DOI: 10.1002/prot.340090104. Rate of β‐structure formation in polypeptides

Rate of β‐structure formation in polypeptides

10.1002/prot.340090104

Crossref journal-article

Wiley

Proteins: Structure, Function, and Bioinformatics (311)

Abstract

AbstractAn explanation is suggested for why a marginally stable β‐structure folds extremely slowly; it is predicted that even a small increase in stability drastically accelerates β‐folding. According to the theory, this folding is a first‐order phase transition, and the rate‐limiting step is nucleation. The rate‐determining “nucleus” (transition state) is the smallest β‐sheet that is sufficiently large to provide an overall free energy reduction during subsequent folding. If the stability of the β‐structure is low, the nucleus is large and possesses a high free energy due to having a large perimeter. When the net stability of the final β‐structure increases (due to either an increase of the β‐sheet stability or a decrease in stability of the competing structures, e.g., α‐helices), the size and energy of a nucleus decrease and the rate of folding increases exponentially. This must result in a fast folding of polypeptides enriched by β‐forming residues (e.g., protein chains). The theory is developed for intramolecular β‐structure, but it can also explain the overall features of intermolecular β‐folding; it is applicable both to antiparallel and parallel β‐sheets. The difference in folding of β‐sheets, α‐helices, and proteins is discussed.

Bibliography

Finkelstein, A. V. (1991). Rate of Î²âstructure formation in polypeptides. Proteins: Structure, Function, and Bioinformatics, 9(1), 23â27. Portico.

Authors 1

A. V. Finkelstein (first)

References 32 Referenced 46

10.1021/bi00820a016
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10.1016/0301-4622(76)80002-6
10.1002/bip.360250904
10.1021/ma00192a022
10.1002/bip.1975.360141010
10.1002/bip.1975.360141116
10.1016/0014-5793(87)80363-0
10.1063/1.1730390
{'key': 'e_1_2_1_12_2', 'volume-title': 'Statistical Physics', 'author': 'Landau L. D.', 'year': '1959'} / Statistical Physics by Landau L. D. (1959)
{'key': 'e_1_2_1_13_2', 'first-page': '78', 'article-title': 'The theory of intramolecular cross β‐coil transitions', 'volume': '5', 'author': 'Birshtein T. M.', 'year': '1971', 'journal-title': 'Mol. Biol. (USSR)'} / Mol. Biol. (USSR) / The theory of intramolecular cross β‐coil transitions by Birshtein T. M. (1971)
10.1002/bip.1976.360150603
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{'key': 'e_1_2_1_17_2', 'volume-title': 'Melting and Crystal Structure', 'author': 'Ubbelohde A. R.', 'year': '1965'} / Melting and Crystal Structure by Ubbelohde A. R. (1965)
10.1002/bip.360240310
10.1016/S0022-2836(65)80171-1
{'key': 'e_1_2_1_20_2', 'volume-title': 'Proteins', 'author': 'Creighton T. E.', 'year': '1984'} / Proteins by Creighton T. E. (1984)
{'key': 'e_1_2_1_21_2', 'first-page': '340', 'article-title': 'Kinetics of the antiparallel β‐structure formation', 'volume': '4', 'author': 'Finkelstein A. V.', 'year': '1978', 'journal-title': 'Bioorgan. Khim. (USSR)'} / Bioorgan. Khim. (USSR) / Kinetics of the antiparallel β‐structure formation by Finkelstein A. V. (1978)
Cosani A. Terbojevich M. Romanin‐Jacur L. Peggion E.Potentiometric and circular dichroism studies of the coil‐β transitions of poly‐L‐lysine. Peptides Polypeptides and Proteins. Proc. Symp. Israel pp.166–176 1974.
10.1002/bip.360101112
{'key': 'e_1_2_1_24_2', 'first-page': '345', 'article-title': 'Secondary structure of the unfolded protein chain', 'volume': '4', 'author': 'Finkelstein A. V.', 'year': '1978', 'journal-title': 'Bioorgan. Khim. (USSR)'} / Bioorgan. Khim. (USSR) / Secondary structure of the unfolded protein chain by Finkelstein A. V. (1978)
10.1002/bip.1977.360160815
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10.1002/bip.360281004

Dates

Type	When
Created	20 years, 3 months ago (May 28, 2005, 9:14 p.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 9:49 p.m.)
Indexed	5 days, 7 hours ago (Aug. 26, 2025, 3:04 a.m.)
Issued	34 years, 7 months ago (Jan. 1, 1991)
Published	34 years, 7 months ago (Jan. 1, 1991)
Published Online	21 years, 6 months ago (Feb. 3, 2004)
Published Print	34 years, 7 months ago (Jan. 1, 1991)

Funders 0

None

BibTeX

@article{Finkelstein_1991, title={Rate of β‐structure formation in polypeptides}, volume={9}, ISSN={1097-0134}, url={http://dx.doi.org/10.1002/prot.340090104}, DOI={10.1002/prot.340090104}, number={1}, journal={Proteins: Structure, Function, and Bioinformatics}, publisher={Wiley}, author={Finkelstein, A. V.}, year={1991}, month=jan, pages={23–27} }

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