DOI: 10.1002/prot.10107. Emergence of highly designable protein‐backbone conformations in an off‐lattice model

Emergence of highly designable protein‐backbone conformations in an off‐lattice model

10.1002/prot.10107

Crossref journal-article

Wiley

Proteins: Structure, Function, and Bioinformatics (311)

Abstract

AbstractDespite the variety of protein sizes, shapes, and backbone configurations found in nature, the design of novel protein folds remains an open problem. Within simple lattice models it has been shown that all structures are not equally suitable for design. Rather, certain structures are distinguished by unusually high designability: the number of amino acid sequences for which they represent the unique lowest energy state; sequences associated with such structures possess both robustness to mutation and thermodynamic stability. Here we report that highly designable backbone conformations also emerge in a realistic off‐lattice model. The highly designable conformations of a chain of 23 amino acids are identified and found to be remarkably insensitive to model parameters. Although some of these conformations correspond closely to known natural protein folds, such as the zinc finger and the helix‐turn‐helix motifs, others do not resemble known folds and may be candidates for novel fold design. Proteins 2002;47:506–512. © 2002 Wiley‐Liss, Inc.

Bibliography

Miller, J., Zeng, C., Wingreen, N. S., & Tang, C. (2002). Emergence of highly designable proteinâbackbone conformations in an offâlattice model. Proteins: Structure, Function, and Bioinformatics, 47(4), 506â512. Portico.

Authors 4

Jonathan Miller (first)
Chen Zeng (additional)
Ned S. Wingreen (additional)
Chao Tang (additional)

References 38 Referenced 40

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Dates

Type	When
Created	20 years, 10 months ago (Oct. 27, 2004, 7:10 a.m.)
Deposited	1 year, 10 months ago (Oct. 16, 2023, 12:10 a.m.)
Indexed	2 months, 2 weeks ago (June 16, 2025, 9:07 a.m.)
Issued	23 years, 4 months ago (April 19, 2002)
Published	23 years, 4 months ago (April 19, 2002)
Published Online	23 years, 4 months ago (April 19, 2002)
Published Print	23 years, 2 months ago (June 1, 2002)

Funders 0

None

BibTeX

@article{Miller_2002, title={Emergence of highly designable protein‐backbone conformations in an off‐lattice model}, volume={47}, ISSN={1097-0134}, url={http://dx.doi.org/10.1002/prot.10107}, DOI={10.1002/prot.10107}, number={4}, journal={Proteins: Structure, Function, and Bioinformatics}, publisher={Wiley}, author={Miller, Jonathan and Zeng, Chen and Wingreen, Ned S. and Tang, Chao}, year={2002}, month=apr, pages={506–512} }

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