DOI: 10.1002/yea.1071. Binding of Cdc48p to a ubiquitin‐related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation

Binding of Cdc48p to a ubiquitin‐related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation

10.1002/yea.1071

Crossref journal-article

Wiley

Yeast (311)

Abstract

AbstractThe Cdc48/p97 AAA‐ATPase functions in membrane fusion and ubiquitin‐dependent protein degradation. Here, we show that, in yeast, Cdc48p interacts with three novel proteins, Cuil–3p, which contain a conserved ubiquitin‐related (UBX) domain. Cui2p and Cui3p are closely related, interact with each other, and are localized at the perinuclear membrane. Cdc48p binds directly the UBX domain of Cui3p in vitro. Multiple deletions of the CUI1, CUI2 and CUI3 genes confer deficiency in sporulation and degradation of model ubiquitin–protein fusions. The Cuil–3 proteins were also found to interact with Ufd3p, a WD repeat protein known to associate with Cdc48p. Together, these results indicate that the Cuil–3 proteins form complexes that are components of the ubiquitin–proteasome system. Copyright © 2003 John Wiley & Sons, Ltd.

Bibliography

Decottignies, A., Evain, A., & Ghislain, M. (2003). Binding of Cdc48p to a ubiquitinârelated UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Yeast, 21(2), 127â139. Portico.

Authors 3

Anabelle Decottignies (first)
Aude Evain (additional)
Michel Ghislain (additional)

References 39 Referenced 56

Dates

Type	When
Created	21 years, 7 months ago (Jan. 27, 2004, 3 a.m.)
Deposited	1 year, 10 months ago (Oct. 6, 2023, 2:23 p.m.)
Indexed	1 month, 2 weeks ago (July 20, 2025, 12:26 a.m.)
Issued	21 years, 8 months ago (Dec. 19, 2003)
Published	21 years, 8 months ago (Dec. 19, 2003)
Published Online	21 years, 8 months ago (Dec. 19, 2003)
Published Print	21 years, 7 months ago (Jan. 30, 2004)

Funders 0

None

BibTeX

@article{Decottignies_2003, title={Binding of Cdc48p to a ubiquitin‐related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation}, volume={21}, ISSN={1097-0061}, url={http://dx.doi.org/10.1002/yea.1071}, DOI={10.1002/yea.1071}, number={2}, journal={Yeast}, publisher={Wiley}, author={Decottignies, Anabelle and Evain, Aude and Ghislain, Michel}, year={2003}, month=dec, pages={127–139} }

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