DOI: 10.1002/yea.320091114. <i>AFG2</i>, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP‐1 family of putative ATPases

AFG2, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP‐1 family of putative ATPases

10.1002/yea.320091114

Crossref journal-article

Wiley

Yeast (311)

Abstract

AbstractA gene from Saccharomyces cerevisiae was sequenced that encodes a protein with homology to a family of putative ATPases. These homologous proteins include the yeast cell division cycle protein Cdc48p and its mammalian homologues VCP and p97; Sec18p and its mammalian homologue NSF, proteins necessary for fusion of transport vesicles to target membranes in the secretory pathway; Pas1p, a protein necessary for peroxisome biosynthesis in yeast; Yme1p, a yeast mitochondrial protein that influences the rate of DNA escape from mitochondria; and TBP‐1, MSS1 and Sug1p, proteins that interact with transcription factors. This newly sequenced gene, named AFG2 for ATPase family gene, is located on chromosome XII 5′ to the SLP1/VPS33 open reading reading frame and encodes an essential protein of 780 amino acids that is most homologous to Cdc48p.

Authors 3

Peter E. Thorsness (first)
Karen H. White (additional)
Weoi‐Choo Ong (additional)

References 18 Referenced 19

10.1128/MCB.10.9.4638
10.1093/nar/16.5.1861
10.1016/S0021-9258(18)37843-8 / J. Biol. Chem. / Sequence of the lon gene in Escherichia coli: A heat shock gene which encodes the ATP‐dependent protease La by Chin D. T. (1988)
10.1128/MCB.8.10.4098
10.1016/0092-8674(91)90234-P
10.1083/jcb.114.3.443
10.1038/325542a0
10.1002/yea.320080912
10.1111/j.1475-4754.1982.tb01001.x
10.1126/science.2194290
10.1002/j.1460-2075.1990.tb08300.x
10.1038/357700a0
10.1038/357698a0
10.1093/genetics/134.1.21
Thorsness P. E. White K. H.andFox T. D.(1993). Inactivation ofYME1 a gene coding a member of theSEC18 PAS1 CDC48family of putative ATPases causes increased escape of DNA from mitochondria inSaccharomyces cerevisiae.Submitted. (10.1128/MCB.13.9.5418)
10.1128/jb.175.5.1344-1351.1993
10.1128/MCB.10.5.2214
10.1038/339355a0

Dates

Type	When
Created	20 years, 2 months ago (May 28, 2005, 7:41 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 9:38 p.m.)
Indexed	5 months ago (March 22, 2025, 4:50 a.m.)
Issued	31 years, 9 months ago (Nov. 1, 1993)
Published	31 years, 9 months ago (Nov. 1, 1993)
Published Online	21 years, 6 months ago (Jan. 29, 2004)
Published Print	31 years, 9 months ago (Nov. 1, 1993)

Funders 0

None

BibTeX

@article{Thorsness_1993, title={AFG2, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP‐1 family of putative ATPases}, volume={9}, ISSN={1097-0061}, url={http://dx.doi.org/10.1002/yea.320091114}, DOI={10.1002/yea.320091114}, number={11}, journal={Yeast}, publisher={Wiley}, author={Thorsness, Peter E. and White, Karen H. and Ong, Weoi‐Choo}, year={1993}, month=nov, pages={1267–1271} }

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