DOI: 10.1002/syn.10081. Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment

Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment

10.1002/syn.10081

Crossref journal-article

Wiley

Synapse (311)

Abstract

AbstractAntipsychotic drugs (APD) are used in the treatment of schizophrenia and other psychotic disorders and exert their effects, in part, through dopamine receptor blockade. APD treatment causes many changes in the brains of humans and experimental animals including therapeutic, pathologic, or changes associated with motor side effects. Typical APD given chronically to animals induce behavioral sequelae that mimic tardive dyskinesia in several ways. Our previous work has shown that chronic treatment with haloperidol decreases striatal synaptic density but that symmetric synapses are lost only in rats that develop oral dyskinesias. The goals of this study were to determine if the density of dopaminergic terminals was affected by chronic haloperidol treatment and/or correlated with dyskinesias. Rats were given haloperidol (1.5 mg/kg/rat) or water, as a control. After 6 months of treatment, rats were divided into nondyskinetic or dyskinetic groups according to the behavior scores determined in the last month. Striatal volume was similar between controls and drug‐treated rats. Synaptic density, calculated using stereological methods, was obtained from the matrix of the ventrolateral striatum. The density of symmetric synapses (mean ± SD, per 100/μm3) formed by tyrosine hydroxylase (TH) containing terminals in haloperidol treated rats (3.58 ± 1.64) was not significantly different from that of controls (3.06 ± 1.00). The density of TH‐labeled terminals forming symmetric synapses in the nondyskinetic group (3.65 ± 1.67) vs. the dyskinetic group (3.54 ± 1.73) was similar and neither was different from that of the controls. These data indicate that terminals other than dopaminergic ones form fewer symmetric synapses in dyskinetic rats. Moreover, these data have implications for interpreting results obtained in humans treated with typical antipsychotic drugs. Synapse 45:78–85, 2002. © 2002 Wiley‐Liss, Inc.

Bibliography

Roberts, R. C., Force, M., & Kung, L. (2002). Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment. Synapse, 45(2), 78â85. Portico.

Authors 3

Rosalinda C. Roberts (first)
Michelle Force (additional)
Lili Kung (additional)

References 50 Referenced 15

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 6, 2002, 7:32 a.m.)
Deposited	1 year, 9 months ago (Nov. 18, 2023, 10:51 a.m.)
Indexed	11 months, 4 weeks ago (Sept. 8, 2024, 6:14 a.m.)
Issued	23 years, 3 months ago (May 16, 2002)
Published	23 years, 3 months ago (May 16, 2002)
Published Online	23 years, 3 months ago (May 16, 2002)
Published Print	23 years, 1 month ago (Aug. 1, 2002)

Funders 0

None

BibTeX

@article{Roberts_2002, title={Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment}, volume={45}, ISSN={1098-2396}, url={http://dx.doi.org/10.1002/syn.10081}, DOI={10.1002/syn.10081}, number={2}, journal={Synapse}, publisher={Wiley}, author={Roberts, Rosalinda C. and Force, Michelle and Kung, Lili}, year={2002}, month=may, pages={78–85} }

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