DOI: 10.1002/tera.1420310212. Hyperthermia as a teratogen: Parameters determining hyperthermia‐induced head defects in the rat

Hyperthermia as a teratogen: Parameters determining hyperthermia‐induced head defects in the rat

10.1002/tera.1420310212

Crossref journal-article

Wiley

Teratology (311)

Abstract

AbstractThis study determined the relationship between the duration and extent of temperature elevation, during a critical period of rat embryonic development, and the induction of congenital malformations. Pregnant Sprague‐Dawley rats, at 9 days 12 hours gestation (gastrulation stage), were partially immersed in a water bath until their core temperature, monitored by a rectal thermistor probe, was elevated to a nominated temperature. Seven temperatures were tested from 40.5°C to 43.5°C, elevations of 2.0–5.0°C in core temperature. Various durations at each of these temperatures were tested for potential teratogenicity. A single elevation of 5.0°C or 4.5°C needed only a “spike” in duration to be teratogenic, 4.0°C was teratogenic within 5 minutes, 3.5°C within 10 minutes, 3.0°C within 20 minutes, and 2.5°C within 1 hour. An elevation of 2.0°C for 8 hours was not teratogenic. Microphthalmia was the most common malformation at all teratogenic temperatures and was frequently the only malformation seen at the shortest time exposure for a particular temperature. Encephalocele, facial clefting, and maxillary hypoplasia were the other frequently seen malformations. Five control rats were placed in the water bath for 2 hours at 38°C so that their core temperature was not elevated. All the control fetuses were normal. An elevation of 2.5°C for 1 hour was the threshold combination for teratogenesis. As the temperature increased above a 2.5°C elevation the necessary duration of exposure for teratogenesis decreased.

Bibliography

Germain, M., Webster, W. S., & Edwards, M. J. (1985). Hyperthermia as a teratogen: Parameters determining hyperthermiaâinduced head defects in the rat. Teratology, 31(2), 265â272. Portico.

Authors 3

Mary‐Ann Germain (first)
William S. Webster (additional)
Marshall J. Edwards (additional)

References 44 Referenced 113

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{'key': 'e_1_2_1_5_1', 'first-page': '94', 'volume-title': 'Proceedings of the Greenwood Genetic Center', 'author': 'Chernoff G. F.', 'year': '1983'} / Proceedings of the Greenwood Genetic Center by Chernoff G. F. (1983)
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{'key': 'e_1_2_1_14_1', 'first-page': '335', 'volume-title': 'Fetal Brain Disorders–Recent Approaches to the Problem of Mental Deficiency', 'author': 'Edwards M. J.', 'year': '1981'} / Fetal Brain Disorders–Recent Approaches to the Problem of Mental Deficiency by Edwards M. J. (1981)
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{'key': 'e_1_2_1_16_1', 'first-page': '593', 'article-title': 'Mitotic cell death and delay in mitotic activity in guinea pig embryos following brief maternal hyperthermia', 'volume': '32', 'author': 'Edwards M. J.', 'year': '1974', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. / Mitotic cell death and delay in mitotic activity in guinea pig embryos following brief maternal hyperthermia by Edwards M. J. (1974)
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{'key': 'e_1_2_1_18_1', 'first-page': '95', 'volume-title': 'Proceeding of the Greenwood Genetic Centre', 'author': 'Finnell R. H.', 'year': '1983'} / Proceeding of the Greenwood Genetic Centre by Finnell R. H. (1983)
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{'key': 'e_1_2_1_25_1', 'first-page': '557', 'article-title': 'Thermal injury due to normal body temperature', 'volume': '66', 'author': 'Johnson H. A.', 'year': '1972', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Thermal injury due to normal body temperature by Johnson H. A. (1972)
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{'key': 'e_1_2_1_30_1', 'first-page': '154', 'article-title': 'Maternal health in early pregnancy and congenital defect. Final report on a prospective study', 'volume': '15', 'author': 'McDonald A. D.', 'year': '1961', 'journal-title': 'Brit. J. Prev. Soc. Med.'} / Brit. J. Prev. Soc. Med. / Maternal health in early pregnancy and congenital defect. Final report on a prospective study by McDonald A. D. (1961)
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{'key': 'e_1_2_1_40_1', 'first-page': '1275', 'article-title': 'Effects of exposure to Finnish sauna', 'volume': '12', 'author': 'Sohar E.', 'year': '1976', 'journal-title': 'Israel J. Med. Sci.'} / Israel J. Med. Sci. / Effects of exposure to Finnish sauna by Sohar E. (1976)
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Dates

Type	When
Created	20 years, 2 months ago (June 11, 2005, 8:15 p.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 5:02 p.m.)
Indexed	1 year, 3 months ago (May 17, 2024, 8:58 a.m.)
Issued	40 years, 5 months ago (April 1, 1985)
Published	40 years, 5 months ago (April 1, 1985)
Published Online	20 years, 3 months ago (May 23, 2005)
Published Print	40 years, 5 months ago (April 1, 1985)

Funders 0

None

BibTeX

@article{Germain_1985, title={Hyperthermia as a teratogen: Parameters determining hyperthermia‐induced head defects in the rat}, volume={31}, ISSN={1096-9926}, url={http://dx.doi.org/10.1002/tera.1420310212}, DOI={10.1002/tera.1420310212}, number={2}, journal={Teratology}, publisher={Wiley}, author={Germain, Mary‐Ann and Webster, William S. and Edwards, Marshall J.}, year={1985}, month=apr, pages={265–272} }

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        1985,
        4
      ]
    ]
  }
}