253 / J. Cell Sci. / Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component by Kill (1996)
10.1016/0955-0674(94)90026-4 / Curr. Opin. Cell Biol. / The nucleolus by Scheer (1994)
10.1016/S0955-0674(99)80054-4 / Curr. Opin. Cell Biol. / Structure and function of the nucleolus by Scheer (1999)
10.1096/fasebj.13.14.1911 / FASEB J. / Molecular dissection of nucleolin's role in growth and cell proliferation: New insights by Srivastava (1999)
10.1016/S0955-0674(97)80005-1 / Curr. Opin. Cell Biol. / Function and synthesis of small nucleolar RNAs by Tollervey (1997)
10.1242/jcs.111.3.359 / J. Cell Sci. / Effects of anti-fibrillarin antibodies on building of functional nucleoli at the end of mitosis by Fomproix (1998)
10.1016/S0968-4328(99)00072-4 / Micron / Proliferation assessment in breast cancer: A double-staining technique for AgNOR quantification in MIB-1 positive cells especially adapted for image cytometry by Lorenzato (2000)
10.1006/excr.1995.1228 / Exp. Cell Res. / Quantitative changes of the two major AgNOR proteins, nucleolin and protein B23, related to stimulation of rDNA transcription by Derenzini (1995)
10.1073/pnas.90.18.8407 / Proc. Natl. Acad. Sci. USA / DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM2 by Taagepera (1993)
10.1073/pnas.86.13.4982 / Proc. Natl. Acad. Sci. USA / Mitosis specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity by Kuang (1989)
10.1002/bies.950160308 / Bioessays / The chromosome periphery during mitosis by Hernandez-Verdun (1994)
10.1023/A:1009210206855 / Chromosome Res. / Association of pKi-67 with satellite DNA of the human genome in early G1 cells by Bridger (1998)
10.1126/science.280.5363.547 / Science / Structure and function of the nucleus by Lamond (1998)
10.1002/cyto.990120511 / Cytometry / Ki-67 labeling in postmitotic cells defines different Ki-67 pathways within the 2c compartment by du Manoir (1991)
10.1111/j.1365-2184.1992.tb01435.x / Cell Prolif. / Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells by Bruno (1992)
10.1002/(SICI)1097-0320(19971101)29:3<233::AID-CYTO6>3.0.CO;2-C / Cytometry / Analysis of cell cycle-related Ki-67 and p120 expression by flow cytometric BrdUrd-Hoechst/7AAD and immunolabeling technique by Endl (1997)
10.1242/jcs.92.4.531 / J. Cell Sci. / Ki67 detects a nuclear matrix associated proliferation related antigen II by Verheijen (1989)
{'key': '10.1006/excr.2000.4888_RF44', 'first-page': '3551', 'article-title': 'A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation', 'volume': '56', 'author': 'Hall', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation by Hall (1996)
10.1016/S0021-9258(17)36919-3 / J. Biol. Chem. / Inhibition of histone phosphorylation by staurosporine leads to chromosome decondensation by Th'ng (1994)
10.1242/jcs.110.1.43 / J. Cell Sci. / Prenucleolar bodies contain coilin and are assembled in Xenopus egg extract depleted of specific nucleolar proteins and U3 RNA by Bell (1997)
10.1242/jcs.112.12.1889 / J. Cell Sci. / The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleogenesis by Savino (1999)
10.1083/jcb.145.6.1119 / J. Cell Biol. / Differences in the localization and morphology of chromosomes in the human nucleus by Croft (1999)
10.1006/excr.1994.1022 / Exp. Cell Res. / The labelling of proliferating cells by Ki67 and MIB-1 antibodies depends on the binding of a nuclear protein to the DNA by Lopez (1994)
10.1016/S0014-5793(97)00948-4 / FEBS Lett. / MPM-2 epitope sequence is not sufficient for recognition and phosphorylation by ME kinase-H by Che (1997)
10.1016/S0960-9822(06)00157-6 / Curr. Biol. / Systematic identification of mitotic phosphoproteins by Stukenberg (1997)
10.1111/j.1432-1033.1997.t01-4-00001.x / Eur. J. Biochem. / Linking protein kinase C to cell-cycle control by Livneh (1997)
10.1242/jcs.112.6.977 / J. Cell Sci. / Sequential PKC- and Cdc2-mediated phosphorylation events elicit zebrafish nuclear envelope disassembly by Collas (1999)
10.1016/0092-8674(90)90093-T / Cell / Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase by Peter (1990)
10.1083/jcb.116.6.1421 / J. Cell Biol. / Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit by Fernandez (1992)
10.1083/jcb.141.5.1207 / J. Cell. Biol. / Differential subcellular localization of protein phosphatase-1α, γ1, and δ isoforms during both interphase and mitosis in mammalian cells by Andreassen (1998)
10.1083/jcb.142.4.1013 / J. Cell Biol. / Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase by Rieder (1998)
10.1091/mbc.5.2.135 / Mol. Biol. Cell / cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor by Kuang (1994)
10.1016/0092-8674(95)90338-0 / Cell / A 20S complex containing cdc27 and cdc16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B by King (1995)
10.1016/S0092-8674(00)80906-X / Cell / Prolyl isomerases and nuclear function by Hunter (1998)
10.1093/emboj/17.5.1315 / EMBO J. / The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1 by Crenshaw (1998)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 16, 2002, 11:46 a.m.)
Deposited	2 years, 4 months ago (April 3, 2023, 2:56 p.m.)
Indexed	1 month ago (July 30, 2025, 9:53 a.m.)
Issued	25 years, 2 months ago (June 1, 2000)
Published	25 years, 2 months ago (June 1, 2000)
Published Print	25 years, 2 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Endl_2000, title={The Ki-67 Protein: Fascinating Forms and an Unknown Function}, volume={257}, ISSN={0014-4827}, url={http://dx.doi.org/10.1006/excr.2000.4888}, DOI={10.1006/excr.2000.4888}, number={2}, journal={Experimental Cell Research}, publisher={Elsevier BV}, author={Endl, Elmar and Gerdes, Johannes}, year={2000}, month=jun, pages={231–237} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        30
      ]
    ],
    "date-time": "2025-07-30T13:53:46Z",
    "timestamp": 1753883626331
  },
  "reference-count": 61,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            6,
            1
          ]
        ],
        "date-time": "2000-06-01T00:00:00Z",
        "timestamp": 959817600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "DOI": "10.1006/excr.2000.4888",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        16
      ]
    ],
    "date-time": "2002-09-16T15:46:56Z",
    "timestamp": 1032191216000
  },
  "page": "231-237",
  "source": "Crossref",
  "is-referenced-by-count": 284,
  "title": "The Ki-67 Protein: Fascinating Forms and an Unknown Function",
  "prefix": "10.1006",
  "volume": "257",
  "author": [
    {
      "given": "Elmar",
      "family": "Endl",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Johannes",
      "family": "Gerdes",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1006/excr.2000.4888_RF1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1111/j.1365-2184.1996.tb00090.x",
      "article-title": "Molecular characterization of the gene locus of the human cell proliferation-associated nuclear protein defined by monoclonal antibody Ki-67",
      "volume": "29",
      "author": "Duchrow",
      "year": "1996",
      "journal-title": "Cell Prolif."
    },
    {
      "key": "10.1006/excr.2000.4888_RF2",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1002/ijc.2910310104",
      "article-title": "Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation",
      "volume": "31",
      "author": "Gerdes",
      "year": "1983",
      "journal-title": "Int. J. Cancer"
    },
    {
      "key": "10.1006/excr.2000.4888_RF3",
      "doi-asserted-by": "crossref",
      "first-page": "513",
      "DOI": "10.1083/jcb.123.3.513",
      "article-title": "The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins",
      "volume": "123",
      "author": "Schl\u00fcter",
      "year": "1993",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF4",
      "first-page": "867",
      "article-title": "Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67",
      "volume": "138",
      "author": "Gerdes",
      "year": "1991",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF5",
      "doi-asserted-by": "crossref",
      "first-page": "186",
      "DOI": "10.1006/excr.1999.4600",
      "article-title": "Biochemical characterization of pKi67 with the identification of a mitotic-specific form associated with hyperphosphorylation and altered DNA binding",
      "volume": "252",
      "author": "MacCallum",
      "year": "1999",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1006/excr.2000.4888_RF6",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1002/(SICI)1097-4652(200003)182:3<371::AID-JCP8>3.0.CO;2-J",
      "article-title": "Post-translational modifications of the Ki-67 protein coincide with two major check points during mitosis",
      "volume": "182",
      "author": "Endl",
      "year": "2000",
      "journal-title": "J. Cell. Physiol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF7",
      "doi-asserted-by": "crossref",
      "first-page": "364",
      "DOI": "10.1126/science.2876518",
      "article-title": "Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis",
      "volume": "234",
      "author": "Rogers",
      "year": "1986",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/excr.2000.4888_RF8",
      "first-page": "347",
      "article-title": "The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors",
      "volume": "20",
      "author": "Hofmann",
      "year": "1995",
      "journal-title": "TIBS"
    },
    {
      "key": "10.1006/excr.2000.4888_RF9",
      "doi-asserted-by": "crossref",
      "first-page": "1710",
      "DOI": "10.4049/jimmunol.133.4.1710",
      "article-title": "Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67",
      "volume": "133",
      "author": "Gerdes",
      "year": "1984",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF10",
      "doi-asserted-by": "crossref",
      "first-page": "311",
      "DOI": "10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9",
      "article-title": "The Ki-67 protein: From the known and the unknown",
      "volume": "182",
      "author": "Scholzen",
      "year": "2000",
      "journal-title": "J. Cell. Physiol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF11",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1002/hon.2900020406",
      "article-title": "Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67",
      "volume": "2",
      "author": "Gerdes",
      "year": "1984",
      "journal-title": "Hematol. Oncol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF12",
      "first-page": "597",
      "article-title": "Little missed markers and Ki-67",
      "volume": "68",
      "author": "Schwarting",
      "year": "1993",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1006/excr.2000.4888_RF13",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1002/path.1711540305",
      "article-title": "The prognostic value of Ki67 immunostaining in non-Hodgkin's lymphoma",
      "volume": "154",
      "author": "Hall",
      "year": "1988",
      "journal-title": "J. Pathol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF14",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1111/j.1365-2559.1990.tb00788.x",
      "article-title": "Monoclonal antibody Ki-67: Its use in histopathology",
      "volume": "17",
      "author": "Brown",
      "year": "1990",
      "journal-title": "Histopathology"
    },
    {
      "key": "10.1006/excr.2000.4888_RF15",
      "doi-asserted-by": "crossref",
      "first-page": "393",
      "DOI": "10.1159/000020039",
      "article-title": "Prognostic value of MIB-1 score, p53, EGFr, mitotic index and papillary status in primary superficial (Stage pTa/T1) bladder cancer: A prospective comparative study",
      "volume": "36",
      "author": "Liukkonen",
      "year": "1999",
      "journal-title": "Eur. Urol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF16",
      "doi-asserted-by": "crossref",
      "first-page": "460",
      "DOI": "10.1038/bjc.1998.515",
      "article-title": "MIB-1 labelling index is an independent prognostic marker in primary breast cancer",
      "volume": "78",
      "author": "Jansen",
      "year": "1998",
      "journal-title": "Br. J. Cancer"
    },
    {
      "key": "10.1006/excr.2000.4888_RF17",
      "doi-asserted-by": "crossref",
      "first-page": "2487",
      "DOI": "10.1128/MCB.9.6.2487",
      "article-title": "Sequence requirements for synthetic peptide-mediated translocation to the nucleus",
      "volume": "9",
      "author": "Chelsky",
      "year": "1989",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF18",
      "doi-asserted-by": "crossref",
      "first-page": "922",
      "DOI": "10.1016/S0960-9822(98)00010-4",
      "article-title": "Nuclear import: A tale of two sites",
      "volume": "8",
      "author": "Dingwall",
      "year": "1998",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF19",
      "doi-asserted-by": "crossref",
      "first-page": "272",
      "DOI": "10.1126/science.281.5374.272",
      "article-title": "Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint",
      "volume": "281",
      "author": "Sun",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/excr.2000.4888_RF20",
      "doi-asserted-by": "crossref",
      "first-page": "2463",
      "DOI": "10.1242/jcs.112.15.2463",
      "article-title": "Chmadrin: A novel Ki-67 antigen-related perichromosomal protein possibly implicated in higher order chromatin structure",
      "volume": "112",
      "author": "Takagi",
      "year": "1999",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF21",
      "first-page": "697",
      "article-title": "Ki-67 immunoexpression is a robust marker of proliferative cells in the rat",
      "volume": "77",
      "author": "Gerlach",
      "year": "1997",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1006/excr.2000.4888_RF22",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1242/jcs.109.1.143",
      "article-title": "The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression",
      "volume": "109",
      "author": "Starborg",
      "year": "1996",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF23",
      "doi-asserted-by": "crossref",
      "first-page": "875",
      "DOI": "10.1083/jcb.141.4.875",
      "article-title": "Nuclear localization of cyclin B controls mitotic entry after DNA damage",
      "volume": "141",
      "author": "Jin",
      "year": "1998",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF24",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1007/BF02889998",
      "article-title": "Cell cycle dependent distribution of the proliferation-associated Ki-67 antigen in human embryonic lung cells",
      "volume": "56",
      "author": "Braun",
      "year": "1988",
      "journal-title": "Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF25",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1242/jcs.92.1.123",
      "article-title": "Ki67 detects a nuclear matrix associated proliferation related antigen I. Intracellular localization during interphase",
      "volume": "92",
      "author": "Verheijen",
      "year": "1989",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF26",
      "first-page": "1165",
      "article-title": "Cell-cycle-related staining patterns of anti-proliferating cell nuclear antigen monoclonal antibodies: Comparison with BrdUrd labeling and Ki-67 staining",
      "volume": "138",
      "author": "van Dierendonck",
      "year": "1991",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF27",
      "doi-asserted-by": "crossref",
      "first-page": "1253",
      "DOI": "10.1242/jcs.109.6.1253",
      "article-title": "Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component",
      "volume": "109",
      "author": "Kill",
      "year": "1996",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF28",
      "doi-asserted-by": "crossref",
      "first-page": "354",
      "DOI": "10.1016/0955-0674(94)90026-4",
      "article-title": "The nucleolus",
      "volume": "6",
      "author": "Scheer",
      "year": "1994",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF29",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1016/S0955-0674(99)80054-4",
      "article-title": "Structure and function of the nucleolus",
      "volume": "11",
      "author": "Scheer",
      "year": "1999",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF30",
      "doi-asserted-by": "crossref",
      "first-page": "1911",
      "DOI": "10.1096/fasebj.13.14.1911",
      "article-title": "Molecular dissection of nucleolin's role in growth and cell proliferation: New insights",
      "volume": "13",
      "author": "Srivastava",
      "year": "1999",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1006/excr.2000.4888_RF31",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1016/S0955-0674(97)80005-1",
      "article-title": "Function and synthesis of small nucleolar RNAs",
      "volume": "9",
      "author": "Tollervey",
      "year": "1997",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF32",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1242/jcs.111.3.359",
      "article-title": "Effects of anti-fibrillarin antibodies on building of functional nucleoli at the end of mitosis",
      "volume": "111",
      "author": "Fomproix",
      "year": "1998",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF33",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/S0968-4328(99)00072-4",
      "article-title": "Proliferation assessment in breast cancer: A double-staining technique for AgNOR quantification in MIB-1 positive cells especially adapted for image cytometry",
      "volume": "31",
      "author": "Lorenzato",
      "year": "2000",
      "journal-title": "Micron"
    },
    {
      "key": "10.1006/excr.2000.4888_RF34",
      "doi-asserted-by": "crossref",
      "first-page": "276",
      "DOI": "10.1006/excr.1995.1228",
      "article-title": "Quantitative changes of the two major AgNOR proteins, nucleolin and protein B23, related to stimulation of rDNA transcription",
      "volume": "219",
      "author": "Derenzini",
      "year": "1995",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1006/excr.2000.4888_RF35",
      "doi-asserted-by": "crossref",
      "first-page": "8407",
      "DOI": "10.1073/pnas.90.18.8407",
      "article-title": "DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM2",
      "volume": "90",
      "author": "Taagepera",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/excr.2000.4888_RF36",
      "doi-asserted-by": "crossref",
      "first-page": "4982",
      "DOI": "10.1073/pnas.86.13.4982",
      "article-title": "Mitosis specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity",
      "volume": "86",
      "author": "Kuang",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/excr.2000.4888_RF37",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1002/bies.950160308",
      "article-title": "The chromosome periphery during mitosis",
      "volume": "16",
      "author": "Hernandez-Verdun",
      "year": "1994",
      "journal-title": "Bioessays"
    },
    {
      "key": "10.1006/excr.2000.4888_RF38",
      "doi-asserted-by": "crossref",
      "first-page": "4951",
      "DOI": "10.1023/A:1009210206855",
      "article-title": "Association of pKi-67 with satellite DNA of the human genome in early G1 cells",
      "volume": "6",
      "author": "Bridger",
      "year": "1998",
      "journal-title": "Chromosome Res."
    },
    {
      "key": "10.1006/excr.2000.4888_RF39",
      "doi-asserted-by": "crossref",
      "first-page": "547",
      "DOI": "10.1126/science.280.5363.547",
      "article-title": "Structure and function of the nucleus",
      "volume": "280",
      "author": "Lamond",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1006/excr.2000.4888_RF40",
      "doi-asserted-by": "crossref",
      "first-page": "455",
      "DOI": "10.1002/cyto.990120511",
      "article-title": "Ki-67 labeling in postmitotic cells defines different Ki-67 pathways within the 2c compartment",
      "volume": "12",
      "author": "du Manoir",
      "year": "1991",
      "journal-title": "Cytometry"
    },
    {
      "key": "10.1006/excr.2000.4888_RF41",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1111/j.1365-2184.1992.tb01435.x",
      "article-title": "Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells",
      "volume": "25",
      "author": "Bruno",
      "year": "1992",
      "journal-title": "Cell Prolif."
    },
    {
      "key": "10.1006/excr.2000.4888_RF42",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1002/(SICI)1097-0320(19971101)29:3<233::AID-CYTO6>3.0.CO;2-C",
      "article-title": "Analysis of cell cycle-related Ki-67 and p120 expression by flow cytometric BrdUrd-Hoechst/7AAD and immunolabeling technique",
      "volume": "29",
      "author": "Endl",
      "year": "1997",
      "journal-title": "Cytometry"
    },
    {
      "key": "10.1006/excr.2000.4888_RF43",
      "doi-asserted-by": "crossref",
      "first-page": "531",
      "DOI": "10.1242/jcs.92.4.531",
      "article-title": "Ki67 detects a nuclear matrix associated proliferation related antigen II",
      "volume": "92",
      "author": "Verheijen",
      "year": "1989",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF44",
      "first-page": "3551",
      "article-title": "A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation",
      "volume": "56",
      "author": "Hall",
      "year": "1996",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1006/excr.2000.4888_RF45",
      "doi-asserted-by": "crossref",
      "first-page": "9568",
      "DOI": "10.1016/S0021-9258(17)36919-3",
      "article-title": "Inhibition of histone phosphorylation by staurosporine leads to chromosome decondensation",
      "volume": "269",
      "author": "Th'ng",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/excr.2000.4888_RF46",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1242/jcs.110.1.43",
      "article-title": "Prenucleolar bodies contain coilin and are assembled in Xenopus egg extract depleted of specific nucleolar proteins and U3 RNA",
      "volume": "110",
      "author": "Bell",
      "year": "1997",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF47",
      "doi-asserted-by": "crossref",
      "first-page": "1889",
      "DOI": "10.1242/jcs.112.12.1889",
      "article-title": "The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleogenesis",
      "volume": "112",
      "author": "Savino",
      "year": "1999",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF48",
      "doi-asserted-by": "crossref",
      "first-page": "1119",
      "DOI": "10.1083/jcb.145.6.1119",
      "article-title": "Differences in the localization and morphology of chromosomes in the human nucleus",
      "volume": "145",
      "author": "Croft",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF49",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1006/excr.1994.1022",
      "article-title": "The labelling of proliferating cells by Ki67 and MIB-1 antibodies depends on the binding of a nuclear protein to the DNA",
      "volume": "210",
      "author": "Lopez",
      "year": "1994",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1006/excr.2000.4888_RF50",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/S0014-5793(97)00948-4",
      "article-title": "MPM-2 epitope sequence is not sufficient for recognition and phosphorylation by ME kinase-H",
      "volume": "413",
      "author": "Che",
      "year": "1997",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/excr.2000.4888_RF51",
      "doi-asserted-by": "crossref",
      "first-page": "338",
      "DOI": "10.1016/S0960-9822(06)00157-6",
      "article-title": "Systematic identification of mitotic phosphoproteins",
      "volume": "7",
      "author": "Stukenberg",
      "year": "1997",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF52",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1111/j.1432-1033.1997.t01-4-00001.x",
      "article-title": "Linking protein kinase C to cell-cycle control",
      "volume": "248",
      "author": "Livneh",
      "year": "1997",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1006/excr.2000.4888_RF53",
      "doi-asserted-by": "crossref",
      "first-page": "977",
      "DOI": "10.1242/jcs.112.6.977",
      "article-title": "Sequential PKC- and Cdc2-mediated phosphorylation events elicit zebrafish nuclear envelope disassembly",
      "volume": "112",
      "author": "Collas",
      "year": "1999",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1006/excr.2000.4888_RF54",
      "doi-asserted-by": "crossref",
      "first-page": "791",
      "DOI": "10.1016/0092-8674(90)90093-T",
      "article-title": "Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase",
      "volume": "60",
      "author": "Peter",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/excr.2000.4888_RF55",
      "doi-asserted-by": "crossref",
      "first-page": "1421",
      "DOI": "10.1083/jcb.116.6.1421",
      "article-title": "Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit",
      "volume": "116",
      "author": "Fernandez",
      "year": "1992",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF56",
      "doi-asserted-by": "crossref",
      "first-page": "1207",
      "DOI": "10.1083/jcb.141.5.1207",
      "article-title": "Differential subcellular localization of protein phosphatase-1\u03b1, \u03b31, and \u03b4 isoforms during both interphase and mitosis in mammalian cells",
      "volume": "141",
      "author": "Andreassen",
      "year": "1998",
      "journal-title": "J. Cell. Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF57",
      "doi-asserted-by": "crossref",
      "first-page": "1013",
      "DOI": "10.1083/jcb.142.4.1013",
      "article-title": "Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase",
      "volume": "142",
      "author": "Rieder",
      "year": "1998",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1006/excr.2000.4888_RF58",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1091/mbc.5.2.135",
      "article-title": "cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor",
      "volume": "5",
      "author": "Kuang",
      "year": "1994",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1006/excr.2000.4888_RF59",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/0092-8674(95)90338-0",
      "article-title": "A 20S complex containing cdc27 and cdc16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B",
      "volume": "81",
      "author": "King",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/excr.2000.4888_RF60",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1016/S0092-8674(00)80906-X",
      "article-title": "Prolyl isomerases and nuclear function",
      "volume": "92",
      "author": "Hunter",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/excr.2000.4888_RF61",
      "doi-asserted-by": "crossref",
      "first-page": "1315",
      "DOI": "10.1093/emboj/17.5.1315",
      "article-title": "The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1",
      "volume": "17",
      "author": "Crenshaw",
      "year": "1998",
      "journal-title": "EMBO J."
    }
  ],
  "container-title": "Experimental Cell Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0014482700948882?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0014482700948882?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        3
      ]
    ],
    "date-time": "2023-04-03T18:56:22Z",
    "timestamp": 1680548182000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0014482700948882"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "references-count": 61,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2000,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0014482700948882"
  ],
  "URL": "http://dx.doi.org/10.1006/excr.2000.4888",
  "relation": {},
  "ISSN": [
    "0014-4827"
  ],
  "subject": [],
  "container-title-short": "Experimental Cell Research",
  "published": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  }
}