DOI: 10.1002/tera.1420250215. Mitotic index in mouse embryos with 6‐aminonicotinamide‐induced and inherited cleft lip

Mitotic index in mouse embryos with 6‐aminonicotinamide‐induced and inherited cleft lip

10.1002/tera.1420250215

Crossref journal-article

Wiley

Teratology (311)

Abstract

AbstractThree types of cleft lip were studied histologically before and during lip formation in mouse embryos. C57BL/6 embryos observed near term following treatment with 6‐aminonicotinamide (6AN) at gestation D9/12 (vp day = day 0) had 18% median cleft lip. Treated embryos observed at D10 and D11 showed retarded somite and nasal placode development. Sections at lip closure time showed marked reduction of medial and some reduction of lateral nasal processes, and the mitotic index was significantly reduced in the nasal area on D10 and D11 but less consistently in the neural area. 6AN‐treatment on D10/8, caused 22% lateral cleft lip. Treated embryos showed initial retardation of somite and nasal placode development that became normal by D11/14. Sections showed reduction of the medial and lateral nasal processes, and less organized denser nasal ectoderm. The mitotic index was significantly reduced in the nasal and neural areas on D10 and D11. In crosses having the major gene mutation dancer (Dc) 20% of embryos had lateral cleft lip and potential cleft lip mutant embryos showed reduced lateral and medial nasal processes. Mitotic index was not reduced in the nasal area but it was in the neural area. The CL/Fr strain, with a predisposing face shape in which 26% of the embryos have cleft lip of multifactorial origin, had a mitotic index similar to that of C57BL/6 (0% cleft lip) at lip closure time, D11/14, and prominent medial nasal processes. It is postulated that 6AN‐induced median cleft lip is due to reduced cell proliferation in and size of the medial nasal processes; 6AN‐induced lateral cleft lip to reduced cell proliferation and reduced medial and lateral nasal processes and dancer lateral cleft lip to reduction of the medial nasals.

Bibliography

Trasler, D. G., & Leong, S. (1982). Mitotic index in mouse embryos with 6âaminonicotinamideâinduced and inherited cleft lip. Teratology, 25(2), 259â265. Portico.

Authors 2

Daphne G. Trasler (first)
Susanna Leong (additional)

References 11 Referenced 9

{'key': 'e_1_2_1_2_1', 'first-page': '543', 'article-title': 'A new gene affecting the morphogenesis of the vestibular part of the inner ear in the mouse', 'volume': '16', 'author': 'Deol M. S.', 'year': '1966', 'journal-title': 'J. Embryol. Exp. Morph.'} / J. Embryol. Exp. Morph. / A new gene affecting the morphogenesis of the vestibular part of the inner ear in the mouse by Deol M. S. (1966)
10.1002/tera.1420140106
Leong S.(1973)Face shape and mitotic index in mice with teratogen‐induced and inherited cleft lip. M.Sc. Thesis McGill University.
10.1159/000239633
10.1136/bmj.2.5193.195
10.1002/ar.1091950201
10.1002/tera.1420010106
10.1007/978-1-4615-8933-4_11
10.1002/tera.1420180108
10.1002/tera.1420190210
10.1002/tera.1420010111

Dates

Type	When
Created	20 years, 2 months ago (June 11, 2005, 10:41 a.m.)
Deposited	1 year, 9 months ago (Nov. 12, 2023, 4:38 a.m.)
Indexed	1 year, 8 months ago (Dec. 14, 2023, 4:01 p.m.)
Issued	43 years, 5 months ago (April 1, 1982)
Published	43 years, 5 months ago (April 1, 1982)
Published Online	20 years, 3 months ago (May 31, 2005)
Published Print	43 years, 5 months ago (April 1, 1982)

Funders 0

None

BibTeX

@article{Trasler_1982, title={Mitotic index in mouse embryos with 6‐aminonicotinamide‐induced and inherited cleft lip}, volume={25}, ISSN={1096-9926}, url={http://dx.doi.org/10.1002/tera.1420250215}, DOI={10.1002/tera.1420250215}, number={2}, journal={Teratology}, publisher={Wiley}, author={Trasler, Daphne G. and Leong, Susanna}, year={1982}, month=apr, pages={259–265} }

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