DOI: 10.1002/prot.340230410. Hinge‐bending motion in citrate synthase arising from normal mode calculations

Hinge‐bending motion in citrate synthase arising from normal mode calculations

10.1002/prot.340230410

Crossref journal-article

Wiley

Proteins: Structure, Function, and Bioinformatics (311)

Abstract

AbstractA normal mode analysis of the closed form of dimeric citrate synthase has been performed. The largest‐amplitude collective motion predicted by this method compares well with the crystallographically observed hinge‐bending motion. Such a result supports those obtained previously in the case of hinge‐bending motions of smaller systems, such as lysozyme or hexokinase. Taken together, all these results suggest that low‐frequency normal modes may become useful for determining a first approximation of the conformational path between the closed and open forms of these proteins. © 1995 Wiley‐Liss, Inc.

Bibliography

Marques, O., & Sanejouand, Y. (1995). Hingeâbending motion in citrate synthase arising from normal mode calculations. Proteins: Structure, Function, and Bioinformatics, 23(4), 557â560. Portico.

Authors 2

Osni Marques (first)
Yves‐Henri Sanejouand (additional)

References 28 Referenced 168

10.1016/0022-2836(82)90452-1
10.1002/bip.360220136
10.1146/annurev.bb.15.060186.000525
10.1016/0022-2836(80)90103-5
10.1038/348263a0
{'key': 'e_1_2_1_7_2', 'volume-title': 'Classical Mechanics', 'author': 'Goldstein H.', 'year': '1950'} / Classical Mechanics by Goldstein H. (1950)
10.1073/pnas.82.15.4995
10.1002/prot.340080308
10.1002/prot.340100204
10.1002/bip.360330409
10.1002/bip.360231216
10.1038/262325a0
10.1021/bi00264a019
10.1073/pnas.79.4.1346
10.1002/bip.360321012
10.1002/bip.360340304
10.1002/bip.360340608
10.1006/jmbi.1993.1135
Perahia D.Application de la méthode des modes normaux à l'étude de la flexibilité des protéines. In “Images de la Recherche. Les systèmes moléculaires organisés.” Paris France: C.N.R.S. 1994:191–194.
Perahia D. Mouawad L.Computation of low‐frequency normal modes in macromolecules: Improvements to the method of diagonalization in a mixed basis and application to hemoglobin.Comput. Chem.1995 in press. (10.1016/0097-8485(95)00011-G)
{'key': 'e_1_2_1_22_2', 'volume-title': 'The Symmetric Eigenvalue Problem', 'author': 'Parlett B. N.', 'year': '1980'} / The Symmetric Eigenvalue Problem by Parlett B. N. (1980)
{'key': 'e_1_2_1_23_2', 'volume-title': 'A shifted block Lanczos algorithm for solving sparse symmetric eigenvalue problems', 'author': 'Grimes R. G.', 'year': '1991'} / A shifted block Lanczos algorithm for solving sparse symmetric eigenvalue problems by Grimes R. G. (1991)
10.1002/jcc.540040211
10.1002/bip.360320512
10.1002/prot.340160408
10.1016/0009-2614(87)80576-6
10.1107/S0021889891004399
10.1016/S0022-2836(77)80200-3

Dates

Type	When
Created	20 years, 2 months ago (May 28, 2005, 9:48 p.m.)
Deposited	1 year, 10 months ago (Oct. 26, 2023, 7:43 p.m.)
Indexed	3 weeks, 6 days ago (July 30, 2025, 11:20 a.m.)
Issued	29 years, 8 months ago (Dec. 1, 1995)
Published	29 years, 8 months ago (Dec. 1, 1995)
Published Online	21 years, 6 months ago (Feb. 3, 2004)
Published Print	29 years, 8 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Marques_1995, title={Hinge‐bending motion in citrate synthase arising from normal mode calculations}, volume={23}, ISSN={1097-0134}, url={http://dx.doi.org/10.1002/prot.340230410}, DOI={10.1002/prot.340230410}, number={4}, journal={Proteins: Structure, Function, and Bioinformatics}, publisher={Wiley}, author={Marques, Osni and Sanejouand, Yves‐Henri}, year={1995}, month=dec, pages={557–560} }

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