The significant other: splicing by the minor spliceosome
10.1002/wrna.1141
Crossref journal-article
Wiley
WIREs RNA (311)
Abstract

AbstractThe removal of non‐coding sequences, introns, from the mRNA precursors is an essential step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns, distinct from the major or U2‐type introns. U12‐type introns are present in most eukaryotes but only account for less than 0.5% of all introns in any given genome. They are processed by a specific U12‐dependent spliceosome, which is similar to, but distinct from, the major spliceosome. U12‐type introns are spliced somewhat less efficiently than the major introns, and it is believed that this limits the expression of the genes containing such introns. Recent findings on the role of U12‐dependent splicing in development and human disease have shown that it can also affect multiple cellular processes not directly related to the functions of the host genes of U12‐type introns. At the same time, advances in understanding the regulation and phylogenetic distribution of the minor spliceosome are starting to shed light on how the U12‐type introns and the minor spliceosome may have evolved. WIREs RNA 2013, 4:61–76. doi: 10.1002/wrna.1141This article is categorized under: RNA Processing > Splicing Mechanisms

Bibliography

Turunen, J. J., Niemelä, E. H., Verma, B., & Frilander, M. J. (2012). The significant other: splicing by the minor spliceosome. WIREs RNA, 4(1), 61–76. Portico.

Authors 4
  1. Janne J. Turunen (first)
  2. Elina H. Niemelä (additional)
  3. Bhupendra Verma (additional)
  4. Mikko J. Frilander (additional)
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Dates
Type When
Created 12 years, 10 months ago (Oct. 16, 2012, 3:31 p.m.)
Deposited 1 year, 11 months ago (Sept. 25, 2023, 4:15 a.m.)
Indexed 3 hours, 42 minutes ago (Sept. 3, 2025, 6:32 a.m.)
Issued 12 years, 10 months ago (Oct. 16, 2012)
Published 12 years, 10 months ago (Oct. 16, 2012)
Published Online 12 years, 10 months ago (Oct. 16, 2012)
Published Print 12 years, 8 months ago (Jan. 1, 2013)
Funders 0

None

@article{Turunen_2012, title={The significant other: splicing by the minor spliceosome}, volume={4}, ISSN={1757-7012}, url={http://dx.doi.org/10.1002/wrna.1141}, DOI={10.1002/wrna.1141}, number={1}, journal={WIREs RNA}, publisher={Wiley}, author={Turunen, Janne J. and Niemelä, Elina H. and Verma, Bhupendra and Frilander, Mikko J.}, year={2012}, month=oct, pages={61–76} }