DOI: 10.1002/tox.10145. Population growth impairment of aliphatic alcohols to <i>Tetrahymena</i>

Population growth impairment of aliphatic alcohols to Tetrahymena

10.1002/tox.10145

Crossref journal-article

Wiley

Environmental Toxicology (311)

Abstract

AbstractThe toxicity of a series of 120 aliphatic alcohols was evaluated using the Tetrahymena pyriformis population growth impairment assay. For tertiary propargylic alcohols; primary, secondary, and tertiary homopropargylic alcohols; allylic alcohols; and saturated alcohols, a statistically robust structure‐activity model was developed for toxicity data [log (IGC50−1)] using the 1‐octanol/water partition coefficient (log Kow) as the lone descriptor [log (IGC50)−1 = 0.74 (log Kow) − 1.73; n = 97; r2 (adj.) = 0.933; r2 (pred.) = 0.932; s = 0.298; F = 1328; Pr > F = 0.0001]. Analysis of data for the primary propargylic alcohols yielded a separate, high‐quality log Kow‐dependent quantitative structure‐activity relationship (QSAR) [log (IGC50)−1 = 0.65 (log Kow) − 1.22; n = 10; r2 (adj.) = 0.969; r2 (pred.) = 0.964; s = 0.222; F = 254; Pr > F = 0.0001]. A comparison of the observed toxicity and that predicted by the first QSAR showed that the primary propargylic alcohols with log Kow values < 2.00 exhibited enhanced toxicity and that this increased toxicity was inversely related to hydrophobicity. In sharp contrast, analysis of the data for the secondary propargylic alcohols exhibited little relationship with log Kow (r2 = 0.339). Although the initial QSAR can be used to model the toxicity of any aliphatic alcohol for the T. pyriformis population growth impairment end point, the estimated potency would be underestimated for primary propargylic alcohols with log Kow values < 2.00. Moreover, estimates of toxic potency of secondary propargylic alcohols based on this QSAR should be viewed with limited confidence. The findings for β‐unsaturated alcohols in Tetrahymena were sharply different from that reported for fathead minnow acute mortality; this difference in toxicity is a result of a difference in the protocol used rather than in metabolism. © 2004 Wiley Periodicals, Inc. Environ Toxicol 19: 1–10, 2004.

Bibliography

Schultz, T. W., SewardâNagel, J., Foster, K. A., & Tucker, V. A. (2004). Population growth impairment of aliphatic alcohols to Tetrahymena. Environmental Toxicology, 19(1), 1â10. Portico.

Authors 4

T. Wayne Schultz (first)
Julie Seward‐Nagel (additional)
Karen A. Foster (additional)
Vera A. Tucker (additional)

References 24 Referenced 20

10.3109/01480549709003877
10.1007/s002449900269
10.1006/eesa.1997.1547
10.1080/10629369808039153
{'key': 'e_1_2_1_6_1', 'series-title': 'Environmental toxicology and risk assessment', 'first-page': '319', 'author': 'Bearden AP', 'year': '1999'} / Environmental toxicology and risk assessment by Bearden AP (1999)
10.1002/etc.5620100907
{'key': 'e_1_2_1_8_1', 'series-title': 'Aquatic toxicology and risk assessment', 'first-page': '267', 'author': 'Dawson DA', 'year': '1990'} / Aquatic toxicology and risk assessment by Dawson DA (1990)
10.3109/10408448909037471
10.1002/qsar.19960150405
10.1016/0300-483X(81)90130-X
{'key': 'e_1_2_1_12_1', 'first-page': '39', 'volume-title': 'QSAR in toxicology and xenobiochemistry', 'author': 'Lipnick RL', 'year': '1985'} / QSAR in toxicology and xenobiochemistry by Lipnick RL (1985)
10.1016/0048-9697(91)90175-E
10.3109/00498258709044200
10.1289/ehp.8771171
10.1002/qsar.19930120204
{'key': 'e_1_2_1_17_1', 'series-title': "SAS/STAT user's guide, version 6", 'first-page': '846', 'author': 'SAS Institute, Inc.', 'year': '1989'} / SAS/STAT user's guide, version 6 by SAS Institute, Inc. (1989)
10.1080/105172397243079
10.1007/BF00201645
10.1007/BF00192030
10.1002/etc.5620170912
10.1016/S0932-4739(00)80032-2
10.1016/S0166-445X(00)00158-2
10.1139/f83-096
10.3109/00498258909042295

Dates

Type	When
Created	21 years, 7 months ago (Jan. 29, 2004, 5 a.m.)
Deposited	1 year, 10 months ago (Oct. 12, 2023, 6:37 a.m.)
Indexed	1 year, 10 months ago (Oct. 17, 2023, 8:31 a.m.)
Issued	21 years, 7 months ago (Jan. 27, 2004)
Published	21 years, 7 months ago (Jan. 27, 2004)
Published Online	21 years, 7 months ago (Jan. 27, 2004)
Published Print	21 years, 6 months ago (Feb. 1, 2004)

Funders 0

None

BibTeX

@article{Schultz_2004, title={Population growth impairment of aliphatic alcohols to Tetrahymena}, volume={19}, ISSN={1522-7278}, url={http://dx.doi.org/10.1002/tox.10145}, DOI={10.1002/tox.10145}, number={1}, journal={Environmental Toxicology}, publisher={Wiley}, author={Schultz, T. Wayne and Seward‐Nagel, Julie and Foster, Karen A. and Tucker, Vera A.}, year={2004}, month=jan, pages={1–10} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>The toxicity of a series of 120 aliphatic alcohols was evaluated using the <jats:italic>Tetrahymena pyriformis</jats:italic> population growth impairment assay. For tertiary propargylic alcohols; primary, secondary, and tertiary homopropargylic alcohols; allylic alcohols; and saturated alcohols, a statistically robust structure\u2010activity model was developed for toxicity data [log (IGC<jats:sub>50</jats:sub><jats:sup>\u22121</jats:sup>)] using the 1\u2010octanol/water partition coefficient (log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub>) as the lone descriptor [log (IGC<jats:sub>50</jats:sub>)<jats:sup>\u22121</jats:sup> = 0.74 (log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub>) \u2212 1.73; <jats:italic>n</jats:italic> = 97; <jats:italic>r</jats:italic><jats:sup>2</jats:sup> (adj.) = 0.933; <jats:italic>r</jats:italic><jats:sup>2</jats:sup> (pred.) = 0.932; <jats:italic>s</jats:italic> = 0.298; <jats:italic>F</jats:italic> = 1328; <jats:italic>Pr</jats:italic> &gt; <jats:italic>F</jats:italic> = 0.0001]. Analysis of data for the primary propargylic alcohols yielded a separate, high\u2010quality log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub>\u2010dependent quantitative structure\u2010activity relationship (QSAR) [log (IGC<jats:sub>50</jats:sub>)<jats:sup>\u22121</jats:sup> = 0.65 (log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub>) \u2212 1.22; <jats:italic>n</jats:italic> = 10; <jats:italic>r</jats:italic><jats:sup>2</jats:sup> (adj.) = 0.969; <jats:italic>r</jats:italic><jats:sup>2</jats:sup> (pred.) = 0.964; <jats:italic>s</jats:italic> = 0.222; <jats:italic>F</jats:italic> = 254; <jats:italic>Pr</jats:italic> &gt; <jats:italic>F</jats:italic> = 0.0001]. A comparison of the observed toxicity and that predicted by the first QSAR showed that the primary propargylic alcohols with log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub> values &lt; 2.00 exhibited enhanced toxicity and that this increased toxicity was inversely related to hydrophobicity. In sharp contrast, analysis of the data for the secondary propargylic alcohols exhibited little relationship with log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub> (<jats:italic>r</jats:italic><jats:sup>2</jats:sup> = 0.339). Although the initial QSAR can be used to model the toxicity of any aliphatic alcohol for the <jats:italic>T. pyriformis</jats:italic> population growth impairment end point, the estimated potency would be underestimated for primary propargylic alcohols with log <jats:italic>K</jats:italic><jats:sub>ow</jats:sub> values &lt; 2.00. Moreover, estimates of toxic potency of secondary propargylic alcohols based on this QSAR should be viewed with limited confidence. The findings for \u03b2\u2010unsaturated alcohols in <jats:italic>Tetrahymena</jats:italic> were sharply different from that reported for fathead minnow acute mortality; this difference in toxicity is a result of a difference in the protocol used rather than in metabolism. \u00a9 2004 Wiley Periodicals, Inc. Environ Toxicol 19: 1\u201310, 2004.</jats:p>",
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