DOI: 10.1006/excr.1999.4670. Cytokines and JAK

Cytokines and JAK–STAT Signaling

10.1006/excr.1999.4670

Crossref journal-article

Elsevier BV

Experimental Cell Research (78)

Bibliography

Schindler, C. (1999). Cytokines and JAKâSTAT Signaling. Experimental Cell Research, 253(1), 7â14.

Authors 1

Christian Schindler (first)

References 69 Referenced 110

10.1016/0092-8674(90)90182-E / Cell / Shared architecture of hormone binding domains in type I and II interferon receptors by Bazan (1990)
10.1016/S1054-3589(08)60111-8 / Advances in Pharmacology / Cytokines and STAT signaling by Schindler (1999)
10.1016/0968-0004(94)90130-9 / Trends Biochem. Sci. / Regulation of signal transduction and signal diversity by receptor oligomerization by Lemmon (1994)
10.1038/377591a0 / Nature / Cytokine receptor signaling by Ihle (1995)
10.1016/S0092-8674(00)81277-5 / Cell / STATs: Signal transducers and activators of transcription by Ihle (1996)
10.1126/science.277.5332.1630 / Science / STATs and gene regulation by Darnell (1997)
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10.1146/annurev.immunol.15.1.563 / Annu. Rev. Immunol. / The IFN gamma receptor: A paradigm for cytokine receptor signaling by Bach (1997)
10.1073/pnas.89.16.7836 / Proc. Natl. Acad. Sci. USA / Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha by Schindler (1992)
10.1126/science.1496401 / Science / Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor by Schindler (1992)
10.1038/366129a0 / Nature / The protein tyrosine kinase Jak-1 complements defects in the Interferon-α/β and -γ signal transduction pathways by Müller (1993)
10.1016/0092-8674(92)90105-L / Cell / A protein tyrosine kinase in the interferon α/β signaling pathway by Velazquez (1992)
10.1089/jir.1997.17.121 / J. Interferon Cytokine Res. / GAS elements: A few nucleotides with a major impact on cytokine-induced gene expression by Decker (1997)
10.1016/S0092-8674(00)81443-9 / Cell / Crystal structure of a tyrosine phosphorylated Stat1 dimer bound to DNA by Chen (1998)
10.1038/28101 / Nature / Three-dimensional structure of the Stat3β homodimer bound to DNA by Becker (1998)
10.1126/science.279.5353.1048 / Science / Structure of the amino-terminal protein interaction domain of Stat-4 by Vinkemeier (1998)
10.1111/j.1432-1033.1997.00615.x / Eur. J. Biochem. / The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs) by Pellegrini (1997)
10.1016/S0092-8674(00)81166-6 / Cell / Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses by Rodig (1998)
10.1016/S0092-8674(00)81168-X / Cell / Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis by Neubauer (1998)
10.1016/S0092-8674(00)81167-8 / Cell / Jak2 is essential for signaling through a variety of cytokine receptors by Parganas (1998)
10.1146/annurev.med.47.1.229 / Annu. Rev. Med / The moleuclar basis of X-linked sever combined immunodeficiency: Defective cytokine receptor signaling by Leonard (1996)
10.1016/1074-7613(95)90066-7 / Immunity / Developmental defects of lymphoid cells in Jak3 kinase-deficient mice by Park (1995)
10.1126/science.270.5237.794 / Science / Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3 by Thomis (1995)
10.1126/science.270.5237.800 / Science / Defective lymphoid development in mice lacking Jak3 by Nosaka (1995)
10.1016/S0092-8674(00)81288-X / Cell / Targeted disruption of the Stat1 gene in mice reveals unexpected physiological specificity in the JAK-STAT pathway by Meraz (1996)
10.1016/S0092-8674(00)81289-1 / Cell / Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease by Durbin (1996)
Park, C, Li, S, and, Schindler, C. 1999, Stat2 null mice are deficient in response to both type I and II interferons. Submitted for publication.
10.1073/pnas.94.8.3801 / Proc. Natl. Acad. Sci. USA / Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality by Takeda (1997)
10.1016/S1074-7613(00)80005-9 / Immunity / Enhanced Th1 activity and development of chornic enteroclolitis in mice devoid of Stat3 in macrophages and neutrophils by Takeda (1999)
10.4049/jimmunol.161.9.4652 / J. Immunol. / Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice by Takeda (1998)
10.1038/382171a0 / Nature / Requirement for Stat4 in interleukin-12 mediated response of natural killer and T cells by Thierfelder (1996)
10.1038/382174a0 / Nature / Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice by Kaplan (1996)
10.1101/gad.11.2.179 / Genes Dev. / Stat5a is mandatory for adult mammary gland development and lactogenesis by Liu (1997)
10.1073/pnas.94.14.7239 / Proc. Natl. Acad. Sci. USA / Requirement of Stat5b for sexual dimorphism of body growth rates and liver gene expression by Udy (1997)
10.1016/S0092-8674(00)81444-0 / Cell / Stat5a and Stat5b proteins have essential roles and nonessential, or redundant, roles in cytokine responses by Teglund (1998)
10.1016/S1074-7613(00)80025-4 / Immunity / Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells by Moriggl (1999)
10.1016/S0092-8674(00)81013-2 / Cell / Fetal anemia and apoptosis of red cell progenitors in Stat5a −/− 5b −/− mice: A direct role for Stat5 in Bcl-XL induction by Socolovsky (1999)
10.1038/380627a0 / Nature / Essential role of Stat6 in IL-4 signalling by Takeda (1996)
10.1038/380630a0 / Nature / Lack of IL-4 induces Th2 response in IgE class switching mice with disrupted Stat6 gene by Shimoda (1996)
10.1016/S1074-7613(00)80439-2 / Immunity / Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells by Kaplan (1996)
10.1016/S0092-8674(00)80276-7 / Cell / SH2 signaling in a lower eukaryote: A STAT protein that regulates stalk cell differentiation in Dictyostelium by Kawata (1997)
10.1007/s000180050397 / CMLS, Cell. Mol. Life Sci. / JAKs and STATs in invertebrate model organisms by Dearolf (1999)
10.1016/S0168-9525(97)01006-8 / Trends Genet. / The Jak-STAT pathway in Drosophila by Hou (1997)
10.1073/pnas.94.7.3082 / Proc. Natl. Acad. Sci. USA / Jak1 kinase is required for cell migrations and anterior specification in zebrafish by Conway (1997)
10.1016/0014-5793(96)01053-8 / FEBS Lett. / Classification of tyrosine kinases form Dictyostelium discoideum with two distinct, complete or incomplete catalytic domains by Adler (1996)
10.1101/gad.13.10.1342 / Genes Dev. / Polarity determination in the Drosophila eye: A novel role for unpaired and JAK/STAT signaling by Zeidler (1999)
10.1093/emboj/17.14.4018 / EMBO J. / Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor by Araki (1998)
10.1074/jbc.272.37.23382 / J. Biol. Chem. / Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellualr carboxyl tail of the angiotensin II AT1 receptor by Ali (1997)
10.1007/s000180050396 / CMLS, Cell. Mol. Life Sci. / Negative regulators of cytokine signal transduction by Hilton (1999)
10.1016/0092-8674(95)90351-8 / Cell / Specefic recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of Jak2 and termination of proliferative signals by Klingmüller (1995)
10.1002/(SICI)1521-1878(199901)21:1<47::AID-BIES6>3.0.CO;2-N / BioEssays / Negative regulation of the JAK/STAT pathway by Starr (1999)
10.1073/pnas.95.1.114 / Proc. Natl. Acad. Sci. USA / Twenty proteins containing a C-terminal SOCS box from five structural classes by Hilton (1998)
10.1073/pnas.95.26.15577 / Proc. Natl. Acad. Sci. USA / Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice by Naka (1998)
10.1073/pnas.95.24.14395 / Proc. Natl. Acad. Sci. USA / Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1 by Starr (1998)
Nicola, N. A, Nicholson, S, Metcalf, D, Zhang, J.-G, Baca, M, Farely, A, et al., 1999. Negative regulation of cytokine signaling by SOCS proteins, Abstr. LXIV Cold Spring Harbor Symp. Quant. Biol. (10.1101/sqb.1999.64.397)
10.1101/gad.12.24.3872 / Genes Dev. / The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families by Kamura (1998)
10.1093/emboj/18.12.3359 / EMBO J. / Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP by Konietzko (1999)
10.1007/s000180050393 / CMLS, Cell. Mol. Life Sci. / Transcription factor activity of STAT proteins: Structural requirements and regulation by phosphorylation and interacting proteins by Kovarik (1999)
10.1016/S0962-8924(98)01233-1 / Trends Cell Biol. / STATs as activators of apoptosis by Schindler (1998)
10.1126/science.7701321 / Science / Requirement of serine phosphorylation for formation of STAT-promoter complexes by Zhang (1995)
10.1016/0092-8674(95)90311-9 / Cell / Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation by Wen (1995)
10.1126/science.272.5262.719 / Science / Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mediated by Stat1 by Chin (1996)
10.1007/BF02258360 / J. Biomed. Sci. / Activation of STAT transcription factors in oncogenic tyrosine kinase signaling by Garcia (1998)
10.1016/S0092-8674(00)81959-5 / Cell / Stat3 as an Oncogene by Bromberg (1999)
10.1084/jem.189.1.63 / J. Exp. Med. / STAT3 is required for the gp130-mediated full activation of the c-myc gene by Kiuchi (1999)
10.1016/S1074-7613(00)80011-4 / Immunity / Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells by Catlett-Falcone (1999)
10.1126/science.278.5343.1630 / Science / Defective TNF-α induced apoptosis in Stat1 null cells due to low constitutive levels of caspases by Kumar (1997)
10.1101/sqb.1999.64.465 / Abstr. LXIV Cold Spring Harbor Symp. Quant. Biol. / Regulation of the interferons and immune systems by the IRF family of transcription factos by Taniguchi (1999)
10.1016/S0092-8674(05)80086-8 / Cell / Targeted disruption of IRF-1 and IRF-2 results in abnormal type I IFN gene induction and abarrant lymphocyte development by Matsuyama (1993)

Dates

Type	When
Created	22 years, 10 months ago (Oct. 7, 2002, 10:19 a.m.)
Deposited	2 years, 4 months ago (April 4, 2023, 11:56 a.m.)
Indexed	1 week, 1 day ago (Aug. 20, 2025, 9:11 a.m.)
Issued	25 years, 9 months ago (Nov. 1, 1999)
Published	25 years, 9 months ago (Nov. 1, 1999)
Published Print	25 years, 9 months ago (Nov. 1, 1999)

Funders 0

None

BibTeX

@article{Schindler_1999, title={Cytokines and JAK–STAT Signaling}, volume={253}, ISSN={0014-4827}, url={http://dx.doi.org/10.1006/excr.1999.4670}, DOI={10.1006/excr.1999.4670}, number={1}, journal={Experimental Cell Research}, publisher={Elsevier BV}, author={Schindler, Christian}, year={1999}, month=nov, pages={7–14} }

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      "journal-title": "Cell"
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      "author": "Darnell",
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      "journal-title": "Science"
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      "article-title": "The human interferon alpha species and hybrid proteins",
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      "volume": "15",
      "author": "Bach",
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      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "journal-title": "Cell"
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      "volume": "382",
      "author": "Kaplan",
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      "volume": "11",
      "author": "Liu",
      "year": "1997",
      "journal-title": "Genes Dev."
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      "volume": "94",
      "author": "Udy",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
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      "volume": "93",
      "author": "Teglund",
      "year": "1998",
      "journal-title": "Cell"
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      "article-title": "Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells",
      "volume": "10",
      "author": "Moriggl",
      "year": "1999",
      "journal-title": "Immunity"
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      "volume": "98",
      "author": "Socolovsky",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
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      "first-page": "627",
      "DOI": "10.1038/380627a0",
      "article-title": "Essential role of Stat6 in IL-4 signalling",
      "volume": "380",
      "author": "Takeda",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
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      "first-page": "630",
      "DOI": "10.1038/380630a0",
      "article-title": "Lack of IL-4 induces Th2 response in IgE class switching mice with disrupted Stat6 gene",
      "volume": "380",
      "author": "Shimoda",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1006/excr.1999.4670_RF40",
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      "first-page": "313",
      "DOI": "10.1016/S1074-7613(00)80439-2",
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      "volume": "4",
      "author": "Kaplan",
      "year": "1996",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1006/excr.1999.4670_RF41",
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      "first-page": "909",
      "DOI": "10.1016/S0092-8674(00)80276-7",
      "article-title": "SH2 signaling in a lower eukaryote: A STAT protein that regulates stalk cell differentiation in Dictyostelium",
      "volume": "89",
      "author": "Kawata",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1006/excr.1999.4670_RF42",
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      "first-page": "1578",
      "DOI": "10.1007/s000180050397",
      "article-title": "JAKs and STATs in invertebrate model organisms",
      "volume": "55",
      "author": "Dearolf",
      "year": "1999",
      "journal-title": "CMLS, Cell. Mol. Life Sci."
    },
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      "key": "10.1006/excr.1999.4670_RF43",
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      "first-page": "105",
      "DOI": "10.1016/S0168-9525(97)01006-8",
      "article-title": "The Jak-STAT pathway in Drosophila",
      "volume": "13",
      "author": "Hou",
      "year": "1997",
      "journal-title": "Trends Genet."
    },
    {
      "key": "10.1006/excr.1999.4670_RF44",
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      "first-page": "3082",
      "DOI": "10.1073/pnas.94.7.3082",
      "article-title": "Jak1 kinase is required for cell migrations and anterior specification in zebrafish",
      "volume": "94",
      "author": "Conway",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1006/excr.1999.4670_RF45",
      "doi-asserted-by": "crossref",
      "first-page": "286",
      "DOI": "10.1016/0014-5793(96)01053-8",
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      "volume": "395",
      "author": "Adler",
      "year": "1996",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1006/excr.1999.4670_RF46",
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      "first-page": "1342",
      "DOI": "10.1101/gad.13.10.1342",
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      "volume": "13",
      "author": "Zeidler",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1006/excr.1999.4670_RF47",
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      "first-page": "4018",
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      "volume": "17",
      "author": "Araki",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1006/excr.1999.4670_RF48",
      "doi-asserted-by": "crossref",
      "first-page": "23382",
      "DOI": "10.1074/jbc.272.37.23382",
      "article-title": "Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellualr carboxyl tail of the angiotensin II AT1 receptor",
      "volume": "272",
      "author": "Ali",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1006/excr.1999.4670_RF49",
      "doi-asserted-by": "crossref",
      "first-page": "1568",
      "DOI": "10.1007/s000180050396",
      "article-title": "Negative regulators of cytokine signal transduction",
      "volume": "55",
      "author": "Hilton",
      "year": "1999",
      "journal-title": "CMLS, Cell. Mol. Life Sci."
    },
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      "DOI": "10.1016/0092-8674(95)90351-8",
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      "volume": "80",
      "author": "Klingm\u00fcller",
      "year": "1995",
      "journal-title": "Cell"
    },
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      "volume": "21",
      "author": "Starr",
      "year": "1999",
      "journal-title": "BioEssays"
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      "first-page": "114",
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      "volume": "95",
      "author": "Hilton",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "volume": "95",
      "author": "Naka",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "DOI": "10.1073/pnas.95.24.14395",
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      "volume": "95",
      "author": "Starr",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
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      "doi-asserted-by": "crossref",
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      "DOI": "10.1101/sqb.1999.64.397"
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      "key": "10.1006/excr.1999.4670_RF56",
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      "volume": "12",
      "author": "Kamura",
      "year": "1998",
      "journal-title": "Genes Dev."
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      "first-page": "3359",
      "DOI": "10.1093/emboj/18.12.3359",
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      "volume": "18",
      "author": "Konietzko",
      "year": "1999",
      "journal-title": "EMBO J."
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      "key": "10.1006/excr.1999.4670_RF58",
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      "first-page": "1535",
      "DOI": "10.1007/s000180050393",
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      "volume": "55",
      "author": "Kovarik",
      "year": "1999",
      "journal-title": "CMLS, Cell. Mol. Life Sci."
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      "volume": "8",
      "author": "Schindler",
      "year": "1998",
      "journal-title": "Trends Cell Biol."
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      "key": "10.1006/excr.1999.4670_RF60",
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      "first-page": "1990",
      "DOI": "10.1126/science.7701321",
      "article-title": "Requirement of serine phosphorylation for formation of STAT-promoter complexes",
      "volume": "267",
      "author": "Zhang",
      "year": "1995",
      "journal-title": "Science"
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      "volume": "82",
      "author": "Wen",
      "year": "1995",
      "journal-title": "Cell"
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      "volume": "272",
      "author": "Chin",
      "year": "1996",
      "journal-title": "Science"
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      "article-title": "Activation of STAT transcription factors in oncogenic tyrosine kinase signaling",
      "volume": "5",
      "author": "Garcia",
      "year": "1998",
      "journal-title": "J. Biomed. Sci."
    },
    {
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      "first-page": "295",
      "DOI": "10.1016/S0092-8674(00)81959-5",
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      "volume": "98",
      "author": "Bromberg",
      "year": "1999",
      "journal-title": "Cell"
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      "volume": "189",
      "author": "Kiuchi",
      "year": "1999",
      "journal-title": "J. Exp. Med."
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      "volume": "10",
      "author": "Catlett-Falcone",
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      "volume": "278",
      "author": "Kumar",
      "year": "1997",
      "journal-title": "Science"
    },
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      "DOI": "10.1101/sqb.1999.64.465",
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      "author": "Taniguchi",
      "year": "1999",
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      "article-title": "Targeted disruption of IRF-1 and IRF-2 results in abnormal type I IFN gene induction and abarrant lymphocyte development",
      "volume": "75",
      "author": "Matsuyama",
      "year": "1993",
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