DOI: 10.1002/prot.10180. Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations

Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations

10.1002/prot.10180

Crossref journal-article

Wiley

Proteins: Structure, Function, and Bioinformatics (311)

Abstract

AbstractAn interesting example of an allosteric protein is the chaperonin GroEL. It undergoes adenosine 5′‐triphosphate‐induced conformational changes that are reflected in binding of adenosine 5′‐triphosphate with positive cooperativity within rings and negative cooperativity between rings. Herein, correlated mutations in chaperonins are analyzed to unravel routes of allosteric communication in GroEL and in its complex with its co‐chaperonin GroES. It is shown that analysis of correlated mutations in the chaperonin family can provide information about pathways of allosteric communication within GroEL and between GroEL and GroES. The results are discussed in the context of available structural, genetic, and biochemical data concerning short‐ and long‐range interactions in the GroE system. Proteins 2002;48:611–617. © 2002 Wiley‐Liss, Inc.

Bibliography

Kass, I., & Horovitz, A. (2002). Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations. Proteins: Structure, Function, and Bioinformatics, 48(4), 611â617. Portico.

Authors 2

Itamar Kass (first)
Amnon Horovitz (additional)

References 36 Referenced 157

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 6, 2002, 8:07 a.m.)
Deposited	1 year, 10 months ago (Oct. 15, 2023, 5:03 p.m.)
Indexed	4 months, 1 week ago (April 25, 2025, 4:25 p.m.)
Issued	23 years, 1 month ago (July 12, 2002)
Published	23 years, 1 month ago (July 12, 2002)
Published Online	23 years, 1 month ago (July 12, 2002)
Published Print	23 years ago (Sept. 1, 2002)

Funders 0

None

BibTeX

@article{Kass_2002, title={Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations}, volume={48}, ISSN={1097-0134}, url={http://dx.doi.org/10.1002/prot.10180}, DOI={10.1002/prot.10180}, number={4}, journal={Proteins: Structure, Function, and Bioinformatics}, publisher={Wiley}, author={Kass, Itamar and Horovitz, Amnon}, year={2002}, month=jul, pages={611–617} }

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