DOI: 10.1002/prot.340210208. A model of the complex between interleukin‐4 and its receptors

A model of the complex between interleukin‐4 and its receptors

10.1002/prot.340210208

Crossref journal-article

Wiley

Proteins: Structure, Function, and Bioinformatics (311)

Abstract

AbstractA three‐dimensional model of interleukin‐4 (IL‐4) bound to one molecule each of the high‐ and low‐affinity receptors (IL‐4R and IL‐2Rγ) was built, using the crystal structure of the complex of human growth hormone (HGH) with its receptor (HGHR) as a starting model. The modeling of IL‐4 with its receptors was based on the conservation of the sequences and on the predicted structural organization for cytokine receptors, and assuming that the binding mode of the ligands would be similar. Analysis of the interface between IL‐4 and both receptor molecules was carried out to reveal which residues are important for complex formation. The modeling procedures showed that there were no major problems in maintaining a reasonable fit of IL‐4 with the two receptor molecules, in a manner analogous to the complex of HGH–HGHR. Many of the residues that appear by modeling to be important for binding between IL‐4 and the receptors have been previously implicated in that role by different methods. A striking motif of aromatic and positively charged residues on the surface of the C‐terminal domains of the receptors is highly conserved in the structure of HGH–HGHR and in the models of IL‐4 complexed with its receptors. © 1995 Wiley‐Liss, Inc.

Bibliography

Gustchina, A., Zdanov, A., SchalkâHihi, C., & Wlodawer, A. (1995). A model of the complex between interleukinâ4 and its receptors. Proteins: Structure, Function, and Bioinformatics, 21(2), 140â148. Portico.

Authors 4

Alla Gustchina (first)
Alexander Zdanov (additional)
Céline Schalk‐Hihi (additional)
Alexander Wlodawer (additional)

References 53 Referenced 23

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Dates

Type	When
Created	20 years, 3 months ago (May 28, 2005, 9:39 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 2:18 p.m.)
Indexed	1 year, 7 months ago (Jan. 13, 2024, 12:27 a.m.)
Issued	30 years, 6 months ago (Feb. 1, 1995)
Published	30 years, 6 months ago (Feb. 1, 1995)
Published Online	21 years, 6 months ago (Feb. 3, 2004)
Published Print	30 years, 6 months ago (Feb. 1, 1995)

Funders 0

None

BibTeX

@article{Gustchina_1995, title={A model of the complex between interleukin‐4 and its receptors}, volume={21}, ISSN={1097-0134}, url={http://dx.doi.org/10.1002/prot.340210208}, DOI={10.1002/prot.340210208}, number={2}, journal={Proteins: Structure, Function, and Bioinformatics}, publisher={Wiley}, author={Gustchina, Alla and Zdanov, Alexander and Schalk‐Hihi, Céline and Wlodawer, Alexander}, year={1995}, month=feb, pages={140–148} }

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