Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells
10.1002/pros.1063
Crossref journal-article
Wiley
The Prostate (311)
Abstract

AbstractBACKGROUNDMxi1, an antagonist of c‐Myc, maps to human chromosome 10q24‐q25, a region altered in a substantial fraction of prostate tumors. Mice deficient for Mxi1 exhibit significant prostate hyperplasia. We studied the ability of Mxi1 to act as a growth suppressor in prostate tumor cells.METHODSWe infected DU145 prostate carcinoma cells with an Mxi1‐expressing adenovirus (AdMxi1) in vitro, and measured Mxi1 expression, cell proliferation, soft agar colony formation, and cell cycle distribution. To explore mechanisms of Mxi1‐induced growth arrest, we performed gene expression analysis.RESULTSAdMxi1 infection resulted in reduced cell proliferation, reduced soft agar colony formation, and a higher proportion of cells in the G2/M phase of the cell cycle. This G2/M growth arrest was associated with elevated levels of cyclin B, and reduced levels of c‐MYC and MDM2.CONCLUSIONSThe ability of AdMxi1 to suppress prostate tumor cell proliferation supports a role for Mxi1 loss in the pathogenesis of a subset of human prostate cancers. Prostate 47:194–204, 2001. © 2001 Wiley‐Liss, Inc.

Bibliography

Taj, M. M., Tawil, R. J., Engstrom, L. D., Zeng, Z., Hwang, C., Sanda, M. G., & Wechsler, D. S. (2001). Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells. The Prostate, 47(3), 194–204. Portico.

Authors 7
  1. Mary M. Taj (first)
  2. Rana J. Tawil (additional)
  3. Lars D. Engstrom (additional)
  4. Zhi Zeng (additional)
  5. Clara Hwang (additional)
  6. Martin G. Sanda (additional)
  7. Daniel S. Wechsler (additional)
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Dates
Type When
Created 22 years, 11 months ago (Sept. 10, 2002, 7:06 p.m.)
Deposited 1 year, 9 months ago (Nov. 18, 2023, 4:11 a.m.)
Indexed 2 months, 1 week ago (June 26, 2025, 2:42 p.m.)
Issued 24 years, 4 months ago (May 1, 2001)
Published 24 years, 4 months ago (May 1, 2001)
Published Online 24 years, 4 months ago (May 1, 2001)
Published Print 24 years, 3 months ago (May 15, 2001)
Funders 0

None

@article{Taj_2001, title={Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells}, volume={47}, ISSN={1097-0045}, url={http://dx.doi.org/10.1002/pros.1063}, DOI={10.1002/pros.1063}, number={3}, journal={The Prostate}, publisher={Wiley}, author={Taj, Mary M. and Tawil, Rana J. and Engstrom, Lars D. and Zeng, Zhi and Hwang, Clara and Sanda, Martin G. and Wechsler, Daniel S.}, year={2001}, month=may, pages={194–204} }