DOI: 10.1002/smll.201000538. Biocompatibility, Biodistribution, and Drug‐Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

Biocompatibility, Biodistribution, and Drug‐Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

10.1002/smll.201000538

Crossref journal-article

Wiley

Small (311)

Abstract

AbstractMesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological, hematological, and histopathological examinations of blood samples and mouse tissues after MSN injection. Biodistribution studies using human cancer xenografts are carried out with in vivo imaging and fluorescent microscopy imaging, as well as with inductively coupled plasma mass spectroscopy. The results show that MSNs preferentially accumulate in tumors. Finally, the drug‐delivery capability of MSNs is demonstrated by following tumor growth in mice treated with camptothecin‐loaded MSNs. These results indicate that MSNs are biocompatible, preferentially accumulate in tumors, and effectively deliver drugs to the tumors and suppress tumor growth.

Bibliography

Lu, J., Liong, M., Li, Z., Zink, J. I., & Tamanoi, F. (2010). Biocompatibility, Biodistribution, and DrugâDelivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals. Small, 6(16), 1794â1805. Portico.

Authors 5

Jie Lu (first)
Monty Liong (additional)
Zongxi Li (additional)
Jeffrey I. Zink (additional)
Fuyuhiko Tamanoi (additional)

References 49 Referenced 946

10.1021/ja901831u
10.1016/j.yexmp.2008.12.004
10.1016/j.biomaterials.2009.09.048
10.1111/j.1551-2916.2008.02722.x
10.2174/138955708783498078
10.1002/smll.200700903
10.1002/smll.200700005
10.1021/nn900918w
10.1021/ja809346n
10.1002/chem.200900851
10.1016/j.biomaterials.2007.03.006
10.1021/jp064941v
10.1021/ja0645943
10.1039/b900559e
10.1039/b701744h
10.1021/ja028650l
10.1039/b904197d
10.1021/ol0612509
10.1021/ja0772086
10.1021/ja807798g
10.1002/anie.200705211
10.1021/nn700008s
10.1021/ja046275m
10.1007/978-1-59745-483-4_34
10.1016/j.addr.2008.03.012
10.1038/nnano.2007.108
10.1166/jnn.2005.146
10.1021/ja070245c
10.1021/nn800072t
10.1021/ja904982j
10.1021/ja9010157
10.1039/b910431c
10.1039/b9nr00162j
10.1002/anie.200805149
10.1002/smll.200700493
10.1002/smll.200701316
10.1002/anie.200802469
10.1016/j.biomaterials.2008.07.007
{'key': 'e_1_2_7_39_2', 'first-page': '6387', 'volume': '46', 'author': 'Matsumura Y.', 'year': '1986', 'journal-title': 'Cancer Res.'} / Cancer Res. by Matsumura Y. (1986)
{'key': 'e_1_2_7_40_2', 'first-page': '7', 'volume': '5', 'author': 'Muggia F. M.', 'year': '1999', 'journal-title': 'Clin. Cancer Res.'} / Clin. Cancer Res. by Muggia F. M. (1999)
10.1021/cm0210041
10.1007/s12030-008-9003-3
{'key': 'e_1_2_7_43_2', 'first-page': '319', 'volume': '49', 'author': 'Ullman‐Cullere M. H.', 'year': '1999', 'journal-title': 'Lab. Anim. Sci.'} / Lab. Anim. Sci. by Ullman‐Cullere M. H. (1999)
10.1021/ac801882g
10.1158/1535-7163.1505.3.12 / Mol. Cancer Ther. by Jhaveri M. S. (2004)
10.1002/adma.200801395
10.1165/rcmb.2006-0319OC
10.1021/nl803405h
10.1002/(SICI)1097-0320(19961101)25:3<271::AID-CYTO8>3.0.CO;2-I

Dates

Type	When
Created	15 years, 1 month ago (July 13, 2010, 6:28 a.m.)
Deposited	1 year, 10 months ago (Oct. 7, 2023, 7:40 a.m.)
Indexed	6 days, 8 hours ago (Aug. 26, 2025, 2:25 a.m.)
Issued	15 years, 1 month ago (July 7, 2010)
Published	15 years, 1 month ago (July 7, 2010)
Published Online	15 years, 1 month ago (July 7, 2010)
Published Print	15 years ago (Aug. 16, 2010)

Funders 0

None

BibTeX

@article{Lu_2010, title={Biocompatibility, Biodistribution, and Drug‐Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals}, volume={6}, ISSN={1613-6829}, url={http://dx.doi.org/10.1002/smll.201000538}, DOI={10.1002/smll.201000538}, number={16}, journal={Small}, publisher={Wiley}, author={Lu, Jie and Liong, Monty and Li, Zongxi and Zink, Jeffrey I. and Tamanoi, Fuyuhiko}, year={2010}, month=jul, pages={1794–1805} }

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