DOI: 10.1002/smll.200900520. A Surface‐Charge Study on Cellular‐Uptake Behavior of F3‐Peptide‐Conjugated Iron Oxide Nanoparticles

A Surface‐Charge Study on Cellular‐Uptake Behavior of F3‐Peptide‐Conjugated Iron Oxide Nanoparticles

10.1002/smll.200900520

Crossref journal-article

Wiley

Small (311)

Abstract

AbstractSurface‐charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta‐potential change to reveal the binding and internalization effects. The experimental results show a distinct pattern of Zeta‐potential change that allows the discrimination of human normal breast epithelial cells (MCF‐10A) from human cancer breast epithelial cells (MCF‐7) when the cells are incubated with dextran coated iron oxide nanoparticles that contain tumor‐homing F3 peptides, where the tumor‐homing F3 peptide specifically bound to nucleolin receptors that are overexpressed in cancer breast cells.

Bibliography

Zhang, Y., Yang, M., Park, J., Singelyn, J., Ma, H., Sailor, M. J., Ruoslahti, E., Ozkan, M., & Ozkan, C. (2009). A SurfaceâCharge Study on CellularâUptake Behavior of F3âPeptideâConjugated Iron Oxide Nanoparticles. Small, 5(17), 1990â1996. Portico.

Authors 9

Yu Zhang (first)
Mo Yang (additional)
Ji‐Ho Park (additional)
Jennifer Singelyn (additional)
Huiqing Ma (additional)
Michael J. Sailor (additional)
Erkki Ruoslahti (additional)
Mihrimah Ozkan (additional)
Cengiz Ozkan (additional)

References 38 Referenced 103

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10.1053/crad.2000.0673
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10.1124/jpet.106.101915
10.1109/TNB.2003.820277
{'key': 'e_1_2_7_8_2', 'first-page': '6641', 'volume': '60', 'author': 'Alexiou C.', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. by Alexiou C. (2000)
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10.1006/jcis.1998.6053
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{'key': 'e_1_2_7_25_2', 'volume-title': 'Zeta Potential in Colloid Science Principles and Applications', 'author': 'Hunter R. J.', 'year': '1981'} / Zeta Potential in Colloid Science Principles and Applications by Hunter R. J. (1981)
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{'key': 'e_1_2_7_33_2', 'first-page': '497', 'volume': '73', 'author': 'Derenzini M.', 'year': '1995', 'journal-title': 'Lab. Invest.'} / Lab. Invest. by Derenzini M. (1995)
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10.1002/adma.200800004
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10.1124/pr.58.1.8

Dates

Type	When
Created	16 years, 2 months ago (June 24, 2009, 10:20 a.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 10:58 a.m.)
Indexed	2 months, 2 weeks ago (June 19, 2025, 10:25 a.m.)
Issued	16 years ago (Aug. 26, 2009)
Published	16 years ago (Aug. 26, 2009)
Published Online	16 years ago (Aug. 26, 2009)
Published Print	15 years, 11 months ago (Sept. 4, 2009)

Funders 0

None

BibTeX

@article{Zhang_2009, title={A Surface‐Charge Study on Cellular‐Uptake Behavior of F3‐Peptide‐Conjugated Iron Oxide Nanoparticles}, volume={5}, ISSN={1613-6829}, url={http://dx.doi.org/10.1002/smll.200900520}, DOI={10.1002/smll.200900520}, number={17}, journal={Small}, publisher={Wiley}, author={Zhang, Yu and Yang, Mo and Park, Ji‐Ho and Singelyn, Jennifer and Ma, Huiqing and Sailor, Michael J. and Ruoslahti, Erkki and Ozkan, Mihrimah and Ozkan, Cengiz}, year={2009}, month=aug, pages={1990–1996} }

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