DOI: 10.1002/prot.20279. Sequence patterns associated with disordered regions in proteins

Sequence patterns associated with disordered regions in proteins

10.1002/prot.20279

Crossref journal-article

Wiley

Proteins: Structure, Function, and Bioinformatics (311)

Abstract

AbstractThe relationship between amino acid sequence and intrinsic disorder in proteins is investigated. Two databases, one of disordered proteins and the other of globular proteins, are analyzed and compared in order to extract simple sequence patterns of a few amino acids or amino acid properties that characterize disordered segments. It is found that a number of reliable, nonrandom associations exists. In particular, two types of patterns appear to be recurrent: a proline‐rich pattern and a (positively or negatively) charged pattern. These results indicate that local sequence information can determine disordered regions in proteins. The derived patterns provide some insights into the physical reasons for disordered structures. They should also be helpful in improving currently available prediction methods. Proteins 2005. © 2004 Wiley‐Liss, Inc.

Bibliography

Lise, S., & Jones, D. T. (2004). Sequence patterns associated with disordered regions in proteins. Proteins: Structure, Function, and Bioinformatics, 58(1), 144â150. Portico.

Authors 2

S. Lise (first)
D. T. Jones (additional)

References 27 Referenced 65

10.1016/S0959-440X(00)00099-3
10.1038/35093574
10.1006/jmbi.1999.3110
10.1021/bi012159
10.1110/ps.29401
10.1016/S1093-3263(00)00138-8
10.1046/j.1365-2443.2001.00384.x
10.1016/S0959-440X(02)00289-0
10.1110/ps.4210102
10.1002/1097-0134(20001115)41:3<415::AID-PROT130>3.0.CO;2-7
10.1002/1097-0134(20010101)42:1<38::AID-PROT50>3.0.CO;2-3
{'key': 'e_1_2_5_13_2', 'first-page': '172', 'article-title': 'Comparing predictors of disordered protein', 'volume': '11', 'author': 'Li X', 'year': '2000', 'journal-title': 'Genome Inform'} / Genome Inform / Comparing predictors of disordered protein by Li X (2000)
10.1016/S0065-3233(02)62004-2
10.1002/prot.10437
10.1002/prot.10528
10.1016/j.jmb.2004.02.002
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10.1016/S0022-2836(05)80195-0
10.1002/prot.340090108
Available online athttp://compbio.iupui.edu/dunker/html/www/Datasets/ALL_dis.htm
Available online athttp://compbio.iupui.edu/dunker/html/www/Datasets/O_PDB_S25_Aug99.htm
10.1002/pro.5560030317
10.1093/nar/gkh044
10.1093/nar/18.20.6097
10.1101/gr.849004
10.1110/ps.0237803

Dates

Type	When
Created	20 years, 10 months ago (Oct. 8, 2004, 6 p.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 3:05 p.m.)
Indexed	1 year ago (Aug. 9, 2024, 11:15 a.m.)
Issued	20 years, 10 months ago (Oct. 8, 2004)
Published	20 years, 10 months ago (Oct. 8, 2004)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Lise_2004, title={Sequence patterns associated with disordered regions in proteins}, volume={58}, ISSN={1097-0134}, url={http://dx.doi.org/10.1002/prot.20279}, DOI={10.1002/prot.20279}, number={1}, journal={Proteins: Structure, Function, and Bioinformatics}, publisher={Wiley}, author={Lise, S. and Jones, D. T.}, year={2004}, month=oct, pages={144–150} }

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