DOI: 10.1002/smll.201100521. Multifunctional Mesoporous Silica Nanospheres with Cleavable Gd(III) Chelates as MRI Contrast Agents: Synthesis, Characterization, Target‐Specificity, and Renal Clearance

Multifunctional Mesoporous Silica Nanospheres with Cleavable Gd(III) Chelates as MRI Contrast Agents: Synthesis, Characterization, Target‐Specificity, and Renal Clearance

10.1002/smll.201100521

Crossref journal-article

Wiley

Small (311)

Abstract

AbstractMesoporous silica nanospheres (MSNs) are a promising material for magnetic resonance imaging (MRI) contrast agents. In this paper multifunctional MSNs with cleavable Gd(III) chelates are synthesized and characterized, and their applicability as MRI contrast agents is demonstrated both in vitro and in vivo. The MSNs contain Gd(III) chelates that are covalently linked via a redox‐responsive disulfide moiety. The MSNs are further functionalized with polyethylene glycol (PEG) and an anisamide ligand to improve their biocompatibility and target specificity. The effectiveness of MSNs as an MRI imaging contrast agent and their targeting ability are successfully demonstrated in vitro using human colon adenocarcinoma and pancreatic cancer cells. Finally, the capability of this platform as an in vivo MRI contrast agent is tested using a 3T scanner. The Gd(III) chelate was quickly cleaved by the blood pool thiols and eliminated through the renal excretion pathway. Further tuning of the Gd(III) chelate release kinetics is needed before the MSN system can be used as target‐specific MRI contrast agents in vivo.

Bibliography

ViveroâEscoto, J. L., TaylorâPashow, K. M. L., Huxford, R. C., Della Rocca, J., Okoruwa, C., An, H., Lin, W., & Lin, W. (2011). Multifunctional Mesoporous Silica Nanospheres with Cleavable Gd(III) Chelates as MRI Contrast Agents: Synthesis, Characterization, TargetâSpecificity, and Renal Clearance. Small, 7(24), 3519â3528. Portico.

Authors 8

Juan L. Vivero‐Escoto (first)
Kathryn M. L. Taylor‐Pashow (additional)
Rachel C. Huxford (additional)
Joseph Della Rocca (additional)
Christie Okoruwa (additional)
Hongyu An (additional)
Weili Lin (additional)
Wenbin Lin (additional)

References 42 Referenced 100

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Dates

Type	When
Created	13 years, 9 months ago (Nov. 9, 2011, 7:30 a.m.)
Deposited	1 year, 10 months ago (Oct. 7, 2023, 9:27 a.m.)
Indexed	16 hours, 6 minutes ago (Aug. 30, 2025, 1:12 p.m.)
Issued	13 years, 9 months ago (Nov. 9, 2011)
Published	13 years, 9 months ago (Nov. 9, 2011)
Published Online	13 years, 9 months ago (Nov. 9, 2011)
Published Print	13 years, 8 months ago (Dec. 16, 2011)

Funders 0

None

BibTeX

@article{Vivero_Escoto_2011, title={Multifunctional Mesoporous Silica Nanospheres with Cleavable Gd(III) Chelates as MRI Contrast Agents: Synthesis, Characterization, Target‐Specificity, and Renal Clearance}, volume={7}, ISSN={1613-6829}, url={http://dx.doi.org/10.1002/smll.201100521}, DOI={10.1002/smll.201100521}, number={24}, journal={Small}, publisher={Wiley}, author={Vivero‐Escoto, Juan L. and Taylor‐Pashow, Kathryn M. L. and Huxford, Rachel C. and Della Rocca, Joseph and Okoruwa, Christie and An, Hongyu and Lin, Weili and Lin, Wenbin}, year={2011}, month=nov, pages={3519–3528} }

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