DOI: 10.1002/rcm.1066. Congener‐specific analysis of hexabromocyclododecane by high‐performance liquid chromatography/electrospray tandem mass spectrometry

Congener‐specific analysis of hexabromocyclododecane by high‐performance liquid chromatography/electrospray tandem mass spectrometry

10.1002/rcm.1066

Crossref journal-article

Wiley

Rapid Communications in Mass Spectrometry (311)

Abstract

AbstractA congener‐specific method based on high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ES‐MS/MS) in the negative ion mode was developed for the analysis of hexabromocyclododecane (HBCDD). On a C18 analytical column, with a methanol/water mobile phase, the α‐isomer was completely resolved from the β‐ and γ‐isomers while the β‐ and γ‐isomers were sufficiently resolved at half their peak heights. The ES spray voltage strongly influenced the intensity of the ion signal. For MS, a source temperature of 500°C and a collision energy of 50 eV were found to be optimum for the [M–H]− to Br− transition. Run‐to‐run and day‐to‐day (n = 3) variability was minimal, with relative standard deviations of 2.6–4.1 and 2.4–4.4%, respectively. The limit of detection was 4–6 pg on‐column. When applied to tissue samples from Lake Winnipeg fish both α‐ and γ‐isomers of HBCDD were found in low‐ng/g (lipid corrected) concentrations. Copyright © 2003 John Wiley & Sons, Ltd.

Bibliography

Budakowski, W., & Tomy, G. (2003). Congenerâspecific analysis of hexabromocyclododecane by highâperformance liquid chromatography/electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 17(13), 1399â1404. Portico.

Authors 2

Wesley Budakowski (first)
Gregg Tomy (additional)

References 13 Referenced 91

10.1016/S0045-6535(01)00225-9
YounesM.Proc. 2nd Int. Workshop on Brominated Flame Retardants Stockholm Sweden 2001;21–22.
10.1002/etc.5620210907
Brominated Diphenyl Ethers. Environmental Health Criteria 162 World Health Organization (ISBN 0250‐863X) Geneva 1994.
AriasPA.Proc. 2nd Int. Workshop on Brominated Flame Retardants Stockholm Sweden 2001;17–19.
American Chemical Council: Brominated Flame Retardant Industry Panel. Document Number AR201‐13459A.2001;2.
10.1002/etc.5620170612
LawRJ AllchinCR.Proc. 2nd Int. Workshop on Brominated Flame Retardants Stockholm Sweden 2001;139–141.
LundBO.Proc. 2nd Int. Workshop on Brominated Flame Retardants Stockholm Sweden 2001;31–32.
de BoerJ KorytarP.Proc. 2nd Int. Workshop on Brominated Flame Retardants Stockholm Sweden 2001;45–49.
10.1002/rcm.281
10.1021/ac961244y
10.1021/es00174a011

Dates

Type	When
Created	22 years, 2 months ago (June 18, 2003, 6:15 a.m.)
Deposited	1 year, 10 months ago (Oct. 15, 2023, 11:37 a.m.)
Indexed	1 year, 1 month ago (July 12, 2024, 9:55 a.m.)
Issued	22 years, 3 months ago (May 22, 2003)
Published	22 years, 3 months ago (May 22, 2003)
Published Online	22 years, 3 months ago (May 22, 2003)
Published Print	22 years, 1 month ago (July 15, 2003)

Funders 0

None

BibTeX

@article{Budakowski_2003, title={Congener‐specific analysis of hexabromocyclododecane by high‐performance liquid chromatography/electrospray tandem mass spectrometry}, volume={17}, ISSN={1097-0231}, url={http://dx.doi.org/10.1002/rcm.1066}, DOI={10.1002/rcm.1066}, number={13}, journal={Rapid Communications in Mass Spectrometry}, publisher={Wiley}, author={Budakowski, Wesley and Tomy, Gregg}, year={2003}, month=may, pages={1399–1404} }

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